未登录 Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS 血浆细胞外囊泡tau和TDP-43作为FTD和ALS的诊断生物标志物 Chatterjee, Madhurima; Ozdemir, Selcuk; Fritz, Christian; Mobius, Wiebke; Kleineidam, Luca; Mandelkow, Eckhard; Biernat, Jacek; Dogdu, Cem; Peters, Oliver; Cosma, Nicoleta Carmen; Wang, Xiao; Schneider, Luisa-Sophia; Priller, Josef; Spruth, Eike; Kuhn, Andrea A.; Krause, Patricia; Klockgether, Thomas; Vogt, Ina R.; Kimmich, Okka; Spottke, Annika; Hoffmann, Daniel C.; Fliessbach, Klaus; Miklitz, Carolin; McCormick, Cornelia; Weydt, Patrick; Falkenburger, Bjorn; Brandt, Moritz; Guenther, Rene; Dinter, Elisabeth; Wiltfang, Jens; Hansen, Niels; Bahr, Mathias; Zerr, Inga; Floel, Agnes; Nestor, Peter J.; Duzel, Emrah; Glanz, Wenzel; Incesoy, Enise; Burger, Katharina; Janowitz, Daniel; Perneczky, Robert; Rauchmann, Boris S.; Hopfner, Franziska; Wagemann, Olivia; Levin, Johannes; Teipel, Stefan; Kilimann, Ingo; Goerss, Doreen; Prudlo, Johannes; Gasser, Thomas; Brockmann, Kathrin; Mengel, David; Zimmermann, Milan; Synofzik, Matthis; Wilke, Carlo; Selma-Gonzalez, Judit; Turon-Sans, Janina; Santos-Santos, Miguel Angel; Alcolea, Daniel; Rubio-Guerra, Sara; Fortea, Juan; Carbayo, Alvaro; Lleo, Alberto; Rojas-Garcia, Ricardo; Illan-Gala, Ignacio; Wagner, Michael; Frommann, Ingo; Roeske, Sandra; Bertram, Lucas; Heneka, Michael T.; Brosseron, Frederic; Ramirez, Alfredo; Schmid, Matthias; Beschorner, Rudi; Halle, Annett; Herms, Jochen; Neumann, Manuela; Barthelemy, Nicolas R.; Bateman, Randall J.; Rizzu, Patrizia; Heutink, Peter; Dols-Icardo, Oriol; Hoeglinger, Guenter; Hermann, Andreas; Schneider, Anja 分享 收藏
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ATM activity in T cells is critical for immune surveillance of lymphoma in vivo Riabinska, Arina; Lehrman, Daria; Jachimowicz, Ron Daniel; Knitter, Gero; Fritz, Christian; Schmitt, Anna; Geyer, Aenne; Heneweer, Carola; Wittersheim, Maike; Frenzel, Lukas P.; Torgovnick, Alessandro; Wiederstein, Janica Lea; Wunderlich, Claudia Maria; Ortmann, Monika; Paillard, Arlette; Woessmann, Wilhelm; Borkhardt, Arndt; Burdach, Stefan; Hansmann, Martin-Leo; Rosenwald, Andreas; Perner, Sven; Mall, Gita; Klapper, Wolfram; Merseburg, Andrea; Krueger, Marcus; Gruell, Holger; Persigehl, Thorsten; Wunderlich, Frank Thomas; Peifer, Martin; Utermoehlen, Olaf; Buettner, Reinhard; Beleggia, Filippo; Reinhardt, Hans Christian 分享 收藏
Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7 CDK7的选择性共价抑制剂SY-1365的发现和表征 Hu, Shanhu; Marineau, Jason J.; Rajagopal, Nisha; Hamman, Kristin B.; Choi, Yoon Jong; Schmidt, Darby R.; Ke, Nan; Johannessen, Liv; Bradley, Michael J.; Orlando, David A.; Alnemy, Sydney R.; Ren, Yixuan; Ciblat, Stephane; Winter, Dana K.; Kabro, Anzhelika; Sprott, Kevin T.; Hodgson, J. Graeme; Fritz, Christian C.; Carulli, John P.; di Tomaso, Emmanuelle; Olson, Eric R. 分享 收藏
SY-1365, a selective CDK7 inhibitor, exhibits potent antitumor activity against ovarian cancer models in vitro and in vivo Konstantinopoulos, Panagiotis A.; Hodgson, Graeme; Rajagopal, Nisha; Johannessen, Liv; Liu, Joyce F.; Kirschmeier, Paul T.; Zhou, Shan; Cam Anh Tran; Orlando, David; Fritz, Christian; di Tomaso, Emmanuelle; Matulonis, Ursula A. 分享 收藏
PK/PD modeling of the first in-class, potent and selective covalent CDK7 inhibitor, SY-1365, provides mechanistic basis for intermittent dosing regimens in preclinical efficacy models of hematologic and solid tumors Waters, Nigel J.; Hu, Shanhu; Matzuka, Brett; Hodgson, Graeme; Ren, Yixuan; Choi, Yoon; Dykstra, Kevin; Roberts, Christopher; Sprott, Kevin; di Tomaso, Emmanuelle; Fritz, Christian 分享 收藏
Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist McKeown, Michael R.; Corces, M. Ryan; Eaton, Matthew L.; Fiore, Chris; Lee, Emily; Lopez, Jeremy T.; Chen, Mei Wei; Smith, Darren; Chan, Steven M.; Koenig, Julie L.; Austgen, Kathryn; Guenther, Matthew G.; Orlando, David A.; Loven, Jakob; Fritz, Christian C.; Majeti, Ravindra 分享 收藏
Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia Knittel, Gero; Rehkaemper, Tim; Korovkina, Darya; Liedgens, Paul; Fritz, Christian; Torgovnick, Alessandro; Al-Baldawi, Yussor; Al-Maarri, Mona; Cun, Yupeng; Fedorchenko, Oleg; Riabinska, Arina; Beleggia, Filippo; Phuong-Hien Nguyen; Wunderlich, F. Thomas; Ortmann, Monika; Montesinos-Rongen, Manuel; Tausch, Eugen; Stilgenbauer, Stephan; Frenzel, Lukas P.; Herling, Marco; Herling, Carmen; Bahlo, Jasmin; Hallek, Michael; Peifer, Martin; Buettner, Reinhard; Persigehl, Thorsten; Reinhardt, H. Christian 分享 收藏
SY-1425, a selective RARa agonist, induces high levels of CD38 expression in RARA-high AML tumors creating a susceptibility to anti-CD38 therapeutic antibody treatment Austgen, Kathryn; McKeown, Michael R.; Smith, Darren; Lee, Emily; Fiore, Chris; Eaton, Matthew L.; Fritz, Christian; Lodie, Tracey; Olson, Eric 分享 收藏
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SY-1365, a potent and selective CDK7 inhibitor, exhibits promising anti-tumor activity in multiple preclinical models of aggressive solid tumors Hu, Shanhu; Ke, Nan; Ren, Yixuan; Miljovska, Sofija; Rajagopal, Nisha; McKeown, Michael; Orlando, David; Sprott, Kevin; Choi, Yoon J.; Olson, Eric; Fritz, Christian C. 分享 收藏
Targeting the transcriptional kinases CDK12 and CDK13 in breast and ovarian cancer Bradley, Michael; Marineau, Jason; Choi, Yoon; Hamman, Kristin; Malojcic, Goran; Orlando, David; Ren, Yixuan; Ke, Nan; Hu, Shanhu; Olson, Eric; Fritz, Christian; Roberts, Christopher 分享 收藏
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Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner Jokic, Mladen; Vlasic, Ignacija; Rinneburger, Miriam; Kluemper, Niklas; Spiro, Judith; Vogel, Wenzel; Offermann, Anne; Kuempers, Christiane; Fritz, Christian; Schmitt, Anna; Riabinska, Arina; Wittersheim, Maike; Michels, Sebastian; Ozretic, Luka; Florin, Alexandra; Welcker, Daniela; Akyuz, Mehmet Deniz; Nowak, Michael; Erkel, Martin; Wolf, Juergen; Buettner, Reinhard; Schumacher, Bjoern; Thomale, Juergen; Persigehl, Thorsten; Maintz, David; Perner, Sven; Reinhardt, Hans Christian 分享 收藏
Selective CDK7 inhibitors suppress super enhancer-genes, induce massive apoptosis in acute myeloid leukemia and demonstrate durable in vivo efficacy Hu, Shanhu; Ke, Nan; Ren, Yixuan; Lopez, Jeremy; Miljovska, Sofija; Orlando, David; Schmidt, Darby; Bradley, Michael; Sprott, Kevin; Olson, Eric; Fritz, Christian C.; Choi, Yoon Jong 分享 收藏
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