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IDE161, a potential first-in-class clinical candidate PARG inhibitor, selectively targets solid tumors with replication stress and DNA repair vulnerabilities Munoz, D. M.; Conway, M. E.; Nagarajan, V.; Lim, P. X.; Rao, A. A.; Shabalin, I.; Trego, K.; Ryan, J.; Choy, R.; Appel, M. J.; Teriete, P.; Zang, R.; Frey, C.; Barsanti, P.; Neilan, C. L.; White, M. A.; Maskey, R. S. 分享 收藏
Exploiting tumor selective vulnerabilities with structure based drug design Maskey, Reeja; Munoz, Diana; Conway, Megan; Rao, Arjun; Nagarajan, Vidhya; Shabalin, Ivan; Trego, Kelly; Ryan, Jonathan; Teriete, Peter; Frey, Christian; Taygerly, Josh; Barsanti, Paul; Neilan, Claire; Sachdev, Jasgit; White, Michael 分享 收藏
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Therapeutic Potential of TLR8 Agonist GS-9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators TLR8激动剂GS-9688 (Selgantolimod) 在慢性乙型肝炎中的治疗潜力: 抗病毒和调节介质的重塑 Amin, Oliver E.; Colbeck, Emily J.; Daffis, Stephane; Khan, Shahzada; Ramakrishnan, Dhivya; Pattabiraman, Divya; Chu, Ruth; Steuer, Holly Micolochick; Lehar, Sophie; Peiser, Leanne; Palazzo, Adam; Frey, Christian; Davies, Jessica; Javanbakht, Hassan; Rosenberg, William M. C.; Fletcher, Simon P.; Maini, Mala K.; Pallett, Laura J. 分享 收藏
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Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection 血清HBsAg清除对HBV感染小鼠模型中CD8 T细胞反应的影响最小 Fumagalli, Valeria; Di Lucia, Pietro; Venzin, Valentina; Bono, Elisa B.; Jordan, Robert; Frey, Christian R.; Delaney, William; Chisari, Francis, V; Guidotti, Luca G.; Iannacone, Matteo 分享 收藏
PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection Salimzadeh, Loghman; Le Bert, Nina; Dutertre, Charles-A; Gill, Upkar S.; Newell, Evan W.; Frey, Christian; Hung, Magdeleine; Novikov, Nikolai; Fletcher, Simon; Kennedy, Patrick T. F.; Bertoletti, Antonio 分享 收藏
Small-molecule antagonists of the Aryl Hydrocarbon Receptor (AhR) promote activation of human PBMCs in vitro and demonstrate significant impact on tumor growth and immune modulation in vivo Joseph, James; Gonzalez-Lopez, Marcos; Galang, Christina; Garcia, Candy; Lemar, Hadia; Lu, Jing; Vaidya, Kedar; Fischer, Marcus; Frey, Christian; Alam, Muzaffar; Yao, Bing; Dillon, Michael; Hager, Jeffrey H.; Venetsanakos, Eleni; Aswad, Fred 分享 收藏
The impact of HBsAg on general and HBV-specific immunity Bert, N. L.; Hong, M.; Tan, D.; Kunasegaran, K.; Cheng, Y.; Brecht, E.; Gill, U. S.; Frey, C.; Newell, E.; Kennedy, P.; Bertoletti, A. 分享 收藏
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The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo Palazzo, Adam; Herter, Sylvia; Grosmaire, Laura; Jones, Randy; Frey, Christian R.; Limani, Florian; Bacac, Marina; Umana, Pablo; Oldham, Robert J.; Marshall, Michael J. E.; Cox, Kerry L.; Turaj, Anna H.; Cragg, Mark S.; Klein, Christian; Carter, Matthew J.; Tannheimer, Stacey 分享 收藏
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A Steadman, Victoria A.; Pettit, Simon B.; Poullennec, Karine G.; Lazarides, Linos; Keats, Andrew J.; Dean, David K.; Stanway, Steven J.; Austin, Carol A.; Sanvoisin, Jonathan A.; Watt, Gregory M.; Fliri, Hans G.; Liclican, Albert C.; Jin, Debi; Wong, Melanie H.; Leavitt, Stephanie A.; Lee, Yu-Jen; Tian, Yang; Frey, Christian R.; Appleby, Todd C.; Schmitz, Uli; Jansa, Petr; Mackman, Richard L.; Schultz, Brian E. 分享 收藏
In vitro and in vivo characterization of the selective toll-like receptor 8 agonist GS-9688 Daffis, S.; Ramakrishnan, D.; Niu, C.; Zheng, J.; Santos, R.; Mish, M.; Chin, G.; Aktoudianakis, V.; Metobo, S.; Pyun, H-J; Yu, H.; Lee, G.; Palazzo, A.; Frey, C.; Pflanz, S.; Delaney, W. E.; Fletcher, S. P.; Mackman, R. 分享 收藏
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A SIGNATURE OF ELEVATED IMMUNE ACTIVATION IS OBSERVED IN THE PERIPHERAL BLOOD OF VIRALLY SUPPRESSED, HBeAg-NEGATIVE CHRONIC HBV PATIENTS Frey, C.; Palazzo, A.; Li, L.; Elazar, Menashe; Pham, E.; Fram, B.; Nguyen, T.; Han, H.; Elazar, Monica; Glenn, J.; Ahmed, A.; Pflanz, S. 分享 收藏
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