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CD22 TCR-engineered T cells exert antileukemia cytotoxicity without causing inflammatory responses CD22 TCR基因工程T细胞在不引起炎症反应的情况下发挥抗白血病细胞毒性作用。 Nguyen, Kilyna A.; Liu, Zhihui; Davies, John S.; McIntosh, Crystal P.; Draper, Lindsey M.; Norberg, Scott M.; Rae, Zachary; Achar, Sooraj R.; Altan-Bonnet, Gregoire; Zhang, Ling; Wu, Xiaolin; Meyer, Thomas J.; Kelly, Michael C.; Taylor, Naomi; Hinrichs, Christian S.; Ishii, Kazusa 分享 收藏
Tumor and blood B-cell abundance outperforms established immune checkpoint blockade response prediction signatures in head and neck cancer 肿瘤和血液B细胞丰度优于头颈部癌症中已建立的免疫检查点阻断反应预测特征。 Chang, T. -g.; Spathis, A.; Schaffer, A. A.; Gavrielatou, N.; Kuo, F.; Jia, D.; Mukherjee, S.; Sievers, C.; Economopoulou, P.; Anastasiou, M.; Moutafi, M.; Pal, L. R.; Vos, J.; Lee, A. S.; Lam, S.; Zhao, K.; Jiang, P.; Allen, C. T.; Foukas, P.; Gomatou, G.; Altan-Bonnet, G.; Morris, L. G. T.; Psyrri, A.; Ruppin, E. 分享 收藏
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Antagonism-enforced braking system to enhance CAR T cell therapeutic specificity Kondo, Taisuke; Bourassa, Francois X.; Achar, Sooraj; DuSold, Justyn; Cespedes, Pablo; Wahlsten, Madison; Kvalvaag, Audun; Gaud, Guillaume; Love, Paul; Dustin, Michael; Altan-Bonnet, Gregoire; Francois, Paul; Taylor, Naomi 分享 收藏
CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides (vol 24, pg 2121, 2023) CD3ζ ITAMs通过抑制响应低亲和力肽的TCR信号传导来实现配体区分和拮抗作用 (第24卷，2121页，2023) Gaud, Guillaume; Achar, Sooraj; Bourassa, Francois X. P.; Davies, John; Hatzihristidis, Teri; Choi, Seeyoung; Kondo, Taisuke; Gossa, Selamawit; Lee, Jan; Juneau, Paul; Taylor, Naomi; Hinrichs, Christian S.; McGavern, Dorian B.; Francois, Paul; Altan-Bonnet, Gregoire; Love, Paul E. 分享 收藏
CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides CD3ζ ITAMs通过抑制响应低亲和力肽的TCR信号传导来实现配体区分和拮抗作用 Gaud, Guillaume; Achar, Sooraj; Bourassa, Francois X. P.; Davies, John; Hatzihristidis, Teri; Choi, Seeyoung; Kondo, Taisuke; Gossa, Selamawit; Lee, Jan; Juneau, Paul; Taylor, Naomi; Hinrichs, Christian S.; Mcgavern, Dorian B.; Francois, Paul; Altan-Bonnet, Gregoire; Love, Paul E. 分享 收藏
TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways Chan, Waipan; Cao, Yuqi M.; Zhao, Xiang; Schrom, Edward C.; Jia, Dongya; Song, Jian; Sibener, Leah V.; Dong, Shen; Fernandes, Ricardo A.; Bradfield, Clinton J.; Smelkinson, Margery; Kabat, Juraj; Hor, Jyh Liang; Altan-Bonnet, Gregoire; Garcia, K. Christopher; Germain, Ronald N. 分享 收藏
A stem cell epigenome is associated with primary nonresponse to CD19 CAR T cells in pediatric acute lymphoblastic leukemia 干细胞表观基因组与儿童急性淋巴细胞白血病对CD19 CAR T细胞的原发性无反应有关 Masih, Katherine E.; Gardner, Rebecca A.; Chou, Hsien-Chao; Abdelmaksoud, Abdalla; Song, Young K.; Mariani, Luca; Gangalapudi, Vineela; Gryder, Berkley E.; Wilson, Ashley L.; Adebola, Serifat O.; Stanton, Benjamin Z.; Wang, Chaoyu; Milewski, David; Kim, Yong Yean; Tian, Meijie; Cheuk, Adam Tai -Chi; Wen, Xinyu; Zhang, Yue; Altan-Bonnet, Gregoire; Kelly, Michael C.; Wei, Jun S.; Bulyk, Martha L.; Jensen, Michael C.; Orentas, Rimas J.; Khan, Javed 分享 收藏
Apoptotic contraction drives target cell release by cytotoxic T cells Sanchez, Elisa E.; Tello-Lafoz, Maria; Guo, Aixuan J.; de Jesus, Miguel; Elbanna, Yassmin A.; Winer, Benjamin Y.; Budhu, Sadna; Chan, Eric; Rosiek, Eric; Kondo, Taisuke; DuSold, Justyn; Taylor, Naomi; Altan-Bonnet, Gregoire; Olson, Michael F.; Huse, Morgan 分享 收藏
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TCR/Chimeric Antigen Receptor (CAR) Cross-Antagonism to Fine-Tune CAR-T cell Immunotherapy Altan-Bonnet, Gregoire; Kondo, Taisuke; Bourassa, Francois X.; Achar, Sooraj; DuSold, Justyn; Cespedes, Pablo; Wahlsten, Madison; Gaud, Guillaume; Love, Paul E.; Dustin, Mike; Francois, Paul; Taylor, Naomi 分享 收藏
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Harnessing arginine metabolism overcomes hyperthermia-induced metabolic dysfunction of CAR T-cells Kondo, Taisuke; DuSold, Justyn; Achar, Sooraj; Adebola, Serifat; Gonzalez-Menendez, Pedro; Perrault, Julie; Jess, Jennifer; Yates, Bonnie; Song, Hannah; Fox, Stephen; Xu, Xia; Chan, King; Abdelmaksoud, Abdalla; Highfill, Steven; Andresson, Thorkell; Shah, Nirali; Dardalhon, Valerie; Altan-Bonnet, Gregoire; Taylor, Naomi 分享 收藏
Hinging on Success: Leveraging the Power of CAR T-Cell Therapy through In-Silico Modeling of Hinge Length and Epitope Location Mirazee, Justin M.; Aranganathan, Akashnathan; Achar, Sooraj; Jia, Dongya; Chen, Xiang; Vani, Bodhi; Chien, Christopher D.; Pouzolles, Marie; DeDe, Kniya; Youkharibache, Philippe; Walters, Kylie; Tiwary, Pratyush; Altan-Bonnet, Gregoire; Taylor, Naomi 分享 收藏
HINGE LENGTH: A NOVEL METHOD OF PREDICTING CYTOTOXICITY OF CAR CONSTRUCTS AGAINST ANTIGEN-LOW LEUKEMIA Mirazee, Justin; Jia, Dongya; Chen, Xiang; Achar, Sooraj; Chien, Chris; Pouzolles, Marie; DeDe, Kniya; Youkharibache, Philippe; Walters, Kylie; Altan-Bonnet, Gregoire; Taylor, Naomi 分享 收藏
The strength of antigenic and IL-2 signals epigenetically programs functional memory CD8+ T cells Guillen, Erik; Chin, Shu Shien; Chorro, Laurent; Achar, Sooraj; Ng, Karina; Oberle, Susanen; Alfei, Francesca; Zehn, Dietmar; Altan-Bonnet, Gregoire; Delahaye, Fabien; Lauvau, Gregoire 分享 收藏
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