Albert R. La Spada - Publications, H-index & Citations

Albert R. La Spada

University of California

62H指数

253论文数

2.2W被引数

收录论文 96

发表时间

Discovery of a mutation-containing circRNA in polyglutamine disease through systematic analysis of RNAs with CAG repeats 通过系统分析含CAG重复序列的RNA，在多聚谷氨酰胺疾病中发现含突变circRNA

RNA Biology

IF3.4

2026-06-24

OAAI

Weronika Pawlik; Magdalena Woźna-Wysocka; Magdalena Jazurek-Ciesiołka; Jarosław Dulski; Tomasz M. Witkoś; Agata Ciołak; Emilia Kozłowska; Edyta Kościańska; Luke C. Bartelt; Julien Philippe; Jarosław Sławek; Paweł M. Świtoński; Albert R. La Spada; Agnieszka Fiszer

PFKM governs metabolic shifts throughout skeletal muscle differentiation PFKM调控骨骼肌分化过程中的代谢转变

Nature Metabolism

IF20.8

2026-02-24

OAAI

Melissa Campos; Steven T. Nguyen; Xiangduo Kong; Ying Yang; Richard L. Watson; Anastasia Gromova; Catherine R. Livelo; Carolina N. Franco; Julia E. Cabral; Laurence J. Seabrook; Shengqi Dai; Yingzi Liu; Mingqi Zhou; Eric A. Hanse; Kaelyn Sumigray; Albert R. La Spada; Marcus M. Seldin; Maksim V. Plikus; Dequina A. Nicholas; Reginald McNulty; Mei Kong; Kyoko Yokomori; Lauren V. Albrecht

The 4E-BPs as Translational Regulators in Neurological Disorders: Molecular Mechanisms and Therapeutic Potential 4E-BPs作为神经系统疾病中的翻译调控因子：分子机制与治疗潜力

Molecular Neurobiology

IF4.3

2025-11-24

OAAI

Sindhu S. Baskarapantula; Venkata Surya Kumar; Priyajit Changdar; Debashree Chakraborty; Yogendra Nayak; Albert R. La Spada; Craig L. Bennett; Somasish G. Dastidar

Bactericidal Activities of Copolymers Incorporating Formylphenyl Motif for Targeting Surface Proteins 含甲酰苯基基元的共聚物的杀菌活性及其对表面蛋白的靶向作用

ACS POLYMERS AU

IF6.9

2025-10-01

PREAI

Bautista, Esteban; Sun, Melody; Colwin, Michael; La Spada, Albert R.; Sim, Seunghyun

Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics R6/2 HD小鼠脑内的独特分子模式：空间-时间转录组学的见解

Neuron

IF15

2025-06-06

OAAI

Mara S. Burns; Ricardo Miramontes; Jie Wu; Ravinder Gulia; Madhu S. Saddala; Alice L. Lau; Tiffany Quach; John C. Reidling; Vivek Swarup; Albert R. La Spada; Ryan G. Lim; Leslie M. Thompson

Neuromuscular junction transcriptome analysis of spinal and bulbar muscular atrophy mice implicates sarcomere gene expression and calcium flux dysregulation in disease pathogenesis 脊髓和球部肌萎缩小鼠的神经肌肉接头转录组分析表明，肌原纤维基因表达和钙离子流失调与疾病发生机制有关。

HUMAN MOLECULAR GENETICS

IF3.2

2025-05-14

PREAI

Gromova, Anastasia; Cha, Byeonggu; Nguyen, Nhat; Garg, Diya; Coscolluela, Connor; Strickland, Laura M.; Luong, David; Longo, Fabiana; Sopher, Bryce L.; ElMallah, Mai K.; La Spada, Albert R.

Increased nuclear import characterizes aberrant nucleocytoplasmic transport in neurons from patients with spinocerebellar ataxia type 7

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2024-11-22

OAAI

Macopson-Jones, Joshua G.; Adams, Maile; Philippe, Julien; La Spada, Albert R.

Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-11-06

PREAI

Bartelt, Luke C.; Switonski, Pawel M.; Adamek, Grazyna; Longo, Fabiana; Carvalho, Juliana; Duvick, Lisa A.; Jarrah, Sabrina I.; Mcloughlin, Hayley S.; Scoles, Daniel R.; Pulst, Stefan M.; Orr, Harry T.; Hull, Court; Lowe, Craig B.; La Spada, Albert R.

Respiratory neuropathology in spinocerebellar ataxia type 7

JCI INSIGHT

IF6.1

2024-07-18

OAAI

Biswas, Debolina D.; Shi, Yihan; El Haddad, Lea; Sethi, Ronit; Huston, Meredith; Kehoe, Sean; Scarrow, Evelyn R.; Strickland, Laura M.; Pucci, Logan A.; Dhindsa, Justin S.; Hunanyan, Ani; La Spada, Albert R.; ElMallah, Mai K.

Antibody-assisted selective isolation of Purkinje cell nuclei from mouse cerebellar tissue

CELL REPORTS METHODS

IF4.5

2024-07-01

OAAI

Bartelt, Luke C.; Fakhri, Mouad; Adamek, Grazyna; Trybus, Magdalena; Samelak-Czajka, Anna; Jackowiak, Paulina; Fiszer, Agnieszka; Lowe, Craig B.; Spada, Albert R. La; Switonski, Pawel M.

Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy (vol 24, pg 427, 2018)

NATURE MEDICINE

IF50

2024-01-08

OAAI

Badders, Nisha M.; Korff, Ane; Miranda, Helen C.; Vuppala, Pradeep K.; Smith, Rebecca B.; Winborn, Brett J.; Quemin, Emmanuelle R.; Sopher, Bryce L.; Dearman, Jennifer; Messing, James; Kim, Nam Chul; Moore, Jennifer; Freibaum, Brian D.; Kanagaraj, Anderson P.; Fan, Baochang; Tillman, Heather; Chen, Ping-Chung; Wang, Yingzhe; Freeman III, Burgess B.; Li, Yimei; Kim, Hong Joo; La Spada, Albert R.; Taylor, J. Paul

Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease

CELL REPORTS

IF6.9

2023-11-01

OAAI

Matthews, Ian; Birnbaum, Allison; Gromova, Anastasia; Huang, Amy W.; Liu, Kailin; Liu, Eleanor A.; Coutinho, Kristen; Mcgraw, Megan; Patterson, Dalton C.; Banks, Macy T.; Nobles, Amber C.; Nguyen, Nhat; Merrihew, Gennifer E.; Wang, Lu; Baeuerle, Eric; Fernandez, Elizabeth; Musi, Nicolas; Maccoss, Michael J.; Miranda, Helen C.; Spada, Albert R. La; Cortes, Constanza J.

Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2023-10-17

OAAI

Bennett, Craig L.; Dastidar, Somasish; Arnold, Frederick J.; McKinstry, Spencer U.; Stockford, Cameron; Freibaum, Brian D.; Sopher, Bryce L.; Wu, Meilin; Seidner, Glen; Joiner, William; Taylor, J. Paul; West, Ryan J. H.; La Spada, Albert R.

Intercellular transmission of pathogenic proteins in ALS: Exploring the pathogenic wave

NEUROBIOLOGY OF DISEASE

IF5.6

2023-08-01

OAAI

Arnold, F. J.; Nguyen, A. D.; Bedlack, R. S.; Bennett, C. L.; La Spada, A. R.

X-linked SBMA model mice display relevant non-neurological phenotypes and their expression of mutant androgen receptor protein in motor neurons is not required for neuromuscular disease

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2023-06-02

OAAI

Gromova, Anastasia; Cha, Byeonggu; Robinson, Erica M.; Strickland, Laura M.; Nguyen, Nhat; ElMallah, Mai K.; Cortes, Constanza J.; La Spada, Albert R.

Chronic BMAA exposure combined with TDP-43 mutation elicits motor neuron dysfunction phenotypes in mice 慢性BMAA暴露联合TDP-43突变诱发小鼠运动神经元功能障碍表型

NEUROBIOLOGY OF AGING

IF3.5

2023-06-01

OAAI

Arnold, F. J.; Burns, M.; Chiu, Y.; Carvalho, J.; Nguyen, A. D.; Ralph, P. C.; La Spada, A. R.; Bennett, C. L.

MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex

LIFE SCIENCE ALLIANCE

IF2.9

2023-05-23

OAAI

Branch, Mary Rose; Hsu, Cynthia L.; Ohnishi, Kohta; Shen, Wen-Chuan; Lee, Elian; Meisenhelder, Jill; Winborn, Brett; Sopher, Bryce L.; Taylor, J. Paul; Hunter, Tony; La Spada, Albert R.

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

NATURE COMMUNICATIONS

IF15.7

2023-02-03

OAAI

Cui, Ya; Arnold, Frederick J.; Peng, Fanglue; Wang, Dan; Li, Jason Sheng; Michels, Sebastian; Wagner, Eric J.; La Spada, Albert R.; Li, Wei

Antagonistic effect of cyclin-dependent kinases and a calcium-dependent phosphatase on polyglutamine-expanded androgen receptor toxic gain of function

SCIENCE ADVANCES

IF12.5

2023-01-06

OAAI

Piol, Diana; Tosatto, Laura; Zuccaro, Emanuela; Anderson, Eric N.; Falconieri, Antonella; Polanco, Maria J.; Marchioretti, Caterina; Lia, Federica; White, Joseph; Bregolin, Elisa; Minervini, Giovanni; Parodi, Sara; Salvatella, Xavier; Arrigoni, Giorgio; Ballabio, Andrea; Spada, Albert R. La; Tosatto, Silvio C. E.; Sambataro, Fabio; Medina, Diego L.; Pandey, Udai B.; Basso, Manuela; Plennuto, Maria

De novo pathogenic variant in SETX causes a rapidly progressive neurodegenerative disorder of early childhood-onset with severe axonal polyneuropathy

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2021-12-18

OAAI

Hadjinicolaou, Aristides; Ngo, Kathie J.; Conway, Daniel Y.; Provias, John P.; Baker, Steven K.; Brady, Lauren I.; Bennett, Craig L.; La Spada, Albert R.; Fogel, Brent L.; Yoon, Grace

研究方向