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Chromatin activity of IκBα mediates the exit from naive pluripotency Palma, Luis G.; Alvarez-Villanueva, Daniel; Maqueda, Maria; Barrero, Mercedes; Iglesias, Arnau; Bertran, Joan; Alvarez, Damiana; Garcia-Prieto, Carlos A.; Ballare, Cecilia; Rodriguez-Cortez, Virginia; Bueno, Clara; Vidal, August; Villanueva, Alberto; Menendez, Pablo; Stik, Gregoire; Di Croce, Luciano; Payer, Bernhard; Esteller, Manel; Espinosa, Lluis; Bigas, Anna 分享 收藏
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Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment Espin, Roderic; Medina-Jover, Ferran; Siguenza-Andrade, Javier; Farran-Matas, Sonia; Mateo, Francesca; Figueras, Agnes; Sanz, Rosario T.; Vicent, Guillermo Pablo; Shabbir, Arzoo; Ruiz-Auladell, Lara; Racionero-Andres, Emilio; Garcia, Irene; Baiges, Alexandra; Franco-Luzon, Lidia; Martinez-Tebar, Adrian; Pardo-Cea, Miguel Angel; Martinez-Iniesta, Maria; Wang, Xieng Chen; Cuyas, Elisabet; Menendez, Javier A.; Lopez-Cerda, Marta; Munoz, Purificacion; Richaud, Ivonne; Raya, Angel; Fabregat, Isabel; Villanueva, Alberto; Serrat, Xenia; Ceron, Julian; Alemany, Montserrat; Guix, Ines; Herencia-Ropero, Andrea; Serra, Violeta; Krishnan, Rehna; Mekhail, Karim; Hakem, Razqallah; Bruna, Jordi; Barcellos-Hoff, Mary Helen; Vinals, Francesc; Aytes, Alvaro; Pujana, Miquel Angel 分享 收藏
In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAF V600E lung adenocarcinoma Nokin, Marie-Julie; Darbo, Elodie; Richard, Elodie; San Jose, Sonia; de Hita, Sergio; Prouzet-Mauleon, Valerie; Turcq, Beatrice; Gerardelli, Laura; Crake, Rebekah; Velasco, Valerie; Koopmansch, Benjamin; Lambert, Frederic; Xue, Jenny Y.; Sang, Ben; Horne, Julie; Ziemons, Eric; Villanueva, Alberto; Blomme, Arnaud; Herfs, Michael; Cataldo, Didier; Calvayrac, Olivier; Porporato, Paolo; Nadal, Ernest; Lito, Piro; Janne, Pasi A.; Ricciuti, Biagio; Awad, Mark M.; Ambrogio, Chiara; Santamaria, David; Consortium, Bolero 分享 收藏
Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy Dias, Matheus Henrique; Friskes, Anoek; Wang, Siying; Neto, Joao M. Fernandes; van Gemert, Frank; Mourragui, Soufiane; Papagianni, Chrysa; Kuiken, Hendrik J.; Mainardi, Sara; Alvarez-Villanueva, Daniel; Lieftink, Cor; Morris, Ben; Dekker, Anna; van Dijk, Emma; Wilms, Lieke H. S.; da Silva, Marcelo S.; Jansen, Robin A.; Mulero-Sanchez, Antonio; Malzer, Elke; Vidal, August; Santos, Cristina; Salazar, Ramon; Wailemann, Rosangela A. M.; Torres, Thompson E. P.; De Conti, Giulia; Raaijmakers, Jonne A.; Snaebjornsson, Petur; Yuan, Shengxian; Qin, Wenxin; Kovach, John S.; Armelin, Hugo A.; te Riele, Hein; van Oudenaarden, Alexander; Jin, Haojie; Beijersbergen, Roderick L.; Villanueva, Alberto; Medema, Rene H.; Bernards, Rene 分享 收藏
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature Tonelotto, Valentina; Costa-Garcia, Marcel; O'Reilly, Eve; Smith, Kaelin Francis; Slater, Kayleigh; Dillon, Eugene T.; Pendino, Marzia; Higgins, Catherine; Sist, Paola; Bosch, Rosa; Passamonti, Sabina; Piulats, Josep M.; Villanueva, Alberto; Tramer, Federica; Vanella, Luca; Carey, Michelle; Kennedy, Breandan N. 分享 收藏
Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: New patient-derived orthotopic xenografts, cell lines and tumor entities Creus-Bachiller, Edgar; Fernandez-Rodriguez, Juana; Magallon-Lorenz, Miriam; Ortega-Bertran, Sara; Navas-Rutete, Susana; Romagosa, Cleofe; Silva, Tulio M.; Pane, Maria; Estival, Anna; Sidelnikova, Diana Perez; Morell, Mireia; Mazuelas, Helena; Carrio, Meritxell; Lausova, Tereza; Reuss, David; Gel, Bernat; Villanueva, Alberto; Serra, Eduard; Lazaro, Conxi 分享 收藏
I?B kinase-a coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy Pecharroman, Irene; Sole, Laura; Alvarez-Villanueva, Daniel; Lobo-Jarne, Teresa; Alonso-Maranon, Josune; Bertran, Joan; Guillen, Yolanda; Montoto, Angela; Martinez-Iniesta, Maria; Garcia-Hernandez, Violeta; Gimenez, Gemma; Salazar, Ramon; Santos, Cristina; Garrido, Marta; Borras, Eva; Sabido, Eduard; Bonfill-Teixidor, Ester; Iurlaro, Raffaella; Seoane, Joan; Villanueva, Alberto; Iglesias, Mar; Bigas, Anna; Espinosa, Lluis 分享 收藏
A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors Da Costa, Maria Eugenia Marques; Zaidi, Sakina; Scoazec, Jean-Yves; Droit, Robin; Lim, Wan Ching; Marchais, Antonin; Salmon, Jerome; Cherkaoui, Sarah; Morscher, Raphael J.; Laurent, Anouchka; Malinge, Sebastien; Mercher, Thomas; Tabone-Eglinger, Severine; Goddard, Isabelle; Pflumio, Francoise; Calvo, Julien; Redini, Francoise; Entz-Werle, Natacha; Soriano, Aroa; Villanueva, Alberto; Cairo, Stefano; Chastagner, Pascal; Moro, Massimo; Owens, Cormac; Casanova, Michela; Hladun-Alvaro, Raquel; Berlanga, Pablo; Daudigeos-Dubus, Estelle; Dessen, Philippe; Zitvogel, Laurence; Lacroix, Ludovic; Pierron, Gaelle; Delattre, Olivier; Schleiermacher, Gudrun; Surdez, Didier; Geoerger, Birgit 分享 收藏
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer 5-甲基胞嘧啶RNA甲基转移酶NSUN7的表观失活与肝癌的临床结果和治疗脆弱性相关 Ortiz-Barahona, Vanessa; Soler, Marta; Davalos, Veronica; Garcia-Prieto, Carlos A. A.; Janin, Maxime; Setien, Fernando; Fernandez-Rebollo, Irene; Bech-Serra, Joan J. J.; De La Torre, Carolina; Guil, Sonia; Villanueva, Alberto; Zhang, Pei-Hong; Yang, Li; Guarnacci, Marco; Schumann, Ulrike; Preiss, Thomas; Balaseviciute, Ugne; Montal, Robert; Llovet, Josep M. M.; Esteller, Manel 分享 收藏
MmCMS: mouse models' consensus molecular subtypes of colorectal cancer Amirkhah, Raheleh; Gilroy, Kathryn; Malla, Sudhir B. B.; Lannagan, Tamsin R. M.; Byrne, Ryan M. M.; Fisher, Natalie C. C.; Corry, Shania M. M.; Mohamed, Noha-Ehssan; Naderi-Meshkin, Hojjat; Mills, Megan L. L.; Campbell, Andrew D. D.; Ridgway, Rachel A. A.; Ahmaderaghi, Baharak; Murray, Richard; Llergo, Antoni Berenguer; Sanz-Pamplona, Rebeca; Villanueva, Alberto; Batlle, Eduard; Salazar, Ramon; Lawler, Mark; Sansom, Owen J. J.; Dunne, Philip D. D. 分享 收藏
1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model Slater, Kayleigh; Bosch, Rosa; Smith, Kaelin Francis; Jahangir, Chowdhury Arif; Garcia-Mulero, Sandra; Rahman, Arman; O'Connell, Fiona; Piulats, Josep M.; O'Neill, Valerie; Horgan, Noel; Coupland, Sarah E.; O'Sullivan, Jacintha; Gallagher, William M.; Villanueva, Alberto; Kennedy, Breandan N. 分享 收藏
Oxidative stress-induced FAK activation contributes to uterine serous carcinoma aggressiveness 氧化应激诱导的FAK激活有助于子宫浆液性癌的侵袭性 Lopez-Mejia, Isabel C.; Pijuan, Jordi; Navaridas, Raul; Santacana, Maria; Gatius, Sonia; Velasco, Ana; Castella, Gerard; Panosa, Anais; Cabiscol, Elisa; Pinyol, Miquel; Coll, Laura; Bonifaci, Nuria; Pena, Laura Plata; Vidal, August; Villanueva, Alberto; Gari, Eloi; Llobet-Navas, David; Fajas, Lluis; Matias-Guiu, Xavier; Yeramian, Andree 分享 收藏
Generation and Integrated Analysis of Advanced Patient-Derived Orthoxenograft Models (PDOX) for the Rational Assessment of Targeted Therapies in Endometrial Cancer Devis-Jauregui, Laura; Vidal, August; Plata-Pena, Laura; Santacana, Maria; Garcia-Mulero, Sandra; Bonifaci, Nuria; Noguera-Delgado, Eulalia; Ruiz, Nuria; Gil, Marta; Dorca, Eduard; Llobet, Francisco J.; Coll-Iglesias, Laura; Gassner, Katja; Martinez-Iniesta, Maria; Rodriguez-Barrueco, Ruth; Barahona, Marc; Marti, Lola; Vinals, Francesc; Ponce, Jordi; Sanz-Pamplona, Rebeca; Piulats, Josep M.; Vivancos, Ana; Matias-Guiu, Xavier; Villanueva, Alberto; Llobet-Navas, David 分享 收藏
p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis Sole, Laura; Lobo-Jarne, Teresa; Alvarez-Villanueva, Daniel; Alonso-Maranon, Josune; Guillen, Yolanda; Guix, Marta; Sangrador, Irene; Rozalen, Catalina; Vert, Anna; Barbachano, Antonio; Lop, Joan; Salido, Marta; Bellosillo, Beatriz; Garcia-Romero, Raquel; Garrido, Marta; Gonzalez, Jessica; Martinez-Iniesta, Maria; Lopez-Arribillaga, Erika; Salazar, Ramon; Montagut, Clara; Torres, Ferran; Iglesias, Mar; Celia-Terrassa, Toni; Munoz, Alberto; Villanueva, Alberto; Bigas, Anna; Espinosa, Lluis 分享 收藏
A High-Throughput Screening Platform Identifies Novel Combination Treatments for Malignant Peripheral Nerve Sheath Tumors Ferna, Juana; Creus-Bachiller, Edgar; Zhang, Xiaohu; Martinez-Iniesta, Maria; Ortega-Bertran, Sara; Guha, Rajarshi; Thomas, Craig J.; Wallace, Margaret R.; Romagosa, Cleofe; Salazar-Huayna, Lourdes; Reilly, Karlyne M.; Blakely, Jaishri O.; Serra-Musach, Jordi; Pujana, Miguel Angel; Serra, Eduard; Villanueva, Alberto; Ferrer, Marc; Lazaro, Conxi 分享 收藏
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR x LGR5 bispecific antibody with efficacy in epithelial tumors Herpers, Bram; Eppink, Berina; James, Mark, I; Cortina, Carme; Canellas-Socias, Adria; Boj, Sylvia F.; Hernando-Momblona, Xavier; Glodzik, Dominik; Roovers, Rob C.; van de Wetering, Marc; Bartelink-Clements, Carina; Zondag-van der Zande, Vanessa; Mateos, Jara Garcia; Yan, Kuan; Salinaro, Lucia; Basmeleh, Abdul; Fatrai, Szabolcs; Maussang, David; van Bueren, Jeroen J. Lammerts; Chicote, Irene; Serna, Garazi; Cabellos, Laia; Ramirez, Lorena; Nuciforo, Paolo; Salazar, Ramon; Santos, Cristina; Villanueva, Alberto; Attolini, Camille Stephan-Otto; Sancho, Elena; Palmer, Hector G.; Tabernero, Josep; Stratton, Michael R.; de Kruif, John; Logtenberg, Ton; Clevers, Hans; Price, Leo S.; Vries, Robert G. J.; Batlle, Eduard; Throsby, Mark 分享 收藏
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