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S

Sascha Rutz

genentech, inc.
H指数:34
被引数:7,828

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Optimization Leading to a Potent and Selective Cbl-b Inactive-State Inhibitor That Demonstrated In Vivo Efficacy

通过优化获得一种具有体内活性的强效且选择性Cbl-b失活态抑制剂

ACS Medicinal Chemistry Letters
IF4
2026-05-270
PRE
Jun Liang; Michael J. Lambrecht; Malcolm P. Huestis; Bingyan Zhu; Lisa M. Barton; Georgette M. Castanedo; Peter Man-Un Ung; Robin Larouche-Gauthier; Araz Jakalian; Jean-Philippe Leclerc; Arun Yadav; Pouyan Haghshenas; Samuel Aubert-Nicol; Hossein Ismaili; Liang Zhao; Melissa Leblanc; Hugo de Almeida; Qiuyue Wang; Thomas Garner; Sophia Tan; Madeleine S. Prangley; Jodie Pang; Jeremy M. Murray; Christine Yu; Peter L. Hsu; Sascha Rutz; Isabel Ishizuka; Haochu Huang; Chan Gao; Min Chen; Liz Mutter-Rottmayer; Satoko Kakiuchi-Kiyota; Dennis H. Leung; Ponien Kou; Linda Bao; Xiaojing Wang
Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

失去自身免疫风险基因TREX1揭示了促进免疫耐受丧失和抗肿瘤免疫机制的汇聚

Science Advances
IF12.5
2026-05-060
OA
Junghyun Lim; Katherine Williams; Stephanie Mittman; Patricia Pacheco Sanchez; Ryan Rodriguez; Annie Ogasawara; Grace Barnett; Mayra Cruz Tleugabulova; Barzin Y. Nabet; Jeffrey Hung; Kevin A. Marroquin; Shari Lau; Serena Y. Lee; Paul Tyler; Elizabeth T. Carbone; Bridget Hough; Janice Corpuz; Haruka Murota; Edward Dere; Smadar Shiffman; Leah K. Schutt; Herman Gill; Julia Lau; Marco De Simone; Lucinda Tam; Merone Roose-Girma; Søren Warming; Soyoung A. Oh; Sascha Rutz; Meng Xiao He; Sören Müller; Nathaniel R. West; Thomas F. Brewer; Prashant Desai; Simon Williams; James Ziai; Yan Qu; Klaus Heger
Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors

假激酶STK40通过COP1依赖性降解AP1家族转录因子来限制T细胞耗竭。

Nature Immunology
IF27.6
2025-11-210
PRE
Svetlana Altshuler-Keylin; Nicole Caduff; Isabel E. Ishizuka; Rohit Reja; Katherine Nutsch; Chan Gao; Joy Wang; Ulrike Kaufmann; Mayra Cruz Tleugabulova; Elizabeth Dixon; Hannah Little-Hooy; Rachana Pradhan; Rosa Barreira da Silva; Teresita L. Arenzana; Min Xu; Mark S. Wilson; Jill Schartner; Soyoung A. Oh; Kim Newton; Vishva M. Dixit; Sascha Rutz
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-05-291
PRE
Liang, Jun; Lambrecht, Michael J.; Arenzana, Teresita L.; Aubert-Nicol, Samuel; Bao, Linda; Broccatelli, Fabio; Cai, Jianping; Eidenschenk, Celine; Everett, Christine; Garner, Thomas; Gruber, Felix; Haghshenas, Pouyan; Huestis, Malcolm P.; Hsu, Peter L.; Kou, Ponien; Jakalian, Araz; Larouche-Gauthier, Robin; Leclerc, Jean-Philippe; Leung, Dennis H.; Martin, Aaron; Murray, Jeremy; Prangley, Madeleine; Rutz, Sascha; Kakiuchi-Kiyota, Satoko; Satz, Alexander Lee; Skelton, Nicholas J.; Steffek, Micah; Stoffler, Daniel; Sudhamsu, Jawahar; Tan, Sophia; Wang, Jian; Wang, Shouliang; Wang, Qiuyue; Wendorff, Timothy J.; Wichert, Moreno; Yadav, Arun; Yu, Christine; Wang, Xiaojing
c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis (vol 20, pg 471, 2019)
NATURE IMMUNOLOGY
IF27.6
2024-05-231
OA
Neumann, Christian; Blume, Jonas; Roy, Urmi; Teh, Peggy P.; Vasanthakumar, Ajithkumar; Beller, Alexander; Liao, Yang; Heinrich, Frederik; Arenzana, Teresita L.; Hackney, Jason A.; Eidenschenk, Celine; Galvez, Eric J. C.; Stehle, Christina; Heinz, Gitta A.; Maschmeyer, Patrick; Sidwell, Tom; Hu, Yifang; Amsen, Derk; Romagnani, Chiara; Chang, Hyun-Dong; Kruglov, Andrey; Mashreghi, Mir-Farzin; Shi, Wei; Strowig, Till; Rutz, Sascha; Kallies, Axel; Scheffold, Alexander
Enhancing TCR T cell function in solid tumors through in vivo combinatorial screens and single-cell analysis
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Polyak, Dina; Fuhriman, Jessica; Susanto, Josephine; Merrell, Allyson; Simon, Mandi; Oh, Catherine; Cordazo, Andrew; DeTomasso, David; Tocchini, Carla; Sail, Vibhavari; Cui, Eric; Milush, Jeff; Gray-Rupp, Levi; Galvin, Brendan; Murriel, Christopher; Zheng, Grace; Boroughs, Angela C.; Thakore, Pratiksha; Oh, Soyoung; Freimer, Jake; Chen, Bob; Eidenschenk, Celine; Wheeler, Emily; Levine, Jacob; Huetter, Jan-Christian; Schartner, Jill; Geiger-Schuller, Katie; Rozenblatt-Rosen, Orit; Rutz, Sascha; Mellman, Ira; Haining, W. Nicholas
Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Joshi, Sahil; Wozniak, Glenn; Gagnon, John; Vucci, Kristina; Merrell, Allyson; Simon, Mandi; Oh, Catherine; Cardozo, Andrew; DeTomaso, David; Chow, Julie; Zheng, Grace; Boroughs, Angela; Joho, Keith; Thakore, Pratiksha; Oh, Soyoung; Freimer, Jake; Cass, Ashley; Sail, Vibhavari; Tocchini, Carla; Sandoval, Marian; Liu, Andrea; Cui, Eric; Drever, Matt; Galvin, Brendan; Milush, Jeff; Gray-Rupp, Levi; Wheeler, Emily; Chen, Bob; Levine, Jacob; Eidenschenk, Celine; Schartner, Jill; Geiger-Schuller, Katie; Huetter, Jan-Christian; Rutz, Sascha; Rozenblatt-Rosen, Orit; Mellman, Ira; Haining, W. Nicholas
Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity
CELL REPORTS
IF6.9
2023-12-011
OA
Guidi, Riccardo; Wedeles, Christopher; Xu, Daqi; Kolmus, Krzysztof; Headland, Sarah E.; Teng, Grace; Guillory, Joseph; Zeng, Yi Jimmy; Cheung, Tommy K.; Chaudhuri, Subhra; Modrusan, Zora; Liang, Yuxin; Horswell, Stuart; Haley, Benjamin; Rutz, Sascha; Rose, Christopher; Franke, Yvonne; Kirkpatrick, Donald S.; Hackney, Jason A.; Wilson, Mark S.
Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8
NATURE COMMUNICATIONS
IF15.7
2023-12-016
OAAI
Sun, Dawei; Sun, Yonglian; Janezic, Eric; Zhou, Tricia; Johnson, Matthew; Azumaya, Caleigh; Noreng, Sigrid; Chiu, Cecilia; Seki, Akiko; Arenzana, Teresita L.; Nicoludis, John M.; Shi, Yongchang; Wang, Baomei; Ho, Hoangdung; Joshi, Prajakta; Tam, Christine; Payandeh, Jian; Comps-Agrar, Laetitia; Wang, Jianyong; Rutz, Sascha; Koerber, James T.; Masureel, Matthieu
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
NATURE IMMUNOLOGY
IF27.6
2022-03-2125
OA
da Silva, Rosa Barreira; Leitao, Ricardo M.; Pechuan-Jorge, Ximo; Werneke, Scott; Oeh, Jason; Javinal, Vincent; Wang, Yingyun; Phung, Wilson; Everett, Christine; Nonomiya, Jim; Arnott, David; Lu, Cheng; Hsiao, Yi-Chun; Koerber, James T.; Hotzel, Isidro; Ziai, James; Modrusan, Zora; Pillow, Thomas H.; Roose-Girma, Merone; Schartner, Jill M.; Merchant, Mark; Rutz, Sascha; Eidenschenk, Celine; Mellman, Ira; Albert, Matthew L.
PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer

树突状细胞的PD-L1表达是癌症中T细胞免疫的关键调节因子

NATURE CANCER
IF28.5
2020-06-22302
PREAI
Oh, Soyoung A.; Wu, Dai-Chen; Cheung, Jeanne; Navarro, Armando; Xiong, Huizhong; Cubas, Rafael; Totpal, Klara; Chiu, Henry; Wu, Yan; Comps-Agrar, Laetitia; Leader, Andrew M.; Merad, Miriam; Roose-Germa, Merone; Warming, Soren; Yan, Minhong; Kim, Jeong M.; Rutz, Sascha; Mellman, Ira
c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis
NATURE IMMUNOLOGY
IF27.6
2019-02-18143
PREAI
Neumann, Christian; Blume, Jonas; Roy, Urmi; Teh, Peggy P.; Vasanthakumar, Ajithkumar; Beller, Alexander; Liao, Yang; Heinrich, Frederik; Arenzana, Teresita L.; Hackney, Jason A.; Eidenschenk, Celine; Galvez, Eric J. C.; Stehle, Christina; Heinz, Gitta A.; Maschmeyer, Patrick; Sidwell, Tom; Hu, Yifang; Amsen, Derk; Romagnani, Chiara; Chang, Hyun-Dong; Kruglov, Andrey; Mashreghi, Mir-Farzin; Shi, Wei; Strowig, Till; Rutz, Sascha; Kallies, Axel; Scheffold, Alexander
Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes
SCIENCE IMMUNOLOGY
IF16.3
2018-04-2731
PREAI
Arenzana, Teresita L.; Lianoglou, Steve; Seki, Akiko; Eidenschenk, Celine; Cheung, Tommy; Seshasayee, Dhaya; Hagenbeek, Thijs; Sambandam, Arivazhagan; Noubade, Rajkumar; Peng, Ivan; Lesch, Justin; DeVoss, Jason; Wu, Xiumin; Lee, Wyne P.; Caplazi, Patrick; Webster, Joshua; Liu, Jinfeng; Pham, Victoria C.; Arnott, David; Lill, Jennie R.; Modrusan, Zora; Dey, Anwesha; Rutz, Sascha

研究方向

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C
Céline Eidenschenk
H 指数:34论文数:60被引数:6,046
W
Wenjun Ouyang
H 指数:77论文数:167被引数:3.6万
A
Alexander Scheffold
H 指数:61论文数:196被引数:1.5万
T
Teresita L. Arenzana
H 指数:13论文数:36被引数:1,021
S
Soyoung Oh
H 指数:19论文数:32被引数:3,104
J
James T. Koerber
H 指数:29论文数:81被引数:4,685
A
Akiko Seki
H 指数:24论文数:100被引数:2,933
J
Jill Schartner
H 指数:22论文数:71被引数:2,810
I
Ira Mellman
H 指数:127论文数:461被引数:8.5万
C
Christian Neumann
H 指数:21论文数:56被引数:1,773