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收藏A TTN Frameshift Mutation Leads to Dysfunctional Sarcomere and Calcium Handling in iPSC-derived Atrial CardiomyocytesTTN基因框移突变导致iPSC来源的心房心肌细胞肌原纤维功能障碍和钙离子处理异常
Baskaran, Abhinaya; Arif, Mahmud; Chen, Hanna; Hill, Michael; Barney, Miles; Owais, Asia; Sridhar, Arvind; DeSantiago, Jaime; Shah, Anish; Griza, Decebal; Chen, Yining; Diaz, Annette; Darbar, Dawood 分享 收藏 Epigenetic Activation of Endothelial to Mesenchymal Transition Links Endothelial Dysfunction to Atrial Fibrillation in Lamin A/C Cardiomyopathy表观遗传激活的上皮-间质转化将内皮功能障碍与心房颤动联系起来，见于拉曼A/C心肌病Owais, Asia; Chen, Hanna; Barney, Miles; Sridhar, Arvind; Baskaran, Abhinaya; Kortan, Elif; DeSantiago, Jaime; Arif, Mahmud; Islam, Abul; Maienschein-Cline, Mark; Ong, Sang; Darbar, Dawood 分享 收藏 分享 收藏 分享 收藏 Genetic Mouse Models of Obesity may provide mechanistic insights into atrial myopathy and atrial fibrillation: Insights from Mc4r-KO Mice肥胖的遗传小鼠模型可能为心房心肌病和心房颤动的机制提供见解：来自Mc4r-KO小鼠的见解Sridhar, Arvind; DeSantiago, Jaime; Arif, Mahmud; Owais, Asia; Barney, Miles; Chen, Hanna; Baskaran, Abhinaya; Hong, Liang; McCauley, Mark; Darbar, Dawood 分享 收藏 Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height333,100个体的全基因组测序揭示了罕见的非编码单一变异和与身高的聚集关联Hawkes, Gareth; Beaumont, Robin N.; Li, Zilin; Mandla, Ravi; Li, Xihao; Albert, Christine M.; Arnett, Donna K.; Ashley-Koch, Allison E.; Ashrani, Aneel A.; Barnes, Kathleen C.; Boerwinkle, Eric; Brody, Jennifer A.; Carson, April P.; Chami, Nathalie; Chen, Yii-Der Ida; Chung, Mina K.; Curran, Joanne E.; Darbar, Dawood; Ellinor, Patrick T.; Fornage, Myrian; Gordeuk, Victor R.; Guo, Xiuqing; He, Jiang; Hwu, Chii-Min; Kalyani, Rita R.; Kaplan, Robert; Kardia, Sharon L. R.; Kooperberg, Charles; Loos, Ruth J. F.; Lubitz, Steven A.; Minster, Ryan L.; Naseri, Take; Viali, Satupa'itea; Mitchell, Braxton D.; Murabito, Joanne M.; Palmer, Nicholette D.; Psaty, Bruce M.; Redline, Susan; Shoemaker, M. Benjamin; Silverman, Edwin K.; Telen, Marilyn J.; Weiss, Scott T.; Yanek, Lisa R.; Zhou, Hufeng; Liu, Ching-Ti; North, Kari E.; Justice, Anne E.; Locke, Jonathan M.; Owens, Nick; Murray, Anna; Patel, Kashyap; Frayling, Timothy M.; Wright, Caroline F.; Wood, Andrew R.; Lin, Xihong; Manning, Alisa; Weedon, Michael N. 分享 收藏 Modulation of NOX2 causes obesity-mediated atrial fibrillationSridhar, Arvind; Desantiago, Jaime; Chen, Hanna; Pavel, Mahmud Arif; Ly, Olivia; Owais, Asia; Barney, Miles; Jousma, Jordan; Nukala, Sarath Babu; Abdelhady, Khaled; Massad, Malek; Rizkallah, Lona Ernst; Ong, Sang-Ling; Rehman, Jalees; Darbar, Dawood 分享 收藏 分享 收藏 Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genesKeener, Rebecca; Chhetri, Surya B.; Connelly, Carla J.; Taub, Margaret A.; Conomos, Matthew P.; Weinstock, Joshua; Ni, Bohan; Strober, Benjamin; Aslibekyan, Stella; Auer, Paul L.; Barwick, Lucas; Becker, Lewis C.; Blangero, John; Bleecker, Eugene R.; Brody, Jennifer A.; Cade, Brian E.; Celedon, Juan C.; Chang, Yi-Cheng; Cupples, L. Adrienne; Custer, Brian; Freedman, Barry I.; Gladwin, Mark T.; Heckbert, Susan R.; Hou, Lifang; Irvin, Marguerite R.; Isasi, Carmen R.; Johnsen, Jill M.; Kenny, Eimear E.; Kooperberg, Charles; Minster, Ryan L.; Naseri, Take; Viali, Satupa'itea; Nekhai, Sergei; Pankratz, Nathan; Peyser, Patricia A.; Taylor, Kent D.; Telen, Marilyn J.; Wu, Baojun; Yanek, Lisa R.; Yang, Ivana V.; Albert, Christine; Arnett, Donna K.; Ashley-Koch, Allison E.; Barnes, Kathleen C.; Bis, Joshua C.; Blackwell, Thomas W.; Boerwinkle, Eric; Burchard, Esteban G.; Carson, April P.; Chen, Zhanghua; Chen, Yii-Der Ida; Darbar, Dawood; de Andrade, Mariza; Ellinor, Patrick T.; Fornage, Myriam; Gelb, Bruce D.; Gilliland, Frank D.; He, Jiang; Islam, Talat; Kaab, Stefan; Kardia, Sharon L. R.; Kelly, Shannon; Konkle, Barbara A.; Kumar, Rajesh; Loos, Ruth J. F.; Martinez, Fernando D.; McGarvey, Stephen T.; Meyers, Deborah A.; Mitchell, Braxton D.; Montgomery, Courtney G.; North, Kari E.; Palmer, Nicholette D.; Peralta, Juan M.; Raby, Benjamin A.; Redline, Susan; Rich, Stephen S.; Roden, Dan; Rotter, Jerome I.; Ruczinski, Ingo; Schwartz, David; Sciurba, Frank; Shoemaker, M. Benjamin; Silverman, Edwin K.; Sinner, Moritz F.; Smith, Nicholas L.; Smith, Albert V.; Tiwari, Hemant K.; Vasan, Ramachandran S.; Weiss, Scott T.; Williams, L. Keoki; Zhang, Yingze; Ziv, Elad; Raffield, Laura M.; Reiner, Alexander P.; Arvanitis, Marios; Greider, Carol W.; Mathias, Rasika A.; Battle, Alexis 分享 收藏 分享 收藏 Genetic Susceptibility to Arrhythmia Phenotypes in a Middle Eastern Cohort of 14,259 Whole-Genome Sequenced IndividualsQafoud, Fatima; Elshrif, Mohamed; Kunji, Khalid; Althani, Asma; Salam, Amar; Al Suwaidi, Jassim; Asaad, Nidal; Darbar, Dawood; Saad, Mohamad 分享 收藏 分享 收藏 分享 收藏 Association of Family History and CardiomyopathyAssociated Gene Variants of Unknown Significance in Ethnic Minority Patients With Early Onset Atrial FibrillationDeshpande, Ashwini; Hill, Michael; Dabbas, Jood; Sandu, Shashank; Boxley, Peter; Arnold, Joshua; Qiao, Victor; Chalazan, Brandon; Tofovic, David; Darbar, Dawood 分享 收藏 PPP1R12C Promotes Atrial Hypocontractility in Atrial FibrillationPerike, Srikanth; Gonzalez-Gonzalez, Francisco J.; Abu-Taha, Issam; Damen, Frederick W.; Hanft, Laurin M.; Lizama, Ken S.; Aboonabi, Anahita; Capote, Andrielle E.; Aguilar-Sanchez, Yuriana; Levin, Benjamin; Han, Zhenbo; Sridhar, Arvind; Grand, Jacob; Martin, Jody; Akar, Joseph G.; Warren, Chad M.; John Solaro, R.; Ong, Sang-Ging; Darbar, Dawood; Mcdonald, Kerry S.; Goergen, Craig J.; Wolska, Beata M.; Dobrev, Dobromir; Wehrens, Xander H. T.; McCauley, Mark D. 分享 收藏 Myosin Light Chain Dephosphorylation By Ppp1r12c Promotes Atria Hypocontractility In Atrial FibrillationGonzalez-Gonzalez, Francisco J.; Perike, Srikanth; Abu-Taha, Issam; Damen, Frederick; Lizama, Ken S.; Aboonabi, Anahita; Capote, Andrielle; Aguilar-Sanchez, Yuriana; Levin, Benjamin; Han, Zhenbo; Sridhar, Arvind; Grand, Jacob; Martin, Jody C.; Akar, Joseph; Warren, Chad M.; Solaro, R. John; Ong, Sang-Ging; Darbar, Dawood; Goergen, Craig J.; Wolska, Beata M.; Dobrev, Dobromir 分享 收藏 Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variantsmRNA剪接的遗传控制是稀有编码变体不完全外显率的潜在机制Einson, Jonah; Glinos, Dafni; Boerwinkle, Eric; Castaldi, Peter; Darbar, Dawood; de Andrade, Mariza; Ellinor, Patrick; Fornage, Myriam; Gabriel, Stacey; Germer, Soren; Gibbs, Richard; Hersh, Craig P.; Johnsen, Jill; Kaplan, Robert; Konkle, Barbara A.; Kooperberg, Charles; Nassir, Rami; Loos, Ruth J. F.; Meyers, Deborah A.; Mitchell, Braxton D.; Psaty, Bruce; Vasan, Ramachandran S.; Rich, Stephen S.; Rienstra, Michael; Rotter, Jerome, I; Saferali, Aabida; Shoemaker, Moore Benjamin; Silverman, Edwin; Smith, Albert Vernon; Mohammadi, Pejman; Castel, Stephane E.; Iossifov, Ivan; Lappalainen, Tuuli 分享 收藏 分享 收藏 The genetic determinants of recurrent somatic mutations in 43,693 blood genomesWeinstock, Joshua S.; Laurie, Cecelia A.; Broome, Jai G.; Taylor, Kent D.; Guo, Xiuqing; Shuldiner, Alan R.; O'Connell, Jeffrey R.; Lewis, Joshua P.; Boerwinkle, Eric; Barnes, Kathleen C.; Chami, Nathalie; Kenny, Eimear E.; Loos, Ruth J. F.; Fornage, Myriam; Redline, Susan; Cade, Brian E.; Gilliland, Frank D.; Chen, Zhanghua; Gauderman, W. James; Kumar, Rajesh; Grammer, Leslie; Schleimer, Robert P.; Psaty, Bruce M.; Bis, Joshua C.; Brody, Jennifer A.; Silverman, Edwin K.; Yun, Jeong H.; Qiao, Dandi; Weiss, Scott T.; Lasky-Su, Jessica; DeMeo, Dawn L.; Palmer, Nicholette D.; Freedman, Barry I.; Bowden, Donald W.; Cho, Michael H.; Vasan, Ramachandran S.; Johnson, Andrew D.; Yanek, Lisa R.; Becker, Lewis C.; Kardia, Sharon; He, Jiang; Kaplan, Robert; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Arnett, Donna K.; Irvin, Marguerite R.; Tiwari, Hemant; Correa, Adolfo; Raffield, Laura M.; Gao, Yan; de Andrade, Mariza; Rotter, Jerome I.; Rich, Stephen S.; Manichaikul, Ani W.; Konkle, Barbara A.; Johnsen, Jill M.; Wheeler, Marsha M.; Custer, Brian S.; Duggirala, Ravindranath; Curran, Joanne E.; Blangero, John; Gui, Hongsheng; Xiao, Shujie; Williams, L. Keoki; Meyers, Deborah A.; Li, Xingnan; Ortega, Victor; McGarvey, Stephen; Gu, C. Charles; Chen, Yii-Der Ida; Lee, Wen-Jane; Shoemaker, M. Benjamin; Darbar, Dawood; Roden, Dan; Albert, Christine; Kooperberg, Charles; Desai, Pinkal; Blackwell, Thomas W.; Abecasis, Goncalo R.; V. Smith, Albert; Kang, Hyun M.; Mathias, Rasika; Natarajan, Pradeep; Jaiswal, Siddhartha; Reiner, Alexander P.; Bick, Alexander G. 分享 收藏 
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