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M

Michael S. Seaman

Beth Israel Deaconess Medical Center
H指数:104
被引数:4.2万

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Once yearly cell-based therapy for sustained and dose-tunable delivery of monoclonal antibodies

每年一次细胞疗法用于持续且剂量可调的单克隆抗体递送

Science Advances
IF12.5
2026-10-020
OAAI
Cody Fell; Anthony E. Davis; Shalini Pandey; Michael T. Guinn; Zeshi Wang; Jonathon DeBonis; Chancellor Smith; Nathan Brown; Danna Murungi; Yeonju Kim; Imaan Mohandessi; Patrick Bednarz; Amir Ardeshir; Erin M. Haupt; Samuel I. Cuevas; Christy L. Lavine; Michael S. Seaman; Oleg Igoshin; Ravi K. Ghanta; Michael R. Diehl; Omid Veiseh
Broadly neutralizing antibodies in adult males living with HIV undergoing analytical treatment interruption: secondary and exploratory outcomes of the phase II randomized controlled RIO trial

在HIV感染者男性接受分析性治疗中断期间的中和抗体：RIO试验II期随机对照试验的次要和探索性结局

Nature Medicine
IF50
2026-09-150
OAAI
Marcilio J. Fumagalli; Anna Kaczynska; Marius Allombert; Ágata Lopes-Ribeiro; Mariângela de Oliveira Silva; Brianna J. Hernandez; Christy Lavine; Sebastian M. Espinosa; Helen Brown; Hanna Box; Emanuela Falaschetti; Louise-Rae Cherrill; Tamara Elliott; Ming Lee; Julie Fox; Sarah Pett; Amanda Clarke; Alison Uriel; Ole Sogaard; Rebecca Sutherland; Marta Boffito; Sabine Kinloch-Loes; Chloe Orkin; Simon Collins; Panagiota Zacharopoulou; Nicola Robison; Cintia Bittar; Thiago Oliveira; Anna Gazumyan; Mila Jankovic; Michael S. Seaman; John Frater; Marina Caskey; Sarah Fidler; Michel C. Nussenzweig
Induction of broadly neutralizing HIV antibodies by a two-step mechanism informs vaccine design

通过两步机制诱导广谱中和HIV抗体为疫苗设计提供信息

Science
IF45.8
2026-05-070
PRE
Ashwin N. Skelly; Harry B. Gristick; Hui Li; Edem Gavor; Andrew J. Connell; Edward F. Kreider; Lorie Marchitto; Michael P. Hogarty; Maddy L. Newby; Joel D. Allen; Weimin Liu; Anthony P. West; Kasirajan Ayyanathan; Mary S. Campion; Kaitlyn Winters; Colette G. Gordon; Rebecca A. Osbaldeston; Macy J. Akeley; Emily Lewis; Yingying Li; Ajay Singh; Kendra Cruickshank; Younghoon Park; Chengyan Zhao; Xuduo Li; Khaled Amereh; Elizabeth Van Itallie; John W. Carey; Amie Albertus; Andrew T. DeLaitsch; Jennifer R. Keeffe; Melinda G. Lituchy; Agnes A. Walsh; Daniel J. Morris; Rumi Habib; Frederic Bibollet-Ruche; Nitesh Mishra; Gabriel Avillion; Nicholas S. Koranda; Samantha J. Plante; Christian L. Martella; Jinery Lora; Eric J. D. Wang; Mark G. Lewis; Malcolm A. Martin; Michel C. Nussenzweig; Michael S. Seaman; Darrell J. Irvine; Kevin J. Wiehe; Barton F. Haynes; Kshitij Wagh; Bette Korber; Raiees Andrabi; Max Crispin; Drew Weissman; Pamela J. Bjorkman; Beatrice H. Hahn; George M. Shaw
B lymphocyte protein factories produced by hematopoietic stem cell gene editing

造血干细胞基因编辑产生的B淋巴细胞蛋白质工厂

Science
IF45.8
2026-04-160
PRE
Harald Hartweger; Chiara Ruprecht; Kai-Hui Yao; Philippe Laffont; Gabriella Lima Dos Reis; Pengcheng Zhou; Thomas Hägglöf; Laurine Binet; Maximilian Loewe; Jun P. Hong; Tianli Xiao; Esen Sefik; Brianna Hernandez; Anna Gazumyan; Mila Jankovic; Michael S. Seaman; Giulia Costa; Sean A. Nelson; Jordan Clark; Sachie Kanatani; Patrick C. Wilson; Florian Krammer; Elena A. Levashina; Jean-Philippe Julien; Hedda Wardemann; Photini Sinnis; Leonidas Stamatatos; Richard A. Flavell; Michel C. Nussenzweig
Mechanisms of early-life immunity associated with induction of heterologous HIV-1 neutralizing antibodies
JOURNAL OF IMMUNOLOGY
IF3.4
2025-11-010
PRE
Holmes, Sommer; Li, Hui; Shen, Shaunna; Martin, Mitchell; Tuck, Ryan; Chen, Yue; Giorgi, Elena; Kirshner, Helene; Berry, Madison; Van Italie, Elizabeth; Venkatayogi, Sravani; Beem, Josh; Edwards, Robert; Mansouri, Katayoun; Denayer, Nicole; Demarco, Todd; Denny, Thomas; Kuykendall, Cindy; Gurley, Thaddeus; Moody, Anthony; Wang, Yunfei; Evangelous, Tyler; Clinton, John; Hora, Bhavna; Wagh, Kshitij; Seaman, Michael; Saunders, Kevin; Solomotis, Nicholas; Misamore, Johnathan; Lewis, Mark; Wiehe, Kevin; Montefiori, David; Shaw, George; Williams, Wilton
Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans

疫苗诱导异源HIV-1中和抗体B细胞谱系在人类中

Cell
IF42.5
2025-11-010
OAAI
Wilton B. Williams; S. Munir Alam; Gilad Ofek; Nathaniel Erdmann; David C. Montefiori; Michael S. Seaman; Kshitij Wagh; Bette Korber; Robert J. Edwards; Katayoun Mansouri; Amanda Eaton; Derek W. Cain; Mitchell Martin; JongIn Hwang; Aria Arus-Altuz; Xiaozhi Lu; Fangping Cai; Nolan Jamieson; Robert Parks; Maggie Barr; Andrew Foulger; Kara Anasti; Parth Patel; Salam Sammour; Ruth J. Parsons; Xiao Huang; Jared Lindenberger; Susan Fetics; Katarzyna Janowska; Aurelie Niyongabo; Benjamin M. Janus; Anagh Astavans; Christopher B. Fox; Ipsita Mohanty; Tyler Evangelous; Yue Chen; Madison Berry; Helene Kirshner; Elizabeth Van Itallie; Kevin O. Saunders; Kevin Wiehe; Kristen W. Cohen; M. Juliana McElrath; Lawrence Corey; Priyamvada Acharya; Stephen R. Walsh; Lindsey R. Baden; Barton F. Haynes
Hydrogel formulations for sustained-release of broadly neutralizing antibodies

长效广谱中和抗体的水凝胶制剂

Journal of Controlled Release
IF11.5
2025-10-310
PRE
Carolyn K. Jons; Catherine M. Kasse; Bryan T. Mayer; Ollivier Hyrien; Samya Sen; Emily L. Meany; Andrea I. d'Aquino; Priya Ganesh; Noah Eckman; Changxin Dong; Jerry Yan; Leslee T. Nguyen; Vanessa M. Doulames; Ye Eun Song; Olivia M. Saouaf; Christian M. Williams; Shoshana C. Williams; Jesus Paredes; Rajeev Raghavan; Martina Palomares; Michael Alpert; Nicole L. Yates; Georgia D. Tomaras; Michael S. Seaman; Michael Farzan; Eric A. Appel
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy

HIV-1精英中和者队列的表征分析揭示了一种靶向CD4bs的广谱中和抗体，可用于HIV-1的预防和治疗

Nature Immunology
IF27.6
2025-10-060
OA
Lutz Gieselmann; Andrew T. DeLaitsch; Malena Rohde; Henning Gruell; Christoph Kreer; Meryem Seda Ercanoglu; Harry B. Gristick; Philipp Schommers; Elvin Ahmadov; Caelan Radford; Andrea Mazzolini; Lily Zhang; Anthony P. West; Johanna Worczinski; Anna Momot; Maren L. Reichwein; Jacqueline Knüfer; Ricarda Stumpf; Nonhlanhla N. Mkhize; Haajira Kaldine; Sinethemba Bhebhe; Sharvari Deshpande; Federico Giovannoni; Erin Stefanutti; Fabio Benigni; Colin Havenar-Daughton; Davide Corti; Arne Kroidl; Anurag Adhikari; Aubin J. Nanfack; Georgia E. Ambada; Ralf Duerr; Lucas Maganga; Wiston William; Nyanda E. Ntinginya; Timo Wolf; Christof Geldmacher; Michael Hoelscher; Clara Lehmann; Penny L. Moore; Thierry Mora; Aleksandra M. Walczak; Peter B. Gilbert; Nicole A. Doria-Rose; Yunda Huang; Jesse D. Bloom; Michael S. Seaman; Pamela J. Bjorkman; Florian Klein
A broad antibody with enhanced HIV-1 neutralization via bispecific antibody-mediated prepositioning

通过双特异性抗体介导的预定位增强的广谱抗体介导的HIV-1中和作用

NATURE COMMUNICATIONS
IF15.7
2025-05-180
OA
Kim, Soohyun; Radford, Caelan E.; Xu, Duo; Zhong, Jianing; Do, Jonathan; Pham, Dominic M.; Travisano, Katie A.; Filsinger Interrante, Maria V.; Bruun, Theodora U. J.; Rezek, Valerie; Wilder, Bailey; Palomares, Martina; Seaman, Michael S.; Kitchen, Scott G.; Bloom, Jesse D.; Kim, Peter S.
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV

一项全面的工程策略提高了针对HIV的近全中和抗体的效力和可制造性。

Structure
IF4.3
2025-05-140
OA
Mohammad M. Sajadi; Abdolrahim Abbasi; Zahra Rikhtegaran Tehrani; Christine Siska; Rutilio Clark; Woo Chi; Michael S. Seaman; Dieter Mielke; Kshitij Wagh; Qingbo Liu; Taylor Jumpa; Randal R. Ketchem; Dung N. Nguyen; William D. Tolbert; Brian G. Pierce; Ben Atkinson; Derrick Deming; Megan Sprague; Andrew Asakawa; David Ferrer; Yasmin Dunn; Sarah Calvillo; Rui Yin; Johnathan D. Guest; Bette Korber; Bryan T. Mayer; Alicia H. Sato; Xin Ouyang; Scott Foulke; Parham Habibzadeh; Maryam Karimi; Arash Aslanabadi; Mahsa Hojabri; Saman Saadat; Roza Zareidoodeji; Mateusz Kędzior; Edwin Pozharski; Alonso Heredia; Hegang Chen; David Montefiori; Guido Ferrari; Marzena Pazgier; George K. Lewis; Joseph G. Jardine; Paolo Lusso; Anthony DeVico
Computationally designed proteins mimic antibody immune evasion in viral evolution

计算设计的蛋白质模拟病毒进化中的抗体免疫逃逸

Immunity
IF26.3
2025-05-080
OA
Noor Youssef; Sarah Gurev; Fadi Ghantous; Kelly P. Brock; Javier A. Jaimes; Nicole N. Thadani; Ann Dauphin; Amy C. Sherman; Leonid Yurkovetskiy; Daria Soto; Ralph Estanboulieh; Ben Kotzen; Pascal Notin; Aaron W. Kollasch; Alexander A. Cohen; Sandra E. Dross; Jesse Erasmus; Deborah H. Fuller; Pamela J. Bjorkman; Jacob E. Lemieux; Jeremy Luban; Michael S. Seaman; Debora S. Marks
Neonatal immunity associated with heterologous HIV-1 neutralizing antibody induction in SHIV-infected Rhesus Macaques
NATURE COMMUNICATIONS
IF15.7
2024-11-270
OAAI
Holmes, Sommer; Li, Hui; Shen, Xiaoying; Martin, Mitchell; Tuck, Ryan; Chen, Yue; Giorgi, Elena E.; Kirshner, Helene Fradin; Berry, Madison; Van Italie, Elizabeth; Venkatayogi, Sravani; Beem, Joshua S. Martin; Edwards, Robert J.; Mansouri, Katayoun; Singh, Ajay; Kuykendall, Cindy; Gurley, Thaddeus; Moody, M. Anthony; Denayer, Nicole; Demarco, Todd; Denny, Thomas N.; Wang, Yunfei; Evangelous, Tyler D.; Clinton, John T.; Hora, Bhavna; Wagh, Kshitij; Seaman, Michael S.; Saunders, Kevin O.; Solomotis, Nicholas; Misamore, Johnathan; Lewis, Mark G.; Wiehe, Kevin; Montefiori, David C.; Shaw, George M.; Williams, Wilton B.
Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial
NATURE MEDICINE
IF50
2024-09-121
OA
Julg, Boris; Walker-Sperling, Victoria E. K.; Wagh, Kshitij; Aid, Malika; Stephenson, Kathryn E.; Zash, Rebecca; Liu, Jinyan; Nkolola, Joseph P.; Hoyt, Amelia; Castro, Mike; Serebryannyy, Leonid; Yanosick, Katherine; Speidel, Tessa; Borducchi, Erica N.; Murzda, Tetyana; Maxfield, Lori; Arduino, Roberto; Mcdermott, Adrian B.; Gama, Lucio; Giorgi, Elena E.; Koup, Richard A.; Seaman, Michael S.; Rolle, Charlotte-Paige; Dejesus, Edwin; Li, Wenjun; Korber, Bette; Barouch, Dan H.
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site

种系靶向HIV疫苗可诱导CD4结合位点的中和抗体

SCIENCE IMMUNOLOGY
IF16.3
2024-08-301
PRE
Caniels, Tom G.; Medina-Ramirez, Max; Zhang, Shiyu; Kratochvil, Sven; Xian, Yuejiao; Koo, Ja-Hyun; Derking, Ronald; Samsel, Jakob; van Schooten, Jelle; Pecetta, Simone; Lamperti, Edward; Yuan, Meng; Carrasco, Maria Rios; del Moral Sanchez, Ivan; Allen, Joel D.; Bouhuijs, Joey H.; Yasmeen, Anila; Ketas, Thomas J.; Snitselaar, Jonne L.; Bijl, Tom P. L.; Martin, Isabel Cuella; Torres, Jonathan L.; Cupo, Albert; Shirreff, Lisa; Rogers, Kenneth; Mason, Rosemarie D.; Roederer, Mario; Greene, Kelli M.; Gao, Hongmei; Silva, Catarina Mendes; Baken, Isabel J. L.; Tian, Ming; Alt, Frederick W.; Pulendran, Bali; Seaman, Michael S.; Crispin, Max; van Gils, Marit J.; Montefiori, David C.; McDermott, Adrian B.; Villinger, Francois J.; Koup, Richard A.; Moore, John P.; Klasse, Per Johan; Ozorowski, Gabriel; Batista, Facundo D.; Wilson, Ian A.; Ward, Andrew B.; Sanders, Rogier W.
Immunogenicity of 2 therapeutic mosaic HIV-1 vaccine strategies in individuals with HIV-1 on antiretroviral therapy
NPJ VACCINES
IF6.5
2024-05-230
OAAI
Julg, Boris; Stephenson, Kathryn E.; Tomaka, Frank; Walsh, Stephen R.; Tan, C. Sabrina; Lavreys, Ludo; Sarnecki, Michal; Ansel, Jessica L.; Kanjilal, Diane G.; Jaegle, Kate; Speidel, Tessa; Nkolola, Joseph P.; Borducchi, Erica N.; Braams, Esmee; Pattacini, Laura; Burgess, Eleanor; Ilan, Shlomi; Bartsch, Yannic; Yanosick, Katherine E.; Seaman, Michael S.; Stieh, Daniel J.; van Duijn, Janine; Willems, Wouter; Robb, Merlin L.; Michael, Nelson L.; Walker, Bruce D.; Pau, Maria Grazia; Schuitemaker, Hanneke; Barouch, Dan H.
Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains
NATURE COMMUNICATIONS
IF15.7
2024-05-210
OAAI
Wang, Shixia; Chan, Kun-Wei; Wei, Danlan; Ma, Xiuwen; Liu, Shuying; Hu, Guangnan; Park, Saeyoung; Pan, Ruimin; Gu, Ying; Nazzari, Alexandra F.; Olia, Adam S.; Xu, Kai; Lin, Bob C.; Louder, Mark K.; Mckee, Krisha; Doria-Rose, Nicole A.; Montefiori, David; Seaman, Michael S.; Zhou, Tongqing; Kwong, Peter D.; Arthos, James; Kong, Xiang-Peng; Lu, Shan
Comparison of the immunogenicity and protective efficacy of ACAM2000, MVA, and vectored subunit vaccines for Mpox in rhesus macaques
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2024-03-272
PRE
Jacob-Dolan, Catherine; Ty, Darren; Hope, David; Mcmahan, Katherine; Liu, Jinyan; Powers, Olivia C.; Cotter, Catherine A.; Sciacca, Michela; Wu, Cindy; Borducchi, Erica; Bouffard, Emily; Richter, Hannah; Velasco, Jason; Teow, Elyse; Boursiquot, Mona; Cook, Anthony; Feliciano, Karen; Yalley-Ogunro, Jake; Seaman, Michael S.; Pessiant, Laurent; Lewis, Mark G.; Andersen, Hanne; Moss, Bernard; Barouch, Dan H.

研究方向

暂未获取到该数据
D
Dan H. Barouch
H 指数:119论文数:675被引数:6.1万
D
David C. Montefiori
H 指数:142论文数:1,167被引数:8.6万
M
Michel C. Nussenzweig
H 指数:183论文数:628被引数:11.7万
B
Bette Korber
H 指数:131论文数:520被引数:5.9万
J
John R. Mascola
H 指数:152论文数:781被引数:8.4万
C
Christy L. Lavine
H 指数:25论文数:54被引数:2,825
G
Georgia D. Tomaras
H 指数:87论文数:538被引数:2.9万
P
Pamela J. Björkman
H 指数:107论文数:526被引数:5.4万
S
Stephen R. Walsh
H 指数:38论文数:201被引数:5,031
B
Bing Chen
H 指数:61论文数:215被引数:1.9万