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L

Laura García-Prat

Princess Margaret Cancer Centre
H指数:24
被引数:4,845

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Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features

B细胞急性淋巴细胞白血病的多能谱系潜能与特定的细胞起源和临床特征相关。

Nature Cancer
IF28.5
2025-06-270
PRE
Ilaria Iacobucci; Andy G. X. Zeng; Qingsong Gao; Laura Garcia-Prat; Pradyumna Baviskar; Sayyam Shah; Alex Murison; Veronique Voisin; Michelle Chan-Seng-Yue; Cheng Cheng; Chunxu Qu; Colin Bailey; Matthew Lear; Matthew T. Witkowski; Xin Zhou; Airen Zaldivar Peraza; Karishma Gangwani; Anjali S. Advani; Selina M. Luger; Mark R. Litzow; Jacob M. Rowe; Elisabeth M. Paietta; Wendy Stock; John E. Dick; Charles G. Mullighan
Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy

表位工程化的人造血干细胞免受CD123-targeted免疫疗法的影响

JOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
2023-09-2915
OAAI
Marone, Romina; Landmann, Emmanuelle; Devaux, Anna; Lepore, Rosalba; Seyres, Denis; Zuin, Jessica; Burgold, Thomas; Engdahl, Corinne; Capoferri, Giuseppina; Dell'Aglio, Alessandro; Larrue, Clement; Simonetta, Federico; Rositzka, Julia; Rhiel, Manuel; Andrieux, Geoffroy; Gallagher, Danielle N.; Schroder, Markus S.; Wiederkehr, Amelie; Sinopoli, Alessandro; Do Sacramento, Valentin; Haydn, Anna; Garcia-Prat, Laura; Divsalar, Christopher; Camus, Anna; Xu, Liwen; Bordoli, Lorenza; Schwede, Torsten; Porteus, Matthew; Tamburini, Jerome; Corn, Jacob E.; Cathomen, Toni; Cornu, Tatjana I.; Urlinger, Stefanie; Jeker, Lukas T.
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness
NATURE CELL BIOLOGY
IF19.1
2022-06-0632
OA
Thomas, Geethu Emily; Egan, Grace; Garcia-Prat, Laura; Botham, Aaron; Voisin, Veronique; Patel, Parasvi S.; Hoff, Fieke W.; Chin, Jordan; Nachmias, Boaz; Kaufmann, Kerstin B.; Khan, Dilshad H.; Hurren, Rose; Wang, Xiaoming; Gronda, Marcela; MacLean, Neil; O'Brien, Cristiana; Singh, Rashim P.; Jones, Courtney L.; Harding, Shane M.; Raught, Brian; Arruda, Andrea; Minden, Mark D.; Bader, Gary D.; Hakem, Razq; Kornblau, Steve; Dick, John E.; Schimmer, Aaron D.
Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target
BLOOD CANCER DISCOVERY
IF11.5
2021-10-076
OA
Vanner, Robert J.; Dobson, Stephanie M.; Gan, Olga, I; McLeod, Jessica; Schoof, Erwin M.; Grandal, Ildiko; Wintersinger, Jeff A.; Garcia-Prat, Laura; Hosseini, Mohsen; Xie, Stephanie Z.; Jin, Liqing; Mbong, Nathan; Voisin, Veronique; Chan-Seng-Yue, Michelle; Kennedy, James A.; Waanders, Esme; Morris, Quaid; Porse, Bo; Chan, Steven M.; Guidos, Cynthia J.; Danska, Jayne S.; Minden, Mark D.; Mullighan, Charles G.; Dick, John E.
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate
CELL STEM CELL
IF20.4
2021-10-0178
OAAI
Garcia-Prat, Laura; Kaufmann, Kerstin B.; Schneiter, Florin; Voisin, Veronique; Murison, Alex; Chen, Jocelyn; Chan-Seng-Yue, Michelle; Gan, Olga, I; McLeod, Jessica L.; Smith, Sabrina A.; Shoong, Michelle C.; Parris, Darrien; Pan, Kristele; Zeng, Andy G. X.; Krivdova, Gabriela; Gupta, Kinam; Takayanagi, Shin-Ichiro; Wagenblast, Elvin; Wang, Weijia; Lupien, Mathieu; Schroeder, Timm; Xie, Stephanie Z.; Dick, John E.
Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia
CANCER DISCOVERY
IF33.3
2021-06-0899
OA
Montefiori, Lindsey E.; Bendig, Sonja; Gu, Zhaohui; Chen, Xiaolong; Polonen, Petri; Ma, Xiaotu; Murison, Alex; Zeng, Andy; Garcia-Prat, Laura; Dickerson, Kirsten; Iacobucci, Ilaria; Abdelhamed, Sherif; Hiltenbrand, Ryan; Mead, Paul E.; Mehr, Cyrus M.; Xu, Beisi; Cheng, Zhongshan; Chang, Ti-Cheng; Westover, Tamara; Ma, Jing; Stengel, Anna; Kimura, Shunsuke; Qu, Chunxu; Valentine, Marcus B.; Rashkovan, Marissa; Luger, Selina; Litzow, Mark R.; Rowe, Jacob M.; den Boer, Monique L.; Wang, Victoria; Yin, Jun; Kornblau, Steven M.; Hunger, Stephen P.; Loh, Mignon L.; Pui, Ching-Hon; Yang, Wenjian; Crews, Kristine R.; Roberts, Kathryn G.; Yang, Jun J.; Relling, Mary, V; Evans, William E.; Stock, Wendy; Paietta, Elisabeth M.; Ferrando, Adolfo A.; Zhang, Jinghui; Kern, Wolfgang; Haferlach, Torsten; Wu, Gang; Dick, John E.; Klco, Jeffery M.; Haferlach, Claudia; Mullighan, Charles G.
The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization
CELL STEM CELL
IF20.4
2021-03-0149
OAAI
Takayama, Naoya; Murison, Alex; Takayanagi, Shin-ichiro; Arlidge, Christopher; Zhou, Stanley; Garcia-Prat, Laura; Chan-Seng-Yue, Michelle; Zandi, Sasan; Gan, Olga, I; Boutzen, Helena; Kaufmann, Kerstin B.; Trotman-Grant, Aaron; Schoof, Erwin; Kron, Ken; Diaz, Noelia; Lee, John J. Y.; Medina, Tiago; De Carvalho, Daniel D.; Taylor, Michael D.; Vaquerizas, Juan M.; Xie, Stephanie Z.; Dick, John E.; Lupien, Mathieu
Biological and therapeutic implications of a unique subtype of NPM1 mutated AML
NATURE COMMUNICATIONS
IF15.7
2021-02-1630
OAAI
Mer, Arvind Singh; Heath, Emily M.; Tonekaboni, Seyed Ali Madani; Dogan-Artun, Nergiz; Nair, Sisira Kadambat; Murison, Alex; Garcia-Prat, Laura; Shlush, Liran; Hurren, Rose; Voisin, Veronique; Bader, Gary D.; Nislow, Corey; Rantalainen, Mattias; Lehmann, Soren; Gower, Mark; Guidos, Cynthia J.; Lupien, Mathieu; Dick, John E.; Minden, Mark D.; Schimmer, Aaron D.; Haibe-Kains, Benjamin
Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote Differentiation
BLOOD CANCER DISCOVERY
IF11.5
2021-01-1331
OA
Xie, Stephanie Z.; Kaufmann, Kerstin B.; Wang, Weijia; Chan-Seng-Yue, Michelle; Gan, Olga, I; Laurenti, Elisa; Garcia-Prat, Laura; Takayanagi, Shin-Ichiro; Ng, Stanley W. K.; Xu, ChangJiang; Zeng, Andy G. X.; Jin, Liqing; McLeod, Jessica; Wagenblast, Elvin; Mitchell, Amanda; Kennedy, James A.; Liu, Qiang; Boutzen, Helena; Kleinau, Melissa; Jargstorf, Joseph; Holmes, Gareth; Zhang, Yang; Voisin, Veronique; Bader, Gary D.; Wang, Jean C. Y.; Hannun, Yusuf A.; Luberto, Chiara; Schroeder, Timm; Minden, Mark D.; Dick, John E.
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
NATURE CELL BIOLOGY
IF19.1
2020-10-26110
OAAI
Garcia-Prat, Laura; Perdiguero, Eusebio; Alonso-Martin, Sonia; Dell'Orso, Stefania; Ravichandran, Srikanth; Brooks, Stephen R.; Juan, Aster H.; Campanario, Silvia; Jiang, Kan; Hong, Xiaotong; Ortet, Laura; Ruiz-Bonilla, Vanessa; Flandez, Marta; Moiseeva, Victoria; Rebollo, Elena; Jardi, Merce; Sun, Hong-Wei; Musaro, Antonio; Sandri, Marco; Sol, Antonio del; Sartorelli, Vittorio; Munoz-Canoves, Pura
Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs
CANCER DISCOVERY
IF33.3
2020-04-0177
OAAI
Dobson, Stephanie M.; Garcia-Prat, Laura; Vanner, Robert J.; Wintersinger, Jeffrey; Waanders, Esme; Gu, Zhaohui; McLeod, Jessica; Gan, Olga I.; Grandal, Ildiko; Payne-Turner, Debbie; Edmonson, Michael N.; Ma, Xiaotu; Fan, Yiping; Voisin, Veronique; Chan-Seng-Yue, Michelle; Xie, Stephanie Z.; Hosseini, Mohsen; Abelson, Sagi; Gupta, Pankaj; Rusch, Michael; Shao, Ying; Olsen, Scott R.; Neale, Geoffrey; Chan, Steven M.; Bader, Gary; Easton, John; Guidos, Cynthia J.; Danska, Jayne S.; Zhang, Jinghui; Minden, Mark D.; Morris, Quaid; Mullighan, Charles G.; Dick, John E.
Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal
CELL STEM CELL
IF20.4
2019-11-0180
OAAI
Xie, Stephanie Z.; Garcia-Prat, Laura; Voisin, Veronique; Ferrari, Robin; Gan, Olga I.; Wagenblast, Elvin; Kaufmann, Kerstin B.; Zeng, Andy G. X.; Takayanagi, Shin-ichiro; Patel, Ishita; Lee, Esther K.; Jargstorf, Joseph; Holmes, Gareth; Romm, Guy; Pan, Kristele; Shoong, Michelle; Vedi, Aditi; Luberto, Chiara; Minden, Mark D.; Bader, Gary D.; Laurenti, Elisa; Dick, John E.

研究方向

暂未获取到该数据
J
John E. Dick
H 指数:107论文数:833被引数:6.5万
P
Pura Muñoz‐Cánoves
H 指数:61论文数:225被引数:1.6万
V
Véronique Voisin
H 指数:35论文数:173被引数:7,324
M
Michelle Chan‐Seng‐Yue
H 指数:45论文数:227被引数:1.8万
S
Stephanie Z. Xie
H 指数:23论文数:123被引数:3,423
O
Olga I. Gan
H 指数:31论文数:192被引数:6,404
A
Andy G.X. Zeng
H 指数:15论文数:185被引数:1,403
K
Kerstin B. Kaufmann
H 指数:24论文数:135被引数:3,104
M
Mark D. Minden
H 指数:92论文数:1,259被引数:4.4万
G
Gary D. Bader
H 指数:125论文数:702被引数:10.3万