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A phase 1 clinical trial of the farnesyltransferase inhibitor KO-2806 in combination with cabozantinib in renal cell carcinoma 肾细胞癌中法尼基转移酶抑制剂KO-2806联合卡博赞尼的I期临床试验 Ayanambakkam, Adanma; Rosen, Lee S.; Garmezy, Benjamin; Pelster, Meredith; Hanna, Glenn J.; Thomas, Jacob; Patel, Manish R.; Bendris, Nawal; Johnson, Paria Mahboub; Dale, Stephen; Saunders, Andrew; Kuan, J. C.; Balsara, Binaifer; Seraj, Jabed; Singer, Adam E. 分享 收藏
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Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies Ib期PRT543研究，PRT543是一种口服蛋白精氨酸甲基转移酶5（PRMT5）抑制剂，用于治疗具有高级别剪接因子突变骨髓性恶性肿瘤的患者 Bewersdorf, Jan Philipp; Mi, Xiaoli; Lu, Bin; Kuykendall, Andrew; Sallman, David; Patel, Manish; Stevens, Don; Philipovskiy, Alexander; Sutamtewagul, Grerk; Masarova, Lucia; Keiffer, Gina; Verma, Amit; Bhagwat, Neha; Wang, Min; Moore, Andrew; Rager, Joseph; Heiser, Diane; Ro, Sunhee; Hong, Wan-Jen; Abdel-Wahab, Omar; Stein, Eytan M. 分享 收藏
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Open-Label, Multicenter, Phase I Study to Assess Safety and Tolerability of Adavosertib Plus Durvalumab in Patients with Advanced Solid Tumors Patel, Manish R.; Falchook, Gerald S.; Wang, Judy S.; Imedio, Esteban Rodrigo; Kumar, Sanjeev; Miah, Kowser; Mugundu, Ganesh M.; Jones, Suzanne F.; Spigel, David R.; Hamilton, Erika P. 分享 收藏
Phase Ib Study of PRT543, an Oral Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, in Patients with Relapsed or Refractory, Splicing Factor-Mutant Myeloid Malignancies Ib期研究：PRT543（一种口服蛋白精氨酸甲基转移酶5 [PRMT5] 抑制剂）在复发或难治性、剪接因子突变性髓系恶性肿瘤患者中的应用 Bewersdorf, Jan Philipp; Mi, Xiaoli; Lu, Bin; Kuykendall, Andrew T.; Sallman, David; Patel, Manish; Stevens, Don A.; Philipovskiy, Alexander; Sutamtewagul, Grerk; Masarova, Lucia; Keiffer, Gina; Uerma, Amit; Bhagwat, Neha; Heiser, Diane; Ro, Sunhee; Hong, Wan-Jen; Abdel-Wahab, Omar; Stein, Eytan M. 分享 收藏
Pirtobrutinib monotherapy in Bruton tyrosine kinase inhibitor-intolerant patients with B-cell malignancies: results of the phase I/II BRUIN trial Shah, Nirav N.; Wang, Michael; Roeker, Lindsey E.; Patel, Krish; Woyach, Jennifer A.; Wierda, William G.; Ujjani, Chaitra S.; Eyre, Toby A.; Zinzani, Pier Luigi; Alencar, Alvaro J.; Ghia, Paolo; Lamanna, Nicole; Hoffmann, Marc S.; Patel, Manish R.; Flinn, Ian; Gerson, James N.; Ma, Shuo; Coombs, Catherine C.; Cheah, Chan Y.; Lech-Maranda, Ewa; Fakhri, Bita; Kim, Won Seog; Barve, Minal A.; Cohen, Jonathon B.; Jurczak, Wojciech; Munir, Talha; Thompson, Meghan C.; Tsai, Donald E.; Bao, Katherine; Cangemi, Nicholas A.; Kherani, Jennifer F.; Walgren, Richard A.; Han, Hongmei; Ruppert, Amy S.; Brown, Jennifer R. 分享 收藏
Clinical and biomarker data from a phase 1/2 trial of ifinatamab deruxtecan (I-DXd; DS-7300) in advanced solid tumors Doi, T.; Patel, M. R.; Koyama, T.; Falchook, G. S.; Friedman, C.; Piha-Paul, S. A.; Gutierrez, M.; Awad, M.; Mattour, A.; Satoh, T.; Takahashi, S.; Tsunoda, T.; Kadowaki, S.; Watanabe, Y.; Okamoto, N.; Goto, H.; Yoshizuka, N.; Qian, M.; Qian, X.; Johnson, M. 分享 收藏
Increased therapeutic index of muzastotug (ADG126), a masked anti-CTLA-4 antibody, in combination with pembrolizumab (pembro) enables significant clinical benefits and supports further clinical development in patients with metastatic MSS CRC 未修饰的抗-CTLA-4抗体muzastotug（ADG126）与pembrolizumab（pembro）联合应用，其治疗指数的增加可实现显著的临床获益，并支持其在转移性MSS结直肠癌患者中进一步的临床开发。 Li, D.; Kim, S. Y.; Kim, H. K.; Sharma, S.; Shin, S. J.; Lee, J.; Im, S-A.; She, X. K.; Li, Y.; Chung, L. E. C.; Xiao, P.; Liu, G.; Zeng, S.; HuLowe, D.; Chisamore, M.; Luo, P. P.; Zha, J.; Patel, M. R. 分享 收藏
T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study 在1期KEYNOTE-603研究中，单独或与Pembrolizumab联合使用个体化新抗原治疗mRNA-4157 (V940) 的T细胞反应 Gainor, Justin F.; Patel, Manish R.; Weber, Jeffrey S.; Gutierrez, Martin; Bauman, Julie E.; Clarke, Jeffrey M.; Julian, Ricklie; Scott, Aaron J.; Geiger, Jessica L.; Kirtane, Kedar; Robert-Tissot, Celine; Coder, Brandon; Tasneem, Moomal; Sun, Jing; Zheng, Wei; Gerbereux, Lauren; Laino, Andressa; Porichis, Filippos; Pollard, Jack Russella; Hou, Peijie; Sehgal, Vasudha; Chen, Xing; Morrissey, Manju; Daghestani, Hikmat N.; Feldman, Igor; Srinivasan, Lakshmi; Frederick, Joshua P.; Brown, Michelle; Aanur, Praveen; Meehan, Robert; Burris III, Howard A. 分享 收藏
Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors Chen, Jian Jenny; Vincent, Melanie Y.; Shepard, Dale; Peereboom, David; Mahalingam, Devalingam; Battiste, James; Patel, Manish R.; Juric, Dejan; Wen, Patrick Y.; Bullock, Andrea; Selfridge, Jennifer Eva; Pant, Shubham; Liu, Joyce; Li, Wendy; Fyfe, Susanne; Wang, Suming; Zota, Victor; Mahoney, James; Watnick, Randolph S.; Cieslewicz, Michael; Watnick, Jing 分享 收藏
A Phase I/IIa clinical trial (TranStar101) to evaluate the safety, tolerability and pharmacokinetics of OSEMITAMAB administered as monotherapy or in combination with nivolumab or standard of care in patients with locally advanced or metastatic solid tumors Janjigian, Yelena; Tolcher, Anthony; Mehta, Rutika; Cecchini, Michael; Van Tine, Brian; Kundranda, Madappa; Olatunji, Alese; Patel, Manish R.; Berlin, Jordan; Rocha-Lima, Caio Max Sao Pedro; Monga, Dulabh; Ben George; Scott, Aaron; Xia, Zhenzhong; Elsafy, Mohamed; Jones, Erikca; Yao, Zhenling; Qi, Chuan; Germa, Caroline; Gabrail, Nash 分享 收藏
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A Phase 1 trial evaluating AC699, an orally bioavailable chimeric estrogen receptor degrader, in patients with advanced or metastatic breast cancer Layman, Rachel M.; Patel, Manish R.; Cosgrove, David; Danso, Michael; Mota, Nancy; Zettler, Marjorie E.; Pehlivan, Katherine C.; Hamilton, Erika 分享 收藏
mRNA-4157 (V940) individualized neoantigen therapy (INT) plus pembrolizumab (pembro) in advanced unresectable HPV- head & neck carcinoma (HNSCC): Clinical & translational analysis Bauman, Julie E.; Julian, Ricklie A.; Geiger, Jessica L.; Mehnert, Janice M.; Clarke, Jeffrey M.; Patel, Manish R.; Gutierrez, Martin; Gainor, Justin F.; Srivats, Shyam; Zhang, Zhaojie; Rao, Anjali; Sehgal, Vasudha; Hou, Peijie; Morrissey, Manju; Feldman, Igor; Srinivasan, Lakshmi; Aanur, Praveen; Brown, Michelle; Meehan, Robert S. 分享 收藏
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