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G

Guido Ghilardi

University of Pennsylvania
H指数:17
被引数:1,537

个人简介

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教育背景

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工作经历

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荣誉奖项

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Chimeric antigen receptor T cells against the IGHV4-34 B cell receptor specifically eliminate neoplastic and autoimmune B cells

针对IGHV4-34 b细胞受体的嵌合抗原受体T细胞特异性消除肿瘤性和自身免疫性b细胞

Science Translational Medicine
IF14.6
2026-02-040
PRE
Ivan J. Cohen; Audrey C. Bochi-Layec; Jean Lemoine; Scott Jenks; Pedram Bayat; Ki Hyun Kim; Huiwu Zhao; Ositadimma Ugwuanyi; Federico Stella; Guido Ghilardi; Giulia Gabrielli; Sarah McCuaig; Anastasia Iatrou; Elisavet Vlachonikola; Maria Karipidou; Eleni Bouziani; David Espie; Ranjani Ramasubramanian; Andreas Agathangelidis; Aditya Bhosale; Luca Paruzzo; Giovanni Medico; Bronte Kolar; Regina Bugrovsky; Puneeth Guruprasad; Li-Ping Wang; Jaryse Harris; Evgeny Arons; Yunlin Zhang; Raymone Pajarillo; Portia A. Kreiger; Chi-Ping Day; S. Cenk Sahinalp; Chih Hao Wu; Alessia Santi; Bria Fulmer; Marcos Cases; Matthew B. Palmer; Patrizia Porazzi; E. John Wherry; Robert J. Kreitman; Enrico Tiacci; Sokratis A. Apostolidis; Edward M. Behrens; Vijay Bhoj; Ignacio Sanz; Giorgio Inghirami; Stephen J. Schuster; Paolo Ghia; Kostas Stamatopoulos; Marco Ruella
CD19 CAR T-Cell Therapy in Richter Transformation: A Multicentre Retrospective Analysis by the European Research Initiative on Chronic Lymphocytic Leukaemia

CD19 CAR T细胞疗法在Richter转化中的研究：欧洲慢性淋巴细胞白血病研究倡议进行的 multicentre 回顾性分析

Journal of Cellular and Molecular Medicine
IF4.2
2025-10-220
OAAI
Ofrat Beyar-Katz; Ohad Benjamini; Julio Delgado; Marco Ruella; Ron Ram; Sigal Grisariu; Andrea Visentin; Elisabeth Vandenberghe; Massimo Gentile; Abraham Avigdor; Avichai Shimoni; Roni Shouval; Ronit Marcus; Stephen J. Schuster; Valentin Ortiz-Maldonado; Guido Ghilardi; Luca Paruzzo; Tsila Zuckerman; Tamar Tadmor; Riva Fineman; Odelia Amit; Nuria Martinez-Cibrian; Giulia Gabrielli; Batia Avni; Eva Minga; Noga Shem-Tov; Lydia Scarfo; Ronit Yerushalmi; Arnon Nagler; Ronit Leiba; Ivetta Danylesko; Kostas Stamatopoulos; Thomas Chatzikonstantinou; Paolo Ghia; Yair Herishanu
CCR5-targeted allogeneic gamma–delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy

CCR5靶向的异基因γ-δ CD19嵌合抗原受体T细胞用于HIV相关B细胞恶性免疫治疗

Nature Biomedical Engineering
IF26.6
2025-10-210
PRE
Ángel Ramírez-Fernández; Alexander J. Dimitri; Fang Chen; Robert Bartoszek; Gregory M. Chen; Laura Córdoba-Espejo; Yuqi Zhou; Yun-hsin Tang; Chien-Ting Lin; Reyes Acosta; John Scholler; Guido Ghilardi; Patrizia Porazzi; Mireia Pellicer; Núria Profitós-Pelejà; Stefan K. Barta; Anne Chew; Julie K. Jadlowsky; Vanessa E. Gonzalez; Donald L. Siegel; Bruce L. Levine; Gaël Roué; Marco Ruella; Michael T. Lotze; Carl H. June; James L. Riley; Joseph A. Fraietta
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells

基于定向进化的体内再刺激嵌合抗原受体T细胞配体的发现

Nature Biomedical Engineering
IF26.6
2025-08-250
OAAI
Tomasz M. Grzywa; Alexandra Neeser; Ranjani Ramasubramanian; Anna Romanov; Ryan Tannir; Naveen K. Mehta; Benjamin Cossette; Duncan M. Morgan; Beatriz Goncalves; Ina Sukaj; Elisa Bergaggio; Stephan Kadauke; Regina M. Myers; Luca Paruzzo; Guido Ghilardi; Austin Cozzone; Stephen J. Schuster; Noelle Frey; Libin Zhang; Parisa Yousefpour; Wuhbet Abraham; Heikyung Suh; Marco Ruella; Stephan A. Grupp; Roberto Chiarle; K. Dane Wittrup; Leyuan Ma; Darrell J. Irvine
Impact of Broad-Spectrum Antibiotic Exposure on CAR-T Therapy Outcomes in B-Cell Lymphoma: A Multicenter International Study

广谱抗生素暴露对B细胞淋巴瘤CAR-T治疗效果的影响：一项多中心国际研究

BLOOD
IF23.1
2024-11-050
PRE
Shouval, Roni; Fei, Teng; Gabrielli, Giulia; Smith, Natalie Grier; Ghilardi, Guido; Slingerland, John; Peled, Jonathan U.; Taur, Ying; Nasta, Sunita D.; Luna, Alejandro; Corona, Magdalena; Rejeski, Kai; Stock, Sophia; Marcus, Ronit; Accav, Noa Golan; Beyar-Katz, Ofrat; Khatib, Hazim; Raj, Sandeep S.; Boardman, Alexander P.; Dahi, Parastoo B.; Lin, Richard J.; Scordo, Michael; Falchi, Lorenzo; Svoboda, Jakub; Chong, Elise A.; Barta, Stefan K.; Landsburg, Daniel J.; Shimoni, Avichai; Nagler, Arnon; Shah, Gunjan L.; Palomba, Maria Lia; Salles, Gilles; Park, Jae H.; Schuster, Stephen J.; Zuckerman, Tsila; Subklewe, Marion; Avigdor, Abraham; Perales, Miguel Angel; van den Brink, Marcel R. M.; Ruella, Marco
Efficacy and Safety of Anti-CDI9 and Anti-BCMA Chimeric Antigen Receptor (CAR) T-Cell Therapies in Patients with Autoimmune Disease and Lymphoma or Myeloma

抗CDI9和抗BCMA嵌合抗原受体（CAR）T细胞疗法在自身免疫性疾病、淋巴瘤或骨髓瘤患者中的疗效与安全性

BLOOD
IF23.1
2024-11-050
PRE
Paruzzo, Luca; Bouvier, Riemke; Ghilardi, Guido; Fardella, Eugenio; Fulmer, Bria; Cohen, Ivan J.; Chong, Elise A.; Svoboda, Jakub; Nasta, Sunita D.; Landsburg, Daniel J.; Patel, Vrutti; Ziyu, Li; Pajarillo, Raymone; Waxman, Adam; Cohen, Adam D.; Vogl, Dan T.; Barta, Stefan K.; Porazzi, Patrizia; Fraietta, Joseph A.; Bhoj, Vijay; Garfall, Alfred L.; Stadtmauer, Edward A.; Schuster, Stephen J.; Carter, Jordan S.; Apostolidis, Sokratis A.; Susanibar-Adaniya, Sandra; Ruella, Marco
Clinical Activity of Tisagenlecleucel in Large B Cell Lymphomas According to the 5 th Edition of the Who Classification

根据《世界卫生组织分类》第5版，tisagenlecleucel在大B细胞淋巴瘤中的临床活性

BLOOD
IF23.1
2024-11-050
PRE
Ghilardi, Guido; Chong, Emeline R.; Paruzzo, Luca; Gabrielli, Giulia; Nasta, Sunita D.; Patel, Vrutti; Fardella, Eugenio; Landsburg, Daniel J.; Carter, Jordan; Thomas, Colin; Barta, Stefan K.; Chong, Elise A.; Svoboda, Jakub; Ruella, Marco; Schuster, Stephen J.
EZHI/2 Inhibition Improves the Anti-Tumor Efficacy of CAR and TCR T-Cell Based Therapies Against Multiple Liquid and Solid Tumors

EZHI/2抑制提高了CAR和TCR T细胞为基础疗法对多种液体和实体肿瘤的抗肿瘤疗效

BLOOD
IF23.1
2024-11-050
PRE
Nason, Siena; Yang, Ziqi; Ghilardi, Guido; Paruzzo, Luca; Carturan, Alberto; Fardella, Eugenio; Guruprasad, Puneeth; Padmanabhan, Anushka Anant; Blanchard, Tatiana; Linette, Gerald; Carreno, Beatriz M.; Susanibar-Adaniya, Sandra; Garfall, Alfred L.; Ruella, Marco; Porazzi, Patrizia
CD5 deletion enhances the antitumor activity of adoptive T cell therapies

CD5缺失增强过继性T细胞疗法的抗肿瘤活性

SCIENCE IMMUNOLOGY
IF16.3
2024-07-195
PRE
Patel, Ruchi P.; Ghilardi, Guido; Zhang, Yunlin; Chiang, Yi-Hao; Xie, Wei; Guruprasad, Puneeth; Kim, Ki Hyun; Chun, Inkook; Angelos, Mathew G.; Pajarillo, Raymone; Hong, Seok Jae; Lee, Yong Gu; Shestova, Olga; Shaw, Carolyn; Cohen, Ivan; Gupta, Aasha; Vu, Trang; Qian, Dean; Yang, Steven; Nimmagadda, Aditya; Snook, Adam E.; Siciliano, Nicholas; Rotolo, Antonia; Inamdar, Arati; Harris, Jaryse; Ugwuanyi, Ositadimma; Wang, Michael; Carturan, Alberto; Paruzzo, Luca; Chen, Linhui; Ballard, Hatcher J.; Blanchard, Tatiana; Xu, Chong; Abdel-Mohsen, Mohamed; Gabunia, Khatuna; Wysocka, Maria; Linette, Gerald P.; Carreno, Beatriz; Barrett, David M.; Teachey, David T.; Posey, Avery D.; Powell, Daniel J.; Sauter, C. Tor; Pileri, Stefano; Pillai, Vinodh; Scholler, John; Rook, Alain H.; Schuster, Stephen J.; Barta, Stefan K.; Porazzi, Patrizia; Ruella, Marco
Efficacy and safety of bendamustine for lymphodepletion before lisocabtagene maraleucel

苯达莫司汀用于利索卡塔烯前淋巴细胞耗竭的疗效和安全性

JOURNAL OF HEMATOLOGY & ONCOLOGY
IF40.4
2024-04-220
OAAI
Ghilardi, Guido; Paruzzo, Luca; Patel, Vrutti; Svoboda, Jakub; Chong, Emeline R.; Fardella, Eugenio; Chong, Elise A.; Gabrielli, Giulia; Nasta, Sunita D.; Landsburg, Daniel J.; Carter, Jordan; Pajarillo, Raymone; Barta, Stefan K.; White, Griffin; Weber, Elizabeth; Napier, Ellen; Porter, David L.; Garfall, Alfred L.; Schuster, Stephen J.; Ruella, Marco
Bendamustine lymphodepletion before axicabtagene ciloleucel is safe and associates with reduced inflammatory cytokines

苯达莫司汀在axicabtagene ciloleucel之前进行淋巴细胞耗竭是安全的，并且与减少的炎症细胞因子有关

BLOOD ADVANCES
IF7.1
2024-01-268
OAAI
Ghilardi, Guido; Paruzzo, Luca; Svoboda, Jakub; Chong, Elise A.; Shestov, Alexander A.; Chen, Linhui; Cohen, Ivan J.; Gabrielli, Giulia; Nasta, Sunita D.; Porazzi, Patrizia; Landsburg, Daniel J.; Gerson, James N.; Carter, Jordan; Barta, Stefan K.; Yelton, Rebecca; Pajarillo, Raymone; Patel, Vrutti; White, Griffin; Ballard, Hatcher J.; Weber, Elizabeth; Napier, Ellen; Chong, Emeline R.; Fraietta, Joseph A.; Garfall, Alfred L.; Porter, David L.; Milone, Michael C.; O'Connor, Roderick; Schuster, Stephen J.; Ruella, Marco
T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy

商业CAR T细胞治疗后T细胞淋巴瘤和继发性原发性恶性肿瘤风险

NATURE MEDICINE
IF50
2024-01-2481
PRE
Ghilardi, Guido; Fraietta, Joseph A.; Gerson, James N.; Van Deerlin, Vivianna M.; Morrissette, Jennifer J. D.; Caponetti, Gabriel C.; Paruzzo, Luca; Harris, Jaryse C.; Chong, Elise A.; Adaniya, Sandra P. Susanibar; Svoboda, Jakub; Nasta, Sunita D.; Ugwuanyi, Ositadimma H.; Landsburg, Daniel J.; Fardella, Eugenio; Waxman, Adam J.; Chong, Emeline R.; Patel, Vrutti; Pajarillo, Raymone; Kulikovskaya, Irina; Lieberman, David B.; Cohen, Adam D.; Levine, Bruce L.; Stadtmauer, Edward A.; Frey, Noelle V.; Vogl, Dan T.; Hexner, Elizabeth O.; Barta, Stefan K.; Porter, David L.; Garfall, Alfred L.; Schuster, Stephen J.; June, Carl H.; Ruella, Marco
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study

靶向CD19近膜域的新型anti-CD19嵌合抗原受体T细胞产品对非霍奇金淋巴瘤的安全性和有效性: 一项首次人体研究

MOLECULAR CANCER
IF33.9
2023-12-098
OAAI
Zhang, Yunlin; Patel, Ruchi P.; Kim, Ki Hyun; Cho, Hyungwoo; Jo, Jae-Cheol; Jeong, Seong Hyun; Oh, Sung Yong; Choi, Yoon Seok; Kim, Sung Hyun; Lee, Ji Hyun; Angelos, Mathew; Guruprasad, Puneeth; Cohen, Ivan; Ugwuanyi, Ositadimma; Lee, Yong Gu; Pajarillo, Raymone; Cho, Jong Hyun; Carturan, Alberto; Paruzzo, Luca; Ghilardi, Guido; Wang, Michael; Kim, Soohwan; Kim, Sung-Min; Lee, Hyun-Jong; Park, Ji-Ho; Cui, Leiguang; Lee, Tae Bum; Hwang, In-Sik; Lee, Young-Ha; Lee, Yong-Jun; Porazzi, Patrizia; Liu, Dongfang; Lee, Yoon; Kim, Jong-Hoon; Lee, Jong-Seo; Yoon, Dok Hyun; Chung, Junho; Ruella, Marco
Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy

调节肠道菌群参与抗原交叉呈递以增强CAR T细胞免疫疗法的抗肿瘤作用

MOLECULAR THERAPY
IF12
2023-03-0120
OAAI
Uribe-Herranz, Mireia; Beghi, Silvia; Ruella, Marco; Parvathaneni, Kalpana; Salaris, Silvano; Kostopoulos, Nektarios; George, Subin S.; Pierini, Stefano; Krimitza, Elisavet; Costabile, Francesca; Ghilardi, Guido; Amelsberg, Kimberly, V; Lee, Yong Gu; Pajarillo, Raymone; Markmann, Caroline; McGettigan-Croce, Bevin; Agarwal, Divyansh; Frey, Noelle; Lacey, Simon F.; Scholler, John; Gabunia, Khatuna; Wu, Gary; Chong, Elise; Porter, David L.; June, Carl H.; Schuster, Stephen J.; Bhoj, Vijaj; Facciabene, Andrea
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy (March, 10.1038/s41591-022-01702-9, 2022)
NATURE MEDICINE
IF50
2022-10-173
OA
Smith, Melody; Dai, Anqi; Ghilardi, Guido; Amelsberg, Kimberly V.; Devlin, Sean M.; Pajarillo, Raymone; Slingerland, John B.; Beghi, Silvia; Herrera, Pamela S.; Giardina, Paul; Clurman, Annelie; Dwomoh, Emmanuel; Armijo, Gabriel; Gomes, Antonio L. C.; Littmann, Eric R.; Schluter, Jonas; Fontana, Emily; Taur, Ying; Park, Jae H.; Palomba, Maria Lia; Halton, Elizabeth; Ruiz, Josel; Jain, Tania; Pennisi, Martina; Afuye, Aishat Olaide; Perales, Miguel-Angel; Freyer, Craig W.; Garfall, Alfred; Gier, Shannon; Nasta, Sunita; Landsburg, Daniel; Gerson, James; Svoboda, Jakub; Cross, Justin; Chong, Elise A.; Giralt, Sergio; Gill, Saar I.; Riviere, Isabelle; Porter, David L.; Schuster, Stephen J.; Sadelain, Michel; Frey, Noelle; Brentjens, Renier J.; June, Carl H.; Pamer, Eric G.; Peled, Jonathan U.; Facciabene, Andrea; van den Brink, Marcel R. M.; Ruella, Marco
Bendamustine is safe and effective for lymphodepletion before tisagenlecleucel in patients with refractory or relapsed large B-cell lymphomas
ANNALS OF ONCOLOGY
IF65.4
2022-09-0147
OAAI
Ghilardi, G.; Chong, E. A.; Svoboda, J.; Wohlfarth, P.; Nasta, S. D.; Williamson, S.; Landsburg, J. D.; Gerson, J. N.; Barta, S. K.; Pajarillo, R.; Myers, J.; Chen, A., I; Schachter, L.; Yelton, R.; Ballard, H. J.; Dwinal, A. Hodges; Gier, S.; Victoriano, D.; Weber, E.; Napier, E.; Garfall, A.; Porter, D. L.; Jaeger, U.; Maziarz, R. T.; Ruella, M.; Schuster, S. J.
Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer
CANCER DISCOVERY
IF33.3
2022-07-2944
OA
Lee, Yong Gu; Guruprasad, Puneeth; Ghilardi, Guido; Pajarillo, Raymone; Sauter, Christopher Tor; Patel, Ruchi; Ballard, Hatcher J.; Hong, Seok Jae; Chun, Inkook; Yang, Nicholas; V. Amelsberg, Kimberly; Cummins, Katherine D.; Svoboda, Jakub; Gill, Saar; Chong, Elise A.; North, Khrystyna; Church, Sarah E.; Fraietta, Joseph A.; Chang, Wan -Jung; Lacey, Simon F.; Lu, Xueqing Maggie; Zhang, Yunlin; Whig, Kanupriya; Schultz, David C.; Cherry, Sara; Gerson, Jame; Schuster, Stephen J.; Porazzi, Patrizia; Ruella, Marco

研究方向

暂未获取到该数据
M
Marco Ruella
H 指数:48论文数:344被引数:1.3万
S
Stephen J. Schuster
H 指数:75论文数:807被引数:3.2万
E
Elise A. Chong
H 指数:29论文数:263被引数:6,208
R
Raymone Pajarillo
H 指数:15论文数:68被引数:1,543
L
Luca Paruzzo
H 指数:16论文数:78被引数:969
S
Stefan K. Barta
H 指数:42论文数:440被引数:7,152
J
Jakub Svoboda
H 指数:46论文数:428被引数:9,118
S
Sunita D. Nasta
H 指数:40论文数:367被引数:9,911
D
Daniel J. Landsburg
H 指数:36论文数:327被引数:8,093
A
Alfred L. Garfall
H 指数:41论文数:312被引数:1.1万