未登录 A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131 (vol 10, 12414, 2020) 一种使用细菌高含量成像的新型治疗性抗体筛选方法揭示了大肠杆菌ST131的功能性抗体结合表型 (第10卷，12414，2020) Maes, Mailis; Dyson, Zoe A.; Smith, Sarah E.; Goulding, David A.; Ludden, Catherine; Baker, Stephen; Kellam, Paul; Reece, Stephen T.; Dougan, Gordon; Scott, Josefin Bartholdson 分享 收藏
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A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131 使用细菌高含量成像的新型治疗性抗体筛选方法揭示了大肠杆菌ST131的功能性抗体结合表型 Maes, Mailis; Dyson, Zoe A.; Smith, Sarah E.; Goulding, David A.; Ludden, Catherine; Baker, Stephen; Kellam, Paul; Reece, Stephen T.; Dougan, Gordon; Scott, Josefin Bartholdson 分享 收藏
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Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain Bat IFITM3限制取决于S-棕榈酰化和CD225域内的多态性位点 Benfield, Camilla T. O.; MacKenzie, Farrell; Ritzefeld, Markus; Mazzon, Michela; Weston, Stuart; Tate, Edward; Teo, Boon Han; Smith, Sarah E.; Kellam, Paul; Holmes, Edward C.; Marsh, Mark 分享 收藏
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3D Printing of Metformin HCl PVA Tablets by Fused Deposition Modeling: Drug Loading, Tablet Design, and Dissolution Studies Ibrahim, Mariam; Barnes, Morgan; McMillin, Robert; Cook, Daniel W.; Smith, Sarah; Halquist, Mathew; Wijesinghe, Dayanjan; Roper, Thomas D. 分享 收藏
Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane 干扰素诱导的跨膜蛋白1限制病毒通过质膜进入细胞的复制 Smith, S. E.; Busse, D. C.; Binter, S.; Weston, S.; Soria, C. Diaz; Laksono, B. M.; Clare, S.; Van Nieuwkoop, S.; Van den Hoogen, B. G.; Clement, M.; Marsden, M.; Humphreys, I. R.; Marsh, M.; de Swart, R. L.; Wash, R. S.; Tregoning, J. S.; Kellam, P. 分享 收藏
Functional analysis of Salmonella Typhi adaptation to survival in water Kingsley, Robert A.; Langridge, Gemma; Smith, Sarah E.; Makendi, Carine; Fookes, Maria; Wileman, Tom M.; Abd El Ghany, Moataz; Turner, A. Keith; Dyson, Zoe A.; Sridhar, Sushmita; Pickard, Derek; Kay, Sally; Feasey, Nicholas; Wong, Vanessa; Barquist, Lars; Dougan, Gordon 分享 收藏
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Investments to reverse biodiversity loss are economically beneficial Sumaila, U. Rashid; Rodriguez, Carlos Manuel; Schultz, Maria; Sharma, Ravi; Tyrrell, Tristan D.; Masundire, Hillary; Damodaran, A.; Bellot-Rojas, Mariana; Rosales, Rina Maria P.; Jung, Tae Yong; Hickey, Valerie; Solhaug, Tone; Vause, James; Ervin, Jamison; Smith, Sarah; Rayment, Matt 分享 收藏
The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis 抗病毒限制因子IFN诱导的跨膜蛋白3阻止细胞因子驱动的CMV发病机制 Stacey, Maria A.; Clare, Simon; Clement, Mathew; Marsden, Morgan; Abdul-Karim, Juneid; Kane, Leanne; Harcourt, Katherine; Brandt, Cordelia; Fielding, Ceri A.; Smith, Sarah E.; Wash, Rachael S.; Brias, Silvia Gimeno; Stack, Gabrielle; Notley, George; Cambridge, Emma L.; Isherwood, Christopher; Speak, Anneliese O.; Johnson, Zoe; Ferlin, Walter; Jones, Simon A.; Kellam, Paul; Humphreys, Ian R. 分享 收藏
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Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening Borthwick, Jennifer A.; Ancellin, Nicolas; Bertrand, Sophie M.; Bingham, Ryan P.; Carter, Paul S.; Chun, Chun-wa; Churcher, Ian; Dodic, Nerina; Fournier, Charlene; Francis, Peter L.; Hobbs, Andrew; Jamieson, Craig; Pickett, Stephen D.; Smith, Sarah E.; Somers, Donald O'N.; Spitzfaden, Claus; Suckling, Colin J.; Young, Robert J. 分享 收藏
Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors Deng, Hongfeng; Zhou, Jingye; Sundersingh, Flora; Messer, Jeffrey A.; Somers, Donald O.; Ajakane, Myriam; Arico-Muendel, Christopher C.; Beljean, Arthur; Belyanskaya, Svetlana L.; Bingham, Ryan; Blazensky, Emily; Boullay, Anne-Benedicte; Boursier, Eric; Chai, Jing; Carter, Paul; Chung, Chun-Wa; Daugan, Alain; Ding, Yun; Herry, Kenny; Hobbs, Clare; Humphries, Eric; Kollmann, Christopher; Van Loc Nguyen; Nicodeme, Edwige; Smith, Sarah E.; Dodic, Nerina; Ancellin, Nicolas 分享 收藏
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease Down, Kenneth; Amour, Augustin; Baldwin, Ian R.; Cooper, Anthony W. J.; Deakin, Angela M.; Felton, Leigh M.; Guntrip, Stephen B.; Hardy, Charlotte; Harrison, Zoe A.; Jones, Katherine L.; Jones, Paul; Keeling, Suzanne E.; Le, Joelle; Livia, Stefano; Lucas, Fiona; Lunniss, Christopher J.; Parr, Nigel J.; Robinson, Ed; Rowland, Paul; Smith, Sarah; Thomas, Daniel A.; Vitulli, Giovanni; Washio, Yoshiaki; Hamblin, J. Nicole 分享 收藏
Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library Deng, Hongfeng; Zhou, Jingye; Sundersingh, Flora S.; Summerfield, Jennifer; Somers, Don; Messer, Jeffrey A.; Satz, Alexander L.; Ancellin, Nicolas; Arico-Muendel, Christopher C.; Bedard, Katie L. (Sargent); Beljean, Arthur; Belyanskaya, Svetlana L.; Bingham, Ryan; Smith, Sarah E.; Boursier, Eric; Carter, Paul; Centrella, Paolo A.; Clark, Matthew A.; Chung, Chun-wa; Davie, Christopher P.; Delorey, Jennifer L.; Ding, Yun; Franklin, G. Joseph; Grady, LaShadric C.; Herry, Kenny; Hobbs, Clare; Kollmann, Christopher S.; Morgan, Barry A.; Kaushansky, Laura J. (Pothier); Zhou, Quan 分享 收藏
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits Bertrand, Sophie M.; Ancellin, Nicolas; Beaufils, Benjamin; Bingham, Ryan P.; Borthwick, Jennifer A.; Boullay, Anne-Benedicte; Boursier, Eric; Carter, Paul S.; Chung, Chun-wa; Churcher, Ian; Dodic, Nerina; Fouchet, Marie-Helene; Foumier, Charlene; Francis, Peter L.; Gummer, Laura A.; Herry, Kenny; Hobbs, Andrew; Hobbs, Clare I.; Homes, Paul; Jamieson, Craig; Nicodeme, Edwige; Pickettlt, Stephen D.; Reid, Fain H.; Simpson, Graham L.; Sloan, Lisa A.; Smith, Sarah E.; Somers, Donald O'N.; Spitzfaden, Claus; Suckling, Cohn J.; Valko, Kara; Washio, Yoshiaki; Young, Robert J. 分享 收藏
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