Adam Shlien - Publications, H-index & Citations

Adam Shlien

The Hospital for Sick Children

49H指数

481论文数

2.2W被引数

收录论文 93

发表时间

Extensive and differential platinum chemotherapy mutagenesis in livers of children 儿童肝脏中广泛且差异化的铂类化疗诱变作用

Science

IF45.8

2026-09-10

PREAI

Anna Wenger; Jean-Baptiste Vannier; Henry Lee-Six; Robin Loesch; Giulia Emanuelli; Manas Dave; Mehdi Layeghifard; Andrew R. J. Lawson; Federico Abascal; Pantelis A. Nicola; Taryn D. Treger; Toochi Ogbonnah; Conor Parks; Thomas R. W. Oliver; Jonathan Kennedy; Angus Hodder; Nathaniel D. Anderson; Felipe Luz Torres Silva; Mi K. Trinh; Thomas Dowe; Marwo Habarwaa; James J. Sun; Sergio Assia-Zamora; Miriam Cortes-Cerisuelo; Wayel Jassem; Charlotte Town; Anil Dhawan; Vandana Jain; Karin Straathof; Maesha Deheragoda; Iñigo Martincorena; Liina Palm; J. Ciaran Hutchinson; Tim H. H. Coorens; Claire Trayers; Mariia Yuneva; Nigel Heaton; Adam Shlien; Yoh Zen; Foad J. Rouhani; Sam Behjati

Prior therapy defines mutation profiles in childhood cancer at relapse 既往治疗定义了儿童癌症复发时的突变谱

Nature

IF48.5

2026-07-22

OAAI

Mehdi Layeghifard; Marcos Díaz-Gay; Erik N. Bergstrom; Mathepan J. Mahendralingam; Nicholas Light; Sasha Blay; Joshua O. Nash; Nathaniel D. Anderson; Jessica N. Au; Scott Davidson; Pedro L. Ballester; Timmy Wen; Syed Kashif Daud; Lisa-Monique Edward; S. M. Ashiqul Islam; Azhar Khandekar; Burçak Otlu; Ledia Brunga; Rawan Hammad; Shimaa Nassif; Nirav H. Thacker; Tara Feltham; Noemi A. Fuentes-Bolanos; Marie Wong-Erasmus; Max F. Levine; Katherine E. Miller; Neerav N. Shukla; Michael D. Kinnaman; Dominik Glodzik; Carol Portwine; Sabrina Millson; Alexandra P. Zorzi; Mariam Mikhail; Conrad V. Fernandez; Laura Wheaton; Gunes Gundem; Andrew L. Kung; Uri Tabori; Chelsea Mayoh; Elli Papaemmanuil; Mark J. Cowley; David Malkin; Anita Villani; Ludmil B. Alexandrov; Adam Shlien

Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma 错配修复缺陷型神经胶质瘤的高突变形状肿瘤发生和免疫治疗反应的模式

Nature Genetics

IF29

2025-12-22

PREAI

Nicholas R. Fernandez; Yuan Chang; Nuno M. Nunes; Jose R. Dimayacyac; Adrian Levine; Amit Ringel; Logine Negm; Ayse Bahar Ercan; Julian M. Hess; Olfat Ahmad; Caitlin Lee; Lucie Stengs; Vanessa Bianchi; Melissa Edwards; Sheradan Doherty; Jiil Chung; Liana Nobre; Julie Bennett; Andrew J. Dodgshun; David T. W. Jones; Stefan M. Pfister; Anita Villani; David Malkin; Vijay Ramaswamy; Annie Huang; Eric Bouffet; Melyssa Aronson; Peter B. Dirks; Adam Shlien; Gad Getz; Yosef E. Maruvka; Birgit Ertl-Wagner; Cynthia Hawkins; Anirban Das; Uri Tabori

Clinical utility of targeted RNA sequencing in cancer molecular diagnostics 靶向RNA测序在癌症分子诊断中的临床应用

Nature Medicine

IF50

2025-07-17

PREAI

Robert Siddaway; Aida I. Glembocki; Anthony Arnoldo; Jordan Staunton; Anthony P. Y. Liu; Kyoko E. Yuki; Man Yu; Sarah Cohen-Gogo; Adam Shlien; Anita Villani; James A. Whitlock; Johann Hitzler; Uri Tabori; Adrian B. Levine; Anthea Lafrenière; Anita Nagy; Haiying Chen; Bo-Yee Ngan; Gino R. Somers; Mohamed Abdelhaleem; Rose Chami; Cynthia Hawkins

Assessing the diagnostic impact of blood transcriptome profiling in a pediatric cohort previously assessed by genome sequencing 评估通过基因组测序预先评估的儿科队列中血液转录组谱的诊断影响

npj Genomic Medicine

IF4.8

2025-07-01

PREAI

Huayun Hou; Kyoko E. Yuki; Gregory Costain; Anna Szuto; Sierra Barnes; Arun K. Ramani; Alper Celik; Michael Braga; Meagan Gloven-Brown; Dimitri J. Stavropoulos; Sarah Bowdin; Ronald D. Cohn; Roberto Mendoza-Londono; Stephen W. Scherer; Michael Brudno; Christian R. Marshall; M. Stephen Meyn; Adam Shlien; James J. Dowling; Michael D. Wilson; Lianna Kyriakopoulou

DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition DNA损伤反应缺陷增强神经母细胞瘤进展和对PARP及ATR抑制剂的联合敏感性

CELL REPORTS

IF6.9

2025-04-01

OAAI

Hayes, Madeline N.; Cohen-Gogo, Sarah; Kee, Lynn; Xiong, Xueting; Weiss, Alex; Layeghifard, Mehdi; Ladumor, Yagnesh; Valencia-Sama, Ivette; Rajaselvam, Anisha; Kaplan, David R.; Villani, Anita; Shlien, Adam; Morgenstern, Daniel A.; Irwin, Meredith S.

Inter-chromosomal contacts demarcate genome topology along a spatial gradient

NATURE COMMUNICATIONS

IF15.7

2024-11-13

OAAI

Mokhtaridoost, Milad; Chalmers, Jordan J.; Soleimanpoor, Marzieh; McMurray, Brandon J.; Lato, Daniella F.; Nguyen, Son C.; Musienko, Viktoria; Nash, Joshua O.; Espeso-Gil, Sergio; Ahmed, Sameen; Delfosse, Kate; Browning, Jared W. L.; Barutcu, A. Rasim; Wilson, Michael D.; Liehr, Thomas; Shlien, Adam; Aref, Samin; Joyce, Eric F.; Weise, Anja; Maass, Philipp G.

Expansion of GATA1-Mutant Clones in Blood Samples of Patients with Transient Abnormal Myelopoiesis (TAM) during Clinical Follow up Heralds Transformation to Myeloid Leukemia Associated with Down Syndrome (ML-DS)GATA1突变克隆在暂时性异常髓系增生（TAM）患者血液样本中的扩增，预示着向Down综合征相关髓系白血病（ML-DS）的转化。

BLOOD

IF23.1

2024-11-05

PREAI

Chen, Jian; Ripsman, Ryan; Vernier, Rose; Schwertschkow, Astra; Shlien, Adam; Hitzler, Johann K.

Characterization of circulating tumor DNA in a pediatric oncology cohort and implementation into the SickKids Cancer Sequencing (KiCS) precision oncology program

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Cohen-Gogo, Sarah; Choi, Taegi; Ripsman, Ryan; Hudson, Matt; Fong, Sandy; Khan, Reem; Venier, Rosemarie E.; Charlinski, Tristan; Villani, Anita; Malkin, David; Shlien, Adam

Chemotherapy is a major mutagen in relapsed childhood cancer

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Layeghifard, Mehdi; Light, Nicholas; Bergstrom, Erik; Gay, Marcos Diaz; Mahendralingam, Mathepan J.; Blay, Sasha; Davidson, Scott; Ballester, Pedro L.; Hammad, Rawan; Bolanos, Noemi Fuentes; Nassif, Shimaa; Thacker, Nirav H.; Mayoh, Chelsea; Malkin, David; Papaemmanuil, Elli; Cowley, Mark J.; Villani, Anita; Alexandrov, Ludmil B.; Shlien, Adam

Transcriptome-based assessment of immune infiltration for molecular selection of pediatric patients with solid tumors for combination immune checkpoint inhibitor therapy

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Shen, Yaoqing; Mayoh, Chelsea; Nabbi, Arash; Santiago, Raoul; Bianco, Stephanie; Bancarz, Iain R.; Williamson, Laura; Corbett, Richard; Krekhno, Zakhar; Davidson, Scott; Fortuna, Alexander; Yuki, Kyoko E.; Connolly, Denise; Morgenstern, Daniel; Ekert, Paul G.; Shlien, Adam; Jones, Steven J. M.; Deyell, Rebecca J.; Cohen-Gogo, Sarah

A transcriptional atlas provides a universal diagnostic platform for mesenchymal tumors and validation of preclinical models

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Nash, Joshua O.; Ballestar, Pedro L.; Davidson, Scott; Schwertschkow, Astra; Babichev, Yael; Lees, Jodi; Alon, Noa; Gokgoz, Nalan; Yu, Stephen M.; Yuki, Kyoko; Lorenti, Miranda; Liu, Zhanqin; McGoey, Alaina; Spatare, Famida; Castro, Bernard; Tsoi, Kim; Peretz-Soroka, Hagit; Brzezinski, Jack; Villani, Anita; Razaq, Albiruni; Gupta, Abha; Demicco, Elizabeth; Przybyl, Joanna; van de Rijn, Matt; Garzia, Livia; Wunder, Jay; Andrulis, Irene L.; Malkin, David; Chami, Rose; Dickson, Brendan C.; Gladdy, Rebecca A.; Shlien, Adam

Infant ALL without KMT2A rearrangements harbor clinically relevant alterations and share common origins with childhood ALL

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Zatzman, Matthew; Seelisch, Jennifer; Comitani, Federico; Fuligni, Fabio; Davidson, Scott; Yuki, Kyoko E.; Edwards, Lisa-Monique; Brunga, Ledia; Guest, Erin; Hunger, Stephen P.; Loh, Mignon L.; Raetz, Elizabeth A.; Chen, John; Bartram, Jack; Hitzler, Johann K.; Brown, Patrick A.; Gupta, Sumit; Shlien, Adam

Timing the development of chemoresistance in relapsed pediatric cancer with mutational signatures

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Blay, Sasha; Layeghifard, Mehdi; Davidson, Scott; Chen, David; Schwertschkow, Astra; Ramaswamy, Vijay; Taylor, Michael; Papaemmanuil, Elli; Villani, Anita; Malkin, David; Alexandrov, Ludmil; Cowley, Mark; Shlien, Adam

DNA damage response deficiency enhances neuroblastoma progression and sensitivity to combination PARP and ATR inhibition

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Hayes, Madeline N.; Cohen-Gogo, Sarah; Kee, Lynn; Layeghifard, Mehdi; Valencia-Sama, Ivette; Rajaselvam, Anisha; Kaplan, David; Villani, Anita; Shlien, Adam; Morgenstern, Daniel A.; Irwin, Meredith S.

LIBERTY: LIquid Biopsy for rElapsed/RefracTorY neuroblastoma - a pilot study of characterization of circulating tumor DNA alterations in patients with relapsed and refractory neuroblastoma using a clinically validated liquid biopsy platform

CANCER RESEARCH

IF16.6

2024-09-05

PREAI

Cohen-Gogo, Sarah; Revon-Riviere, Gabriel; Jegathisawaran, Jathishinie; Shlien, Adam; Villani, Anita; Irwin, Meredith; Morgenstern, Daniel A.

Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns 来自种系TP53突变携带者的无细胞DNA反映了癌症样片段化模式

NATURE COMMUNICATIONS

IF15.7

2024-08-27

OAAI

Wong, Derek; Tageldein, Maha; Luo, Ping; Ensminger, Erik; Bruce, Jeffrey; Oldfield, Leslie; Gong, Haifan; Fischer, Nicholas William; Laverty, Brianne; Subasri, Vallijah; Davidson, Scott; Khan, Reem; Villani, Anita; Shlien, Adam; Kim, Raymond H.; Malkin, David; Pugh, Trevor J.

A systematic assessment of the impact of rare canonical splice site variants on splicing using functional and in silico methods

HUMAN GENETICS AND GENOMICS ADVANCES

IF3.6

2024-07-01

OAAI

Oh, Rachel Y.; Almail, Ali; Cheerie, David; Guirguis, George; Hou, Huayun; Yuki, Kyoko E.; Haque, Bushra; Thiruvahindrapuram, Bhooma; Marshall, Christian R.; Mendoza-Londono, Roberto; Shlien, Adam; Kyriakopoulou, Lianna G.; Walker, Susan; Dowling, James J.; Wilson, Michael D.; Costain, Gregory

miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage

PLOS GENETICS

IF3.7

2024-05-28

OAAI

Prykhozhij, Sergey V.; Ban, Kevin; Brown, Zane L.; Kobar, Kim; Wajnberg, Gabriel; Fuller, Charlotte; Chacko, Simi; Lacroix, Jacynthe; Crapoulet, Nicolas; Midgen, Craig; Shlien, Adam; Malkin, David; Berman, Jason N.

The Virtual Child 虚拟的孩子

CANCER DISCOVERY

IF33.3

2024-04-04

OAAI

Gilbertson, Richard J.; Behjati, Sam; Boettcher, Anna-Lisa; Bronner, Marianne E.; Burridge, Matthew; Clausing, Henrick; Clifford, Harry; Danaher, Tracey; Donovan, Laura K.; Drost, Jarno; Eggermont, Alexander M. M.; Emerson, Chris; Flores, Mona G.; Hamerlik, Petra; Jabado, Nada; Jones, Andrew; Kaessmann, Henrick; Kleinman, Claudia L.; Kool, Marcel; Kutscher, Lena M.; Lindberg, Gavin; Linnane, Emily; Marioni, John C.; Maris, John M.; Monje, Michelle; Macaskill, Alexandra; Niederer, Steven; Northcott, Paul A.; Peeters, Elizabeth; Plieger-van Solkema, Willemijn; Preussner, Liane; Rios, Anne C.; Rippe, Karsten; Sandford, Peter; Sgourakis, Nikolaos G.; Shlien, Adam; Smith, Pete; Straathof, Karin; Sullivan, Patrick J.; Suva, Mario L.; Taylor, Michael D.; Thompson, Emma; Vento-Tormo, Roser; Wainwright, Brandon J.; Wechsler-Reya, Robert J.; Westermann, Frank; Winslade, Shannon; Al-Lazikani, Bissan; Pfister, Stefan M.

研究方向