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Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: a phase 1 trial Bullock, Andrea J.; Schlechter, Benjamin L.; Fakih, Marwan G.; Tsimberidou, Apostolia M.; Grossman, Joseph E.; Gordon, Michael S.; Wilky, Breelyn A.; Pimentel, Agustin; Mahadevan, Daruka; Balmanoukian, Ani S.; Sanborn, Rachel E.; Schwartz, Gary K.; Abou-Alfa, Ghassan K.; Segal, Neil H.; Bockorny, Bruno; Moser, Justin C.; Sharma, Sunil; Patel, Jaymin M.; Wu, Wei; Chand, Dhan; Rosenthal, Katherine; Mednick, Gabriel; Delepine, Chloe; Curiel, Tyler J.; Stebbing, Justin; Lenz, Heinz-Josef; O'Day, Steven J.; El-Khoueiry, Anthony B. 分享 收藏
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First-in-human study of ENPP1 inhibitor, SR-8541A, for the treatment of solid tumors Weston, Alexis S.; Thode, Trason; Shah, Monil; Seiz, Amanda; Northrup, Jonathan; Kasibhatla, Srinivas; Kaadige, Mohan; Sharma, Sunil 分享 收藏
Development of a novel, selective, and potent inhibitor of RON kinase Kaadige, Mohan Rao; Thode, Trason; Fornetti, Jaime; Weston, Alexis; Ng, Serina; Ghosh-Halder, Tithi; Bargenquast, Taylor; Durbin, Brian; Kasibhatla, Srinivas; Soldi, Raffaella; Welm, Alana; Sharma, Sunil 分享 收藏
G- protein coupled receptor (GPCR) screening library identifies sertindole, an antipsychotic, as potential therapeutic option to target GNAQ mutation Q209L in uveal melanoma Rheinschmidt, Shelby; Bargenquast, Taylor; Adamson, Sydney; Thode, Trason; Weston, Alexis; Halder, Tithi Ghosh; Ng, Serina; Tulasi, Harini; Durbin, Brian; Moser, Justin; Kaadige, Mohan; Soldi, Raffaella; Sharma, Sunil 分享 收藏
Preclinical efficacy of targeting epigenetic mechanisms in AML with 3q26 lesions and EVI1 overexpression Birdwell, Christine E.; Fiskus, Warren; Kadia, Tapan M.; Mill, Christopher P.; Sasaki, Koji; Daver, Naval; Dinardo, Courtney D.; Pemmaraju, Naveen; Borthakur, Gautam; Davis, John A.; Das, Kaberi; Sharma, Sunil; Horrigan, Stephen; Ruan, Xinjia; Su, Xiaoping; Khoury, Joseph D.; Kantarjian, Hagop; Bhalla, Kapil N. 分享 收藏
Results from an expanded phase 1 trial of botensilimab (BOT), a multifunctional anti-CTLA-4, plus balstilimab (BAL; anti-PD-1) for metastatic heavily pretreated microsatellite stable colorectal cancer (MSS CRC) Bullock, A.; Fakih, M.; Gordon, M.; Tsimberidou, A.; El-Khoueiry, A.; Wilky, B.; Pimentel, A.; Margolin, K.; Mahadevan, D.; Balmanoukian, A.; Sanborn, R.; Schwartz, G.; Abou-Alfa, G.; Bockorny, B.; Moser, J.; Sharma, S.; Grossman, J.; Rosenthal, K.; O'Day, S.; Lenz, H.; Schlechter, B. 分享 收藏
Initial results of a phase 1b/2 study of ADG126 (a masked anti-CTLA-4 SAFEbody ®) in combination with pembrolizumab (an anti-PD-1 antibody) in patients with advanced/metastatic solid tumors Li, Daneng; Sharma, Sunil; She, Kristine; Li, Wenda; Li, Ai; Zheng, Songmao; Liu, Guizhong; Ndukwo, Ogon; Hu-Lowe, Dana; Chisamore, Michael; Luo, Peter; Zha, Jiping; Patel, Manish R. 分享 收藏
Novel peptides target the β-catenin/TBL1 complex to competitively inhibit dysregulated Wnt signaling in cancer Rheinschmidt, Shelby; Thode, Trason; Sampson, Samuel; Weston, Alexis; Halder, Tithi Ghosh; Ng, Serina; Adamson, Sydney; Gutowsky, Kate; Kaadige, Mohan; Soldi, Raffaella; Sharma, Sunil 分享 收藏
A Closer Look at EGFR Inhibitor Resistance in Non-Small Cell Lung Cancer through the Lens of Precision Medicine Sattler, Martin; Mambetsariev, Isa; Fricke, Jeremy; Tan, Tingting; Liu, Sariah; Vaidehi, Nagarajan; Pisick, Evan; Mirzapoiazova, Tamara; Rock, Adam G. G.; Merla, Amartej; Sharma, Sunil; Salgia, Ravi 分享 收藏
A phase Ib/II, open-label, multicenter, dose-escalation and dose-expansion study of NKTR-255 plus cetuximab as a salvage regimen in patients with solid tumors Altan, M.; Patnaik, A.; Barve, M. A.; Dunn, L.; Cobb, P. W.; Rosenberg, A.; Sharma, S.; Sukari, A.; Lee, Z.; Marcondes, M. Q.; Zalevsky, J.; Tagliaferri, M. A.; Kotzin, B.; Sacco, A. G. 分享 收藏
The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin β-Like 1-β-Catenin Protein Complex Soldi, Raffaella; Halder, Tithi Ghosh; Sampson, Samuel; Vankayalapati, Hariprasad; Weston, Alexis; Thode, Trason; Bhalla, Kapil N.; Ng, Serina; Del Villar, Ryan Rodriguez; Drenner, Kevin; Kaadige, Mohan R.; Horrigan, Stephen K.; Batra, Surinder K.; Salgia, Ravi; Sharma, Sunil 分享 收藏
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Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM) Lapidot, Moshe; Case, Abigail E.; Weisberg, Ellen L.; Meng, Chengcheng; Walker, Sarah R.; Garg, Swati; Ni, Wei; Podar, Klaus; Hung, Yin P.; Carrasco, Ruben D.; Knott, Aine; Gokhale, Prafulla C.; Sharma, Sunil; Pozhitkov, Alex; Kulkarni, Prakash; Frank, David A.; Salgia, Ravi; Griffin, James D.; Saladi, Srinivas V.; Bueno, Raphael; Sattler, Martin 分享 收藏
Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells Fiskus, Warren; Mill, Christopher P.; Nabet, Behnam; Perera, Dimuthu; Birdwell, Christine; Manshouri, Taghi; Lara, Bernardo; Kadia, Tapan M.; DiNardo, Courtney; Takahashi, Koichi; Daver, Naval; Bose, Prithviraj; Masarova, Lucia; Pemmaraju, Naveen; Kornblau, Steven; Borthakur, Gautam; Montalban-Bravo, Guillermo; Manero, Guillermo Garcia; Sharma, Sunil; Stubbs, Matthew; Su, Xiaoping; Green, Michael R.; Coarfa, Cristian; Verstovsek, Srdan; Khoury, Joseph D.; Vakoc, Christopher R.; Bhalla, Kapil N. 分享 收藏
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Inhibition of LSD1 using the reversible inhibitor SP2577 promotes Interferon dependent anti-tumor response in adrenocortical carcinoma Sharma, Sunil; Soldi, Raffaella; Weston, Alexis; Sampson, Samuel; Ampanattu, Sherin Daniel; Celinski, Scott; Han, Haiyong; Kaadige, Mohan; Berens, Michael; Trent, Jeffrey 分享 收藏
Development of TGN-1076, a selective and reversible small molecule inhibitor of CDK7 Thode, Trason; Li, Zhaoliang; Weston, Alexis; Dana, Srikanta; Ampanattu, Sherin Daniel; Soldi, Raffaella; Kaadige, Mohan Rao; Vankayalapti, Hariprasad; Chung, Vincent; Chao, Joseph; Von Hoff, Daniel D.; Sharma, Sunil 分享 收藏
Circulating immune cell phenotype dynamics reflect the strength of tumor-immune cell interactions in patients during immunotherapy Griffiths, Jason, I; Wallet, Pierre; Pflieger, Lance T.; Stenehjem, David; Liu, Xuan; Cosgrove, Patrick A.; Leggett, Neena A.; McQuerry, Jasmine A.; Shrestha, Gajendra; Rossetti, Maura; Sunga, Gemalene; Moos, Philip J.; Adler, Frederick R.; Chang, Jeffrey T.; Sharma, Sunil; Bild, Andrea H. 分享 收藏
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