未登录 Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts Lin, Xiaohui; Gupta, Dipika; Vaitsiankova, Alina; Bhandari, Seema Khattri; Leung, Kay Sze Karina; Menolfi, Demis; Lee, Brian J.; Russell, Helen R.; Gershik, Steven; Huang, Xiaoyu; Gu, Wei; Mckinnon, Peter J.; Rothenberg, Eli; Dantzer, Francoise; Tomkinson, Alan E.; Zha, Shan 分享 收藏
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy 卡马替尼是MET融合驱动的小儿高级别胶质瘤的有效治疗方法，并与放疗协同作用 Zuckermann, Marc; He, Chen; Andrews, Jared; Bagchi, Aditi; Sloan-Henry, Roketa; Bianski, Brandon; Xie, Jia; Wang, Yingzhe; Twarog, Nathaniel; Onar-Thomas, Arzu; Ernst, Kati J.; Yang, Lei; Li, Yong; Zhu, Xiaoyan; Ocasio, Jennifer K.; Budd, Kaitlin M.; Dalton, James; Li, Xiaoyu; Chepyala, Divyabharathi; Zhang, Junyuan; Xu, Ke; Hover, Laura; Roach, Jordan T.; Chan, Kenneth Chun-Ho; Hofmann, Nina; Mckinnon, Peter J.; Pfister, Stefan M.; Shelat, Anang A.; Rankovic, Zoran; Freeman, Burgess B.; Chiang, Jason; Jones, David T. W.; Tinkle, Christopher L.; Baker, Suzanne J. 分享 收藏
Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers high-grade gliomas Reuss, David E.; Downing, Susanna M.; Camacho, Cristel V.; Wang, Yong-Dong; Piro, Rosario M.; Herold-Mende, Christel; Wang, Zhao-Qi; Hofmann, Thomas G.; Sahm, Felix; von Deimling, Andreas; McKinnon, Peter J.; Frappart, Pierre-Olivier 分享 收藏
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The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer Schuendeln, MM; Piekorz, RP; Wichmann, C; Lee, Y; McKinnon, PJ; Boyd, K; Takahashi, Y; Ihle, JN 分享 收藏
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Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration Kwak, Young Don; Shaw, Timothy, I; Downing, Susanna M.; Tewari, Ambika; Jin, Hongjian; Li, Yang; Dumitrache, Lavinia C.; Katyal, Sachin; Khodakhah, Kamran; Russell, Helen R.; McKinnon, Peter J. 分享 收藏
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The dystonia gene THAP1 controls DNA double-strand break repair choice Shinoda, Kenta; Zong, Dali; Callen, Elsa; Wu, Wei; Dumitrache, Lavinia C.; Belinky, Frida; Chari, Raj; Wong, Nancy; Ishikawa, Momoko; Stanlie, Andre; Multhaupt-Buell, Trisha; Sharma, Nutan; Ozelius, Laurie; Ehrlich, Michelle; McKinnon, Peter J.; Nussenzweig, Andre 分享 收藏
Parp1 hyperactivity couples DNA breaks to aberrant neuronal calcium signalling and lethal seizures Komulainen, Emilia; Badman, Jack; Rey, Stephanie; Rulten, Stuart; Ju, Limei; Fennell, Kate; Kalasova, Ilona; Ilievova, Kristyna; McKinnon, Peter J.; Hanzlikova, Hana; Staras, Kevin; Caldecott, Keith W. 分享 收藏
The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange Milanovic, Maja; Houghton, Lisa M.; Menolfi, Demis; Lee, Ji-Hoon; Yamamoto, Kenta; Li, Yang; Lee, Brian J.; Xu, Jun; Estes, Verna M.; Wang, Dong; Mckinnon, Peter J.; Paull, Tanya T.; Zha, Shan 分享 收藏
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination Callen, Elsa; Zong, Dali; Wu, Wei; Wong, Nancy; Stanlie, Andre; Ishikawa, Momoko; Pavani, Raphael; Dumitrache, Lavinia C.; Byrum, Andrea K.; Mendez-Dorantes, Carlos; Martinez, Paula; Canela, Andres; Maman, Yaakov; Day, Amanda; Kruhlak, Michael J.; Blasco, Maria A.; Stark, Jeremy M.; Mosammaparast, Nima; McKinnon, Peter J.; Nussenzweig, Andre 分享 收藏
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Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors Ratnaparkhe, Manasi; Wong, John K.; Wei, Pei-Chi; Hlevnjak, Mario; Kolb, Thorsten; Simovic, Milena; Haag, Daniel; Paul, Yashna; Devens, Frauke; Northcott, Paul; Jones, David T.; Kool, Marcel; Jauch, Anna; Pastorczak, Agata; Mlynarski, Wojciech; Korshunov, Andrey; Kumar, Rajiv; Downing, Susanna M.; Pfister, Stefan M.; Zapatka, Marc; McKinnon, Peter J.; Alt, Frederick W.; Lichter, Peter; Ernst, Aurelie 分享 收藏
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