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A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo Xie, Stanley C.; Tai, Chia-Wei; Morton, Craig J.; Ma, Liting; Huang, Shih-Chung; Wittlin, Sergio; Du, Yawei; Hu, Yongbo; Dogovski, Con; Salimimarand, Mina; Griffin, Robert; England, Dylan; de la Cruz, Elisa; Deni, Ioanna; Yeo, Tomas; Burkhard, Anna Y.; Striepen, Josefine; Schindler, Kyra A.; Crespo, Benigno; Gamo, Francisco J.; Khandokar, Yogesh; Hutton, Craig A.; Rabie, Tayla; Birkholtz, Lyn-Marie; Famodimu, Mufuliat T.; Delves, Michael J.; Bolsher, Judith; Koolen, Karin M. J.; van der Laak, Rianne; Aguiar, Anna C. C.; Pereira, Dhelio B.; Guido, Rafael V. C.; Creek, Darren J.; Fidock, David A.; Dick, Lawrence R.; Brand, Stephen L.; Gould, Alexandra E.; Langston, Steven; Griffin, Michael D. W.; Tilley, Leann 分享 收藏
Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation Zeller, Johannes; Loseff-Silver, Julia; Khoshmanesh, Khashayar; Baratchi, Sara; Lai, Austin; Nero, Tracy L.; Roy, Abhishek; Watson, Anna; Dayawansa, Nalin; Sharma, Prerna; Barbaro-Wahl, Anastasia; Chen, Yung Chih; Moon, Mitchell; Vidallon, Mark Louis P.; Huang, Angela; Thome, Julia; Shing, Karen S. Cheung Tung; Harvie, Dalton; Bongiovanni, Marie N.; Braig, David; Morton, Craig J.; Htun, Nay M.; Stub, Dion; Walton, Anthony; Horowitz, John; Wang, Xiaowei; Pietersz, Geoffrey; Parker, Michael W.; Eisenhardt, Steffen U.; McFadyen, James D.; Peter, Karlheinz 分享 收藏
Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria Abrahamsen, Hunter L.; Sanford, Tristan C.; Collamore, Casie E.; Johnstone, Bronte A.; Coyne, Michael J.; Garcia-Bayona, Leonor; Christie, Michelle P.; Evans, Jordan C.; Farrand, Allison J.; Flores, Katia; Morton, Craig J.; Parker, Michael W.; Comstock, Laurie E.; Tweten, Rodney K. 分享 收藏
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase Xie, Stanley C.; Wang, Yinuo; Morton, Craig J.; Metcalfe, Riley D.; Dogovski, Con; Pasaje, Charisse Flerida A.; Dunn, Elyse; Luth, Madeline R.; Kumpornsin, Krittikorn; Istvan, Eva S.; Park, Joon Sung; Fairhurst, Kate J.; Ketprasit, Nutpakal; Yeo, Tomas; Yildirim, Okan; Bhebhe, Mathamsanqa N.; Klug, Dana M.; Rutledge, Peter J.; Godoy, Luiz C.; Dey, Sumanta; De Souza, Mariana Laureano; Siqueira-Neto, Jair L.; Du, Yawei; Puhalovich, Tanya; Amini, Mona; Shami, Gerry; Loesbanluechai, Duangkamon; Nie, Shuai; Williamson, Nicholas; Jana, Gouranga P.; Maity, Bikash C.; Thomson, Patrick; Foley, Thomas; Tan, Derek S.; Niles, Jacquin C.; Han, Byung Woo; Goldberg, Daniel E.; Burrows, Jeremy; Fidock, David A.; Lee, Marcus C. S.; Winzeler, Elizabeth A.; Griffin, Michael D. W.; Todd, Matthew H.; Tilley, Leann 分享 收藏
Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant 白介素11信号复合物的结构揭示了gp130动力学和细胞因子变体的抑制机制 Metcalfe, Riley D.; Hanssen, Eric; Fung, Ka Yee; Aizel, Kaheina; Kosasih, Clara C.; Zlatic, Courtney O.; Doughty, Larissa; Morton, Craig J.; Leis, Andrew P.; Parker, Michael W.; Gooley, Paul R.; Putoczki, Tracy L.; Griffin, Michael D. W. 分享 收藏
A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein 一种新的磷酸胆碱模拟物抑制C反应蛋白的促炎构象变化 Zeller, Johannes; Shing, Karen S. Cheung Tung; Nero, Tracy L.; McFadyen, James D.; Krippner, Guy; Bogner, Balazs; Kreuzaler, Sheena; Kiefer, Jurij; Horner, Verena K.; Braig, David; Danish, Habiba; Baratchi, Sara; Fricke, Mark; Wang, Xiaowei; Kather, Michel G.; Kammerer, Bernd; Woollard, Kevin J.; Sharma, Prerna; Morton, Craig J.; Pietersz, Geoffrey; Parker, Michael W.; Peter, Karlheinz; Eisenhardt, Steffen U. 分享 收藏
Heparin Inhibits SARS-CoV-2 Replication in Human Nasal Epithelial Cells 肝素抑制人鼻上皮细胞的SARS-CoV-2复制 Lee, Leo Yi Yang; Suryadinata, Randy; McCafferty, Conor; Ignjatovic, Vera; Purcell, Damian F. J.; Robinson, Phil; Morton, Craig J.; Parker, Michael W.; Anderson, Gary P.; Monagle, Paul; Subbarao, Kanta; Neil, Jessica A. 分享 收藏
C-reactive protein, immunothrombosis and venous thromboembolism C反应蛋白、免疫血栓和静脉血栓栓塞 Dix, Caroline; Zeller, Johannes; Stevens, Hannah; Eisenhardt, Steffen U.; Shing, Karen S. Cheung Tung; Nero, Tracy L.; Morton, Craig J.; Parker, Michael W.; Peter, Karlheinz; McFadyen, James D. 分享 收藏
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Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases Zeller, J.; Bogner, B.; McFadyen, J. D.; Kiefer, J.; Braig, D.; Pietersz, G.; Krippner, G.; Nero, T. L.; Morton, C. J.; Shing, K. S. Cheung Tung; Parker, M. W.; Peter, K.; Eisenhardt, S. U. 分享 收藏
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome 设计具有体内抗恶性疟原虫的口服功效和对人蛋白酶体的选择性的蛋白酶体抑制剂 Xie, Stanley C.; Metcalfe, Riley D.; Mizutani, Hirotake; Puhalovich, Tanya; Hanssen, Eric; Morton, Craig J.; Du, Yawei; Dogovski, Con; Huang, Shih-Chung; Ciavarri, Jeffrey; Hales, Paul; Griffin, Robert J.; Cohen, Lawrence H.; Chuang, Bei-Ching; Wittlin, Sergio; Deni, Ioanna; Yeo, Tomas; Ward, Kurt E.; Barry, Daniel C.; Liu, Boyin; Gillett, David L.; Crespo-Fernandez, Benigno F.; Ottilie, Sabine; Mittal, Nimisha; Churchyard, Alisje; Ferguson, Daniel; Aguiar, Anna Caroline C.; Guido, Rafael V. C.; Baum, Jake; Hanson, Kirsten K.; Winzeler, Elizabeth A.; Gamo, Francisco-Javier; Fidock, David A.; Baud, Delphine; Parker, Michael W.; Brand, Stephen; Dick, Lawrence R.; Griffin, Michael D. W.; Gould, Alexandra E.; Tilley, Leann 分享 收藏
Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome 导致隐性高IgE综合征的细胞因子选择性IL6ST缺陷的功能和结构分析 Chen, Yin-Huai; Zastrow, Diane B.; Metcalfe, Riley D.; Gartner, Lisa; Krause, Freia; Morton, Craig J.; Marwaha, Shruti; Fresard, Laure; Huang, Yong; Zhao, Chunli; McCormack, Colleen; Bick, David; Worthey, Elizabeth A.; Eng, Christine M.; Gold, Jessica; Montgomery, Stephen B.; Fisher, Paul G.; Ashley, Euan A.; Wheeler, Matthew T.; Parker, Michael W.; Shanmugasundaram, Veerabahu; Putoczki, Tracy L.; Schmidt-Arras, Dirk; Laurence, Arian; Bernstein, Jonathan A.; Griffin, Michael D. W.; Uhlig, Holm H. 分享 收藏
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