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T

Timothy Tree

king's collegelondon
H指数:42
被引数:8,704

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IL-2 mutein-engrafted antibody MHS552 selectively expands functional regulatory T cells in nonclinical models and healthy participants

IL-2 mutein-engrafted抗体MHS552在非临床模型和健康受试者中选择性扩增功能性调节性T细胞

Nature Communications
IF15.7
2026-08-120
OA
Igor Radanović; Michael DiDonato; Anouk C. Meijs; David A. Schubert; Yaiza Diaz-de-Durana; Andrea Kiessling; Thierry Flandre; Hannah Morgan; Claudia Simonett; Justin McMullen; Manon AA. Jansen; Thomas P. Buters; Mahdi Saghari; Pim Gal; Jacobus J. Bosch; Sjoerd H. van der Burg; Susanne Osanto; Morten Bagger; Claudio Calonder; Darbi Witmer; Ulrike Sommer; Frank Waldron-Lynch; Peter Gergely; Nadege Pelletier; Nicole Hartmann; Esther Kamphausen; Magdalena Kistowska; Helene Marsot; Anita Auger-Sarrazin; Celine Rauld; Camille Regairaz; Timothy Tree; Yann Ladner; Naomi B. Klarenbeek; Matthijs Moerland; Robert Rissmann; Glen Spraggon; Leona Gabryšová
Nrf2-mediated metabolic reprogramming drives regulatory T cell accumulation in hepatocellular carcinoma

Nrf2介导的代谢重编程驱动肝细胞癌中调节性T细胞积累

Nature Communications
IF15.7
2026-07-130
OA
E. Perpiñán; N. Sompairac; D. Marin Correa; E. Ramon-Gil; RCH Man; D. Camell-Raventos; R. Savoldelli; M. Fleming; L. Bellersheim; CX Santos; M. Elgosbi; JJ Lozano; M. Maddaloni; C. Schmidl; E. Kodela; M. Piqué-Gili; AH de Sande; R. Pinyol; S. Higginbotham; Q. Peng; E. Landman; J. Torres-Yaguana; V. Sharma; C. Zhang; A. Kurt; X. Liao; T. Dowe; M. Habarwaa; Z. Liu; Y. Zen; R. Miquel; D. Sarker; S. Kordasti; T. Tree; AM Shah; GO Fruhwirth; AT Dinkova-Kostova; EL Pearce; J. Leslie; JM Llovet; A. Sánchez-Fueyo; N. Safinia
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial

抗胸腺细胞球蛋白在5～25岁近期发病的1型糖尿病3期患者中的最低有效低剂量（MELD-ATG）：一项Ⅱ期、多中心、双盲、随机、安慰剂对照、适应性剂量范围试验

lancet
IF0
2025-09-180
PRE
Chantal Mathieu; Julie Wych; A Emile J Hendriks; Lisa Van Ryckeghem; Timothy Tree; Piotr Chmura; Christopher Möller; Kristina Casteels; Thomas Danne; Felix Reschke; Darja Šmigoc Schweiger; Tadej Battelino; Jesper Johannesen; Birgit Rami-Merhar; Thomas Pieber; Christophe De Block; Mark Evans; Robert Hilbrands; Emanuele Bosi; Ruben H Willemsen; Supriyo Basu; Mari-Anne Pulkkinen; Mikael Knip; Miriam Cnop; Almut Nitsche; Anke M Schulte; Elisabeth Niemöller; Mark Peakman; Charlotte Wilhelm-Benartzi; David Gillespie; Lut Overbergh; Adrian P Mander; M Loredana Marcovecchio
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial

乌司他单抗治疗青少年1型糖尿病: 一项多中心、双盲、随机2期试验

NATURE MEDICINE
IF50
2024-07-303
OAAI
Tatovic, Danijela; Marwaha, Ashish; Taylor, Peter; Hanna, Stephanie J.; Carter, Kym; Cheung, W. Y.; Luzio, Steve; Dunseath, Gareth; Hutchings, Hayley A.; Holland, Gail; Hiles, Steve; Fegan, Greg; Williams, Evangelia; Yang, Jennie H. M.; Domingo-Vila, Clara; Pollock, Emily; Wadud, Muntaha; Ward-Hartstonge, Kirsten; Marques-Jones, Susie; Bowen-Morris, Jane; Stenson, Rachel; Levings, Megan K.; Gregory, John W.; Tree, Timothy I. M.; Dayan, Colin; USTEKID Study Gp, Evelien
A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes
CELL REPORTS MEDICINE
IF10.6
2024-06-010
OAAI
Sebastiani, Guido; Grieco, Giuseppina Emanuela; Bruttini, Marco; Auddino, Stefano; Mori, Alessia; Toniolli, Mattia; Fignani, Daniela; Licata, Giada; Aiello, Elena; Nigi, Laura; Formichi, Caterina; Fernandez-Tajes, Juan; Pugliese, Alberto; Evans-Molina, Carmella; Overbergh, Lut; Tree, Timothy; Peakman, Mark; Mathieu, Chantal; Dotta, Francesco
Pharmacometabolomics applied to low-dose interleukin-2 treatment in amyotrophic lateral sclerosis
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
IF4.8
2024-05-210
OAAI
Alarcan, Hugo; Bruno, Clement; Emond, Patrick; Raoul, Cedric; Vourc'h, Patrick; Corcia, Philippe; Camu, William; Veyrune, Jean-Luc; Garlanda, Cecilia; Locati, Massimo; Juntas-Morales, Raul; Saker, Safaa; Suehs, Carey; Masseguin, Christophe; Kirby, Janine; Shaw, Pamela; Malaspina, Andrea; De Vos, John; Al-Chalabi, Ammar; Leigh, P. Nigel; Tree, Timothy; Bensimon, Gilbert; Blasco, Helene
Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

人类遗传性PD-L1缺乏症在临床和免疫学上不如PD-1缺乏症严重

JOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
2024-04-181
PRE
Johnson, Matthew B.; Ogishi, Masato; Domingo-Vila, Clara; De Franco, Elisa; Wakeling, Matthew N.; Imane, Zineb; Resnick, Brittany; Williams, Evangelia; Galao, Rui Pedro; Caswell, Richard; Russ-Silsby, James; Seeleuthner, Yoann; Rinchai, Darawan; Fagniez, Iris; Benson, Basilin; Dufort, Matthew J.; Speake, Cate; Smithmyer, Megan E.; Hudson, Michelle; Dobbs, Rebecca; Quandt, Zoe; Hattersley, Andrew T.; Zhang, Peng; Boisson-Dupuis, Stephanie; Anderson, Mark S.; Casanova, Jean-Laurent; Tree, Timothy I.; Oram, Richard A.
Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans

在人类皮内注射载有糖尿病自身抗原的金纳米颗粒后，单细胞RNAseq鉴定克隆扩增的抗原特异性T细胞

FRONTIERS IN IMMUNOLOGY
IF5.9
2023-10-165
OAAI
Hanna, Stephanie J.; Thayer, Terri C.; Robinson, Emma J. S.; Vinh, Ngoc-Nga; Williams, Nigel; Landry, Laurie G.; Andrews, Robert; Siah, Qi Zhuang; Leete, Pia; Wyatt, Rebecca; Mcateer, Martina A.; Nakayama, Maki; Wong, F. Susan; Yang, Jennie H. M.; Tree, Timothy I. M.; Ludvigsson, Johnny; Dayan, Colin M.; Tatovic, Danijela
Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes

低剂量IL-2降低1型糖尿病IL-21 T细胞频率并诱导抗炎基因表达

NATURE COMMUNICATIONS
IF15.7
2022-11-2812
OAAI
Zhang, Jia-Yuan; Hamey, Fiona; Trzupek, Dominik; Mickunas, Marius; Lee, Mercede; Godfrey, Leila; Yang, Jennie H. M.; Pekalski, Marcin L.; Kennet, Jane; Waldron-Lynch, Frank; Evans, Mark L.; Tree, Timothy I. M.; Wicker, Linda S.; Todd, John A.; Ferreira, Ricardo C.
Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study
LANCET RHEUMATOLOGY
IF16.4
2022-01-0166
OAAI
Mahil, Satveer K.; Bechman, Katie; Raharja, Antony; Domingo-Vila, Clara; Baudry, David; Brown, Matthew A.; Cope, Andrew P.; Dasandi, Tejus; Graham, Carl; Khan, Hataf; Lechmere, Thomas; Malim, Michael H.; Meynell, Freya; Pollock, Emily; Sychowska, Kamila; Barker, Jonathan N.; Norton, Sam; Galloway, James B.; Doores, Katie J.; Tree, Timothy; Smith, Catherine H.

研究方向

暂未获取到该数据
M
Mark Peakman
H 指数:72论文数:418被引数:1.6万
B
Bart O. Roep
H 指数:84论文数:469被引数:2.3万
J
Jennie H. M. Yang
H 指数:21论文数:40被引数:5,535
C
Colin Dayan
H 指数:73论文数:545被引数:2.0万
S
Sefina Arif
H 指数:23论文数:60被引数:3,079
C
Clara Domingo‐Vila
H 指数:11论文数:38被引数:1,113
E
Evangelia Williams
H 指数:8论文数:20被引数:264
F
F. Susan Wong
H 指数:62论文数:344被引数:1.4万
E
Emily Pollock
H 指数:14论文数:44被引数:781
J
James L. Reading
H 指数:37论文数:148被引数:8,217