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H

Holger Heyn

centro nacional de analisis genomico

68H指数
303论文数
2.1W被引数
收录论文 107
发表时间
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p38α orchestrates BRAFV600E-melanoma progression and immunotherapy response via tumor fitness and immune microenvironment modulationp38α通过调节肿瘤适应性及免疫微环境调控BRAFV600E-黑色素瘤的进展和免疫治疗反应
errNature Communications
IF15.7
err2026-09-22
err0
errOAAI
errPaula Granado-Martínez; Kimberley McGrail; Roberto Orsenigo; Ginevra Caratù; Paula Nieto; Yuxin Ding; Ángel Nebreda; Juan Martín-Caballero; Iván Ortega; Herena Eixarch; Carmen Espejo; Adrià Molero-Valenzuela; Javier Hernandez-Losa; Berta Ferrer; Holger Heyn; Eva Muñoz-Couselo; Vicenç García-Patos; Juan A. Recio
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Publisher Correction: Interpretable inflammation landscape of circulating immune cells出版商更正: 循环免疫细胞的可解释炎症景观
errNature Medicine
IF50
err2026-01-26
err0
errOAAI
errLaura Jiménez-Gracia; Davide Maspero; Sergio Aguilar-Fernández; Francesco Craighero; Maria Boulougouri; Max Ruiz; Domenica Marchese; Ginevra Caratù; Jose Liñares-Blanco; Miren Berasategi; Ricardo O. Ramirez Flores; Angela Sanzo-Machuca; Ana M. Corraliza; Hoang A. Tran; Rachelly Normand; Jacquelyn Nestor; Yourae Hong; Tessa Kole; Petra van der Velde; Frederique Alleblas; Flaminia Pedretti; Adrià Aterido; Martin Banchero; German Soriano; Eva Román; Maarten van den Berge; Azucena Salas; Jose Manuel Carrascosa; Antonio Fernández Nebro; Eugeni Domènech; Juan D. Cañete; Jesús Tornero; Javier P. Gisbert; Ernest Choy; Giampiero Girolomoni; Britta Siegmund; Antonio Julià; Violeta Serra; Roberto Elosua; Sabine Tejpar; Silvia Vidal; Martijn C. Nawijn; Ivo Gut; Julio Saez-Rodriguez; Sara Marsal; Alexandra-Chloé Villani; Juan C. Nieto; Holger Heyn
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Interpretable inflammation landscape of circulating immune cells循环免疫细胞的可解释性炎症景观
errNature Medicine
IF50
err2026-01-12
err0
errOAAI
errLaura Jiménez-Gracia; Davide Maspero; Sergio Aguilar-Fernández; Francesco Craighero; Maria Boulougouri; Max Ruiz; Domenica Marchese; Ginevra Caratù; Jose Liñares-Blanco; Miren Berasategi; Ricardo O. Ramirez Flores; Angela Sanzo-Machuca; Ana M. Corraliza; Hoang A. Tran; Rachelly Normand; Jacquelyn Nestor; Yourae Hong; Tessa Kole; Petra van der Velde; Frederique Alleblas; Flaminia Pedretti; Adrià Aterido; Martin Banchero; German Soriano; Eva Román; Maarten van den Berge; Azucena Salas; Jose Manuel Carrascosa; Antonio Fernández Nebro; Eugeni Domènech; Juan Cañete; Jesús Tornero; Javier P. Gisbert; Ernest Choy; Giampiero Girolomoni; Britta Siegmund; Antonio Julià; Violeta Serra; Roberto Elosua; Sabine Tejpar; Silvia Vidal; Martijn C. Nawijn; Ivo Gut; Julio Saez-Rodriguez; Sara Marsal; Alexandra-Chloé Villani; Juan C. Nieto; Holger Heyn
err分享
err收藏
Architecture of the neutrophil compartment中性粒细胞分区的架构
errNature
IF48.5
err2025-12-03
err0
errOAAI
errDaniela Cerezo-Wallis; Andrea Rubio-Ponce; Mathis Richter; Emanuele Pitino; Immanuel Kwok; Giovanni Marteletto; Ana Cristina Guanolema-Coba; Changming Shih; Run-Kai Huang; Ana Moraga; Natalia Borbaran Bravo; Samuel Doré; Sergio Callejas; David G. Aragonés; Daniel Jiménez-Carretero; Daniel Martin; Samuel Ovadia; Tommaso Vicanolo; Georgiana Crainiciuc; Jon Sicilia; Tong Deng; Anjelica Martin; Jing Zhang; Maria Isabel Cuartero; Diego Moncada Giraldo; Alicia Garcia-Culebras; Alejandra Aroca-Crevillen; Sandra Martín-Salamanca; Carlos Torroja; Max Ruiz; Irene Ruano; Melissa S. F. Ng; Jian Hou; You Wang; Ming Zhang; Jun Pu; Ana Herruzo; David Chang van Oordt; Seokyoon Chang; Alexander E. Downie; Fei Chen; Andrea L. Graham; William C. Gause; Pierre O. Fiset; Jonathan D. Spicer; Holger Heyn; Maria A. Zuriaga; Juan A. Bernal; Irina A. Udalova; Maria A. Moro; Katrien de Bock; Ana Dopazo; Jose J. Fuster; Fátima Sánchez-Cabo; Juan C. Nieto; Gabriel F. Calvo; Julia Skokowa; Oliver Soehnlein; Daniela F. Quail; Logan A. Walsh; Lai Guan Ng; Andrés Hidalgo; Iván Ballesteros
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Role of CEBPa in trophectoderm competence installmentCEBPa在滋养外胚层分化能力建立中的作用
errScience Advances
IF12.5
err2025-11-28
err0
PREAI
errXiao Wei; Irepan Salvador-Martinez; Maciej Meglicki; Marcos Plana-Carmona; Antonios Klonizakis; Barbara Pernaute; Manuel Irimia; Gregoire Stik; Mina Popovic; Guillem Torcal Garcia; Holger Heyn; Magdalena Zernicka-Goetz; Thomas Graf
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err收藏
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophagesTGF-β通过抑制T细胞募集并指导免疫抑制性SPP1+巨噬细胞，在结直肠癌中构建双重免疫屏障。
errNature Genetics
IF29
err2025-11-07
err0
PREAI
errAna Henriques; Maria Salvany-Celades; Paula Nieto; Sergio Palomo-Ponce; Marta Sevillano; Xavier Hernando-Momblona; Emily Middendorp-Guerra; Montserrat Llanses Martinez; Elisabeth Marjolein Haak; Juan Nieto; Ginevra Caratú; Domenica Marchese; Max Ruiz Gil; Sebastien Tosi; Theresa Suckert; Jordi Badia-Ramentol; Adrià Caballé-Mestres; Carolina Sanchez-Zarzalejo; Lidia Mateo; Daniele V. F. Tauriello; Antoni Riera; Elena Sancho; Camille Stephan-Otto Attolini; Alejandro Prados; Holger Heyn; Eduard Batlle
err分享
err收藏
Uncovering combination therapies for Immune-Mediated Inflammatory Diseases through systems biology analysis on longitudinal patient data
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errJuli, Antonio; Lasanta, Maria Lopez; Choy, Ernest; Vela-Casasempere, Paloma; Castaneda, Santos; Fernandez Nebro, Antonio; Calvo-Alen, Jaime; Marras, Carlos; Tornero, Jesus; Canete, Juan D.; Domenech, Eugeni; Gisbert, Javier; Carrascosa, Jose Manuel; Fonseca, Eduardo; Bujanda, Luis; Garcia, Valle; Siegmund, Britta; Girolomoni, Giampiero; Heyn, Holger; Santamaria, Pere; Myers, Richard; Guillen, Yolanda; Martinez-Mateu, Sergio H.; Marsal, Sara
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A IMMUNOMODULATORY EFFECTS OF PREOPERATIVE STEREOTACTIC RADIOSURGERY IN BRAIN METASTASES: PROSPECTIVE INTEGRATION OF TISSUE AND CEREBROSPINAL FLUID PROFILING术前立体定向放射外科对脑转移瘤的免疫调节作用：组织和脑脊液谱分析的预期整合
errNEURO-ONCOLOGY
IF13.4
err2025-10-01
err0
errOAAI
errSteinhauser, E.; Klinsing, S.; Borkus, I; Schaeffer, A.; Nieto, P.; Vogt, I; Diehl, B.; Broggini, T.; Czabanka, M.; Plate, K.; Harter, P.; Wolff, R.; Wenger-Alakmeh, K.; Reiss, Y.; Imkeller, K.; Luger, A.; Heyn, H.; Medyouf, H.; Nieto, J. C.; Weber, K. J.; Steinbach, J.; Zeiner, P. S.
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HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetesHNF1A和A1CF协调一个在2型糖尿病中失调的β细胞转录-剪接轴。
errCell Metabolism
IF30.9
err2025-08-06
err0
errOAAI
errEdgar Bernardo; Matías Gonzalo De Vas; Diego Balboa; Mirabai Cuenca-Ardura; Sílvia Bonàs-Guarch; Mercè Planas-Fèlix; Fanny Mollandin; Miquel Torrens-Dinarès; Miguel Angel Maestro; Javier García-Hurtado; Sonia Moratinos; Philippe Ravassard; Haiqiang Dou; Holger Heyn; Alexander van Oudenaarden; Nathalie Groen; Eelco de Koning; Christian Conrad; Roland Eils; Santiago Vernia; Patrik Rorsman; Jorge Ferrer
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Single-cell RNA-sequencing as a potential approach for studying intratumor heterogeneity in pleural mesothelioma单细胞RNA测序作为研究胸膜间皮瘤肿瘤内异质性的潜在方法
errLung Cancer
IF4.4
err2025-08-05
err0
PREAI
errAnia Alay; Raúl Marín; Elisabet Aliagas; Mireia Gausachs; Max Ruiz-Gil; Ivan Macia; Amaia Ojanguren; Susana Padrones; Eduard Dorca; Jesús Brenes; Ramón Palmero; Víctor Moreno; Holger Heyn; David Cordero; Ernest Nadal; Xavier Solé
err分享
err收藏
STAMP: Single-cell transcriptomics analysis and multimodal profiling through imagingSTAMP：单细胞转录组学分析与成像多模态分析
errCell
IF42.5
err2025-06-17
err0
errOAAI
errEmanuele Pitino; Anna Pascual-Reguant; Felipe Segato-Dezem; Kellie Wise; Irepan Salvador-Martinez; Helena Lucia Crowell; Maycon Marção; Max Ruiz; Elise Courtois; William F. Flynn; Santhosh Sivajothi; Emily Soja; Ginevra Caratù; German Atzin Mora-Roldan; B. Kate Dredge; Yutian Liu; Hannah Chasteen; Monika Mohenska; Juan C. Nieto; Raymond K.H. Yip; Ruvimbo D. Mishi; José M. Polo; Mohmed Abdalfttah; Adrienne E. Sullivan; Jasmine T. Plummer; Holger Heyn; Luciano G. Martelotto
err分享
err收藏
Spatiotemporal T-cell tracking for personalized T-cell receptor T-cell therapy designs in childhood cancer时空T细胞追踪在儿童癌症个性化T细胞受体T细胞疗法设计中的应用
errAnnals of Oncology
IF65.4
err2025-05-20
err0
errOAAI
errI. Sentís; J.L. Melero; A. Cebria-Xart; M. Grzelak; M. Soto; A. Michel; Q. Rovira; C.J. Rodriguez-Hernandez; G. Caratù; A. Urpi; C. Sauvage; A. Mendizabal-Sasieta; D. Maspero; C.E. Lavarino; A. Pascual-Reguant; A. Castañeda Heredia; J.P. Muñoz Perez; J. Mora; A. Harari; J.C. Nieto; A. Avgustinova; H. Heyn
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err收藏
Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes新生期紫外线辐射或Lkb1缺失触发的转录重编程，可阻止BRAFV600E诱导的黑素细胞生长停滞。
errONCOGENE
IF7.3
err2025-03-08
err0
errOAAI
errMcgrail, Kimberley; Granado-Martinez, Paula; Orsenigo, Roberto; Caratu, Ginevra; Nieto, Paula; Heyn, Holger; Ferrer, Berta; Hernandez-Losa, Javier; Munoz-Couselo, Eva; Garcia-Patos, Vicenc; Recio, Juan A.
err分享
err收藏
Linking tumor immune infiltration to enhanced longevity in recurrence-free breast cancer
errESMO OPEN
IF8.3
err2025-01-01
err0
errOAAI
errAngelats, L.; Pare, L.; Rubio-Perez, C.; Sanfeliu, E.; Gonzalez, A.; Segui, E.; Villacampa, G.; Marin-Aguilera, M.; Pernas, S.; Conte, B.; Albarran-Fernandez, V.; Martinez-Saez, O.; Aguirre, A.; Galvan, P.; Fernandez-Martinez, A.; Cobo, S.; Rey, M.; Martinez-Romero, A.; Walbaum, B.; Schettini, F.; Vidal, M.; Buckingham, W.; Munoz, M.; Adamo, B.; Agrawal, Y.; Guedan, S.; Pascual, T.; Agudo, J.; Grzelak, M.; Borcherding, N.; Heyn, H.; Vivancos, A.; Parker, J. S.; Villagrasa, P.; Perou, C. M.; Prat, A.; Braso-Maristany, F.
err分享
err收藏
Adaptation in human immune cells residing in tissues at the frontline of infections
errNATURE COMMUNICATIONS
IF15.7
err2024-11-28
err0
errOAAI
errSalvador-Martinez, Irepan; Murga-Moreno, Jesus; Nieto, Juan C.; Alsinet, Clara; Enard, David; Heyn, Holger
err分享
err收藏
Albumin reprograms the B cell transcriptional landscape and improves neutrophil antimicrobial function in patients with decompensated cirrhosis白蛋白重新编程b细胞转录景观并改善失代偿期肝硬化患者的中性粒细胞抗菌功能
errJHEP REPORTS
IF7.5
err2024-11-01
err0
errOAAI
errClaria, Joan; Aguilar, Ferran; Lozano, Juan-Jose; Jimenez-Gracia, Laura; Nieto, Juan C.; Romero-Grimaldo, Berta; Marcos-Fa, Xavi; Giarracco, Emma; Weiss, Emmanuel; Trebicka, Jonel; Hernandez, Inmaculada; Fernandez, Javier; Casulleras, Mireia; Lopez-Vicario, Cristina; Muldur, Sinan; Hopke, Alex; Vlagea, Alexandru; Aransay, Ana M.; Marchese, Domenica; Bernardi, Mauro; Jalan, Rajiv; Angeli, Paolo; Magri, Giuliana; Cerutti, Andrea; Irimia, Daniel; Heyn, Holger; Arroyo, Vicente; Moreau, Richard
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err收藏
Integrative single-cell multi-omics of CD19-CARpos and CARneg T cells suggest drivers of immunotherapy response in B cell neoplasiasCD19-CARpos和CARneg T细胞的整合单细胞多组学提示b细胞肿瘤中免疫治疗反应的驱动因素
errCELL REPORTS MEDICINE
IF10.6
err2024-11-01
err0
errOAAI
errGuerrero-Murillo, Mercedes; Rill-Hinarejos, Aina; Trincado, Juan L.; Bataller, Alex; Ortiz-Maldonado, Valentin; Benitez-Ribas, Daniel; Espanol-Rego, Marta; Gonzalez-Navarro, Eazucena; Martinez-Cibrian, Nuria; Marchese, Domenica; Martin-Martin, Lourdes; Garcia-Sancho, Alejandro Martin; Rives, Susana; Heyn, Holger; Juan, Manel; Urbano-Ispizua, Alvaro; Delgado, Julio; Orfao, Alberto; Mereu, Elisabetta; Bueno, Clara; Menendez, Pablo
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err收藏
Impact of B cell and plasma cell infiltration on survival in early-stage breast cancer (BC) without recurrenceB细胞和浆细胞浸润对无复发生存期的早期乳腺癌（BC）的影响
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errAngelats, L.; Brunet, L. Pare; Rubio-Perez, C.; Torres, E. Sanfeliu; Solis, E. Segui; Villacampa, G.; Marin, M.; Conte, B.; Saez, O. Martinez; Fernandez-Martinez, A.; Buckingham, W.; Guedan, S.; Heyn, H.; Vivancos, A.; Parker, J.; Gonzalez, P. Villagrasa; Perou, C. M.; Prat, A.; Maristany, F. Braso
err分享
err收藏
Liquid biopsy tracking of immunotherapy-induced T cell dynamics in MSS colorectal and endometrial tumors液体活检追踪免疫疗法诱导的T细胞动态变化在微卫星稳定性结直肠癌和子宫内膜肿瘤中的作用
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errHeyn, H.; Melero, J. L.; Deuner, G.; Baraibar Argota, I.; Grzelak, M.; Caratu, G.; Garcia Duran, C.; Grau Bejar, J. F.; Illescas, D. G.; Farinas Madrid, L.; Nieto, P.; Morabito, S.; Rotem, A.; Casbas-Hernandez, P.; Gros, A.; Tabernero, J.; Oaknin, A.; Sachica, J. N.; Borcherding, N.; Elez Fernandez, M. E.
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err收藏
Decoding the muscle transcriptome of patients with late-onset Pompe disease reveals markers of disease progression
errBRAIN
IF11.7
err2024-07-24
err0
errOAAI
errMonceau, Alexandra; Nath, Rasya Gokul; Suarez-Calvet, Xavier; Musumeci, Olimpia; Toscano, Antonio; Kierdaszuk, Biruta; Kostera-Pruszczyk, Anna; Dominguez-Gonzalez, Cristina; Hernandez-Lain, Aurelio; Paradas, Carmen; Rivas, Eloy; Papadimas, George; Papadopoulos, Constantinos; Chrysanthou-Piterou, Margarita; Gallardo, Eduard; Olive, Montse; Lilleker, James; Roberts, Mark E.; Marchese, Domenica; Lunazzi, Giulia; Heyn, Holger; Fernandez-Simon, Esther; Villalobos, Elisa; Clark, James; Katsikis, Panos; Collins, Catherine; Mehra, Priyanka; Laidler, Zoe; Vincent, Amy; Tasca, Giorgio; Marini-Bettolo, Chiara; Guglieri, Michela; Straub, Volker; Raben, Nina; Diaz-Manera, Jordi
err分享
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研究方向

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合作学者
合作期刊
王
王军 (Jun Wang)
H 指数: 222 · 论文数: 3.2K
A
Aviv Regev
H 指数: 208 · 论文数: 965
E
Elı́as Campo
H 指数: 173 · 论文数: 1.6K
J
Joshua M. Stuart
H 指数: 170 · 论文数: 578
M
Manel Esteller
H 指数: 165 · 论文数: 1.6K
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