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B

Bruno Sáinz

Department of Cancer Biology
H指数:49
被引数:7,725

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Aptamer-based inhibition of MNK1 reduces pancreatic ductal adenocarcinoma growth by targeting cancer stem cells

基于适配体的MNK1抑制通过靶向癌细胞干细胞来减少胰腺导管腺癌的生长

Journal of Biomedical Science
IF12.1
2026-07-060
OAAI
Alberto Pérez-Ruiz; Laura Ruiz-Cañas; Sandra Batres; Raquel Ferreras-Martín; Celia Pinto-Díez; Balbino Yagüe; Maria Isabel Pérez-Morgado; Silvia Sacristán; Ignacio Ruz-Caracuel; Sonia Camaño Páez; Isabel Sanchez-Perez; Víctor M. González; Sonia Alcalá; María Elena Martín; Bruno Sainz
A CXCR4 targeting peptide delivered by silica nanoparticles eliminates migrating cancer stem cells in pancreatic ductal adenocarcinoma

二氧化硅纳米颗粒递送的CXCR4靶向肽可消除胰腺导管腺癌中的迁移癌干细胞

Scientific Reports
IF3.9
2026-04-010
PRE
Tiwary, Kanishka; Lahusen, Anton; Inaas, Syeda; Beitzinger, Bastian; Schmid, Roman; Harms, Mirja; Hauff, Stefanie; Arnold, Frank; Walter, Karolin; Alcala, Sonia; Hahn, Stephan; Hessmann, Elisabeth; Kleger, Alexander; Azoitei, Ninel; Seufferlein, Thomas; Sainz, Bruno; Munch, Jan; Linden, Mika; Hermann, Patrick C.
c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT

c-Rel通过纤维连接蛋白-整合素信号通路诱导的隔离应激抵抗和EMT来驱动胰腺癌转移

Molecular Cancer
IF33.9
2025-12-150
OAAI
D. Bakırdöğen; K. Görgülü; J. Xin; L. Richter; S. Alcalá; L. Ruiz-Cañas; C. Dai; K. J. Frank; N. Wu; K. N. Diakopoulos; H. Ozturk; D. Demircioğlu; K. Peschke; R. Ranjan; F. Fusco; J. Martinez-Useros; M. J. Fernandez-Aceñero; N. F. Chhabra; J. C. López-Gil; J. Ai; D. A. Ruess; E. Kaya-Aksoy; F. Schmidt; L. Kohlmann; A. Berninger; H. Yangin; F. Schicktanz; K. Steiger; I. E. Demir; R. M. Schmid; M. Reichert; M. Adli; M. Lesina; B. Sainz; H. Algül
A PGLYRP1-related signaling cascade initiated by cancer stem cells influences subtype identity in pancreatic ductal adenocarcinoma

PGLYRP1相关的信号级联由癌症干细胞启动，影响胰腺导管腺癌的亚型特性

Pancreatology
IF2.7
2025-10-310
PRE
Juan Carlos López-Gil; Andrea Dieguez; Antonio Giráldez-Trujillo; Sonia Alcalá; Germán Vallejo-Palma; Diego Navarro; Laura Ruiz-Cañas; Sandra Batres-Ramos; Elisa Espinet; Víctor Javier Sánchez-Arévalo Lobo; Direna Alonso-Curbelo; Carmen Guerra; Bruno Sainz
Aurora kinase A inhibition as a synthetic lethality strategy in ARID1A-mutated gastroenteropancreatic neuroendocrine carcinoma

ARID1A突变胃肠道胰腺神经内分泌癌中，Aurora kinase A抑制作为一种合成致死策略。

Cancer Letters
IF10.1
2025-09-160
PREAI
Maria Urbanova; Fabrice Viol; Laura Ruiz Canas; Efthymios Koniaris; Rihards Saksis; Sandra Batres Ramos; Julie Earl; Agapi Kataki; Verona Buocikova; Monika Burikova; Marina Cihova; Lucia Rojikova; Peter Makovicky; Miroslava Matuskova; Yvonne Kohl; Andrea Riedmayer; Marianna Makova; Ladislav Baciak; Daniel Gogola; Olesja Rogoza; Vita Rovite; Bruno Sainz; Bozena Smolkova; Joerg Schrader
TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis

TGF-β1介导的L1CAM在胰腺导管腺癌中的下调驱动了COL17A1和MMP2的上调，促进肿瘤侵袭和转移。

Cell Death & Disease
IF9.6
2025-08-060
OA
Donatella Delle Cave; Annalisa Di Domenico; Marco Fantuz; Marianna Ciotola; Maria Mangini; Silvia Buonaiuto; Brunella Corrado; Marco Corona; Federica Saracino; Gennaro Andolfi; Ilaria Di Biase; Antonio Cucciardi; Alessandro Carrer; Bruno Sainz; Teresa Pirozzi; Daniele Lo Re; Vincenza Colonna; Gabriella Minchiotti; Anna Chiara De Luca; Enza Lonardo
Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism

三维环境通过重编程能量代谢使胰腺癌细胞对布地奈德的抗增殖效应敏感

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
2024-06-140
OAAI
Ibello, Eduardo; Saracino, Federica; Delle Cave, Donatella; Buonaiuto, Silvia; Amoroso, Filomena; Andolfi, Gennaro; Corona, Marco; Guardiola, Ombretta; Colonna, Vincenza; Sainz Jr, Bruno; Altucci, Lucia; De Cesare, Dario; Cobellis, Gilda; Lonardo, Enza; Patriarca, Eduardo Jorge; D'Aniello, Cristina; Minchiotti, Gabriella
Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
2024-01-2710
OAAI
Alcala, Sonia; Villarino, Lara; Ruiz-Canas, Laura; Couceiro, Jose R.; Martinez-Calvo, Miguel; Palencia-Campos, Adrian; Navarro, Diego; Cabezas-Sainz, Pablo; Rodriguez-Arabaolaza, Iker; Cordero-Barreal, Alfonso; Trilla-Fuertes, Lucia; Rubiolo, Juan A.; Batres-Ramos, Sandra; Vallespinos, Mireia; Gonzalez-Paramos, Cristina; Rodriguez, Jessica; Gamez-Pozo, Angelo; Vara, Juan angel Fresno; Fernandez, Sara Fra; Berlinches, Amparo Benito; Moreno-Mata, Nicolas; Redondo, Ana Maria Torres; Carrato, Alfredo; Hermann, Patrick C.; Sanchez, Laura; Torrente, Susana; Fernandez-Moreno, Miguel Angel; Mascarenas, Jose L.; Sainz Jr, Bruno
Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new approach to treat pancreatic cancer
CANCER RESEARCH
IF16.6
2024-01-161
PRE
Sainz, Bruno Jr; Alcala, Sonia; Villarino, Lara; Ruiz-Canas, Laura; Couceiro, Jose; Martinez-Calvo, Miguel; Palencia-Campos, Adrian; Navarro, Diego; Cabezas-Sainz, Pablo; Cordero-Barreal, Alfonso; Rubiolo, Juan A.; Gonzalez-Paramos, Cristina; Carrato, Alfredo; Hermann, Patrick C.; Sanchez, Laura; Torrente, Susana; Fernandez-Moreno, Miguel Angel; Mascarenas, Jose L.
Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival

纳米医学和表观遗传学: 增加胰腺癌生存几率的新联盟

BIOMEDICINE & PHARMACOTHERAPY
IF7.5
2023-09-019
OAAI
Urbanova, Maria; Cihova, Marina; Buocikova, Verona; Slopovsky, Jan; Dubovan, Peter; Pindak, Daniel; Tomas, Miroslav; Garcia-Bermejo, Laura; Rodriguez-Garrote, Mercedes; Earl, Julie; Kohl, Yvonne; Kataki, Agapi; Dusinska, Maria; Sainz, Bruno, Jr.; Smolkova, Bozena; Gabelova, Alena
An Aptamer against MNK1 for Non-Small Cell Lung Cancer Treatment

针对MNK1的适体用于非小细胞肺癌的治疗

PHARMACEUTICS
IF5.5
2023-04-183
OAAI
Carrion-Marchante, Rebeca; Pinto-Diez, Celia; Ignacio Klett-Mingo, Jose; Palacios, Esther; Barragan-Usero, Miriam; Isabel Perez-Morgado, M.; Pascual-Mellado, Manuel; Alcala, Sonia; Ruiz-Canas, Laura; Sainz Jr, Bruno; Gonzalez, Victor M.; Martin, M. Elena
Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical for KRAS mutant cancer
CELL REPORTS MEDICINE
IF10.6
2022-11-0122
OAAI
Frank, Katrin J.; Mulero-Sanchez, Antonio; Berninger, Alexandra; Ruiz-Canas, Laura; Bosma, Astrid; Gorgulu, Kivanc; Wu, Nan; Diakopoulos, Kalliope N.; Kaya-Aksoy, Ezgi; Ruess, Dietrich A.; Kabacaoglu, Derya; Schmidt, Franze; Kohlmann, Larissa; van Tellingen, Olaf; Thijssen, Bram; van de Ven, Marieke; Proost, Natalie; Kossatz, Susanne; Weber, Wolfgang A.; Sainz Jr, Bruno; Bernards, Rene; Algul, Hana; Lesina, Marina; Mainardi, Sara
LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
2022-10-2626
OAAI
Delle Cave, Donatella; Buonaiuto, Silvia; Sainz, Bruno, Jr.; Fantuz, Marco; Mangini, Maria; Carrer, Alessandro; Di Domenico, Annalisa; Iavazzo, Tea Teresa; Andolfi, Gennaro; Cortina, Carme; Sevillano, Marta; Heeschen, Christopher; Colonna, Vincenza; Corona, Marco; Cucciardi, Antonio; Di Guida, Martina; Batlle, Eduard; De Luca, Annachiara; Lonardo, Enza

研究方向

暂未获取到该数据
S
Sonia Alcalá
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C
Christopher Heeschen
H 指数:82论文数:343被引数:3.0万
P
Patrick Hermann
H 指数:33论文数:144被引数:6,988
L
Laura Ruíz-Cañas
H 指数:15论文数:93被引数:971
P
Patricia Sancho
H 指数:37论文数:132被引数:5,360
M
Mireia Vallespinós
H 指数:10论文数:36被引数:733
S
Susan L. Uprichard
H 指数:30论文数:98被引数:5,401
J
Julie Earl
H 指数:27论文数:190被引数:3,036
D
Diego Navarro
H 指数:11论文数:27被引数:741
L
Laura Sánchez
H 指数:41论文数:254被引数:4,542