未登录 Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story Moraru, Ruxandra; Valle-Argos, Beatriz; Minton, Annabel; Buermann, Lara; Pan, Suyin; Wales, Thomas E.; Joseph, Raji E.; Andreotti, Amy H.; Strefford, Jonathan C.; Packham, Graham; Baud, Matthias G. J. 分享 收藏
Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL 网络分析揭示了14q32簇mirna在确定IGHV突变和未突变CLL之间的转录差异中的主要作用 Bryant, Dean; Smith, Lindsay; Rogers-Broadway, Karly Rai; Karydis, Laura; Woo, Jeongmin; Blunt, Matthew D.; Forconi, Francesco; Stevenson, Freda K.; Goodnow, Christopher; Russell, Amanda; Humburg, Peter; Packham, Graham; Steele, Andrew J.; Strefford, Jonathan C. 分享 收藏
Inhibition of the Single Downstream Target BAG1 Activates the Latent Apoptotic Potential of MYC Zhang, Xiao-Yong; Pfeiffer, Harla K.; Mellert, Hestia S.; Stanek, Timothy J.; Sussman, Robyn T.; Kumari, Alpana; Yu, Duonan; Rigoutsos, Isidore; Thomas-Tikhonenko, Andrei; Seidel, Hans E.; Chodosh, Lewis A.; Packham, Graham; Baserga, Renato; McMahon, Steven B. 分享 收藏
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B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells B细胞受体信号通过MEK1/2和mTORC1诱导恶性b细胞中PDCD4的蛋白酶体降解 Taylor, Joe; Wilmore, Sarah; Marriot, Sophie; Rogers-Broadway, Karly-Rai; Fell, Rachel; Minton, Annabel R.; Branch, Tom; Ashton-Key, Meg; Coldwell, Mark; Stevenson, Freda K.; Forconi, Francesco; Steele, Andrew J.; Packham, Graham; Yeomans, Alison 分享 收藏
Editor's Note: miR-153 Supports Colorectal Cancer Progression via Pleiotropic Effects That Enhance Invasion and Chemotherapeutic Resistance Zhang, Lei; Pickard, Karen; Jenei, Veronika; Bullock, Marc D.; Bruce, Amanda; Mitter, Richard; Kelly, Gavin; Paraskeva, Christos; Strefford, John; Primrose, John; Thomas, Gareth J.; Packham, Graham; Mirnezami, Alex H. 分享 收藏
Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells 靶向抑制eIF4A抑制b细胞受体诱导的慢性淋巴细胞白血病细胞中MYC和MCL1的翻译和表达 Wilmore, Sarah; Rogers-Broadway, Karly-Rai; Taylor, Joe; Lemm, Elizabeth; Fell, Rachel; Stevenson, Freda K.; Forconi, Francesco; Steele, Andrew J.; Coldwell, Mark; Packham, Graham; Yeomans, Alison 分享 收藏
DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity 滤泡性淋巴瘤中dc-sign与甘露糖基化b细胞受体的结合下调了受体的信号传导能力 Valle-Argos, Beatriz; Chiodin, Giorgia; Bryant, Dean J.; Taylor, Joe; Lemm, Elizabeth; Duriez, Patrick J.; Rock, Philip J.; Strefford, Jonathan C.; Forconi, Francesco; Burack, Richard W.; Packham, Graham; Stevenson, Freda K. 分享 收藏
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Synthesis of Carboxamide-Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia Teresa Borrello, Maria; Benelkebir, Hanae; Lee, Adam; Hin Tam, Chak; Shafat, Manar; Rushworth, Stuart A.; Bowles, Kristian M.; Douglas, Leon; Duriez, Patrick J.; Bailey, Sarah; Crabb, Simon J.; Packham, Graham; Ganesan, A. 分享 收藏
BET inhibitors synergize with venetoclax to induce apoptosis in MYC-driven lymphomas with high BCL-2 expression BET抑制剂与venetoclax协同诱导MYC驱动的BCL-2高表达淋巴瘤的凋亡 Cummin, Thomas E. C.; Cox, Kerry L.; Murray, Tom D.; Turaj, Anna H.; Dunning, Lisa; English, Vikki L.; Fell, Rachel; Packham, Graham; Ma, Yan; Powell, Ben; Johnson, Peter W. M.; Cragg, Mark S.; Carter, Matthew J. 分享 收藏
Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells Lemm, Elizabeth A.; Valle-Argos, Beatriz; Smith, Lindsay D.; Richter, Johanna; Gebreselassie, Yohannes; Carter, Matthew J.; Karolova, Jana; Svaton, Michael; Helman, Karel; Weston-Bell, Nicola J.; Karydis, Laura; Williamson, Chris T.; Lenz, Georg; Pettigrew, Jeremy; Harwig, Curtis; Stevenson, Freda K.; Cragg, Mark; Forconi, Francesco; Steele, Andrew J.; Cross, Jennifer; Mackenzie, Lloyd; Klener, Pavel; Packham, Graham 分享 收藏
Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications (vol 34, pg 462, 2020) Arruga, Francesca; Bracciama, Valeria; Vitale, Nicoletta; Vaisitti, Tiziana; Gizzi, Katiuscia; Yeomans, Alison; Coscia, Marta; D'Arena, Giovanni; Gaidano, Gianluca; Allan, John N.; Furman, Richard R.; Packham, Graham; Forconi, Francesco; Deaglio, Silvia 分享 收藏
LSC-2019-Novel cellular effects of ultrafine particulate matter from an underground railway station uncovered through RNAseq Loxham, Matthew; Woo, Jeongmin; Singhania, Akul; Smithers, Natalie; Yeomans, Alison; Packham, Graham; Crainic, Alina; Cook, Richard; Cassee, Flemming; Woelk, Christopher; Davies, Donna 分享 收藏
Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications Arruga, Francesca; Bracciama, Valeria; Vitale, Nicoletta; Vaisitti, Tiziana; Gizzi, Katiuscia; Yeomans, Alison; Coscia, Marta; D'Arena, Giovanni; Gaidano, Gianluca; Allan, John N.; Furman, Richard R.; Packham, Graham; Forconi, Francesco; Deaglio, Silvia 分享 收藏
BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia BCR信号通路在慢性淋巴细胞白血病自噬调节中的作用 Smith, Lindsay D.; Minton, Annabel R.; Blunt, Matthew D.; Karydis, Laura I.; Dutton, David A.; Rogers-Broadway, Karly-Rai; Dobson, Rachel; Liu, Rena; Norster, Faith; Hogg, Elizabeth; Ashton-Key, Margaret; Strefford, Jonathan C.; Jia, Li; Efremov, Dimitar G.; Helgason, G. Vignir; Johnson, Peter W. M.; Stevenson, Freda K.; Forconi, Francesco; Cragg, Mark S.; Tumbarello, David A.; Packham, Graham; Steele, Andrew J. 分享 收藏
Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients Ibrutinib疗法从慢性淋巴细胞白血病患者的抗原驱动中释放白血病表面IgM Drennan, Samantha; Chiodin, Giorgia; D'Avola, Annalisa; Tracy, Ian; Johnson, Peter W.; Trentin, Livio; Steele, Andrew J.; Packham, Graham; Stevenson, Freda K.; Forconi, Francesco 分享 收藏
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity Peters, Tam L.; Tillotson, Joseph; Yeomans, Alison M.; Wilmore, Sarah; Lemm, Elizabeth; Jimenez-Romero, Carlos; Amador, Luis A.; Li, Lingxiao; Amin, Amit D.; Pongtornpipat, Praechompoo; Zerio, Christopher J.; Ambrose, Andrew J.; Paine-Murrieta, Gillian; Greninger, Patricia; Vega, Francisco; Benes, Cyril H.; Packham, Graham; Rodriguez, Abimael D.; Chapman, Eli; Schatz, Jonathan H. 分享 收藏
CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM Lezina, Larissa; Spriggs, Ruth, V; Beck, Daniel; Jones, Carolyn; Dudek, Kate M.; Bzura, Aleksandra; Jones, George D. D.; Packham, Graham; Willis, Anne E.; Wagner, Simon D. 分享 收藏
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