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Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells Gampa, Gautham; Spinosa, Phillip; Getz, Jennifer; Zhong, Yu; Halpern, Wendy; Esen, Emel; Davies, John; Chou, Cassie; Kwong, Mandy; Wang, Yingyun; Arenzana, Teresita L.; Shivva, Vittal; Huseni, Mahrukh; Hsieh, Robert; Schartner, Jill; Koerber, James T.; Rutz, Sascha; Hosseini, Iraj 分享 收藏
Application of N-Terminal Site-Specific Biotin and Digoxigenin Conjugates to Clinical Anti-drug Antibody Assay Development Wang, Xiangdan; Chang, Wenping; Khosraviani, Mehraban; Phung, Wilson; Peng, Lingling; Cohen, Sivan; Andrews, Benjamin T.; Sun, Yonglian; Davies, Christopher W.; Koerber, James T.; Yang, Jihong; Song, Aimin 分享 收藏
Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8 Sun, Dawei; Sun, Yonglian; Janezic, Eric; Zhou, Tricia; Johnson, Matthew; Azumaya, Caleigh; Noreng, Sigrid; Chiu, Cecilia; Seki, Akiko; Arenzana, Teresita L.; Nicoludis, John M.; Shi, Yongchang; Wang, Baomei; Ho, Hoangdung; Joshi, Prajakta; Tam, Christine; Payandeh, Jian; Comps-Agrar, Laetitia; Wang, Jianyong; Rutz, Sascha; Koerber, James T.; Masureel, Matthieu 分享 收藏
High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry Shi, Rachel Liuqing; Dillon, Michael A.; Compton, Philip D.; Sawyer, William S.; Thorup, John R.; Kwong, Mandy; Chan, Pamela; Chiu, Cecilia P. C.; Li, Ran; Yadav, Rajbharan; Lee, Genee Y.; Gober, Joshua G.; Li, Zhiyu; Elsohly, Adel M.; Ovacik, Ayse Meric; Koerber, James T.; Spiess, Christoph; Josephs, Jonathan L.; Tran, John C. 分享 收藏
A novel, label-free, pre-equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells Janezic, Eric M.; Doan, Alexander; Mai, Elaine; Bravo, Daniel D.; Wang, Jianyong; Kim, Hok Seon; Spiess, Christoph; Bewley, Kathryn; Elsohly, Adel; Liang, Wei-Ching; Koerber, James T.; Richalet, Pascale; Vanhove, Marc; Comps-Agrar, Laetitia 分享 收藏
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors 联合PD-L1/tgf β 阻断可在免疫排除的肿瘤中扩增和分化干细胞样CD8 T细胞 Castiglioni, Alessandra; Yang, Yagai; Williams, Katherine; Gogineni, Alvin; Lane, Ryan S.; Wang, Amber W.; Shyer, Justin A.; Zhang, Zhe; Mittman, Stephanie; Gutierrez, Alan; Astarita, Jillian L.; Thai, Minh; Hung, Jeffrey; Yang, Yeqing Angela; Pourmohamad, Tony; Himmels, Patricia; De Simone, Marco; Elstrott, Justin; Capietto, Aude-Helene; Cubas, Rafael; Modrusan, Zora; Sandoval, Wendy; Ziai, James; Gould, Stephen E.; Fu, Wenxian; Wang, Yulei; Koerber, James T.; Sanjabi, Shomyseh; Mellman, Ira; Turley, Shannon J.; Mueller, Soeren 分享 收藏
Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys Cai, Hao; Tao, Xun; Shim, Jeongsup; Bauer, Rebecca N.; Bremer, Meire; Bu, Wei; LaMar, Jason; Basile, Rachel; Dere, Edward; Nguyen, Tien; Laing, Steven; Chan, Pamela; Yi, Tangsheng; Koerber, James T.; Sperinde, Gizette; Stefanich, Eric 分享 收藏
Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action Chan, Jocelyn; Chan, Joyce; Shao, Lily; Stawicki, Scott S.; Pham, Victoria C.; Akita, Rob W.; Hafner, Marc; Crocker, Lisa; Yu, Kebing; Koerber, James T.; Schaefer, Gabriele; Comps-Agrar, Laetitia 分享 收藏
Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis Chavarria-Smith, Joseph; Chiu, Cecilia P. C.; Jackman, Janet K.; Yin, Jianping; Zhang, Juan; Hackney, Jason A.; Lin, Wei-Yu; Tyagi, Tulika; Sun, Yonglian; Tao, Janet; Dunlap, Debra; Morton, William D.; Ghodge, Swapnil, V; Maun, Henry R.; Li, Hong; Hernandez-Barry, Hilda; Loyet, Kelly M.; Chen, Emily; Liu, John; Tam, Christine; Yaspan, Brian L.; Cai, Hao; Balazs, Mercedesz; Arron, Joseph R.; Li, Jing; Wittwer, Arthur J.; Pappu, Rajita; Austin, Cary D.; Lee, Wyne P.; Lazarus, Robert A.; Sudhamsu, Jawahar; Koerber, James T.; Yi, Tangsheng 分享 收藏
Development of an 18F-labeled anti-human CD8 VHH for same-day immunoPET imaging Sriraman, Shravan Kumar; Davies, Christopher W.; Gill, Herman; Kiefer, James R.; Yin, Jianping; Ogasawara, Annie; Urrutia, Alejandra; Javinal, Vincent; Lin, Zhonghua; Seshasayee, Dhaya; Abraham, Ryan; Haas, Phil; Koth, Christopher; Marik, Jan; Koerber, James T.; Williams, Simon Peter 分享 收藏
Structure of the core human NADPH oxidase NOX2 核心人类NADPH氧化酶NOX2的结构 Noreng, Sigrid; Ota, Naruhisa; Sun, Yonglian; Ho, Hoangdung; Johnson, Matthew; Arthur, Christopher P.; Schneider, Kellen; Lehoux, Isabelle; Davies, Christopher W.; Mortara, Kyle; Wong, Kit; Seshasayee, Dhaya; Masureel, Matthieu; Payandeh, Jian; Yi, Tangsheng; Koerber, James T. 分享 收藏
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma Jackman, Janet K.; Stockwell, Amy; Choy, David F.; Xie, Markus M.; Lu, Peipei; Jia, Guiquan; Li, Hong; Abbas, Alexander R.; Bronson, Paola G.; Lin, Wei-Yu; Chiu, Cecilia P. C.; Maun, Henry R.; Roose-Girma, Merone; Tam, Lucinda; Zhang, Juan; Modrusan, Zora; Graham, Robert R.; Behrens, Timothy W.; White, Steven R.; Naureckas, Ted; Ober, Carole; Ferreira, Manuel; Sedlacek, Radislav; Wu, Jiansheng; Lee, Wyne P.; Lazarus, Robert A.; Koerber, James T.; Arron, Joseph R.; Yaspan, Brian L.; Yi, Tangsheng 分享 收藏
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity da Silva, Rosa Barreira; Leitao, Ricardo M.; Pechuan-Jorge, Ximo; Werneke, Scott; Oeh, Jason; Javinal, Vincent; Wang, Yingyun; Phung, Wilson; Everett, Christine; Nonomiya, Jim; Arnott, David; Lu, Cheng; Hsiao, Yi-Chun; Koerber, James T.; Hotzel, Isidro; Ziai, James; Modrusan, Zora; Pillow, Thomas H.; Roose-Girma, Merone; Schartner, Jill M.; Merchant, Mark; Rutz, Sascha; Eidenschenk, Celine; Mellman, Ira; Albert, Matthew L. 分享 收藏
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors Davies, Christopher W.; Oh, Angela J.; Mroue, Rana; Steffek, Micah; Bruning, John M.; Xiao, Yang; Feng, Siyu; Jayakar, Sangeeta; Chan, Emily; Arumugam, Vidhyalakshmi; Uribe, Sean Carlo; Drummond, Jake; Frommlet, Alexandra; Lu, Cheng; Franke, Yvonne; Merchant, Mark; Koeppen, Hartmut; Quinn, John G.; Malhotra, Sushant; Do, Steve; Gazzard, Lewis; Purkey, Hans E.; Rudolph, Joachim; Mulvihill, Melinda M.; Koerber, James T.; Wang, Weiru; Evangelista, Marie 分享 收藏
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