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I

Ignaty Leshchiner

broad institute of mit and harvard
H指数:58
被引数:3.4万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Actionable genetic landscape and dynamics in circulating DNA from 12,827 patients with metastatic breast cancer

来自12,827例转移性乳腺癌患者循环DNA中可操作的遗传景观和动态

Nature Communications
IF15.7
2026-09-220
OAAI
Ignaty Leshchiner; Arielle J. Medford; Justin Cha; Lesli A. Kiedrowski; Andrzej Niemierko; Jennifer C. Keenan; Charles S. Dai; Laura M. Spring; Beverly Moy; Seth A. Wander; Neelima Vidula; Steven J. Isakoff; Dejan Juric; Mendy Miller; Andrew A. Davis; Lorenzo Gerratana; Ami Shah; Ben H. Park; Adam Brufsky; Joyce O’Shaughnessy; Rebecca J. Nagy; Leif W. Ellisen; Massimo Cristofanilli; Aditya Bardia; Gad Getz
Tamoxifen induces PI3K activation in uterine cancer

他莫昔芬诱导子宫癌中PI3K的激活

Nature Genetics
IF0
2025-08-220
OAAI
Kirsten Kübler; Agostina Nardone; Shankara Anand; Daniel Gurevich; Jianjiong Gao; Marjolein Droog; Francisco Hermida-Prado; Tara Akhshi; Ariel Feiglin; Avery S. Feit; Gabriella Cohen Feit; Gwen Dackus; Matthew Pun; Yanan Kuang; Justin Cha; Mendy Miller; Sebastian Gregoricchio; Mirthe Lanfermeijer; Sten Cornelissen; William J. Gibson; Cloud P. Paweletz; Eliezer M. Van Allen; Flora E. van Leeuwen; Petra M. Nederlof; Quang-Dé Nguyen; Marian J. E. Mourits; Milan Radovich; Ignaty Leshchiner; Chip Stewart; Ursula A. Matulonis; Wilbert Zwart; Yosef E. Maruvka; Gad Getz; Rinath Jeselsohn
A model for decoding resistance in precision oncology: acquired resistance to FGFR inhibitors in cholangiocarcinoma

精准肿瘤学中耐药性解码模型：胆管癌对FGFR抑制剂的获得性耐药

ANNALS OF ONCOLOGY
IF65.4
2024-12-011
OAAI
Goyal, L.; DiToro, D.; Facchinetti, F.; Martin, E. E.; Peng, P.; Baiev, I.; Iyer, R.; Maurer, J.; Reyes, S.; Zhang, K.; Majeed, U.; Berchuck, J. E.; Chen, C. T.; Walmsley, C.; Pinto, C.; Vasseur, D.; Gordan, J. D.; Mody, K.; Borad, M.; Karasic, T.; Damjanov, N.; Danysh, B. P.; Wehrenberg-Klee, E.; Kambadakone, A. R.; Saha, S. K.; Hoffman, I. D.; Nelson, K. J.; Iyer, S.; Qiang, X.; Sun, C.; Wang, H.; Li, L.; Javle, M.; Lin, B.; Harris, W.; Zhu, A. X.; Cleary, J. M.; Flaherty, K. T.; Harris, T.; Shroff, R. T.; Leshchiner, I.; Parida, L.; Kelley, R. K.; Fan, J.; Stone, J. R.; Uboha, N. V.; Hirai, H.; Sootome, H.; Wu, F.; Bensen, D. C.; Hollebecque, A.; Friboulet, L.; Lennerz, J. K.; Getz, G.; Juric, D.
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors

表现为多原发肿瘤的EGFR突变肺癌的发育镶嵌

NATURE CANCER
IF28.5
2024-10-151
OAAI
Burr, Risa; Leshchiner, Ignaty; Costantino, Christina L.; Blohmer, Martin; Sundaresan, Tilak; Cha, Justin; Seeger, Karsen; Guay, Sara; Danysh, Brian P.; Gore, Ira; Jacobs, Raquel A.; Slowik, Kara; Utro, Filippo; Rhrissorrakrai, Kahn; Levovitz, Chaya; Barth, Jaimie L.; Dubash, Taronish; Chirn, Brian; Parida, Laxmi; Sequist, Lecia V.; Lennerz, Jochen K.; Mino-Kenudson, Mari; Maheswaran, Shyamala; Naxerova, Kamila; Getz, Gad; Haber, Daniel A.
Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations
BLOOD CANCER DISCOVERY
IF11.5
2024-09-050
PRE
Penter, Livius; Cieri, Nicoletta; Maurer, Katie; Kwok, Marwan; Lyu, Haoxiang; Lu, Wesley S.; Oliveira, Giacomo; Gohil, Satyen H.; Leshchiner, Ignaty; Lareau, Caleb A.; Ludwig, Leif S.; Neuberg, Donna S.; Kim, Haesook T.; Li, Shuqiang; Bullinger, Lars; Ritz, Jerome; Getz, Gad; Garcia, Jacqueline S.; Soiffer, Robert J.; Livak, Kenneth J.; Wu, Catherine J.
Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations
CANCER RESEARCH
IF16.6
2024-05-020
PRE
Varkaris, Andreas; de la Cruz, Ferran Fece; Martin, Elizabeth; Nordern, Bryanna; Chevalier, Nicholas; Leshchiner, Ignaty; Stavridi, Anastasia; Kim, Janice; Papatheodoridi, Alkistis; Gunaydin, Hakan; Danysh, Brian; Parida, Laxmi; Sanidas, Ioannis; Ji, Yongli; Lau, Kayao; Wulf, Gerburg; Bardia, Aditya; Spring, Laura; Isakoff, Steven; Lennerz, Jochen; Pierce, Levi; Pazolli, Ermira; Getz, Gad; Corcoran, Ryan; Juric, Dejan
Strategies to overcome resistance to PI3Kalpha-selective inhibitors mediated by acquired alterations in the PI3K/AKT pathway
CANCER RESEARCH
IF16.6
2024-04-050
PRE
de la Cruz, Ferran Fece; Varkaris, Andreas; Martin, Elizabeth E.; Norden, Bryanna L.; Chevalier, Nicholas; Kehlmann, Allison M.; Leshchiner, Ignaty; Barnes, Haley; Ehnstrom, Sara; Patel, Parasvi; Kim, Janice S.; Ellis, Haley; Sanidas, Ioannis; Lau, Kayao T.; Bardia, Aditya; Spring, Laura M.; Isakoff, Steven J.; Lennerz, Jochen K.; Getz, Gad; Corcoran, Ryan B.; Juric, Dejan
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

变构PI3Kα 抑制克服了继发性PIK3CA突变介导的对正构抑制剂的靶向抗性

CANCER DISCOVERY
IF33.3
2023-10-3114
OAAI
Varkaris, Andreas; de la Cruz, Ferran Fece; Martin, Elizabeth E.; Norden, Bryanna L.; Chevalier, Nicholas; Kehlmann, Allison M.; Leshchiner, Ignaty; Barnes, Haley; Ehnstrom, Sara; Stavridi, Anastasia-Maria; Yuan, Xin; Kim, Janice S.; Ellis, Haley; Papatheodoridi, Alkistis; Gunaydin, Hakan; Danysh, Brian P.; Parida, Laxmi; Sanidas, Ioannis; Ji, Yongli; Lau, Kayao; Wulf, Gerburg M.; Bardia, Aditya; Spring, Laura M.; Isakoff, Steven J.; Lennerz, Jochen K.; Del Vecchio, Kathryn; Pierce, Levi; Pazolli, Ermira; Getz, Gad; Corcoran, Ryan B.; Juric, Dejan
Tumor-specific immunity generated by a personalized neoantigen vaccination incorporating locally delivered ipilimumab in renal cell carcinoma.
CANCER RESEARCH
IF16.6
2023-08-151
PRE
Braun, David A.; Keskin, Derin B.; Shukla, Sachet A.; McGregor, Bradley A.; Schindler, Nicholas R.; Blass, Eryn; Klaeger, Susan; Pomerance, Lucas; Sarkizova, Siranush; Li, Shuqiang; Southard, Jackson; Moranzoni, Giorgia; Pedersen, Christina B.; Liu, Yiwen; Chang, Steven L.; Hirsch, Michelle S.; LeBoeuf, Nicole R.; Mossanen, Matthew; Chea, Vipheaviny; Carulli, Isabel; Olive, Oriol; Mehndiratta, Ambica; Greenslade, Haley; Oliveira, Giacomo; Iorgulescu, J. Bryan; Signoretti, Sabina; Aster, Jon C.; Elagina, Liudmila; Leshchiner, Ignaty; Getz, Gad; Harden, Maegan; Gabriel, Stacey; Olsen, Lars R.; Neuberg, Donna S.; Fritsch, Edward F.; Hacohen, Nir; Livak, Kenneth J.; Carr, Steven; Ott, Patrick A.; Wu, Catherine J.; Choueiri, Toni K.
Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance
BLOOD ADVANCES
IF7.1
2023-05-0934
OAAI
Naeem, Aishath; Utro, Filippo; Wang, Qing; Cha, Justin; Vihinen, Mauno; Martindale, Stephen; Zhou, Yinglu; Ren, Yue; Tyekucheva, Svitlana; Kim, Annette S.; Fernandes, Stacey M.; Saksena, Gordon; Rhrissorrakrai, Kahn; Levovitz, Chaya; Danysh, Brian P.; Slowik, Kara; Jacobs, Raquel A.; Davids, Matthew S.; Lederer, James A.; Zain, Rula; Smith, C. I. Edvard; Leshchiner, Ignaty; Parida, Laxmi; Getz, Gad; Brown, Jennifer R.
Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer
NATURE GENETICS
IF31.8
2023-04-0656
OAAI
Ravi, Arvind; Hellmann, Matthew D.; Arniella, Monica B.; Holton, Mark; Freeman, Samuel S.; Naranbhai, Vivek; Stewart, Chip; Leshchiner, Ignaty; Kim, Jaegil; Akiyama, Yo; Griffin, Aaron T.; Vokes, Natalie I.; Sakhi, Mustafa; Kamesan, Vashine; Rizvi, Hira; Ricciuti, Biagio; Forde, Patrick M.; Anagnostou, Valsamo; Riess, Jonathan W.; Gibbons, Don L.; Pennell, Nathan A.; Velcheti, Vamsidhar; Digumarthy, Subba R.; Mino-Kenudson, Mari; Califano, Andrea; Heymach, John V.; Herbst, Roy S.; Brahmer, Julie R.; Schalper, Kurt A.; Velculescu, Victor E.; Henick, Brian S.; Rizvi, Naiyer; Jaenne, Pasi A.; Awad, Mark M.; Chow, Andrew; Greenbaum, Benjamin D.; Luksza, Marta; Shaw, Alice T.; Wolchok, Jedd; Hacohen, Nir; Getz, Gad; Gainor, Justin F.
Immunoproteasome expression and checkpoint blockade response in advanced non-small cell lung cancer
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Naranbhai, Vivek; Ravi, Arvind; Hellmann, Matthew; Arniella, Monica; Holton, Mark; Freeman, Samuel; Stewart, Chip; Leshchiner, Ignaty; Kim, Jaegil; Akiyama, Yo; Griffin, Aaron; Vokes, Natalie; Sakhi, Mustafa; Kamesan, Vashine; Rizvi, Hira; Ricciuti, Biagio; Forde, Patrick; Anagnostou, Valsamo; Riess, Jonathan; Gibbons, Don; Pennell, Nathan; Velcheti, Vamsidhar; Digumarthy, Subba; Mino-Kenudson, Mari; Califano, Andrea; Heymach, John; Herbst, Roy; Brahmer, Julie; Schalper, Kurt; Velculescu, Victor; Henick, Brian; Rizvi, Naiyer; Janne, Pasi; Awad, Mark; Chow, Andrew; Greenbaum, Benjamin; Luksza, Marta; Shaw, Alice; Wolchok, Jedd; Hacohen, Nir; Getz, Gad; Gainor, Justin
Mechanisms of genetic predisposition to multifocal lung cancer

多灶性肺癌的遗传易感性机制

CANCER RESEARCH
IF16.6
2023-04-040
PRE
Burr, Risa; Leshchiner, Ignaty; Costantino, Christina L.; Blohmer, Martin; Sundaresan, Tilak; Cha, Justin; Seeger, Karsen; Guay, Sara; Danysh, Brian P.; Gore, Ira; Jacobs, Raquel A.; Slowik, Kara; Utro, Filippo; Rhrissorrakrai, Kahn; Levovitz, Chaya; Barth, Jaimie L.; Dubash, Taronish; Chirn, Brian; Parida, Laxmi; Sequist, Lecia V.; Mino-Kenudson, Mari; Naxerova, Kamila; Maheswaran, Shyamala; Getz, Gad; Haber, Daniel A.
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

慢性淋巴细胞白血病向Richter综合征转化的进化史

NATURE MEDICINE
IF50
2023-01-0940
OA
Parry, Erin M.; Leshchiner, Ignaty; Guieze, Romain; Johnson, Connor; Tausch, Eugen; Parikh, Sameer A.; Lemvigh, Camilla; Broseus, Julien; Hergalant, Sebastien; Messer, Conor; Utro, Filippo; Levovitz, Chaya; Rhrissorrakrai, Kahn; Li, Liang; Rosebrock, Daniel; Yin, Shanye; Deng, Stephanie; Slowik, Kara; Jacobs, Raquel; Huang, Teddy; Li, Shuqiang; Fell, Geoff; Redd, Robert; Lin, Ziao; Knisbacher, Binyamin A.; Livitz, Dimitri; Schneider, Christof; Ruthen, Neil; Elagina, Liudmila; Taylor-Weiner, Amaro; Persaud, Bria; Martinez, Aina; Fernandes, Stacey M.; Purroy, Noelia; Anandappa, Annabelle J.; Ma, Jialin; Hess, Julian; Rassenti, Laura Z.; Kipps, Thomas J.; Jain, Nitin; Wierda, William; Cymbalista, Florence; Feugier, Pierre; Kay, Neil E.; Livak, Kenneth J.; Danysh, Brian P.; Stewart, Chip; Neuberg, Donna; Davids, Matthew S.; Brown, Jennifer R.; Parida, Laxmi; Stilgenbauer, Stephan; Getz, Gad; Wu, Catherine J. J.
Tamoxifen instigates uterine cancer development by activating PI3K signaling and supersedes PIK3CA driver mutations
CANCER RESEARCH
IF16.6
2022-02-151
PRE
Kubler, Kirsten; Nardone, Agostina; Anand, Shankara; Gorvich, Daniel; Droog, Marjolein; Hermida-Prado, Francisco; Akshi, Tara; Feit, Avery S.; Cohen, Gabriella; Dackus, Gwen; Pun, Matthew; Kuang, Yanan; Cha, Justin; Miller, Mendy; Gibson, William J.; Paweletz, Cloud P.; Van Allen, Eliezer M.; van Leeuwen, Flora E.; Nederlof, Petra; Hollema, Harry; Quang-De Nguyen; Mourits, Marian J. E.; Leshchiner, Ignaty; Stewart, Chip; Matulonis, Ursula A.; Zwart, Wilbert; Maruvka, Yosef E.; Getz, Gad; Jeselsohn, Rinath
Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma
CELL REPORTS MEDICINE
IF10.6
2022-02-0118
OAAI
Freeman, Samuel S.; Sade-Feldman, Moshe; Kim, Jaegil; Stewart, Chip; Gonye, Anna L. K.; Ravi, Arvind; Arniella, Monica B.; Gushterova, Irena; LaSalle, Thomas J.; Blaum, Emily M.; Yizhak, Keren; Frederick, Dennie T.; Sharova, Tatyana; Leshchiner, Ignaty; Elagina, Liudmila; Spiro, Oliver G.; Livitz, Dimitri; Rosebrock, Daniel; Aguet, Francois; Carrot-Zhang, Jian; Ha, Gavin; Lin, Ziao; Chen, Jonathan H.; Barzily-Rokni, Michal; Hammond, Marc R.; von Eckstaedt, Hans C. Vitzthum; Blackmon, Shauna M.; Jiao, Yunxin J.; Gabriel, Stacey; Lawrence, Donald P.; Duncan, Lyn M.; Stemmer-Rachamimov, Anat O.; Wargo, Jennifer A.; Flaherty, Keith T.; Sullivan, Ryan J.; Boland, Genevieve M.; Meyerson, Matthew; Getz, Gad; Hacohen, Nir

研究方向

暂未获取到该数据
G
Gad Getz
H 指数:248论文数:1,851被引数:35.2万
D
Dimitri Livitz
H 指数:49论文数:131被引数:2.7万
D
Daniel Rosebrock
H 指数:47论文数:106被引数:2.4万
L
Laxmi Parida
H 指数:44论文数:477被引数:7,606
C
Chip Stewart
H 指数:84论文数:386被引数:6.6万
B
Brian P. Danysh
H 指数:21论文数:95被引数:2,298
D
Dejan Juric
H 指数:59论文数:732被引数:2.0万
K
Kahn Rhrissorrakrai
H 指数:19论文数:93被引数:3,350
C
Chaya Levovitz
H 指数:13论文数:71被引数:1,681
F
Filippo Utro
H 指数:20论文数:129被引数:3,178