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G

Gerald S. Shadel

Salk Institute for Biological Studies

76H指数
195论文数
2.4W被引数
收录论文 94
发表时间
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Chronic type II interferon promotes tumor growth through mitochondrial RNA–induced type I interferon and prostaglandin synthesis慢性II型干扰素通过线粒体RNA诱导的I型干扰素和前列腺素合成促进肿瘤生长
errScience
IF45.8
err2026-09-10
err0
PREAI
errMelissa A. Johnson; Siva Karthik Varanasi; Kailash Chandra Mangalhara; Kathryn Lande; Gladys R. Rojas; Pau B. Esparza-Moltó; Mack B. Reynolds; Neva Olliffe; Karl Wessendorf-Rodriguez; Sagnika Ghosh; Dan Chen; Alexandra G. Moyzis; Matthew P. Donnelly; Rebecca Chinn; Ziyan Xu; Kym J. Grae; Victoria Tripple; Michael A. LaPorta; Christian M. Metallo; Diana C. Hargreaves; Susan M. Kaech; Gerald S. Shadel
err分享
err收藏
Kidney mitochondrial DNA contributes to systemic IL-6 release in sepsis-associated acute kidney injury肾脏线粒体DNA在脓毒症相关性急性肾损伤中促进全身IL-6释放
errJCI INSIGHT
IF6.1
err2025-12-08
err0
PREAI
errKumar, Avnee J.; Epler, Katharine; Wang, Jing; Shen, Alice; Samandari, Negin; Rolfsen, Mark L.; Barnes, Laura A.; Shadel, Gerald S.; Moyzis, Alexandra G.; Sainz, Alva G.; Ulubabyan, Karlen; Li, Kefeng; Jepsen, Kristen; Li, Xinrui; Fuster, Mark M.; Spragg, Roger G.; Sasik, Roman; Vallon, Volker; Goodluck, Helen; Ix, Joachim H.; Singh, Prabhleen; Hepokoski, Mark L.
err分享
err收藏
Retraction Notice to “Aberrant CD8+ T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling” [Am J Pathol 178 (2011) 2740–2751]撤稿通知：“由超激活Akt和mTORC1信号驱动的共济失调-毛细血管扩张症小鼠模型在病毒感染后的异常CD8+ T细胞反应和记忆分化”[Am J Pathol 178 (2011) 2740–2751]
errThe American Journal of Pathology
IF0
err2025-09-23
err0
PREAI
errAnthony D. D’Souza; Ian A. Parish; Sharen E. McKay; Susan M. Kaech; Gerald S. Shadel
err分享
err收藏
ROS-dependent localization of glycolytic enzymes to mitochondria线粒体依赖的糖酵解酶定位
errRedox Biology
IF11.9
err2025-08-05
err0
errOAAI
errPau B. Esparza-Moltó; Arvind V. Goswami; Süleyman Bozkurt; Christian Münch; Laura E. Newman; Alexandra G. Moyzis; Gladys R. Rojas; Deann Guan; Jeffrey R. Jones; Fred H. Gage; Gerald S. Shadel
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FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletionFAM43A协调mtDNA复制和线粒体生物发生以响应mtDNA耗竭
errJOURNAL OF CELL BIOLOGY
IF6.4
err2025-01-27
err0
PREAI
errSainz, Alva G.; Rojas, Gladys R.; Moyzis, Alexandra G.; Donnelly, Matthew P.; Mangalhara, Kailash C.; Johnson, Melissa A.; Esparza-Molto, Pau B.; Grae, Kym J.; Shaw, Reuben J.; Shadel, Gerald S.
err分享
err收藏
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal
errNATURE CELL BIOLOGY
IF19.1
err2024-02-08
err17
PREAI
errNewman, Laura E.; Weiser Novak, Sammy; Rojas, Gladys R.; Tadepalle, Nimesha; Schiavon, Cara R.; Grotjahn, Danielle A.; Towers, Christina G.; Tremblay, Marie-eve; Donnelly, Matthew P.; Ghosh, Sagnika; Medina, Michaela; Rocha, Sienna; Rodriguez-Enriquez, Ricardo; Chevez, Joshua A.; Lemersal, Ian; Manor, Uri; Shadel, Gerald S.
err分享
err收藏
Mitochondrial DNA Release in Innate Immune Signaling
errANNUAL REVIEW OF BIOCHEMISTRY
IF20.5
err2023-06-20
err58
errOAAI
errNewman, Laura E.; Shadel, Gerald S.
err分享
err收藏
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
errHUMAN MOLECULAR GENETICS
IF3.2
err2023-05-02
err12
errOAAI
errAl Khatib, Iman; Deng, Jingti; Lei, Yuanjiu; Torres-Odio, Sylvia; Rojas, Gladys R.; Newman, Laura E.; Chung, Brian K.; Symes, Andrew; Zhang, Hongliang; Huang, Shar-yin N.; Pommier, Yves; Khan, Aneal; Shadel, Gerald S.; West, Andrew Phillip; Gibson, William T.; Shutt, Timothy E.
err分享
err收藏
A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err201
errOAAI
errMcCulloch, V; Seidel-Rogol, BL; Shadel, GS
err分享
err收藏
Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err151
errOAAI
errMcCulloch, V; Shadel, GS
err分享
err收藏
Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err152
errOAAI
errDoudican, NA; Song, BW; Shadel, GS; Doetsch, PW
err分享
err收藏
Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err139
errOAAI
errBonawitz, Nicholas D.; Rodeheffer, Matthew S.; Shadel, Gerald S.
err分享
err收藏
Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err124
errOAAI
errO'Rourke, TW; Doudican, NA; Mackereth, MD; Doetsch, PW; Shadel, GS
err分享
err收藏
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophagesDNA甲基转移酶3α 和TET甲基胞嘧啶双加氧酶2抑制线粒体DNA介导的巨噬细胞干扰素信号
errIMMUNITY
IF26.3
err2022-08-01
err33
errOAAI
errCobo, Isidoro; Tanaka, Tiffany N.; Mangalhara, Kailash Chandra; Lana, Addison; Yeang, Calvin; Han, Claudia; Schlachetzki, Johannes; Challcombe, Jean; Fixsen, Bethany R.; Sakai, Mashito; Li, Rick Z.; Fields, Hannah; Mokry, Michal; Tsai, Randy G.; Bejar, Rafael; Prange, Koen; de Winther, Menno; Shadel, Gerald S.; Glass, Christopher K.
err分享
err收藏
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling
errIMMUNITY
IF26.3
err2022-08-01
err282
errOAAI
errXian, Hongxu; Watari, Kosuke; Sanchez-Lopez, Elsa; Offenberger, Joseph; Onyuru, Janset; Sampath, Harini; Ying, Wei; Hoffman, Hal M.; Shadel, Gerald S.; Karin, Michael
err分享
err收藏
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions
errAMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
IF3.5
err2022-07-01
err15
errOAAI
errHepokoski, Mark L.; Odish, Mazen; Lam, Michael T.; Coufal, Nicole G.; Rolfsen, Mark L.; Shadel, Gerald S.; Moyzis, Alexandra G.; Sainz, Alva G.; Takiar, Puja G.; Patel, Sagar; Leonard, Austin J.; Samandari, Negin; Hansen, Emily; Trescott, Samantha; Nguyen, Celina; Jepsen, Kristen; Cutter, Gary; Gillespie, Mark N.; Spragg, Roger G.; Sasik, Roman; Ix, Joachim H.
err分享
err收藏
ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
errJOURNAL OF CELL BIOLOGY
IF6.4
err2022-06-03
err48
errOAAI
errHancock-Cerutti, William; Wu, Zheng; Xu, Peng; Yadavalli, Narayana; Leonzino, Marianna; Tharkeshwar, Arun Kumar; Ferguson, Shawn M.; Shadel, Gerald S.; De Camilli, Pietro
err分享
err收藏
Mitochondrial DNA: cellular genotoxic stress sentinel
errTRENDS IN BIOCHEMICAL SCIENCES
IF11
err2021-10-01
err55
errOAAI
errWu, Zheng; Sainz, Alva G.; Shadel, Gerald S.
err分享
err收藏
The San Diego Nathan Shock Center: tackling the heterogeneity of aging
errGEROSCIENCE
IF5.4
err2021-08-09
err3
errOAAI
errShadel, Gerald S.; Adams, Peter D.; Berggren, W. Travis; Diedrich, Jolene K.; Diffenderfer, Kenneth E.; Gage, Fred H.; Hah, Nasun; Hansen, Malene; Hetzer, Martin W.; Molina, Anthony J. A.; Manor, Uri; Marek, Kurt; O'Keefe, David D.; Pinto, Antonio F. M.; Sacco, Alessandra; Sharpee, Tatyana O.; Shokriev, Maxim N.; Zambetti, Stefania
err分享
err收藏
RNA reports breaking news from mitochondria
errMOLECULAR CELL
IF16.6
err2021-05-01
err3
errOAAI
errTadepalle, Nimesha; Shadel, Gerald S.
err分享
err收藏

研究方向

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合作学者
合作期刊
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Michael Karin
H 指数: 254 · 论文数: 904
F
Fred H. Gage
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G
Gerald I. Shulman
H 指数: 183 · 论文数: 821
C
Christopher K. Glass
H 指数: 170 · 论文数: 569
P
Pietro De Camilli
H 指数: 146 · 论文数: 565
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