Todd M. Brusko - Publications, H-index & Citations

Todd M. Brusko

university of florida

59H指数

270论文数

1.2W被引数

收录论文 140

发表时间

Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata 成像质谱流式细胞术揭示人类胰腺在1型糖尿病进展过程中的功能与免疫变化

Nature Metabolism

IF20.8

2026-07-02

OAAI

Nathan Steenbuck; Nicolas Damond; Stefanie Engler; Irina Kusmartseva; Amanda L. Posgai; Denise M. Drotar; MacKenzie D. Williams; Natalie de Souza; Todd M. Brusko; Maigan A. Brusko; Clive H. Wasserfall; Mark A. Atkinson; Bernd Bodenmiller

Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells 不同的转录因子控制婴儿和成人记忆T细胞的组织适应和效应功能

Nature Immunology

IF27.6

2026-06-02

OAAI

Peter A. Szabo; Hanna M. Levitin; Siddhi Nargund; Thomas J. Connors; David Chen; Jenny Jin; Puspa Thapa; Rebecca Guyer; Daniel P. Caron; Joshua I. Gray; Rei Matsumoto; Masaru Kubota; Maigan Brusko; Todd M. Brusko; Donna L. Farber; Peter A. Sims

Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes (Vol 11, e207149, 2026)1型糖尿病中具有共享种系样α链的自身反应性T细胞受体 (Vol 11, e207149, 2026)

JCI Insight

IF6.1

2026-04-22

PREAI

Linsley, Peter S.; Barahmand-pour-Whitman, Fariba; Balmas, Elisa; DeBerg, Hannah A.; Flynn, Kaitlin J.; Hu, Alex K.; Rosasco, Mario G.; Chen, Janice; O'Rourke, Colin; Serti, Elisavet; Gersuk, Vivian H.; Motwani, Keshav; Seay, Howard R.; Brusko, Todd M.; Kwok, William W.; Speake, Cate; Greenbaum, Carla J.; Nepom, Gerald T.; Cerosaletti, Karen

Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices Beta cell–targeted PD-1 agonist抑制胰腺组织切片中的细胞介导的自身免疫。

Science Advances

IF12.5

2026-04-01

OAAI

Matthew W. Becker; Matthew E. Brown; Katherine Wiseman; Ana Laura Chiodetti; Mollie K. Huber; Alexandra E. Cuaycal; Pumin Sintara; Sandra M. Ferreira; Dylan Smurlick; Jessie M. Barra; Andrew M. Ladd; Denise M. Drotar; Mark A. Atkinson; Peter Weber; Hussein Al-Mossawi; Holger A. Russ; Tara M. Mahon; Todd M. Brusko; Giovanna Bossi; Edward A. Phelps

Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes 胰腺和局部引流淋巴结组织的空间转录组学揭示人类1型糖尿病中存在淋巴毒素-β特征

Cell Reports

IF6.9

2026-03-23

OAAI

Miguel A. Medina-Serpas; Maigan Brusko; Gregory J. Golden; Martha Campbell-Thompson; Trevor Rogers; Shay Reardon; Amanda L. Posgai; Rhonda Bacher; Eline T. Luning Prak; Chengyang Liu; Klaus H. Kaestner; Ali Naji; Michael R. Betts; Lauren M. McIntyre; Mark A. Atkinson; Todd M. Brusko

Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion 黄, X.; 张, M.; Pearce, A.D.; Gibbons, M.D.; 金, D.; 李, L.; 胡, D.; 刘, R.; 于, M.; 谭, M.; 等. 上皮-间质转化激活YAP以驱动恶性进展和免疫逃逸. Cancers 2025, 17, 2767. [Google Scholar] [CrossRef]

Cancers

IF4.4

2026-03-03

OAAI

Xi Huang; Mingyan Zhang; Alexander D. Pearce; Matthew D. Gibbons; Dan Jin; Lu Li; Dongxin Hu; Renbin Liu; Mu Yu; Ming Tan; Jia Chang; Jixin Dong; Mingyi Xie; Weizhou Zhang; Lizi Wu; Catherine Flores; Jörg Bungert; Todd M. Brusko; Jianrong Lu

Identification of a type 1 diabetes–associated T cell receptor repertoire signature from the human peripheral blood 从人外周血中鉴定出与1型糖尿病相关的T细胞受体谱特征

Science Advances

IF12.5

2026-02-13

OAAI

Puneet Rawat; Melanie R. Shapiro; Leeana D. Peters; Michael Widrich; Koshlan Mayer-Blackwell; Keshav Motwani; Milena Pavlović; Ghadi al Hajj; Amanda L. Posgai; Chakravarthi Kanduri; Giulio Isacchini; Maria Chernigovskaya; Lonneke Scheffer; Kartik Motwani; Leandro Octavio Balzano-Nogueira; Camryn M. Pettenger-Willey; Sebastiaan Valkiers; Laura M. Jacobsen; Michael J. Haller; Desmond A. Schatz; Clive H. Wasserfall; Ryan O. Emerson; Andrew J. Fiore-Gartland; Mark A. Atkinson; Günter Klambauer; Geir Kjetil Sandve; Victor Greiff; Todd M. Brusko

Human stem cell-derived β cells expressing an optimized CD155 reduce cytotoxic immune cell function for application in type 1 diabetes 人源干细胞来源的β细胞表达优化后的CD155，以降低细胞毒性免疫细胞功能，用于1型糖尿病的应用

Science Advances

IF12.5

2025-11-07

PREAI

Matthew E. Brown; Jessie M. Barra; Marcus R. Pina; James Proia; Todd M. Brusko; Holger A. Russ

Regulatory T cells modulate presentation of autoantigens via pMHCII removal

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Akkaya, Billur; Singh, Vishal; Akkaya, Munir; Brusko, Todd M.; Shevach, Ethan M.

Overexpression of CD155 in human stem cell-derived β-cells diminishes autoreactive T cell responses

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Barra, Jessie M.; Brown, Matthew E.; Pina, Marcus R.; Proia, James; Brusko, Todd M.; Russ, Holger

Asynchronous aging and turnover of human circulating and tissue-resident memory T cells across sites 人类循环和组织驻留记忆T细胞在不同部位的非同步衰老与更新

Immunity

IF26.3

2025-07-29

PREAI

Nora Lam; J. Carlos Angel; Bruce A. Buchholz; YoonSeung Lee; Stuart P. Weisberg; Brea H. Brown; Julia Davis-Porada; Daniel P. Caron; Isaac J. Jensen; Peter A. Szabo; Basak B. Ural; Steven B. Wells; Masaru Kubota; Rei Matsumoto; Maigan Brusko; Todd M. Brusko; Chao Lu; Andrew J. Yates; Donna L. Farber

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset 1型糖尿病发病前后人类胰腺淋巴组织中的免疫扰动

NATURE COMMUNICATIONS

IF15.7

2025-05-18

OAAI

Golden, Gregory J.; Wu, Vincent H.; Hamilton, Jacob T.; Amses, Kevin R.; Shapiro, Melanie R.; Japp, Alberto Sada; Liu, Chengyang; Pampena, M. Betina; Kuri-Cervantes, Leticia; Knox, James J.; Gardner, Jay S.; Atkinson, Mark A.; Brusko, Todd M.; Prak, Eline T. Luning; Kaestner, Klaus H.; Naji, Ali; Betts, Michael R.

Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes

BMJ OPEN DIABETES RESEARCH & CARE

IF4.1

2025-01-04

OAAI

Williams, MacKenzie D.; Grace, Catherine Ramsey; Posgai, Amanda L.; Mcgrail, Kieran M.; Brusko, Maigan A.; Haller, Michael J.; Jacobsen, Laura; Schatz, Desmond; Brusko, Todd M.; Atkinson, Mark; Bacher, Rhonda; Wasserfall, Clive H.

Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes

DIABETOLOGIA

IF10.2

2024-12-19

OAAI

Shapiro, Melanie R.; Tallon, Erin M.; Brown, Matthew E.; Posgai, Amanda L.; Clements, Mark A.; Brusko, Todd M.

Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes 无高危HLA-DR4-DQ8或HLA-DR3-DQ2单倍型的自身抗体阳性个体的特征

DIABETOLOGIA

IF10.2

2024-12-13

OAAI

Redondo, Maria J.; Cuthbertson, David; Steck, Andrea K.; Herold, Kevan C.; Oram, Richard; Atkinson, Mark; Brusko, Todd M.; Parikh, Hemang M.; Krischer, Jeffrey P.; Onengut-Gumuscu, Suna; Rich, Stephen S.; Sosenko, Jay M.

Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function

DIABETOLOGIA

IF10.2

2024-12-05

OAAI

Brown, Matthew E.; Thirawatananond, Puchong; Peters, Leeana D.; Kern, Elizabeth J.; Vijay, Sonali; Sachs, Lindsey K.; Posgai, Amanda L.; Brusko, Maigan A.; Shapiro, Melanie R.; Mathews, Clayton E.; Bacher, Rhonda; Brusko, Todd M.

Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness

FRONTIERS IN IMMUNOLOGY

IF5.9

2024-12-03

OAAI

Barrios, Evan L.; Balzano-Nogueira, Leandro; Polcz, Valerie E.; Rodhouse, Christine; Leary, Jack R.; Darden, Dijoia B.; Rincon, Jaimar C.; Dirain, Marvin L.; Ungaro, Ricardo; Nacionales, Dina C.; Larson, Shawn D.; Sharma, Ashish; Upchurch, Gilburt; Wallet, Shannon M.; Brusko, Todd M.; Loftus, Tyler J.; Mohr, Alicia M.; Maile, Robert; Bacher, Rhonda; Cai, Guoshuai; Kladde, Michael P.; Mathews, Clayton E.; Moldawer, Lyle L.; Brusko, Maigan A.; Efron, Philip A.

The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium AIRR数据共享中的1型糖尿病T细胞受体和b细胞受体库: 通过1型糖尿病AIRR联盟访问，使用和贡献的实用指南

DIABETOLOGIA

IF10.2

2024-10-29

OAAI

Hanna, Stephanie J.; Bonami, Rachel H.; Corrie, Brian; Westley, Monica; Posgai, Amanda L.; Prak, Eline T. Luning; Breden, Felix; Michels, Aaron W.; Brusko, Todd M.

Low Morning Cortisol in Early Life Associated with Increased Risk of Islet Autoimmunity

DIABETES

IF7.5

2024-06-14

PREAI

Vehik, Kendra; Lynch, Kristian F.; Parikh, Hemang M.; Lernmark, Ake; Rewers, Marian; McIndoe, Richard; Toppari, Jorma; Ziegler, Anette-Gabriele; Akolkar, Beena; Hagopian, William; Brusko, Todd M.; Krischer, Jeffrey; Roth, Roswith L.; Johnson, Suzanne B.

Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

DIABETES

IF7.5

2024-06-14

PREAI

Tallon, Erin M.; Shapiro, Melanie R.; Waghmode, Amey Shrikrishna; Merritt, Ryan; Wasserfall, Clive; Bacher, Rhonda; Lockee, Brent; Vandervelden, Craig; Panfil, Kelsey; Moore, Wayne V.; Atkinson, Mark A.; Brusko, Todd M.; Clements, Mark A.

研究方向