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Serena Nik‐Zainal

university of cambridge

85H指数
309论文数
5.9W被引数
收录论文 104
发表时间
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High-depth whole genome sequencing of premalignant breast lesions reveals rearrangement hotspots and personalized management opportunities高危癌前乳腺癌病变的高深度全基因组测序揭示重排热点及个性化管理机会
errNature Communications
IF15.7
err2026-05-19
err0
errOAAI
errLucia Chmelova; Helen R. Davies; Andrea Degasperi; Giuseppe Rinaldi; Leon Wils; Daniella Black; Yasin Memari; Gene C. C. Koh; Scott Shooter; Lennart Mulder; Petra Kristel; Karoly Szuhai; Gino Prasad; Ivy Tsz-Lo Wong; Jens Luebeck; Yogesh Kumar; Jan Czarnecki; Shadi Basyuni; Zoya Kingsbury; Mark T. Ross; Øystein Garred; Margit Riis; Karin T. Lande; Johan Vallon-Christersson; Anna Ehinger; Amit Agrawal; Stuart A. McIntosh; Vineet Bafna; Paul S. Mischel; Jelle Wesseling; Johan Staaf; Therese Sørlie; Esther H. Lips; Serena Nik-Zainal
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Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancer原发ER阳性、HER2阴性乳腺癌中的同源重组缺陷
errCommunications Medicine
IF6.3
err2026-02-16
err0
errOAAI
errHelen R. Davies; Daniella Black; Anders Kvist; Kristín Sigurjónsdóttir; Ana Bosch; Ramsay Bowden; Yasin Memari; Ziqian Chen; Giuseppe Rinaldi; Frida Rosengren; Deborah F. Nacer; Srinivas Veerla; Lennart Hohmann; Nicklas Nordborg; Jari Häkkinen; Johan Vallon-Christersson; Åke Borg; Serena Nik-Zainal; Johan Staaf
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A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription一种反复出现的致病性BRCA2截断变异揭示了BRCA2-PCAF复合物在调节NF-κB驱动的转录中的作用
errNature Communications
IF15.7
err2025-12-10
err0
errOAAI
errAnna Minello; Jesus Gomez-Escudero; Sreerama Chaitanya Sridhara; Charlotte Martin; Elodie Girard; Juan C. Cañas; Yasin Memari; Maria Rose Bustos; Antonio Galarreta; Virginie Boucherit; Evgeny Imyanitov; Sigridur Klara Bodvarsdottir; Sylvain Baulande; Anne Vincent-Salomon; Nicolas Servant; Matthias Altmeyer; Stefan Sigurdsson; Dominique Stoppa-Lyonnet; Serena Nik-Zainal; Aura Carreira
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Molecular profiling of the Basal-like intrinsic molecular subtype in primary ER-positive HER2-negative breast cancer基底样固有分子亚型在原发性ER阳性HER2阴性乳腺癌中的分子特征分析
errGenome Medicine
IF11.2
err2025-12-01
err0
errOAAI
errLennart Hohmann; Deborah F. Nacer; Mattias Aine; Yasin Memari; Daniella Black; Ramsay Bowden; Helen R. Davies; Åke Borg; Johan Vallon-Christersson; Serena Nik-Zainal; Johan Staaf
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Clinical potential of whole-genome data linked to mortality statistics in patients with breast cancer in the UK: a retrospective analysis英国乳腺癌患者全基因组数据与死亡率统计数据的关联：一项回顾性分析
errThe Lancet Oncology
IF0
err2025-10-07
err0
errOAAI
errDaniella Black; Helen Ruth Davies; Gene Ching Chiek Koh; Lucia Chmelova; Marko Cubric; Georgia Chalivelaki Chan; Andrea Degasperi; Jan Czarnecki; Ping Jing Toong; Yasin Memari; James Whitworth; Salome Jingchen Zhao; Yogesh Kumar; Shadi Basyuni; Giuseppe Rinaldi; Scott Shooter; Vladyslav Dembrovskyi; Rosie Davies; Maria Chatzou Dunford; Ellen Copson; Carlo Palmieri; Åke Borg; John Ambrose; Catey Bunce; Alona Sosinsky; Prabhu Arumugam; Matthew Arthur Brown; Johan Staaf; Nicholas Turner; Serena Nik-Zainal
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Metastatic malignant cylindroma arising on a background of digenic inheritance of BRCA2 and CYLD pathogenic variants targeted with PARP inhibition
errCLINICAL AND EXPERIMENTAL DERMATOLOGY
IF2.8
err2025-02-05
err0
PREAI
errFostier, William; Husain, Akhtar; Namini, Shirin; Mathew, Bipin; Holt, Georgie; Memari, Yasin; Davies, Helen; Koh, Gene C. C.; Nik-Zainal, Serena; Rajan, Neil
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Insights from multi-omic modeling of neurodegeneration in xeroderma pigmentosum using an induced pluripotent stem cell system使用诱导的多能干细胞系统对着色性干皮病神经变性进行多组建模的见解
errCELL REPORTS
IF6.9
err2024-06-01
err1
errOAAI
errBadja, Cherif; Momen, Sophie; Koh, Gene Ching Chiek; Boushaki, Soraya; Roumeliotis, Theodoros I.; Kozik, Zuza; Jones, Ian; Bousgouni, Vicky; Dias, Joao M. L.; Krokidis, Marios G.; Young, Jamie; Chen, Hongwei; Yang, Ming; Docquier, France; Memari, Yasin; Valcarcel-Zimenez, Lorea; Gupta, Komal; Kong, Li Ren; Fawcett, Heather; Robert, Florian; Zhao, Salome; Degasperi, Andrea; Kumar, Yogesh; Davies, Helen; Harris, Rebecca; Frezza, Christian; Chatgilialoglu, Chryssostomos; Sarkany, Robert; Lehmann, Alan; Bakal, Chris; Choudhary, Jyoti; Fassihi, Hiva; Nik-Zainal, Serena
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The origins and clinical impact of extrachromosomal DNA across 39 cancers
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errBailey, Chris; Pich, Oriol; Thol, Kerstin; Luebeck, Jens; Stavrou, Georgia; Watkins, Thomas B.; Weiser, Natasha E.; Lu, Wei-Ting; Kittel, Jeanette; Bentham, Robert; Sharma, Natasha; Salgado, Roberto; Moore, Dave; Litovchenko, Maria; Hung, King L.; Cornish, Alex J.; Dameracharla, Bhargavi; Nik-Zainal, Serena; Bafna, Vineet; Chang, Howard; McGranahan, Nicholas; Kanu, Nnennaya; Mischel, Paul S.; Jamal-Hanjani, Mariam; Swanton, Charles
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Comprehensive characterization of the HER2-enriched intrinsic molecular subtype in ER-positive HER2-negative breast cancer
errANNALS OF ONCOLOGY
IF65.4
err2023-10-01
err0
errOAAI
errHohmann, L.; Sigurjonsdottir, K.; Bosch, A.; Nacer, D. F.; Veerla, S.; Hakkinen, J.; Vallon-Christersson, J.; Borg, A.; Memari, Y.; Davies, H.; Nik-Zainal, S.; Staaf, J.
err分享
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Whole-genome sequencing of malignant cylindroma in CYLD cutaneous syndrome reveals a clinically targetable somatic driver mutation
errBRITISH JOURNAL OF DERMATOLOGY
IF9.6
err2023-07-07
err0
PREAI
errFostier, William; Koh, Ching Chiek; Husain, Akhtar; Namini, Shirin; Nik-Zainal, Serena; Rajan, Neil
err分享
err收藏
Coinheritance of BRCA2 and CYLD germline pathogenic variants associated with targetable metastatic malignant cylindroma
errBRITISH JOURNAL OF DERMATOLOGY
IF9.6
err2023-06-26
err0
errOAAI
errFostier, William; Husain, Akhtar; Namini, Shirin; Nik-Zainal, Serena; Rajan, Neil
err分享
err收藏
Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness
errBREAST CANCER RESEARCH
IF5.6
err2023-06-14
err0
errOAAI
errAndersen, Lars v. B.; Larsen, Martin J.; Davies, Helen; Degasperi, Andrea; Nielsen, Henriette Roed; Jensen, Louise A.; Kroeldrup, Lone; Gerdes, Anne-Marie; Laenkholm, Anne-Vibeke; Kruse, Torben A.; Nik-Zainal, Serena; Thomassen, Mads
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Genomic characterisation of hormone receptor-positive breast cancer arising in very young women
errANNALS OF ONCOLOGY
IF65.4
err2023-04-01
err15
errOAAI
errLuen, S. J.; Viale, G.; Nik-Zainal, S.; Savas, P.; Kammler, R.; Dell'Orto, P.; Biasi, O.; Degasperi, A.; Brown, L. C.; Lang, I.; MacGrogan, G.; Tondini, C.; Bellet, M.; Villa, F.; Bernardo, A.; Ciruelos, E.; Karlsson, P.; Neven, P.; Climent, M.; Mueller, B.; Jochum, W.; Bonnefoi, H.; Martino, S.; Davidson, N. E.; Geyer, C.; Chia, S. K.; Ingle, J. N.; Coleman, R.; Solbach, C.; Thurlimann, B.; Colleoni, M.; Coates, A. S.; Goldhirsch, A.; Fleming, G. F.; Francis, P. A.; Speed, T. P.; Regan, M. M.; Loi, S.
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FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-03
err17
errOAAI
errKratz, Katja; Artola-Boran, Mariela; Kobayashi-Era, Saho; Koh, Gene; Oliveira, Goncalo; Kobayashi, Shunsuke; Oliveira, Andreia; Zou, Xueqing; Richter, Julia; Tsuda, Masataka; Sasanuma, Hiroyuki; Takeda, Shunichi; Loizou, Joanna, I; Sartori, Alessandro A.; Nik-Zainal, Serena; Jiricny, Josef
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Learning to distinguish progressive and non-progressive ductal carcinoma in situ (vol 22, pg 663, 2022)学习区分进行性和非进行性原位导管癌 (第22卷，663页，2022)
errNATURE REVIEWS CANCER
IF66.8
err2022-12-15
err0
errOAAI
errCasasent, Anna R.; Almekinders, Mathilde; Mulder, Charlotta E.; Bhattacharjee, Proteeti; Collyar, Deborah; Thompson, Alastair; Jonkers, Jos; Lips, Esther; van Rheenen, Jacco; Hwang, E. Shelley; Nik-Zainal, Serena; Navin, Nicholas; Wesseling, Jelle; Grand Challenge PRECISION Consortium, Grand Challenge P. R. E. C. I. S. I. O. N. Consortium
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A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer
errSCIENTIFIC REPORTS
IF3.9
err2022-10-27
err21
errOAAI
errInglebert, Marine; Dettwiler, Martina; Hahn, Kerstin; Letko, Anna; Drogemuller, Cord; Doench, John; Brown, Adam; Memari, Yasin; Davies, Helen R.; Degasperi, Andrea; Nik-Zainal, Serena; Rottenberg, Sven
err分享
err收藏
Learning to distinguish progressive and non-progressive ductal carcinoma in situ学习区分进行性和非进行性导管原位癌
errNATURE REVIEWS CANCER
IF66.8
err2022-10-19
err20
PREAI
errCasasent, Anna K.; Almekinders, Mathilde M.; Mulder, Charlotta; Bhattacharjee, Proteeti; Collyar, Deborah; Thompson, Alastair M.; Jonkers, Jos; Lips, Esther H.; van Rheenen, Jacco; Hwang, E. Shelley; Nik-Zainal, Serena; Navin, Nicholas E.; Wesseling, Jelle
err分享
err收藏
Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells
errNATURE GENETICS
IF31.8
err2022-08-11
err49
errOAAI
errRouhani, Foad J.; Zou, Xueqing; Danecek, Petr; Amarante, Tauanne Dias; Koh, Gene; Wu, Qianxin; Memari, Yasin; Durbin, Richard; Martincorena, Inigo; Bassett, Andrew R.; Gaffney, Daniel; Nik-Zainal, Serena
err分享
err收藏
Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests
errONCOGENE
IF7.3
err2022-06-03
err10
errOAAI
errMeijer, Titia G.; Nguyen, Luan; Van Hoeck, Arne; Sieuwerts, Anieta M.; Verkaik, Nicole S.; Ladan, Marjolijn M.; Ruigrok-Ritstier, Kirsten; van Deurzen, Carolien H. M.; van de Werken, Harmen J. G.; Lips, Esther H.; Linn, Sabine C.; Memari, Yasin; Davies, Helen; Nik-Zainal, Serena; Kanaar, Roland; Martens, John W. M.; Cuppen, Edwin; Jager, Agnes; van Gent, Dik C.
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Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification用于鉴定同源重组缺陷肿瘤和患者分层的RAD51测试的临床前体内验证
errCANCER RESEARCH
IF16.6
err2022-02-16
err45
errOAAI
errPellegrino, Benedetta; Herencia-Ropero, Andrea; Llop-Guevara, Alba; Pedretti, Flaminia; Moles-Fernandez, Alejandro; Viaplana, Cristina; Villacampa, Guillermo; Guzman, Marta; Rodriguez, Olga; Grueso, Judit; Jimenez, Jose; Arenas, Enrique J.; Degasperi, Andrea; Dias, Joao M. L.; Forment, Josep, V; O'Connor, Mark J.; Deas, Olivier; Cairo, Stefano; Zhou, Yinghui; Musolino, Antonino; Caldas, Carlos; Nik-Zainal, Serena; Clarke, Robert B.; Nuciforo, Paolo; Diez, Orland; Serres-Creixams, Xavier; Peg, Vicente; Espinosa-Bravo, Martin; Macarulla, Teresa; Oaknin, Ana; Mateo, Joaquin; Arribas, Joaquin; Dienstmann, Rodrigo; Bellet, Meritxell; Oliveira, Mafalda; Saura, Cristina; Gutierrez-Enriquez, Sara; Balmana, Judith; Serra, Violeta
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研究方向

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合作学者
合作期刊
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Evan E. Eichler
H 指数: 191 · 论文数: 864
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Michael R. Stratton
H 指数: 179 · 论文数: 644
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Douglas F. Easton
H 指数: 177 · 论文数: 1.2K
E
Elı́as Campo
H 指数: 173 · 论文数: 1.6K
H
Howard Y. Chang
H 指数: 162 · 论文数: 737
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