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A FIRST-IN-HUMAN TRIAL OF INTRATHECAL CDC1 THERAPY FOR BREAST CANCER LEPTOMENINGEAL DISEASE INDUCES ADAPTIVE IMMUNITY WITH TRANSCRIPTOMIC EVIDENCE OF IMMUNE AWAKENING IN THE CSF 一项关于鞘内CDC1疗法治疗乳腺癌软脑膜疾病的首次人体临床试验,诱导了适应性免疫,并在脑脊液中观察到转录组学证据表明免疫系统被激活。 Forsyth, Peter; Gandhi, Shipra; Law, Vincent; Ahmed, Kamran; Piteo, Cecily; Evernden, Brittany; Pina, Yolanda; Smalley, Inna; Tran, Nam; Kalinski, Pawel; Czerniecki, Brian 分享 收藏
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EnTrega CSF circulation and drug delivery system improves drug distribution in brain parenchyma EnTrega CSF循环和药物递送系统改善了药物在脑实质中的分布 Kumthekar, Priya; Schwartz, Margaret; Nagpal, Seema; Glitza, Isabella; Forsyth, Peter; Sonabend, Adam Sonabend; Ruiz, Ernesto; Kalish, Kevin; DePasqua, Anthony; Gormley, William; Glicksman, Marcie 分享 收藏
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A A FIRST IN HUMAN PHASE I TRIAL OF INTRATHECAL DENDRITIC CELLS PRIMED AGAINST HER2/HER3 IN PATIENTS WITH LEPTOMENINGEAL DISEASE FROM TRIPLE-NEGATIVE OR HER2+BREAST CANCER SHOW DEVELOPMENT OF ADAPTIVE IMMUNE RESPONSES 一项首次人体I期临床试验,评估鞘内注射针对HER2/HER3的树突状细胞在来自三阴性或HER2+乳腺癌患者的软脑膜疾病患者中诱导适应性免疫反应的发展。 Forsyth, P. A.; Gandhi, S.; Law, V; Ahmed, K. A.; Piteo, C.; Evernden, B. R.; Pina, Y.; Smalley, I; Tran, N.; Kalinski, P.; Czerniecki, B. J. 分享 收藏
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Phase IB study of Avelumab and whole brain radiotherapy in patients with leptomeningeal disease from solid tumors: Results and molecular analyses Avelumab联合全脑放射疗法治疗实体瘤所致软脑膜疾病的IB期研究:结果与分子分析 Pina, Yolanda; Law, Vincent; Sahebjam, Solmaz; Tran, Nam; Siddarajappa, Navya; Li, Jiannong; Mo, Qianxing; Phadke, Manali S.; Arrington, John; Macaulay, Robert; Mokhtari, Sepideh; Evernden, Brittany; Ahmed, Kamran A.; Smalley, Inna; Yu, Michael; Smalley, Keiran S. M.; Forsyth, Peter A. 分享 收藏
Nivolumab and stereotactic radiosurgery for patients with breast cancer brain metastases: long-term results and biomarker analysis from a non-randomized, open-label, phase Ib study Nivolumab和立体定向放射外科治疗乳腺癌脑转移患者:一项非随机、开放标签、Ib期研究的长期结果和生物标志物分析 Ahmed, Kamran A.; Kim, Younchul; Kim, Sungjune; Wang, Min Hsuan; DeJesus, Michelle; Arrington, John A.; Soyano, Aixa E.; Armaghani, Avan J.; Costa, Ricardo L. B.; Loftus, Loretta S.; Rosa, Marilin; Caudell, Jimmy J.; Diaz, Roberto; Etame, Arnold B.; Tran, Nam D.; Soliman, Hatem; Czerniecki, Brian J.; Forsyth, Peter A.; Yu, Hsiang-Hsuan Michael; Han, Hyo S. 分享 收藏
Intravenous Immunoglobulin (IVIG) for Patients with Severe Neurotoxicity Associated with Chimeric Antigen Receptor T-Cell (CAR-T) Therapy 静脉免疫球蛋白(IVIG)用于与嵌合抗原受体T细胞(CAR-T)疗法相关的严重神经毒性患者 Mokhtari, Sepideh; Asquith, Justin M.; Kareem, Syeda Saba; Bachmeier, Christina A.; Pina, Yolanda; Faramand, Rawan G.; Kim, Youngchul; Peguero, Edwin N.; Sahebjam, Solmaz; Jaffer, Mohammad H.; Iacono, David P.; Jain, Michael D.; Vogelbaum, Michael A.; Davila, Marco L.; Forsyth, Peter A.; Locke, Frederick L.; Lazaryan, Aleksandr 分享 收藏
Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas Sahebjam, Solmaz; Raval, Raju R.; Forsyth, Peter A.; Enderling, Heiko; Tran, Nam D.; Arrington, John A.; Macaulay, Robert; Perlow, Haley K.; Palmer, Joshua D.; Ghose, Jayeeta; Rajappa, Prajwal; Giglio, Pierre; Li, Zihai; Etame, Arnold B.; Mokhtari, Sepideh; Cruz-Chamorro, Ruben J.; Bhandari, Menal; Thapa, Ram; Robinson, Timothy J.; Chen, Dung-Tsa; Yu, Hsiang-Hsuan Michael 分享 收藏
Phase II trial of brain MRI surveillance in stage IV breast cancer IV期乳腺癌中脑MRI监测的II期临床试验 Ahmed, Kamran A.; Kim, Youngchul; Armaghani, Avan J.; Arrington, John A.; Costa, Ricardo L.; Czerniecki, Brian J.; Diaz, Roberto; Dowell, Robin A.; Extermann, Martine; Forsyth, Peter A.; Lee, Kimberley T.; Loftus, Loretta; Mills, Matthew N.; Phuoc, Vania H.; Rosa, Marilin; Soliman, Hatem H.; Sam, Christine S.; Washington, Iman R.; Soyano, Aixa E.; Han, Hyo S. 分享 收藏
MULTI-OMIC CHARACTERIZATION OF A SYNGENEIC MOUSE CANCER STEM CELL MODEL OF GBM FOR PRECLINICAL APPLICATIONS Heemskerk, Kyle; Assaf, Samir; Hao, Xiaguang; Meode, Mathieu; Kala, Smriti; Pemberton, James; Mirzaei, Reza; Cairncross, J. Gregory; Forsyth, Peter; Yong, V. Wee; Weiss, Samuel; Zemp, Franz; Luchman, H. Artee 分享 收藏
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NANO-LM: An updated scorecard for the clinical assessment of patients with leptomeningeal metastases Nano-lm: 用于软脑膜转移患者临床评估的更新记分卡 Le Rhun, Emilie; Nayak, Lakshmi; Lim-Fat, Mary Jane; Ruda, Roberta; Pentsova, Elena; Forsyth, Peter; O'Brien, Barbara J.; Preusser, Matthias; Kumthekar, Priya; Brandsma, Dieta; Weller, Michael 分享 收藏
Clinical Outcomes of Patients with Non-Small Cell Lung Cancer Leptomeningeal Disease Following Receipt of EGFR-Targeted Therapy, Immune-Checkpoint Blockade, Intrathecal Chemotherapy, or Radiation Therapy Alone Mills, Matthew N.; Uno, Akihiro; Li, Pinxue; Liveringhouse, Casey; Kim, Youngchul; Oliver, Daniel E.; Perez, Bradford A.; Creelan, Benjamin C.; Yu, Michael; Forsyth, Peter A.; Pina, Yolanda; Ahmed, Kamran A. 分享 收藏
Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions 实体瘤的软脑膜转移: 神经肿瘤学会和美国临床肿瘤学会关于临床管理和未来方向的共识评论 Wilcox, Jessica A.; Chukwueke, Ugonma N.; Ahn, Myung-Ju; Aizer, Ayal A.; Bale, Tejus A.; Brandsma, Dieta; Brastianos, Priscilla K.; Chang, Susan; Daras, Mariza; Forsyth, Peter; Garzia, Livia; Glantz, Michael; Oliva, Isabella C. Glitza; Kumthekar, Priya; Le Rhun, Emilie; Nagpal, Seema; O'Brien, Barbara; Pentsova, Elena; Lee, Eudocia Quant; Remsik, Jan; Ruda, Roberta; Smalley, Inna; Taylor, Michael D.; Weller, Michael; Wefel, Jeffrey; Yang, Jonathan T.; Young, Robert J.; Wen, Patrick Y.; Boire, Adrienne A. 分享 收藏
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Virtual multi-institutional tumor board: a strategy for personalized diagnoses and management of rare CNS tumors 虚拟多机构肿瘤委员会: 罕见中枢神经系统肿瘤的个性化诊断和管理策略 Rogers, James L.; Wall, Thomas; Acquaye-Mallory, Alvina A.; Boris, Lisa; Kim, Yeonju; Aldape, Kenneth; Quezado, Martha M.; Butman, John A.; Smirniotopoulos, James G.; Chaudhry, Huma; Tsien, Christina I.; Chittiboina, Prashant; Zaghloul, Kareem; Aboud, Orwa; Avgeropoulos, Nicholas G.; Burton, Eric C.; Cachia, David M.; Dixit, Karan S.; Drappatz, Jan; Dunbar, Erin M.; Forsyth, Peter; Komlodi-Pasztor, Edina; Mandel, Jacob; Ozer, Byram H.; Lee, Eudocia Q.; Ranjan, Surabhi; Lukas, Rimas V.; Raygada, Margarita; Salacz, Michael E.; Smith-Cohn, Matthew A.; Snyder, James; Soldatos, Ariane; Theeler, Brett J.; Widemann, Brigitte C.; Camphausen, Kevin A.; Heiss, John D.; Armstrong, Terri S.; Gilbert, Mark R.; Penas-Prado, Marta 分享 收藏