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S

Sabina Signoretti

Dana-Farber Cancer Institute
H指数:130
被引数:9.6万

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Final results and predictive biomarkers of response and long-term outcomes with first-line pembrolizumab monotherapy in advanced renal cell carcinoma in the phase II KEYNOTE-427 study

KEYNOTE-427研究：晚期肾细胞癌患者接受一线帕博利珠单抗单药治疗的最终结果、疗效预测生物标志物及长期结局

Annals of Oncology
IF65.4
2026-09-290
PRE
D.F. McDermott; S. Signoretti; J.-L. Lee; F. Donskov; S.S. Tykodi; P. Tomczak; G.A. Bjarnason; J.M.G. Larkin; M.D. Kochenderfer; R.A. Gafanov; R. Cristescu; J. Markensohn; M. Nebozhyn; Y. Zhang; X. Peng; K. Rodriguez-Lopez; J. Burgents; R.F. Perini; M.B. Atkins
70 Lymphocyte Hsp70 is a Novel Predictive Biomarker for Response to Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma

70 淋巴细胞Hsp70是转移性肾细胞癌对免疫检查点抑制剂反应的新型预测生物标志物

Oncologist
IF4.2
2026-09-020
OAAI
Ethan Burns; Soki Kashima; Rishabh Rout; Miya Hugaboom; Mustafa Saleh; Zhaochen Ye; Nicholas Schindler; Anasuya Dighe; Maxine Sun; Gwo-Shu Mary Lee; Wenxin Xu; Michael Atkins; Sabina Signoretti; Bradley McGregor; Rana McKay; Toni Choueiri; David Braun
75 Transcriptional Correlates of ARNT Expression and its Impact on Survival Outcomes in Clear-Cell Renal Cell Carcinoma (ccRCC)

75 ARNT表达的相关转录特征及其对透明细胞肾细胞癌(ccRCC)生存结局的影响

Oncologist
IF4.2
2026-09-020
OAAI
Wassim Daoud Khatoun; Ali Hajj Ali; Eddy Saad; Mustafa Saleh; Jad El Masri; Pablo Barrios; Chris Labaki; Harry Kane; Kevin Meli; Renee Maria Saliby; Ro Malik; Sabina Signoretti; David McDermott; Rana McKay; Eli Van Allen; David Braun; Toni Choueiri
51 Discovery of Exhausted CD8+ T-cell States Associated with Clinical Outcomes in Renal Cell Carcinoma

51 与肾细胞癌临床结局相关的耗竭CD8+ T细胞状态的发现

Oncologist
IF4.2
2026-09-020
OAAI
Zhaochen Ye; Soki Kashima; Rishabh Rout; Colin Laughlin; Nicholas Schindler; Ro Malik; Maxine Sun; Mustafa Saleh; Gwo-Shu Mary Lee; Wenxin Xu; Sabina Signoretti; Michael Hurwitz; Adebowale Adeniran; Peter Humphrey; Patrick Kenney; Bradley McGregor; Rana Mckay; Toni Choueiri; David Braun
8 Single Cell Transcriptomic Investigation of Renal Cell Carcinoma (RCC) Reveals Tissue Resident Memory Exhausted CD8+ T Cell Signature Associated with Resistance to Immune Checkpoint Inhibition (ICI)

8 单细胞转录组学分析揭示肾细胞癌（RCC）中与免疫检查点抑制（ICI）耐药性相关的组织驻留记忆耗竭型CD8+ T细胞特征

Oncologist
IF4.2
2026-09-020
OAAI
Rishabh Rout; Soki Kashima; Miya Hugaboom; Zhaochen Ye; Nicholas Schindler; Anasuya Dighe; Maxine Sun; Mustafa Saleh; Gwo-Shu Mary Lee; Wenxin Xu; Sabina Signoretti; Bradley McGregor; Rana R McKay; Toni Choueiri; David A Braun; null
Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma

融合驱动致癌程序塑造重排型肾细胞癌的免疫景观

Nature Communications
IF15.7
2026-08-260
OA
Prathyusha Konda; Alexandra J. Wakolbinger; Yantong Cui; Gabriel Roberti de Oliveira; Yasmin L. Nabil; Cary N. Weiss; Maxwell D. Seager; Riva Deodhar; Jiao Li; Sayed Matar; Jinyu Wang; Jack Horst; Sabrina Y. Camp; Aseman B. Sheshdeh; Jonathan L. Hecht; David J. Einstein; Yashika Rustagi; Anwesha Nag; Aaron R. Thorner; Cheng-Zhong Zhang; Eliezer M. Van Allen; Sabina Signoretti; Toni K. Choueiri; Srinivas R. Viswanathan
Tertiary lymphoid structures harbour stem-like tumour-specific T cells

三级淋巴结构中存在干细胞样肿瘤特异性T细胞

Nature
IF48.5
2026-07-220
PRE
Alexander B. Afeyan; Adi Nagler; Chloe R. Tu; Gabriel Roberti De Oliveira; Berkay Simsek; Maxwell D. Seager; Nourhan El Ahmar; Haley E. Sax; Emma Lin; Amit Sud; Mehdi Borji; Cleo Forman; Sophia Liu; Patrick A. Ott; Toni K. Choueiri; Jennifer G. Abelin; Richard Burack; Shuqiang Li; Kenneth J. Livak; Svitlana Tyekucheva; Derin B. Keskin; Fei Chen; Michael B. Atkins; Jeremy M. Simon; Sabina Signoretti; Giacomo Oliveira; David A. Braun; Catherine J. Wu
Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells

单核多模态空间转录组学揭示表达新抗原的肿瘤细胞与其配体T细胞的共定位

Nature Biotechnology
IF41.7
2026-07-220
PRE
Adi Nagler; Amit Sud; Jack Y. Ghannam; Lucas Pomerance; Camila Robles-Oteiza; Alexander B. Afeyan; Jackson A. Weir; Andrew J. C. Russell; Wesley S. Lu; McKayla Van Orden; Andrea Sonnenholzner; Giovanni J. Marrero; Qiyu Gong; Vipin Kumar; Kun Huang; Chloe Tu; Emma Lin; Bohoon Shim; Gabriel R. De Oliveira; MacLean C. Sellars; Charles H. Yoon; David A. Reardon; Toni K. Choueiri; Lars R. Olsen; Sabina Signoretti; Patrick A. Ott; David A. Braun; Giacomo Oliveira; Shuqiang Li; Kenneth J. Livak; Nir Hacohen; Fei Chen; Catherine J. Wu
Pan-tumor harmonization of pathologic response assessment for standardized data collection in neoadjuvant trials (PATHdata): results of a Society for Immunotherapy of Cancer multi-institutional reproducibility study

Deutsch, J.; Cottrell, T.; Chen, K.; De Andrea, C.; Baraban, E.; Fiset, P.; Jedrych, J.; Orr, C.; Real, F.; Salgado, R.; 等. 新辅助临床试验中病理反应评估的泛肿瘤标准化数据收集（PATHdata）：癌症免疫治疗学会多机构可重复性研究的结果。Ann. Oncol. 2026, 在印刷中。 [Google Scholar] [CrossRef]

Annals of Oncology
IF65.4
2026-02-020
PRE
J.S. Deutsch; T.R. Cottrell; K.Y. Chen; C.E. De Andrea; E. Baraban; P.O. Fiset; J.J. Jedrych; C.E. Orr; F.X. Real; R. Salgado; C.M. Schürch; R.A. Scolyer; R. Seethala; L.M. Sholl; S. Signoretti; M. Tetzlaff; H. Wang; T. Wang; A. Weissferdt; X. Xu
The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs

SLC1A1/EAAT3二羧基氨基酸转运蛋白是一种表观遗传失调的营养载体，可维持致癌性代谢程序。

Nature Communications
IF15.7
2025-11-140
OAAI
Treg Grubb; Pooneh Koochaki; Sayed Matar; Fatme Ghandour; Marc Machaalani; Eddy Saad; Cerise Tang; Eduard Reznik; Jesminara Khatun; Carleigh Salem; Noah Dubasik; David A. Orlando; Matthew G. Guenther; Gyanu Parajuli; Raghvendra M. Srivastava; Steven R. Martinez; Jesse A. Coker; Ritesh R. Kotecha; A. Ari Hakimi; John M. Asara; Timothy A. Chan; Sakari Vanharanta; Shaun R. Stauffer; William G. Kaelin; Sabina Signoretti; Toni K. Choueiri; Abhishek A. Chakraborty
Updated pan-tumor guidelines for neoadjuvant scoring of pathologic response: A joint SITC and INMC effort

病理反应新辅助评分的更新的全肿瘤指南: SITC和INMC的联合努力

Annals of Oncology
IF65.4
2025-11-040
PRE
J.S. Deutsch; R.A. Scolyer; E. Burton; K.J. Busam; K.Y. Chen; A. Cimino-Mathews; T.R. Cottrell; C.E. de Andrea; P.O. Fiset; G.V. Long; J. Messina; R.V. Rawson; R. Salgado; C.M. Schürch; R.R. Seethala; L.M. Sholl; S. Signoretti; S.L. Topalian; B.A. van de Wiel; X. Xu; J.E. Gershenwald; M.T. Tetzlaff; J.M. Taube
Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma
JOURNAL OF IMMUNOLOGY
IF3.4
2025-11-010
PRE
Wirth, Lena Vanessa; Hugaboom, Miya B.; Street, Kelly; Ruthen, Neil; Jegede, Opeyemi; Schindler, Nicholas; Shah, Valisha; Zaemes, Jacob; El Ahmar, Nourhan; Matar, Sayed; Savla, Varunika; Choueiri, Toni; Denize, Thomas; West, Destiny; Mcdermott, David F.; Plimack, Elizabeth R.; Sosman, Jeffrey; Haas, Naomi; Hurwitz, Michael E.; Hammers, Hans; Stein, Mark; Alter, Robert; Bilen, Mehmet; Signoretti, Sabina; Atkins, Michael B.; Wu, Catherine J.; Braun, David
Author Correction: An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

作者更正：异常的SREBP依赖性脂生成程序促进转移性前列腺癌

Nature Genetics
IF29
2025-10-220
OAAI
Ming Chen; Jiangwen Zhang; Katia Sampieri; John G. Clohessy; Lourdes Mendez; Enrique Gonzalez-Billalabeitia; Xue-Song Liu; Yu-Ru Lee; Jacqueline Fung; Jesse M. Katon; Archita Venugopal Menon; Kaitlyn A. Webster; Christopher Ng; Maria Dilia Palumbieri; Moussa S. Diolombi; Susanne B. Breitkopf; Julie Teruya-Feldstein; Sabina Signoretti; Roderick T. Bronson; John M. Asara; Mireia Castillo-Martin; Carlos Cordon-Cardo; Pier Paolo Pandolfi
International neoadjuvant kidney cancer consortium guidelines on assessing pathological response after neoadjuvant therapy in kidney cancer

国际肾癌新辅助治疗联合研究组关于评估肾癌新辅助治疗后病理反应的指南

ONCOLOGIST
IF4.2
2025-10-010
OAAI
Jones, James; Blackmur, James; van der Mijn, Koen; Warren, Anne; Browning, Lisa; Burgers, Femke; Hirsch, Michelle S.; Kapur, Payal; Mehra, Rohit; Rao, Priya; Signoretti, Sabina; Bex, Axel; Stewart, Grant; van Montfoort, Maurits
Integrative clinical, genomic, transcriptomic, and immunopathologic characterization of circulating KIM-1 in metastatic RCC

整合临床、基因组学、转录组学和免疫病理学特征，对转移性RCC外周血中KIM-1的综合性研究

ONCOLOGIST
IF4.2
2025-10-010
OAAI
Machaalani, Marc; Saliby, Renee Maria; Zhong, Caiwei; Saad, Eddy; Steiner, Clara; Yekeduz, Emre; Ascione, Liliana; Saleh, Mustafa; Masri, Jad El; Barrios, Pablo; Liu, Xiaowen; Cai, Ti; Sun, Maxine; Lee, Gwo-Shu Mary; Xie, Wanling; Signoretti, Sabina; McDermott, David; Choueri, Toni; Xu, Wenxin (Vincent)
The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs

SLC1A1/EAAT3二羧基氨基酸转运蛋白是一种表观遗传失调的营养载体，能够维持致癌性代谢程序。

ONCOLOGIST
IF4.2
2025-10-010
OAAI
Grubb, Treg; Koochaki, Pooneh; Matar, Sayed; Ghandour, Fatme; Machaalani, Marc; Saad, Eddy; Tang, Cerise; Reznik, Eduard; Khatun, Jesminara; Salem, Carleigh; Dubasik, Noah; Orlando, David A.; Guenther, Matthew G.; Parajuli, Gyanu; Srivastava, Raghvendra M.; Martinez, Steven R.; Coker, Jesse; Kotecha, Ritesh; Hakimi, A. Ari; Asara, John; Chan, Timothy; Vanharanta, Sakari; Stauffer, Shaun; Kaelin, William G.; Signoretti, Sabina; Choueri, Toni; Chakraborty, Abhishek
Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma

三级淋巴结构的存在和耗竭性组织驻留T细胞决定了肾细胞癌对PD-1阻断的临床反应

ONCOLOGIST
IF4.2
2025-10-010
OAAI
Wirth, Lena; Hugaboom, Miya; Street, Kelly; Ruthen, Neil; Jegede, Opeyemi; Schindler, Nicholas; Shah, Valisha; Zaemes, Jacob; El Ahmar, Nourhan; Matar, Sayed; Savla, Varunika; Choueri, Toni; Denize, Thomas; West, Destiny; Mcdermott, David; Plimack, Elizabeth; Sosman, Jeffrey A.; Haas, Naomi B.; Hurwitz, Michael; Hammers, Hans J.; Stein, Mark N.; Alter, Robert; Bilen, Mehmet; Signoretti, Sabina; Atkins, Michael B.; Wu, Catherine; Braun, David
fusion derived oncogenic programs shape the immune landscape in translocation renal cell carcinoma

融合衍生致癌程序塑造易位性肾细胞癌的免疫景观

ONCOLOGIST
IF4.2
2025-10-010
OAAI
Konda, Prathyusha; Weiss, Cary; Cui, Yantong; Wang, Jinyu; Matar, Sayed; Laimon, Yasmin Nabil; Sheshdeh, Aseman; Deodhar, Riva; Camp, Sabrina; Horst, Jack; Hecht, Jonathan; Einstein, David; Nag, Anwesha; Thorner, Aaron; Van Allen, Eliezer; Zhang, Cheng-Zhong; Signoretti, Sabina; Choueri, Toni; Viswanathan, Srinivas
Single-cell dissection of immunosuppressive myeloid subclusters driving resistance to immune checkpoint therapy in renal cell carcinoma (RCC)

单细胞解析驱动肾细胞癌（RCC）对免疫检查点疗法产生耐药性的免疫抑制性髓系亚群。

ONCOLOGIST
IF4.2
2025-10-010
OAAI
Kashima, Soki; Rout, Rishabh; Hugaboom, Miya; Ye, Zhaochen; Schindler, Nicholas; Dighe, Anasuya; Sun, Maxine; Lee, Gwo-Shu Mary; Xu, Wenxin (Vincent); Signoretti, Sabina; McGregor, Bradley A.; McKay, Rana; Choueri, Toni; Braun, David

研究方向

暂未获取到该数据
T
Toni K. Choueiri
H 指数:149论文数:2,478被引数:12.6万
M
Massimo Loda
H 指数:133论文数:1,585被引数:8.0万
D
David F. McDermott
H 指数:109论文数:1,058被引数:8.8万
M
Michael B. Atkins
H 指数:121论文数:1,038被引数:9.3万
E
Eliezer M. Van Allen
H 指数:112论文数:1,455被引数:8.0万
D
David A. Braun
H 指数:36论文数:471被引数:7,405
P
Pier Paolo Pandolfi
H 指数:160论文数:818被引数:10.7万
Y
Yasmin Nabil Laimon
H 指数:7论文数:36被引数:228
W
William G. Kaelin
H 指数:138论文数:495被引数:6.8万
B
Bradley A. McGregor
H 指数:36论文数:501被引数:7,219