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C

Caroline J. Springer

University of Manchester
H指数:51
被引数:1.3万

个人简介

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教育背景

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工作经历

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The paradox-breaking panRAF plus SRC family kinase inhibitor, CCT3833, is effective in mutant KRAS-driven cancers

打破悖论的panRAF加SRC家族激酶抑制剂CCT3833对突变KRAS驱动的癌症有效

ANNALS OF ONCOLOGY
IF65.4
2021-02-0114
OAAI
Saturno, G.; Lopes, F.; Niculescu-Duvaz, I; Niculescu-Duvaz, D.; Zambon, A.; Davies, L.; Johnson, L.; Preece, N.; Lee, R.; Viros, A.; Holovanchuk, D.; Pedersen, M.; McLeary, R.; Lorigan, P.; Dhomen, N.; Fisher, C.; Banerji, U.; Dean, E.; Krebs, M. G.; Gore, M.; Larkin, J.; Marais, R.; Springer, C.
Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-05-0949
OAAI
Leung, Leo; Niculescu-Duyaz, Dan; Smithen, Deborah; Lopes, Filipa; Callens, Cedric; McLeary, Robert; Saturno, Grazia; Davies, Lawrence; Aljarah, Mohammed; Brown, Michael; Johnson, Louise; Zambon, Alfonso; Chambers, Tim; Menard, Delphine; Bayliss, Natasha; Knight, Ruth; Fish, Laura; Lawrence, Rae; Challinor, Mairi; Tang, HaoRan; Marais, Richard; Springer, Caroline
Lymph node metastasis evolution drives immune evasion and targeted therapy resistance in gastro-esophageal adenocarcinomas (GEAs)
CANCER RESEARCH
IF16.6
2017-07-010
PRE
Davies, Matthew N.; Barber, Louise J.; Spain, Georgia; Lopes, Filipa; von Loga, Katharina; Griffiths, Beatrice; Woolston, Andrew; Alpar, Donat; Gomez, Marta; Lipinski, Kamil A.; Fenwick, Kerry; Eltahir, Zakaria; Lise, Stefano; Agoston, Emese I.; Harsanyi, Laszlo; Marais, Richard; Wotherspoon, Andrew; Szasz, A.; Springer, Caroline; Gerlinger, Marco
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
EMBO MOLECULAR MEDICINE
IF8.3
2015-06-15228
OAAI
Miller, Bryan W.; Morton, Jennifer P.; Pinese, Mark; Saturno, Grazia; Jamieson, Nigel B.; McGhee, Ewan; Timpson, Paul; Leach, Joshua; McGarry, Lynn; Shanks, Emma; Bailey, Peter; Chang, David; Oien, Karin; Karim, Saadia; Au, Amy; Steele, Colin; Carter, Christopher Ross; McKay, Colin; Anderson, Kurt; Evans, Thomas R. Jeffry; Marais, Richard; Springer, Caroline; Biankin, Andrew; Erler, Janine T.; Sansom, Owen J.
Novel panRAF inhibitors active in melanomas that are resistant to BRAF-selective, or BRAF-selective/MEK inhibitor combinations
CANCER RESEARCH
IF16.6
2014-10-010
PRE
Girotti, Maria R.; Lopes, Filipa; Preece, Natasha; Niculescu-Duvaz, Dan; Zambon, Alfonso; Davies, Lawrence; Whittaker, Steven; Saturno, Grazia; Viros, Amaya; Pedersen, Malin; Suijkerbuijk, Bart M. J. M.; Menard, Delphine; Mcleary, Robert; Johnson, Louise; Fish, Laura; Ejiama, Sarah; Sanchez-Laorden, Berta; Carragher, Neil; Macleod, Kenneth; Ashton, Garry; Marusiak, Anna; Fusi, Alberto; Brognard, John; Frame, Margaret; Lorigan, Paul; Springer, Caroline J.; Marais, Richard
BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells By Reactivating MEK and ERK Signaling

BRAF抑制剂通过重新激活MEK和ERK信号诱导RAS突变或抑制剂抗性黑色素瘤细胞的转移

SCIENCE SIGNALING
IF6.6
2014-03-25127
PREAI
Sanchez-Laorden, Berta; Viros, Amaya; Girotti, Maria Romina; Pedersen, Malin; Saturno, Grazia; Zambon, Alfonso; Niculescu-Duvaz, Dan; Turajlic, Samra; Hayes, Andrew; Gore, Martin; Larkin, James; Lorigan, Paul; Cook, Martin; Springer, Caroline; Marais, Richard

研究方向

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R
Richard Marais
H 指数:98论文数:624被引数:4.8万
D
Dan Niculescu‐Duvaz
H 指数:26论文数:120被引数:6,672
I
Ion Niculescu‐Duvaz
H 指数:27论文数:153被引数:3,098
A
Alfonso Zambon
H 指数:27论文数:154被引数:3,615
F
Frank Friedlos
H 指数:35论文数:92被引数:4,007
A
Amaya Virós
H 指数:27论文数:169被引数:6,128
L
Lawrence Davies
H 指数:21论文数:50被引数:1,196
D
Douglas Hedley
H 指数:15论文数:35被引数:1,594
S
Steven R. Whittaker
H 指数:27论文数:127被引数:5,669
F
Filipa M. Lopes
H 指数:18论文数:60被引数:1,248