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J

Joseph D. Schonhoft

Johns Hopkins University
H指数:22
被引数:1,547

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工作经历

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荣誉奖项

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Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor

RP-1664的发现：一种具有口服生物利用度、选择性的首创新药PLK4抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-160
PRE
Vallee, Frederic; Casas-Selves, Matias; Bubenik, Monica; Duplessis, Martin; Sow, Boubacar; Suarez, Catalina; Sangiorgi, Bruno; Li, Li; Hyer, Marc; Papp, Robert; Leclaire, Marie-Eve; Perryman, Alexander L.; Liu, Bingcan; Surprenant, Simon; Mochirian, Philippe; Pau, Victor; Maderova, Zdenka; Mader, Pavel; Yin, Shou Yun; Goodfellow, Elliot; Roulston, Anne; Stocco, Rino; Godbout, Claude; Baruah, Prasamit; Bonneau-Fortin, Alexanne; Schonhoft, Joseph D.; Nejad, Parham; Norman, David; Truong, Vouy Linh; Crane, Sheldon; Attia, Mohamed A.; Mao, Daniel; Sicheri, Frank; Marshall, C. Gary; Zimmermann, Michal; Bendahan, David; Gallant, Michel; Black, W. Cameron
Ataxia telangiectasia and Rad3-related (ATR) inhibitor camonsertib dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study)
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
IF7.2
2024-05-062
OAAI
Fontana, Elisa; Rosen, Ezra; Lee, Elizabeth K.; Hojgaard, Martin; Mettu, Niharika B.; Lheureux, Stephanie; Carneiro, Benedito A.; Cote, Gregory M.; Carter, Louise; Plummer, Ruth; Mahalingam, Devalingam; Fretland, Adrian J.; Schonhoft, Joseph D.; Silverman, Ian M.; Wainszelbaum, Marisa; Xu, Yi; Ulanet, Danielle; Koehler, Maria; Yap, Timothy A.
Identification of monoallelic ATM loss-of-function and homologous recombination deficiency (HRD) in high-grade ovarian tumor with prolonged response to camonsertib and low-dose gemcitabine combination therapy
CANCER RESEARCH
IF16.6
2024-01-090
PRE
Lheureux, Stephanie; Schonhoft, Joseph D.; Silverman, Ian M.; Yang, Julia; Johnson, Adrienne; Grant, Brooke; Fortuna, Alexander; Pugh, Trevor J.; Nejad, Parham; Lam, Bernard; Arora, Sahaj; Adile, Ashley; Prokopec, Stephenie D.; Bruce, Jeffrey; Ulanet, Danielle; Koehler, Maria; Rosen, Ezra; Rimkunas, Victoria
Ataxia telangiectasia- and Rad3-related kinase inhibitor (ATRi) camonsertib in combination with low dose gemcitabine in patients with solid tumors with DNA damage response (DDR) aberrations: Preclinical and Phase 1b results
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Rosen, Ezra; Yap, Timothy A.; Fontana, Elisa; Lee, Elizabeth K.; Mahalingam, Devalingam; Hojgaard, Martin; Mettu, Niharika B.; Cote, Gregory M.; Plummer, Ruth; Silverman, Ian M.; Schonhoft, Joseph D.; Bacque, Emeline; Fretland, Adrian J.; Gomez, Gabriela; Ulanet, Danielle; Fei, Kezhen; Yang, Julia; Koehler, Maria; Roulston, Anne; Li, Li; Zimmermann, Michel; Carneiro, Benedito A.; Lheureux, Stephanie
Circulating tumor DNA (ctDNA) genomic and epigenomic profiling (GuardantINFINITY) for diagnosis of DNA damage repair (DDR) loss of function (LOF) and response monitoring in the TRESR and ATTACC trials
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-010
PRE
Rosen, Ezra; Schonhoft, Joseph D.; Silverman, Ian M.; Yablonovitch, Arielle; Sethuraman, Sunantha; Nejad, Parham; Ulanet, Danielle; Yang, Julia; Kim, Insil; Fei, Kezhen; Xu, Yi; Lagow, Errin; Zhang, Shile; Cai, Mingyang; Koehler, Maria; Carneiro, Benedito A.; Lheureux, Stephanie; Cecchini, Michael; Herzberg, Benjamin; Reis-Filho, Jorge S.; Rimkunas, Victoria; Yap, Timothy A.
Phase 1b study of enzalutamide plus CC-115, a dual mTORC1/2 and DNA-PK inhibitor, in men with metastatic castration-resistant prostate cancer (mCRPC)
BRITISH JOURNAL OF CANCER
IF6.8
2023-11-187
OA
Zhao, Jimmy L.; Antonarakis, Emmanuel S.; Cheng, Heather H.; George, Daniel J.; Aggarwal, Rahul; Riedel, Elyn; Sumiyoshi, Takayuki; Schonhoft, Joseph D.; Anderson, Amanda; Mao, Ninghui; Haywood, Samuel; Decker, Brooke; Curley, Tracy; Abida, Wassim; Feng, Felix Y.; Knudsen, Karen; Carver, Brett; Lacouture, Mario E.; Wyatt, Alexander W.; Rathkopf, Dana
Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results
NATURE MEDICINE
IF50
2023-06-0530
OAAI
Yap, Timothy A. A.; Fontana, Elisa; Lee, Elizabeth K.; Spigel, David R. R.; Hojgaard, Martin; Lheureux, Stephanie; Mettu, Niharika B. B.; Carneiro, Benedito A. A.; Carter, Louise; Plummer, Ruth; Cote, Gregory M. M.; Meric-Bernstam, Funda; O'Connell, Joseph; Schonhoft, Joseph D. D.; Wainszelbaum, Marisa; Fretland, Adrian J. J.; Manley, Peter; Xu, Yi; Ulanet, Danielle; Rimkunas, Victoria; Zinda, Mike; Koehler, Maria; Silverman, Ian M. M.; Reis-Filho, Jorge S. S.; Rosen, Ezra
Safety and efficacy of three PARP inhibitors (PARPi) combined with the ataxia telangiectasia- and Rad3-related kinase inhibitor (ATRi) camonsertib in patients (pts) with solid tumors harboring DNA damage response (DDR) alterations
CANCER RESEARCH
IF16.6
2023-04-140
PRE
Yap, Timothy A.; Yadav, Siddhartha; Herzberg, Benjamin; Carneiro, Benedito A.; Fontana, Elisa; Hojgaard, Martin; Pishvaian, Michael J.; Plummer, Ruth; Werner, Theresa L.; Sahai, Vaibhav; Lheureux, Stephanie; Lee, Elizabeth K.; Mettu, Niharika B.; Cote, Gregory M.; Schonhoft, Joseph D.; Rimkunas, Victoria; Silverman, Ian M.; Wainszelbaum, Marisa; Peltz, Gerson; Fretland, Adrian J.; Fei, Kezhen; Ulanet, Danielle; Kim, Insil; Koehler, Maria; Rosen, Ezra; Cecchini, Michael
Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer
BRITISH JOURNAL OF CANCER
IF6.8
2022-04-1918
OA
Zhang, Bingnan; Stewart, C. Allison; Wang, Qi; Cardnell, Robert J.; Rocha, Pedro; Fujimoto, Junya; Soto, Luisa M. Solis; Wang, Runsheng; Novegil, Veronica; Ansell, Peter; He, Lei; Fernandez, Luisa; Jendrisak, Adam; Gilbertson, Cole; Schonhoft, Joseph D.; Byun, Jiyun; Jones, Joshua; Anderson, Amanda K. L.; Aparicio, Ana; Tran, Hai; Negrao, Marcelo, V; Zhang, Jianjun; Wang, Wei-lien; Wistuba, Ignacio I.; Wang, Jing; Wenstrup, Rick; Byers, Lauren A.; Gay, Carl M.

研究方向

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D
Danielle Ulanet
H 指数:14论文数:70被引数:1,609
I
Ian M. Silverman
H 指数:24论文数:116被引数:2,521
T
Timothy A. Yap
H 指数:77论文数:1,361被引数:2.6万
M
María Koehler
H 指数:34论文数:226被引数:1.1万
E
Ezra Y. Rosen
H 指数:18论文数:174被引数:3,178
J
Jerry Lee
H 指数:40论文数:182被引数:8,622
V
Victoria Rimkunas
H 指数:17论文数:177被引数:1,706
R
Ryan Dittamore
H 指数:29论文数:182被引数:4,130
R
Rick Wenstrup
H 指数:5论文数:59被引数:165
A
Adam Jendrisak
H 指数:14论文数:114被引数:1,613