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E

Emmanuel C. Patin

The Institute of Cancer Research
H指数:19
被引数:2,186

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Preclinical efficacy of a systemically-administered, second-generation STING agonist that promotes anti-tumour immunity in combination with radiotherapy

系统给药的第二代STING激动剂与放疗联合促进抗肿瘤免疫的预临床疗效

British Journal of Cancer
IF6.8
2026-10-150
OAAI
Malin Pedersen; Lisa C. Hubbard; Shane Foo; Anton Patrikeev; Antonio Rullan; Holly Baldock; Christian Mandl; Paolo Chetta; Jehanne Hassan; Isaac Dean; Naomi Guppy; Philippe Slos; Charleen Chan Wah Hak; Elizabeth Appleton; Emmanuel C. Patin; Rachel Hunt; Justin Weir; Masahiro Ono; Thorsten Oost; Ulrich Reiser; Thomas Zichner; Kevin Morse; Mary Murphy; Lingqi Luo; Reniqua House; Louise Giffin; Alan A. Melcher; Anne Vogt; Sebastian Carotta; Kevin J. Harrington
Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer

Xevinapant联合放化疗对头颈癌肿瘤免疫微环境的负面影响

Cancer Research Communications
IF0
2025-11-010
OA
Chan Wah Hak, Charleen; Patin, Emmanuel C.; Patrikeev, Anton; Nicastri, Annalisa; Kozik, Zuza; Baldock, Holly; Kyula-Currie, Joan N.; Roulstone, Victoria; Wongariyapak, Amarin; Gifford, Valentina; Tenev, Tencho; Appleton, Elizabeth S.; Hubbard, Lisa C.; Foo, Shane; Pedersen, Malin; Choudhary, Jyoti S.; Ono, Masahiro; Melcher, Alan A.; Rullan, Antonio; Harrington, Kevin J.
Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial

通过姑息性放疗和ATR抑制实现肿瘤控制和免疫激活，PATRIOT Part C：一项 Ib 期临床试验

Nature Communications
IF15.7
2025-08-010
OAAI
Magnus T. Dillon; Emmanuel C. Patin; Kabir Mohammed; Jeane Guevara; Simon A. Smith; Emma Dean; Heba Soliman; Pablo Nenclares; Motoko Ryugenji; Davina Northcote; Neel Shah; Lorna Grove; Christopher J. Lord; Stephen Pettit; Matt Tall; Karen E. Swales; Udai Banerji; Alan A. Melcher; Mark Saunders; Martin D. Forster; Kevin J. Harrington
Author Correction: Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

作者更正: Palbociclib和dsRNA传感器合作通过ER应激和调节免疫逃避来增强抗癌作用

Nature Communications
IF15.7
2025-07-150
OAAI
Victoria Roulstone; Joan Kyula-Currie; James Wright; Emmanuel C. Patin; Isaac Dean; Lu Yu; Aida Barreiro-Alonso; Miriam Melake; Jyoti Choudhary; Richard Elliott; Christopher J. Lord; David Mansfield; Nik Matthews; Ritika Chauhan; Victoria Jennings; Charleen Chan Wah Hak; Holly Baldock; Francesca Butera; Elizabeth Appleton; Pablo Nenclares; Malin Pedersen; Shane Foo; Amarin Wongariyapak; Antonio Rullan; Tencho Tenev; Pascal Meier; Richard Vile; Hardev Pandha; Alan Melcher; Martin McLaughlin; Kevin J. Harrington
The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

PARP抑制剂talazoparib与呼肠孤病毒协同作用，在小鼠模型中体内诱导癌症杀伤和肿瘤控制

Nature Communications
IF15.7
2025-07-080
OAAI
Joan Kyula-Currie; Victoria Roulstone; James Wright; Francesca Butera; Arnaud Legrand; Richard Elliott; Martin McLaughlin; Galabina Bozhanova; Dragomir Krastev; Stephen Pettitt; Tencho Tenev; Magnus Dillon; Shane Foo; Emmanuel C. Patin; Victoria Jennings; Charleen Chan Wah Hak; Elizabeth Appleton; Amarin Wongariyapak; Malin Pedersen; Antonio Rullan; Jyoti Choudhary; Chris Bakal; Pascal Meier; Christopher J. Lord; Alan Melcher; Kevin J. Harrington
Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion
Nature Communications
IF15.7
2025-05-250
OAAI
Victoria Roulstone; Joan Kyula-Currie; James Wright; Emmanuel C. Patin; Isaac Dean; Lu Yu; Aida Barreiro-Alonso; Miriam Melake; Jyoti Choudhary; Richard Elliott; Christopher J. Lord; David Mansfield; Nik Matthews; Ritika Chauhan; Victoria Jennings; Charleen Chan Wah Hak; Holly Baldock; Francesca Butera; Elizabeth Appleton; Pablo Nenclares; Malin Pedersen; Shane Foo; Amarin Wongariyapak; Antonio Rullan; Tencho Tenev; Pascal Meier; Richard Vile; Hardev Pandha; Alan Melcher; Martin McLaughlin; Kevin J. Harrington
Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy
NATURE COMMUNICATIONS
IF15.7
2024-08-130
OAAI
Patin, Emmanuel C.; Nenclares, Pablo; Hak, Charleen Chan Wah; Dillon, Magnus T.; Patrikeev, Anton; Mclaughlin, Martin; Grove, Lorna; Foo, Shane; Soliman, Heba; Barata, Joao P.; Marsden, Joanna; Baldock, Holly; Gkantalis, Jim; Roulstone, Victoria; Kyula, Joan; Burley, Amy; Hubbard, Lisa; Pedersen, Malin; Smith, Simon A.; Clancy-Thompson, Eleanor; Melcher, Alan A.; Ono, Masahiro; Rullan, Antonio; Harrington, Kevin J.
Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling
JOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
2024-07-250
OAAI
Armstrong, Edward; Chiu, Matthew K. L.; Foo, Shane; Appleton, Lizzie; Nenclares, Pablo; Patrikeev, Anton; Mohan, Nitya; Mclaughlin, Martin; Bozhanova, Galabina; Hoebart, Julia; Roulstone, Victoria; Patin, Emmanuel; Pedersen, Malin; Kyula, Joan; Ono, Masahiro; Errington-Mais, Fiona; Bell, John; Harrington, Kevin J.; Melcher, Alan; Jennings, Victoria
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

RIPK1-specific的PROTAC降解剂通过增强免疫原性细胞死亡来实现有效的抗肿瘤活性

IMMUNITY
IF26.3
2024-07-013
OA
Mannion, Jonathan; Gifford, Valentina; Bellenie, Benjamin; Fernando, Winnie; Garcia, Laura Ramos; Wilson, Rebecca; John, Sidonie Wicky; Udainiya, Savita; Patin, Emmanuel C.; Tiu, Crescens; Smith, Angel; Goicoechea, Maria; Craxton, Andrew; Vasconcelos, Nathalia Moraes de; Cheung, Kwai-Ming J.; Cundy, Nicholas J.; Pierrat, Olivier; Brennan, Alfie; Benstead-Hume, Graeme; Roumeliotis, Theodoros I.; Alexander, John; Muirhead, Gareth; Layzell, Scott; Lyu, Wenxin; Roulstone, Victoria; Baldock, Holly; Legrand, Arnaud; Gabel, Florian; Serrano-Aparicio, Natalia; Starling, Chris; Guo, Hongyan; Upton, Jason; Gyrd-Hansen, Mads; Seddon, Benedict; Roxanis, Ioannis; Harrington, Kevin; Haider, Syed; Choudhary, Jyoti S.; Haider, Swen; Tenev, Tencho; Meier, Pascal
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2024-01-168
OAAI
Dillon, Magnus T.; Guevara, Jeane; Mohammed, Kabir; Patin, Emmanuel C.; Smith, Simon A.; Dean, Emma; Jones, Gemma N.; Willis, Sophie E.; Petrone, Marcella; Silva, Carlos; Thway, Khin; Bunce, Catey; Roxanis, Ioannis; Nenclares, Pablo; Wilkins, Anna; Mclaughlin, Martin; Jayme-Laiche, Adoracion; Benafif, Sarah; Nintos, Georgios; Kwatra, Vineet; Grove, Lorna; Mansfield, David; Proszek, Paula; Martin, Philip; Moore, Luiza; Swales, Karen E.; Banerji, Udai; Saunders, Mark P.; Spicer, James; Forster, Martin D.; Harrington, Kevin J.

研究方向

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K
Kevin J. Harrington
H 指数:115论文数:1,484被引数:7.2万
A
Alan Melcher
H 指数:71论文数:552被引数:1.6万
M
Malin Pedersen
H 指数:26论文数:170被引数:4,081
S
Shane Foo
H 指数:12论文数:63被引数:1,432
V
Victoria Roulstone
H 指数:23论文数:105被引数:1,949
A
Antonio Rullan
H 指数:16论文数:120被引数:1,519
J
Joan Kyula
H 指数:24论文数:115被引数:1,583
C
Charleen Chan Wah Hak
H 指数:9论文数:40被引数:497
P
Pablo Nenclares
H 指数:12论文数:64被引数:698
M
Martin McLaughlin
H 指数:28论文数:79被引数:2,989