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H

Hayk Davtyan

University of California Irvine
H指数:32
被引数:5,044

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Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice

人源iPSC来源的小胶质细胞移植可改善粒细胞缺乏小鼠的神经病理学和回路功能障碍

Molecular Neurodegeneration
IF17.5
2026-07-160
OA
Hayk Davtyan; Sarah Naguib; Yuliya Voskobiynyk; Jean Paul Chadarevian; Joia K. Capocchi; Jeannie L. Giacchino; Ghazaleh Eskandari-Sedighi; Vivianna DeNittis; Jeremy B. Ford; Ani Agababian; Jasmine Nguyen; Alina L. Chadarevian; Madison S. Sutherland; Sepideh Kiani Shabestari; Kayla Tran; Bret Holt; Alissa L. Nana; Jiasheng Zhang; Salvatore Spina; Man Ying Wong; Lea T. Grinberg; William W. Seeley; Eric Huang; Claire D. Clelland; Shiaoching Gong; Li Fan; Jeanne T. Paz; Mathew Blurton-Jones; Li Gan
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease

PILRA的缺失促进小胶质细胞免疫代谢，以减少阿尔茨海默病细胞和动物模型中的淀粉样蛋白病理。

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2025-12-030
PRE
Weerakkody, Tanya N.; Sabelstrom, Hanna; Andrews, Shan V.; Chadarevian, Jean Paul; Chin, Marcus Y.; Tatarakis, David; Propson, Nicholas E.; Kim, Do Jin; Theolis, Richard; Parico, Gian Carlo G.; Misker, Hiwot; Kung, Jennifer E.; Bandyopadhyay, Abira; Robles Colmenares, Yaneth; Jackson, Taggra-Nicole; Qerqez, Ahlam N.; Balasundar, Srijana; Davis, Sonnet S.; Ha, Connie; Ghosh, Rajarshi; Ravi, Ritesh; Rana, Anil; Germain, Kyla; Tao, Arnold; Xiong, Ken; Braun, Dylan; Raju, Karthik; Huang, Kang-Chieh; Zhan, Lihong; Guo, Jing L.; Safari Yazd, Hoda; Sarrafha, Lily; Capocchi, Joia Kai; Hasselmann, Jonathan; Chadarevian, Alina L.; Tu, Christina; Mansour, Kimiya; Eskandari-Sedighi, Ghazaleh; Tesi, Niccolo; Van Der Lee, Sven; Hulsman, Marc; Oshegov, Georgii; Pijnenburg, Yolande; Calvert, Meredith; Holstege, Henne; Suh, Jung H.; Di Paolo, Gilbert; Davtyan, Hayk; Lewcock, Joseph W.; Blurton-Jones, Mathew; Monroe, Kathryn M.
Human microglia differentially respond to β-amyloid, tau, and combined Alzheimer's disease pathologies in vivo

人源小胶质细胞在体内对β-淀粉样蛋白、tau蛋白以及联合阿尔茨海默病病理的不同反应

ALZHEIMERS & DEMENTIA
IF11.1
2025-11-210
OAAI
Coburn, Morgan A.; Eskandari-sedighi, Ghazaleh; Hasselmann, Jonathan; England, Whitney; Shabestari, Sepideh Kiani; Mansour, Kimiya; McQuade, Amanda; Mgerian, Michael Armen; Chadarevian, Jean Paul; Tu, Christina; Silva, Jorge; Beck, Jaclyn; Keulen, Zahara; Spitale, Robert C.; Davtyan, Hayk; Blurton-jones, Mathew
CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies

CSF1R抑制剂抗性模型用于全中枢神经系统小胶质细胞替换策略

Molecular Therapy
IF12
2025-11-120
OAAI
Jean Paul Chadarevian; Jasmine Nguyen; Lauren Le; L. Angel Ayala; Alina L. Chadarevian; Cuiwen Zhou; Adrian Escobar; Abby T. Do; Ekaterina Deynega; Kimiya Mansour; Jonathan Hasselmann; Ghazaleh Eskandari-Sedighi; Sonia I. Lombroso; F. Chris Bennett; Matthew A. Inlay; Hayk Davtyan; Mathew Blurton-Jones
RETRACTION: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies

撤稿：基于MultiTEP的针对人α-突触核蛋白的DNA疫苗的疗效和免疫原性：用于支持IND的启始研究

NPJ VACCINES
IF6.5
2025-03-120
OA
Kim, Changyoun; Hovakimyan, Armine; Zagorski, Karen; Antonyan, Tatevik; Petrushina, Irina; Davtyan, Hayk; Chailyan, Gor; Hasselmann, Jonathan; Iba, Michiyo; Adame, Anthony; Rockenstein, Edward; Szabo, Marcell; Blurton-Jones, Mathew; Cribbs, David H.; Ghochikyan, Anahit; Masliah, Eliezer; Agadjanyan, Michael G.
Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism
NEURON
IF15
2024-09-011
OAAI
Profaci, Caterina P.; Harvey, Sean S.; Bajc, Kaja; Zhang, Tony Z.; Jeffrey, Danielle A.; Zhang, Alexander Z.; Nemec, Kelsey M.; Davtyan, Hayk; O'Brien, Carleigh A.; Mckinsey, Gabriel L.; Longworth, Aaron; Mcmullen, Timothy P.; Capocchi, Joia K.; Gonzalez, Jessica G.; Lawson, Devon A.; Arnold, Thomas D.; Davalos, Dimitrios; Blurton-Jones, Mathew; Dabertrand, Fabrice; Bennett, F. Chris; Daneman, Richard
Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease

性别依赖的APOE4中性粒细胞-小胶质细胞相互作用驱动阿尔茨海默病的认知障碍

NATURE MEDICINE
IF50
2024-07-035
PRE
Rosenzweig, Neta; Kleemann, Kilian L.; Rust, Thomas; Carpenter, Madison; Grucci, Madeline; Aronchik, Michael; Brouwer, Nieske; Valenbreder, Isabel; Cooper-Hohn, Joya; Iyer, Malvika; Krishnan, Rajesh K.; Sivanathan, Kisha N.; Brandao, Wesley; Yahya, Taha; Durao, Ana; Yin, Zhuoran; Chadarevian, Jean Paul; Properzi, Michael J.; Nowarski, Roni; Davtyan, Hayk; Weiner, Howard L.; Blurton-Jones, Mathew; Yang, Hyun-Sik; Eggen, Bart J. L.; Sperling, Reisa A.; Butovsky, Oleg
Age related neuropathology in a novel mouse model of Adult‐onset leukoencephalopathy

成年发病性白质脑病新型小鼠模型中的年龄相关神经病理学

Alzheimers & Dementia
IF11.1
2023-12-250
PRE
Sepideh Kiani Shabestari; Hamsi Radhakrishnan; Winston Chang Rothermich; Joia Kai Capocchi; Amandine Jullienne; Jasmine Nguyen; Kayla Nhi Tran; Jesse R. Pascual; Alessandra Cadete Martini; Elizabeth Head; David A Hume; Clare Pridans; Andre Obenaus; Craig E.L. Stark; Hayk Davtyan; Mathew Blurton‐Jones
Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3

在hiPSC衍生的额颞叶痴呆小胶质细胞模型中，小胶质细胞代谢和炎症特征的改变有助于神经毒性3

BRAIN BEHAVIOR AND IMMUNITY
IF7.6
2023-10-012
OAAI
Haukedal, Henriette; Lorenzen, Signe Syshoj; Westi, Emil Winther; Corsi, Giulia I.; Gadekar, Veerendra P.; McQuade, Amanda; Davtyan, Hayk; Doncheva, Nadezhda T.; Schmid, Benjamin; Chandrasekaran, Abinaya; Seemann, Stefan E.; Cirera, Susanna; Blurton-Jones, Mathew; Meyer, Morten; Gorodkin, Jan; Aldana, Blanca I.; Freude, Kristine
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease (vol 11, 5370, 2020)
NATURE COMMUNICATIONS
IF15.7
2023-03-021
OAAI
McQuade, Amanda; Kang, You Jung; Hasselmann, Jonathan; Jairaman, Amit; Sotelo, Alexandra; Coburn, Morgan; Shabestari, Sepideh Kiani; Chadarevian, Jean Paul; Fote, Gianna; Tu, Christina H.; Danhash, Emma; Silva, Jorge; Martinez, Eric; Cotman, Carl; Prieto, G. Aleph; Thompson, Leslie M.; Steffan, Joan S.; Smith, Ian; Davtyan, Hayk; Cahalan, Michael; Cho, Hansang; Blurton-Jones, Mathew
Engineering an inhibitor-resistant human CSF1R variant for microglia replacement
JOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
2022-12-3030
OAAI
Chadarevian, Jean Paul; Lombroso, Sonia I.; Peet, Graham C.; Hasselmann, Jonathan; Tu, Christina; Marzan, Dave E.; Capocchi, Joia; Purnell, Freddy S.; Nemec, Kelsey M.; Lahian, Alina; Escobar, Adrian; England, Whitney; Chaluvadi, Sai; O'Brien, Carleigh A.; Yaqoob, Fazeela; Aisenberg, William H.; Porras-Paniagua, Matias; Bennett, Mariko L.; Davtyan, Hayk; Spitale, Robert C.; Blurton-Jones, Mathew; Bennett, F. Chris
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice
CELL REPORTS
IF6.9
2022-06-0171
OAAI
Shabestari, Sepideh Kiani; Morabito, Samuel; Danhash, Emma Pascal; McQuade, Amanda; Sanchez, Jessica Ramirez; Miyoshi, Emily; Chadarevian, Jean Paul; Claes, Christel; Coburn, Morgan Alexandra; Hasselmann, Jonathan; Hidalgo, Jorge; Tran, Kayla Nhi; Martini, Alessandra C.; Rothermich, Winston Chang; Pascual, Jesse; Head, Elizabeth; Hume, David A.; Pridans, Clare; Davtyan, Hayk; Swarup, Vivek; Blurton-Jones, Mathew

研究方向

暂未获取到该数据
M
Mathew Blurton‐Jones
H 指数:56论文数:203被引数:1.6万
A
Anahit Ghochikyan
H 指数:30论文数:87被引数:2,157
M
Michael G. Agadjanyan
H 指数:39论文数:118被引数:5,687
I
Irina Petrushina
H 指数:24论文数:112被引数:1,768
D
David H. Cribbs
H 指数:64论文数:255被引数:2.2万
A
Armine Hovakimyan
H 指数:14论文数:46被引数:615
J
Jean Paul Chadarevian
H 指数:14论文数:40被引数:1,337
J
Jonathan Hasselmann
H 指数:17论文数:51被引数:2,371
K
Karen Zagorski
H 指数:14论文数:38被引数:611
S
Sepideh Kiani Shabestari
H 指数:14论文数:36被引数:1,600