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D
Dong-Yan Jin
H指数:78
被引数:2.9万
个人简介
I did my PhD study with Prof. Yun-De Hou at the State Key Laboratory for Molecular Virology in Beijing in 1986-1991. I received postdoctoral training with Dr. Kuan-Teh Jeang at the National Institute of Allergy and Infectious Diseases in 1994-1999. I joined the University of Hong Kong in 1999 and am now Clara and Lawrence Fok Professor in Precision Medicine. My research is focusing primarily on the molecular basis of viral diseases and cancer. We use a combination of biochemical and genetic approaches to conduct basic research in molecular virology and oncology with the aim of applying the knowledge gained to prevention and control of human diseases. In my study of a viral oncogenic protein named Tax produced by human T-cell leukemia virus type 1, which causes a highly lethal blood cancer known as adult T-cell leukemia, I identified in 1998 a cellular protein named MAD1, a key component of a cell cycle checkpoint that guard against abnormal division of cells. In 2006, my group characterized another cellular protein, which is also crippled by Tax to give rise to abnormal numbers of chromosomes in leukemic cells. Our work in 2008 revealed how Epstein-Barr virus uses a viral small RNA molecule to promote the survival of tumor cells in nasopharyngeal carcinoma. In 2011, we found that the virus sensor RIG-I needs an RNA-binding protein partner called PACT to initiate and sustain host antiviral defense. One major area of my current research is in the regulatory mechanism of innate antiviral response. Novel cellular and viral regulatory factors that govern antiviral response will be identified and characterized. Particularly, cellular machinery to sense viral nucleic acids, features of viral nucleic acids being sensed, and enzymes that cleave the second messenger will be dissected. We aspire to substantially advance current understanding of viral and cellular regulators of innate antiviral response. Our findings might also reveal novel strategies for developing antiviral and immunomodulatory agents including vaccine adjuvants. We also have a long-standing interest in studying oncogenic viruses including human T-cell leukemia virus type 1, hepatitis B virus and Epstein-Barr virus. Areas of special interst include the switch between lytic replication and latency, the regulatory mechanism of viral transcription and the role of genome instability in viral oncogenesis. Our work might provide new thoughts and targets for prevention and intervention of human cancer of a viral etiology.
教育背景
1986.01 – 1991.12
State Key Laboratory for Molecular Virology PhD
工作经历
1999.01 – 至今
University of Hong Kong
Clara and Lawrence Fok Professor in Precision Medicine
1994.01 – 1999.12
National Institute of Allergy and Infectious Diseases
postdoctoral
荣誉奖项
暂无内容
宿主转录辅抑制因子TLE1常被RNA病毒利用以进行复制
Molecular Cell
IF16.6
LOX 由唾液腺腺样囊性癌相关成纤维细胞产生，促进肺前转移微环境中的纤维化。
填埋场渗滤液承压区中塑料废物的微塑料动态形成
HDAC抑制剂通过抑制Hippo/YAP信号通路增强骨肉瘤细胞对依托泊苷的化疗敏感性。
整合素β4富集的小型外泌体作为靶向肝癌肺转移的药物递送载体
PKCα磷酸化FACI，使其在笼蛋白介导的内吞作用中的功能转变为在肠道和肝细胞中巨胞饮作用中的假定作用。
CXCR7通过失活Hippo-YAP信号通路促进HCC细胞增殖、迁移和侵袭。
DISCOVER ONCOLOGY
IF2.9
Mpox病毒poxin-schlafen融合蛋白通过隔离STAT2抑制先天抗病毒反应
C1orf115与网格蛋白适配器相互作用以进行内吞作用并诱导ABCA1促进肠胆固醇流出
SARS-CoV-2新型小分子抑制剂的化学遗传学鉴定
Nsp1通过钙调神经磷酸酶-NFAT信号促进SARS-CoV-2复制
MBIO
IF4.7
NATURE COMMUNICATIONS
IF15.7
LINC00942通过招募IGF2BP3/SLC7A11抑制铁死亡并诱导调节性T细胞在肝细胞癌中的免疫抑制作用
灭活SARS-CoV-2 BA.5的单价疫苗接种可保护仓鼠免受Omicron的侵害，但不能保护非Omicron变体
NPJ VACCINES
IF6.5
