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C

Christopher Heeschen

candiolo cancer institute fpo-irccs

82H指数
342论文数
3.0W被引数
收录论文 121
发表时间
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Targeting TMED4 enhances CD8+ T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis靶向TMED4通过IRE1α-自噬轴增强CD8+ T细胞功能和CAR T细胞在实体瘤中的疗效
errScience Advances
IF12.5
err2026-06-12
err0
errOAAI
errHuizi Wang; Licai Shi; Ke Jiang; Shuyao Wu; Zhenyan Jiang; Yuexiao Tao; Jia Li; Xin Li; Jiamin Liu; Jun Ni; Emily Jiatong Wu; Sophia Jiaxin Wu; Guang Chen; Ming Qin; Lin Xu; Chu-Hu Lai; Alexandra Aicher; Youqiong Ye; Christopher Heeschen; Yu J. Cao; Xuefeng Wu
err分享
err收藏
RHOV couples EMT-associated plasticity to cytoskeletal execution of invasion and metastasisRHOV将EMT相关的可塑性偶联到细胞骨架对侵袭和转移的执行
errCell Death Discovery
IF7
err2026-05-07
err0
errOAAI
errQi Wang; Yaru Zhao; Shenghui Huang; Haiyan Fu; Chiara Reina; Alexandra Aicher; Jiajia Tang; Christopher Heeschen
err分享
err收藏
GPTBioInsightor-leveraging large language models for transparent scRAN-seq cell type annotationsGPTBioInsightor：利用大型语言模型实现透明的scRNA-seq细胞类型注释
errBioinformatics Advances
IF2.8
err2026-01-01
err0
PREAI
errHuang, Shenghui; Sabanovic, Berina; Peng, Yuzhong; Zheng, Quan; Alessandri, Luca; Heeschen, Christopher
err分享
err收藏
Engineering the tumor microenvironment: oncolytic NDV to facilitate CAR-T cell therapy工程化肿瘤微环境：利用溶瘤NDV促进CAR-T细胞疗法
errJournal of Translational Medicine
IF7.5
err2025-11-19
err0
errOAAI
errMei Wang; Ke Jiang; Alexandra Aicher; Christopher Heeschen
err分享
err收藏
Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis抗凝血酶结合肝素硫酸盐在上皮细胞中广泛表达，并抑制胰腺肿瘤发生
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-11-17
err0
PREAI
errClausen, Thomas Mandel; Weiss, Ryan J.; Tremblay, Jacob R.; Kellman, Benjamin P.; Coker, Joanna; Dworkin, Leo A.; Rodriguez, Jessica P.; Chang, Ivy M.; Chen, Timothy; Padala, Vikram; Karlsson, Richard; Song, Hyemin; Peck, Kristina L.; Ogawa, Satoshi; Sandoval, Daniel R.; Joshi, Hiren J.; Wang, Gaowei; Ferguson, L. Paige; Bhalerao, Nikita; Moores, Allison; Reya, Tannishtha; Sander, Maike; Caffrey, Thomas C.; Grem, Jean L.; Aicher, Alexandra; Heeschen, Christopher; Le, Dzung; Lewis, Nathan E.; Hollingsworth, Michael A.; Grandgenett, Paul M.; Bellis, Susan L.; Miller, Rebecca L.; Fuster, Mark M.; Dawson, David W.; Engle, Dannielle D.; Esko, Jeffrey D.
err分享
err收藏
The interplay between tissue-resident microbiome and host proteins by integrated multi-omics during progression of colorectal adenoma to carcinoma通过整合多组学研究结直肠腺瘤向癌进展过程中组织驻留微生物组与宿主蛋白之间的相互作用
erriMeta
IF33.2
err2025-11-04
err0
errOAAI
errDi Wu; An-Jun Wang; De-Chao Bu; Yan-Yan Sun; Chen-Hao Li; Yue-Mei Hong; Shan Zhang; Shi-Yang Chen; Jin-An Zhou; Tian-Yi Zhang; Min-Hao Yu; Yong-Jing Ma; Xiu-Li Wang; Jia Xu; Wei He; Christopher Heeschen; Jian-Feng Chen; Wen-Jun Mao; Hui Ding; Wen-Juan Wu; Yi Zhao; Hui Wang; Ning-Ning Liu
err分享
err收藏
Elesclomol-Copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in pancreatic ductal adenocarcinomaElesclomol-铜组合协同靶向癌细胞干细胞中的线粒体代谢，以克服胰腺导管腺癌的化疗耐药性。
errMolecular Therapy
IF12
err2025-09-10
err0
errOAAI
errQian Yu; Ke Jiang; Siyu Ma; Quan Zheng; Serena Tondi; Chiara Reina; Berina Šabanović; Chenlei Wen; Baiyong Shen; Alexandra Aicher; Haiyun Song; Yinxing Ma; Christopher Heeschen
err分享
err收藏
Single-cell multi-omics and machine learning for dissecting stemness in cancer单细胞多组学与机器学习在解析癌症干性中的应用
errBRIEFINGS IN BIOINFORMATICS
IF7.7
err2025-09-01
err0
PREAI
errHuang, Xinyang; Huang, Shenghui; Reina, Chiara; Sabanovic, Berina; Roberto, Miriam; Aicher, Alexandra; Tang, Jiajia; Heeschen, Christopher
err分享
err收藏
CLDN18.2 CAR-derived Extracellular Vesicle Immunotherapy Improves Outcome in Murine Pancreatic CancerCLDN18.2 CAR衍生的外泌体免疫疗法可改善小鼠胰腺癌的预后
errADVANCED HEALTHCARE MATERIALS
IF9.6
err2025-05-19
err0
errOAAI
errQing, Y; Jiang, K; Jiang, H; Zhao, YR; Lai, CH; Aicher, A; Li, ZH; Heeschen, C
err分享
err收藏
Unlocking the future of cancer diagnosis - promises and challenges of ctDNA-based liquid biopsies in non-small cell lung cancer开启癌症诊断的未来-基于ctDNA的液体活检在非小细胞肺癌中的承诺和挑战
errTRANSLATIONAL RESEARCH
IF5.9
err2024-10-01
err3
PREAI
errReina, Chiara; Sabanovic, Berina; Lazzari, Chiara; Gregorc, Vanesa; Heeschen, Christopher
err分享
err收藏
Gasdermin C promotes Stemness and Immune Evasion in Pancreatic Cancer via Pyroptosis-Independent MechanismGasdermin C通过非焦亡机制促进胰腺癌的Stemness和免疫逃避
errADVANCED SCIENCE
IF14.1
err2024-09-19
err1
errOAAI
errWu, Renfei; Li, Jingwei; Aicher, Alexandra; Jiang, Ke; Tondi, Serena; Dong, Shuang; Zheng, Quan; Tang, Siqi; Chen, Minchun; Guo, Zhenyang; Sabanovic, Berina; Ananthanarayanan, Preeta; Jiang, Lingxi; Sapino, Anna; Wen, Chenlei; Fu, Da; Shen, Baiyong; Heeschen, Christopher
err分享
err收藏
CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approachesCTC衍生的胰腺癌模型可作为研究工具，适用于精准医学方法
errCELL REPORTS MEDICINE
IF10.6
err2024-09-01
err0
errOAAI
errTang, Jiajia; Zheng, Quan; Wang, Qi; Zhao, Yaru; Ananthanarayanan, Preeta; Reina, Chiara; Sabanovic, Berina; Jiang, Ke; Yang, Ming-Hsin; Meny, Clara Csilla; Wang, Huimin; Agerbaek, Mette O.; Clausen, Thomas Mandel; Gustavsson, Tobias; Wen, Chenlei; Borghi, Felice; Mellano, Alfredo; Fenocchio, Elisabetta; Gregorc, Vanesa; Sapino, Anna; Theander, Thor G.; Fu, Da; Aicher, Alexandra; Salanti, Ali; Shen, Baiyong; Heeschen, Christopher
err分享
err收藏
Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells脂肪酸氧化对于胰腺癌干细胞的致瘤潜力和化学抗性至关重要
errJOURNAL OF TRANSLATIONAL MEDICINE
IF7.5
err2024-08-28
err5
errOAAI
errMascaraque, Marta; Courtois, Sarah; Royo-Garcia, Alba; Barneda, David; Stoian, Andrei M.; Villaoslada, Isabel; Espiau-Romera, Pilar; Bokil, Ansooya; Cano-Galiano, Andres; Jagust, Petra; Heeschen, Christopher; Sancho, Patricia
err分享
err收藏
A Self-Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer
errADVANCED HEALTHCARE MATERIALS
IF9.6
err2024-03-22
err2
errOAAI
errLiu, Ying; Okesola, Babatunde O.; de la Pena, David Osuna; Li, Weiqi; Lin, Meng-Lay; Trabulo, Sara; Tatari, Marianthi; Lawlor, Rita T.; Scarpa, Aldo; Wang, Wen; Knight, Martin; Loessner, Daniela; Heeschen, Christopher; Mata, Alvaro; Pearce, Oliver M. T.
err分享
err收藏
Disulfiram and its metal complexes reversed hypoxia induced stemness and synergized with first line drugs in primary patient derived pancreatic ductal adenocarcinoma cells
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errSmall, Benjamin J.; Nkeonye, Ogechi; Kannappan, Vinodh; Kumarasamy, Shalini; Butcher, Kate; Azar, Karim; Rajendran, Gowtham; Lakshmanan, Yoshitha Lakshmanan; Morris, Mark; Heeschen, Christopher; Wang, Yaohe; Wang, Weiguang
err分享
err收藏
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity
errJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
err2023-11-28
err8
errOAAI
errZheng, Quan; Tang, Jiajia; Aicher, Alexandra; Bou Kheir, Tony; Sabanovic, Berina; Ananthanarayanan, Preeta; Reina, Chiara; Chen, Minchun; Gu, Jian-Min; He, Bin; Alcala, Sonia; Behrens, Diana; Lawlo, Rita T.; Scarpa, Aldo; Hidalgo, Manuel; Sainz Jr, Bruno; Sancho, Patricia; Heeschen, Christopher
err分享
err收藏
Single-cell omics: a new perspective for early detection of pancreatic cancer?
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2023-09-01
err4
PREAI
errWang, Qi; Sabanovic, Berina; Awada, Azhar; Reina, Chiara; Aicher, Alexandra; Tang, Jiajia; Heeschen, Christopher
err分享
err收藏
Liquid biopsy in pancreatic cancer-Current perspective and future outlook
errBIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
IF8.3
err2023-05-01
err23
PREAI
errZhao, Yaru; Tang, Jiajia; Jiang, Ke; Liu, Shin-Yi; Aicher, Alexandra; Heeschen, Christopher
err分享
err收藏
Bispecific T cell-engager targeting oncofetal chondroitin sulfate induces complete tumor regression and protective immune memory in mice
errJOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
IF12.8
err2023-04-28
err3
errOAAI
errSkeltved, Nanna; Nordmaj, Mie A. A.; Berendtsen, Nicolai T. T.; Dagil, Robert; Stormer, Emilie M. R.; Al-Nakouzi, Nader; Jiang, Ke; Aicher, Alexandra; Heeschen, Christopher; Gustavsson, Tobias; Choudhary, Swati; Gogenur, Ismail; Christensen, Jan P. P.; Theander, Thor G. G.; Daugaard, Mads; Salanti, Ali; Nielsen, Morten A. A.
err分享
err收藏
Identification of membrane-expressed CAPRIN-1 as a novel and universal cancer target and generation of a therapeutic anti-CAPRIN-1 antibody TRK-950
errCANCER RESEARCH
IF16.6
err2023-04-04
err0
PREAI
errOkano, Fumiyoshi; Saito, Takanori; Minamida, Yoshitaka; Kobayashi, Shinichi; Ido, Takayoshi; Miyauchi, Yasushi; Wasai, Ukei; Ke, Jiang; Aicher, Alexandra; Heeschen, Christopher; Yonehara, Tetsu
err分享
err收藏

研究方向

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