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J

Jean-Philippe Julien

University of Toronto
H指数:59
被引数:1.7万

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B lymphocyte protein factories produced by hematopoietic stem cell gene editing

造血干细胞基因编辑产生的B淋巴细胞蛋白质工厂

Science
IF45.8
2026-04-160
PRE
Harald Hartweger; Chiara Ruprecht; Kai-Hui Yao; Philippe Laffont; Gabriella Lima Dos Reis; Pengcheng Zhou; Thomas Hägglöf; Laurine Binet; Maximilian Loewe; Jun P. Hong; Tianli Xiao; Esen Sefik; Brianna Hernandez; Anna Gazumyan; Mila Jankovic; Michael S. Seaman; Giulia Costa; Sean A. Nelson; Jordan Clark; Sachie Kanatani; Patrick C. Wilson; Florian Krammer; Elena A. Levashina; Jean-Philippe Julien; Hedda Wardemann; Photini Sinnis; Leonidas Stamatatos; Richard A. Flavell; Michel C. Nussenzweig
A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity

一种稳定的串联抗原嵌合体，可引发有效的疟疾传播减少活性

Nature Communications
IF15.7
2026-01-240
OAAI
Danton Ivanochko; Kazutoyo Miura; Sophia Hailemariam; Rashmi Ravichandran; Yiting Song; Wei-Chiao Huang; Rianne Stoter; Karina Teelen; Geert-Jan van Gemert; Elizabeth M. Leaf; Sidney Chan; Christine Men; Anthony Semesi; Carol Shiu; Randall S. MacGill; Carole A. Long; Matthijs M. Jore; Neil P. King; Jonathan F. Lovell; Jean-Philippe Julien
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions

人源抗体靶向冠状病毒刺突蛋白S2亚单位与介导Fc效应功能的保护作用相关

JOURNAL OF VIROLOGY
IF3.8
2025-11-010
PRE
Muthuraman, Krithika; Jackman, Matthew; Liang, Yu; Garrett, Meghan E.; Cui, Hong; Nguyen, Loan Vu Hong; Ivanochko, Danton; Ye, Chengjin; Pino, Paula A.; Hicks, Amberlee; Maingot, Billie; Yusko, Erik; Benzeno, Sharon; Martinez-Sobrido, Luis; Torrelles, Jordi B.; Gilbert, Amy E.; Rubin, Benjamin Evan Russell; Keitany, Gladys; Jetha, Arif; Julien, Jean-Philippe
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity

内源性Pfs230:Pfs48/45复合物与六种抗体的冷冻电镜结构揭示了疟疾传播阻断活性的机制

Immunity
IF26.3
2025-10-090
OAAI
Ezra T. Bekkering; Randy Yoo; Sophia Hailemariam; Fabian Heide; Danton Ivanochko; Matthew Jackman; Nicholas I. Proellochs; Rianne Stoter; Geert-Jan van Gemert; Ayana Maeda; Takaaki Yuguchi; Oscar T. Wanders; Renate C. van Daalen; Maartje R. Inklaar; Carolina M. Andrade; Pascal W.T.C. Jansen; Michiel Vermeulen; Teun Bousema; Eizo Takashima; John L. Rubinstein; Taco W.A. Kooij; Matthijs M. Jore; Jean-Philippe Julien
Priming or Boosting Plasmodium falciparum Transmission-Blocking Responses With Recombinant Vaccines or Gametocyte Extract

利用重组疫苗或配子体提取物对恶性疟原虫传播阻断反应进行预激活或增强

JOURNAL OF INFECTIOUS DISEASES
IF4.5
2025-07-010
PRE
Song, Yiting; Deng, Bingbing; Long, Carole A.; Li, Qinzhe; Diakite, Mahamadou; Huang, Wei-Chiao; Zhou, Shiqi; Luo, Yuan; Ivanochko, Danton; MacGill, Randall S.; Julien, Jean-Philippe; Miura, Kazutoyo; Lovell, Jonathan F.
Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort

在加拿大队列中，SARS-CoV-2感染和杂交免疫引起的中和抗体反应的持久性和衰减

MICROBIOLOGY SPECTRUM
IF3.8
2025-02-190
OAAI
Nouanesengsy, Amy; Semesi, Anthony; Quach, Kim; Ivanochko, Danton; Byrne, Walter; Hwang, Matthew; La Neve, Maria-Rosa; Leon-Ponte, Matilde; Litosh, Alice; Wisener, Nicole; Adeli, Khosrow; Campigotto, Aaron; Grunebaum, Eyal; Mcgeer, Allison; Moraes, Theo J.; Sepiashvili, Lusia; Upton, Julia; Julien, Jean-Philippe; Allen, Upton
PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse immunogenicity studies
HUMAN VACCINES & IMMUNOTHERAPEUTICS
IF3.5
2025-02-040
OAAI
Hickey, John M.; Sharma, Nitya; Fairlamb, Max; Doering, Jennifer; Adewunmi, Yetunde; Prieto, Katherine; Costa, Giulia; Wizel, Benjamin; Levashina, Elena A.; Mantis, Nicholas J.; Julien, Jean-Philippe; Joshi, Sangeeta B.; Volkin, David B.
Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis
JOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
2024-11-110
OAAI
Ghasempour, Sina; Warner, Neil; Guan, Rei; Rodari, Marco M.; Ivanochko, Danton; Whittaker Hawkins, Ryder; Marwaha, Ashish; Nowak, Jan K.; Liang, Yijing; Mulder, Daniel J.; Stallard, Lorraine; Li, Michael; Yu, Daniel D.; Pluthero, Fred G.; Batura, Vritika; Zhao, Mo; Siddiqui, Iram; Upton, Julia E. M.; Hulst, Jessie M.; Kahr, Walter H. A.; Mendoza-Londono, Roberto; Charbit-Henrion, Fabienne; Hoefsloot, Lies H.; Khiat, Anis; Moreira, Diana; Trindade, Eunice; Espinheira, Maria do Ceu; Pinto Pais, Isabel; Weerts, Marjolein J. A.; Douben, Hannie; Kotlarz, Daniel; Snapper, Scott B.; Klein, Christoph; Dowling, James J.; Julien, Jean-Philippe; Joosten, Marieke; Cerf-Bensussan, Nadine; Freeman, Spencer A.; Parlato, Marianna; van Ham, Tjakko J.; Muise, Aleixo M.
A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates

非人灵长类动物R21疟疾疫苗的多种临床阶段佐剂的比较免疫学评估

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-07-310
PRE
Arunachalam, Prabhu S.; Ha, NaYoung; Dennison, S. Moses; Spreng, Rachel L.; Seaton, Kelly E.; Xiao, Peng; Feng, Yupeng; Zarnitsyna, Veronika I.; Kazmin, Dmitri; Hu, Mengyun; Santagata, Jordan M.; Xie, Xia; Rogers, Kenneth; Shirreff, Lisa M.; Chottin, Claire; Spencer, Alexandra J.; Dutta, Sheetij; Prieto, Katherine; Julien, Jean-Philippe; Tomai, Mark; Fox, Christopher B.; Villinger, Francois; Hill, Adrian V. S.; Tomaras, Georgia D.; Pulendran, Bali
Disproportionate Rates of COVID-19 Among Black Canadian Communities: Lessons from a Cross-Sectional Study in the First Year of the Pandemic
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
IF2.4
2024-01-222
OAAI
Allen, Upton D.; Barton, Michelle; Upton, Julia; Bailey, Annette; Campigotto, Aaron; Abdulnoor, Mariana; Julien, Jean-Philippe; Gubbay, Jonathan; Kissoon, Niranjan; Litosh, Alice; La Neve, Maria-Rosa; Wong, Peter; Allen, Andrew; Bailey, Renee; Byrne, Walter; Jagoowani, Ranjeeta; Phillips, Chantal; Merreles-Pulcini, Manuela; Polack, Alicia; Prescod, Cheryl; Siddiqi, Arjumand; Summers, Alexander; Thompson, Kimberly; Thompson, Sylvanus; James, Carl
Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein

VH3-33针对恶性疟原虫环子孢子蛋白的抗体的交叉反应性和效力的分子决定因素

CELL REPORTS
IF6.9
2023-11-012
OAAI
Thai, Elaine; Murugan, Rajagopal; Binter, Spela; Aschner, Clare Burn; Prieto, Katherine; Kassardjian, Audrey; Obraztsova, Anna S.; Kang, Ryu Won; Flores-Garcia, Yevel; Mathis-Torres, Shamika; Li, Kan; Horn, Gillian Q.; Huntwork, Richard H. C.; Bolscher, Judith M.; de Bruijni, Marloes H. C.; Sauerwein, Robert; Dennison, S. Moses; Tomaras, Georgia D.; Zavala, Fidel; Kellam, Paul; Wardemann, Hedda; Julien, Jean-Philippe
Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model (vol 8, 52, 2023)

基于糖基化纳米颗粒的PfCSP疫苗在小鼠疟疾模型中赋予持久的抗体反应和无菌保护 (vol 8，52, 2023)

NPJ VACCINES
IF6.5
2023-06-052
OAAI
Ludwig, Julia; Scally, Stephen W.; Costa, Giulia; Hoffmann, Sandro; Murugan, Rajagopal; Lossin, Jana; Prieto, Katherine; Obraztsova, Anna; Lobeto, Nina; Franke-Fayard, Blandine; Janse, Chris J.; Lebas, Celia; Collin, Nicolas; Binter, Spela; Kellam, Paul; Levashina, Elena A.; Wardemann, Hedda; Julien, Jean-Philippe
A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-05-245
OA
Aschner, Clare Burn; Muthuraman, Krithika; Kucharska, Iga; Cui, Hong; Prieto, Katherine; Nair, Manoj S.; Wang, Maple; Huang, Yaoxing; Christie-Holmes, Natasha; Poon, Betty; Lam, Jessica; Sultana, Azmiri; Kozak, Robert; Mubareka, Samira; Rubinstein, John L.; Rujas, Edurne; Treanor, Bebhinn; Ho, David D.; Jetha, Arif; Julien, Jean -Philippe

研究方向

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