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Selective inhibition of canonical STAT3 signaling suppresses K-ras mutant lung tumorigenesis and reinvigorates anti-tumor immunity 选择性抑制经典STAT3信号通路可抑制K-ras突变型肺癌发生并增强抗肿瘤免疫。 Clowers, Michael J.; Rahal, Zahraa; Cho, Sung-Nam; Krishna, Avantika; Yuan, Bo; Zorrilla, Leticia G. Hamana; Eckols, T. Kris; Kasembeli, Moses M.; Liu, Samuel; Peng, Stephen; Ramos-Castaneda, Marco; Thompson, Annamarie L.; Reyna, Carlos Ignacio Rodriguez; Larsen, Katherine E.; Grimaldo, Maria T.; Deng, Shanshan; Karimi, Nastaran; Chou, Cody; Velasco, Walter V.; Zarghooni, Melody; Alekseev, Sayan; Soto, Luisa M. Solis; Ostrin, Edwin J.; Kadara, Humam; Ekmekcioglu, Suhendan; Tweardy, David J.; Moghaddam, Seyed Javad 分享 收藏
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METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics Jiang, Jiahui; Liu, Yunhe; Qin, Jiangjiang; Chen, Jianfeng; Wu, Jingjing; Pizzi, Melissa P.; Lazcano, Rossana; Yamashita, Kohei; Xu, Zhiyuan; Pei, Guangsheng; Cho, Kyung Serk; Chu, Yanshuo; Sinjab, Ansam; Peng, Fuduan; Yan, Xinmiao; Han, Guangchun; Wang, Ruiping; Dai, Enyu; Dai, Yibo; Czerniak, Bogdan A.; Futreal, Andrew; Maitra, Anirban; Lazar, Alexander; Kadara, Humam; Jazaeri, Amir A.; Cheng, Xiangdong; Ajani, Jaffer; Gao, Jianjun; Hu, Jian; Wang, Linghua 分享 收藏
Lung epithelial specific IL-1R promotes K-ras mutant lung cancer by inducing angiogenesis that might be medicated via myeloid tumor microenvironment 肺上皮特异性IL-1R通过诱导血管生成促进k-ras突变型肺癌，这可能是通过髓系肿瘤微环境来实现的 Krishna, Avantika; Clowers, Michael J.; Yuan, Bo; Ha, Vivian; Larsen, Katherine; Karimi, Nastaran; Gaitonde, Arnav; Colunga, Jocelynn; Grimaldo, Maria T.; Sancristobal, Maria Jose Arredondo; Villalba-Sabat, Valentina; De Anda, Angelica Baca; Rezai, Yasmina; Sharma, Jyotika; Kadara, Humam; Moghaddam, Seyed Javad 分享 收藏
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Pan-cancer characterization of cancer cell state and plasticity using spatially resolved transcriptomics Pei, Guangsheng; Cho, Kyung S.; Liu, Yunhe; Alejandra, Serrano; Lazcano, Rossana; Dai, Enyu; Han, Guangchun; Peng, Fuduan; Zhang, Daiwei; Chu, Yanshuo; Sinjab, Ansam F.; Jiang, Jiahui; Li, Mingyao; Yee, Cassian; Futreal, Andrew; Lazar, Alex; Kadara, Humam; Gao, Jianjun; Soto, Luisa M.; Maitra, Anirban; Ajani, Jaffer; Wang, Linghua 分享 收藏
METI: Deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics Jiang, Jiahui; Liu, Yunhe; Qin, Jiangjiang; Wu, Jingjing; Chen, Jianfeng; Pizzi, Melissa; Segura, Rossana; Yamashita, Kohei; Xu, Zhiyuan; Pei, Guangsheng; Cho, Kyung Serk; Chu, Yanshuo; Sinjab, Ansam; Peng, Fuduan; Han, Guangchun; Wang, Ruiping; Yan, Xinmiao; Dai, Enyu; Li, Mingyao; Futreal, Andrew; Maitra, Anirban; Lazar, Alexander; Cheng, Xiangdong; Kadara, Humam; Ajani, Jaffer; Jazaeri, Amir; Hu, Jian; Wang, Linghua; Gao, Jianjun 分享 收藏
Pan-cancer single-cell and subcellular characterization of lymphoid aggregates and tertiary lymphoid structures using high-plex spatial molecular imaging Liu, Yunhe; Zhang, Yuanyuan; Han, Guangchun; Pei, Guangsheng; Cho, Kyung Serk; Dai, Enyu; Chu, Yanshuo; Jiang, Jiahui; Sinjab, Ansam; Soto, Luisa M.; Serrano, Alejandra; Gao, Jianjun; Kadara, Humam; Fridman, Catherine; Fridman, Wolf Herve; Wang, Linghua 分享 收藏
SpatialCS: A tool to effectively integrate histological annotations and spatial transcriptomics analysis Chu, Yanshuo; Cho, Kyung Serk; Khanduri, Isha; Zhou, Tieling; Jiang, Jiahui; Liu, Yunhe; Yan, Xinmiao; Pei, Guangsheng; Dai, Yibo; Liu, Yang; Wang, Ruiping; Jadhav, Akshaya S.; Hernandez, Sharia; Kadara, Humam; Soto, Luisa Maren Solis; Kopetz, Scott; Maru, Dipen Maheshbhai; Wang, Linghua 分享 收藏
A multimodal spatial-omics atlas of lung precancer and progression to adenocarcinoma Sinjab, Ansam; Peng, Fuduan; Liu, Yunhe; Yang, Sujuan; Zhou, Tieling; Serrano, Alejandra G.; Feng, Jiping; Bolanos, Lorena Gomez; Han, Guangchun; Rosen, Daniel Gustavo; Swisher, Stephen G.; Spira, Avrum; Dubinett, Steven M.; Soto, Luisa M. Solis; Li, Mingyao; Fujimoto, Junya; Burks, Jared; Wistuba, Ignacio I.; Wang, Linghua; Kadara, Humam 分享 收藏
iStarTLS: Advanced detection and phenotyping of tertiary lymphoid structures Cho, Kyung Serk; Jiang, Jiahui; Zhang, Daiwei; Liu, Yunhe; Chen, Jianfeng; Segura, Rossana L.; Yan, Xinmiao; Pei, Guangsheng; Soto, Luisa M.; Chu, Yanshuo; Sinjab, Ansam F.; Yee, Cassian; Kopetz, Scott; Maitra, Anirban; Futreal, Andrew; Lazar, Alexander; Jazaeri, Amir A.; Kadara, Humam; Gao, Jianjun; Li, Mingyao; Wang, Linghua 分享 收藏
Multimodal spatial transcriptomics and proteomics analysis of the resectable NSCLC ecosystem following neoadjuvant chemoimmunotherapy Rahal, Zahraa; Zhou, Tieling; Yang, Sujuan; Serrano, Alejandra; Feng, Jiping; Sinjab, Ansam; Le, John T.; Sun, Xin; Wang, Michael; Hu, Wei; Zang, Jianjun; Bruno, Tullia; Tran, Hai T.; Swisher, Stephen G.; Leung, Cheuk Hong; Lin, Heather Y.; Lee, J. Jack; Wang, Jing; Heymach, John Victor; Gibbons, Don Lynn; Wistuba, Ignacio Ivan; Weissferdt, Annikka; Burks, Jared K.; Soto, Luisa Maren Solis; Kadara, Humam; Cascone, Tina 分享 收藏
High-fiber diet induces favorable gut microbiota, reduces immunosuppression, and inhibits lung cancer development Sharma, Manvi; Liu, Yuejiang; Moreno, Hannah; Reischle, Inti C.; Jamal, Mohamed A.; Zhou, Tieling; Rahal, Zahraa; Chukwuocha, Chidera O.; Liang, Ke; Jenq, Robert R.; Ross, Matthew C.; Hoffman, Kristi L.; Kadara, Humam 分享 收藏
Single-Cell Characterization of Pulmonary Nodules Implicates Suppression of Immunosurveillance across Early Stages of Lung Adenocarcinoma Yanagawa, Jane; Tran, Linh M.; Salehi-Rad, Ramin; Lim, Raymond J.; Dumitras, Camelia; Fung, Eileen; Wallace, William D.; Prosper, Ashley E.; Fishbein, Gregory; Shea, Conor; Hong, Rui; Kahangi, Bitta; Deng, John J.; Gower, Adam C.; Liu, Bin; Campbell, Joshua D.; Mazzilli, Sarah A.; Beane, Jennifer E.; Kadara, Humam; Lenburg, Marc E.; Spira, Avrum E.; Aberle, Denise R.; Krysan, Kostyantyn; Dubinett, Steven M. 分享 收藏
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Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance 泛癌T细胞图谱将细胞应激反应状态与免疫疗法抗性联系起来 Chu, Yanshuo; Dai, Enyu; Li, Yating; Han, Guangchun; Pei, Guangsheng; Ingram, Davis R. R.; Thakkar, Krupa; Qin, Jiang-Jiang; Dang, Minghao; Le, Xiuning; Hu, Can; Deng, Qing; Sinjab, Ansam; Gupta, Pravesh; Wang, Ruiping; Hao, Dapeng; Peng, Fuduan; Yan, Xinmiao; Liu, Yunhe; Song, Shumei; Zhang, Shaojun; Heymach, John V. V.; Reuben, Alexandre; Elamin, Yasir Y. Y.; Pizzi, Melissa P. P.; Lu, Yang; Lazcano, Rossana; Hu, Jian; Li, Mingyao; Curran, Michael; Futreal, Andrew; Maitra, Anirban; Jazaeri, Amir A. A.; Ajani, Jaffer A. A.; Swanton, Charles; Cheng, Xiang-Dong; Abbas, Hussein A. A.; Gillison, Maura; Bhat, Krishna; Lazar, Alexander J. J.; Green, Michael; Litchfield, Kevin; Kadara, Humam; Yee, Cassian; Wang, Linghua 分享 收藏
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