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M

Mark Peakman

Sanofi
H指数:72
被引数:1.6万

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A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent-Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

一项Frexalimab（一种CD40L拮抗剂）在近期发病的1型糖尿病青少年和成人中的2期试验（FABULINUS）：研究依据和试验设计

diabetes, obesity and metabolism
IF0
2026-05-270
OAAI
Andriy Cherkas; Baerbel Rotthaeuser; Niels Porksen; Pascale Labard; My-Liên Nguyên-Pascal; Mathieu Coudert; Baptiste Berthou; Marie Baccara-Dinet; Gabor Boka; Mark Peakman; Felix Reschke; Michael J. Haller
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial

抗胸腺细胞球蛋白在5～25岁近期发病的1型糖尿病3期患者中的最低有效低剂量（MELD-ATG）：一项Ⅱ期、多中心、双盲、随机、安慰剂对照、适应性剂量范围试验

lancet
IF0
2025-09-180
PRE
Chantal Mathieu; Julie Wych; A Emile J Hendriks; Lisa Van Ryckeghem; Timothy Tree; Piotr Chmura; Christopher Möller; Kristina Casteels; Thomas Danne; Felix Reschke; Darja Šmigoc Schweiger; Tadej Battelino; Jesper Johannesen; Birgit Rami-Merhar; Thomas Pieber; Christophe De Block; Mark Evans; Robert Hilbrands; Emanuele Bosi; Ruben H Willemsen; Supriyo Basu; Mari-Anne Pulkkinen; Mikael Knip; Miriam Cnop; Almut Nitsche; Anke M Schulte; Elisabeth Niemöller; Mark Peakman; Charlotte Wilhelm-Benartzi; David Gillespie; Lut Overbergh; Adrian P Mander; M Loredana Marcovecchio
HLA A*24:02-restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2024-09-170
OAAI
Dolton, Garry; Bulek, Anna; Wall, Aaron; Thomas, Hannah; Hopkins, Jade R.; Rius, Cristina; Galloway, Sarah A. E.; Whalley, Thomas; Tan, Li Rong; Morin, Theo; Omidvar, Nader; Fuller, Anna; Topley, Katie; Hasan, Md Samiul; Jain, Shikha; D'Souza, Nirupa; Hodges-Hoyland, Thomas; Spiller, Owen B.; Kronenberg-Versteeg, Deborah; Szomolay, Barbara; van den Berg, Hugo A.; Jones, Lucy C.; Peakman, Mark; Cole, David K.; Rizkallah, Pierre J.; Sewell, Andrew K.
A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes
CELL REPORTS MEDICINE
IF10.6
2024-06-010
OAAI
Sebastiani, Guido; Grieco, Giuseppina Emanuela; Bruttini, Marco; Auddino, Stefano; Mori, Alessia; Toniolli, Mattia; Fignani, Daniela; Licata, Giada; Aiello, Elena; Nigi, Laura; Formichi, Caterina; Fernandez-Tajes, Juan; Pugliese, Alberto; Evans-Molina, Carmella; Overbergh, Lut; Tree, Timothy; Peakman, Mark; Mathieu, Chantal; Dotta, Francesco
A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism
COMMUNICATIONS MEDICINE
IF6.3
2024-03-261
OAAI
Ptacin, Jerod L.; Ma, Lina; Caffaro, Carolina E.; Acuff, Nicole V.; Germar, Kristine; Severy, Peter; Qu, Yanyan; Vela, Jose-Luis; Cai, Xinming; San Jose, Kristine M.; Aerni, Hans R.; Chen, David B.; Esche, Ean; Ismaili, Taylor K.; Herman, Rob; Pavlova, Yelena; Pena, Michael J.; Nguyen, Jasmine; Koriazova, Lilia K.; Shawver, Laura K.; Joseph, Ingrid B.; Mooney, Jill; Peakman, Mark; Milla, Marcos E.
The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults

INNODIA 1型糖尿病自然史研究: 欧洲新诊断的儿童、青少年和成人队列

DIABETOLOGIA
IF10.2
2024-03-225
OAAI
Marcovecchio, M. Loredana; Hendriks, A. Emile J.; Delfin, Carl; Battelino, Tadej; Danne, Thomas; Evans, Mark L.; Johannesen, Jesper; Kaur, Simranjeet; Knip, Mikael; Overbergh, Lut; Pociot, Flemming; Todd, John A.; van der Schueren, Bart; Wicker, Linda S.; Peakman, Mark; Mathieu, Chantal
Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory

新诊断的1型糖尿病青年纵向样本的靶向血清蛋白质组学区分疾病标志物和c肽轨迹

DIABETOLOGIA
IF10.2
2023-08-047
OAAI
Moulder, Robert; Valikangas, Tommi; Hirvonen, M. Karoliina; Suomi, Tomi A.; Brorsson, Caroline A.; Lietzen, Niina; Bruggraber, Sylvaine F. A.; Overbergh, Lut; Dunger, David B.; Peakman, Mark; Chmura, Piotr J.; Brunak, Soren; Schulte, Anke M.; Mathieu, Chantal; Knip, Mikael; Elo, Laura L.; Lahesmaa, Riitta
Gene expression signature predicts rate of type 1 diabetes progression
EBIOMEDICINE
IF10.8
2023-06-019
OAAI
Suomi, Tomi; Starskaia, Inna; Kalim, Ubaid Ullah; Rasool, Omid; Jaakkola, Maria K.; Gronroos, Toni; Valikangas, Tommi; Brorsson, Caroline; Mazzoni, Gianluca; Bruggraber, Sylvaine; Overbergh, Lut; Dunger, David; Peakman, Mark; Chmura, Piotr; Brunak, Seren; Schulte, Anke M.; Mathieu, Chantal; Knip, Mikael; Lahesmaa, Riitta; Elo, Laura L.
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage

外周血单核细胞中肠病毒RNA的检测与1型糖尿病风险基因IFIH1的易感等位基因的存在以及疾病阶段相关

DIABETOLOGIA
IF10.2
2022-07-224
OAAI
Sioofy-Khojine, Amir-Babak; Richardson, Sarah J.; Locke, Jonathan M.; Oikarinen, Sami; Nurminen, Noora; Laine, Antti-Pekka; Downes, Kate; Lempainen, Johanna; Todd, John A.; Veijola, Riitta; Ilonen, Jorma; Knip, Mikael; Morgan, Noel G.; Hyoty, Heikki; Peakman, Mark; Eichmann, Martin
Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function
AMERICAN JOURNAL OF TRANSPLANTATION
IF8.2
2021-03-014
OAAI
Sabbah, Shereen; Liew, Aaron; Brooks, Augustin M.; Kundu, Rhiannon; Reading, James L.; Flatt, Anneliese; Counter, Claire; Choudhary, Pratik; Forbes, Shareen; Rosenthal, Miranda J.; Rutter, Martin K.; Cairns, Stephanie; Johnson, Paul; Casey, John; Peakman, Mark; Shaw, James A.; Tree, Timothy I. M.
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

滤泡辅助T细胞谱可预测1型糖尿病对共刺激阻滞的反应

NATURE IMMUNOLOGY
IF27.6
2020-08-0375
OAAI
Edner, Natalie M.; Heuts, Frank; Thomas, Niclas; Wang, Chun Jing; Petersone, Lina; Kenefeck, Rupert; Kogimtzis, Alexandros; Ovcinnikovs, Vitalijs; Ross, Ellen M.; Ntavli, Elisavet; Elfaki, Yassin; Eichmann, Martin; Baptista, Roman; Ambery, Philip; Jermutus, Lutz; Peakman, Mark; Rosenthal, Miranda; Walker, Lucy S. K.

研究方向

暂未获取到该数据
B
Bart O. Roep
H 指数:84论文数:469被引数:2.3万
S
Sefina Arif
H 指数:23论文数:60被引数:3,077
A
Ania Skowera
H 指数:24论文数:65被引数:2,550
T
Timothy Tree
H 指数:42论文数:166被引数:8,699
A
Andrew K. Sewell
H 指数:70论文数:338被引数:1.7万
G
Garry Dolton
H 指数:31论文数:83被引数:4,945
M
Martin Eichmann
H 指数:14论文数:22被引数:1,035
C
Colin Dayan
H 指数:73论文数:545被引数:2.0万
A
Anna Lorenc
H 指数:25论文数:83被引数:3,675
D
David K. Cole
H 指数:42论文数:181被引数:6,681