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Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice (vol 17, pg 530, 2016) A152T人tau的表达导致转基因小鼠中年龄依赖性神经元功能障碍和丧失 (第17卷，530页，2016) Maeda, Sumihiro; Djukic, Biljana; Taneja, Praveen; Yu, Gui-Qiu; Lo, Iris; Davis, Allyson; Craft, Ryan; Guo, Weikun; Wang, Xin; Kim, Daniel; Ponnusamy, Ravikumar; Gill, T. Michael; Masliah, Eliezer; Mucke, Lennart 分享 收藏
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models 增加阿尔茨海默病风险的TREM2变体导致异常的皮质突触密度并促进小鼠模型中的网络过度兴奋 Das, Melanie; Mao, Wenjie; Voskobiynyk, Yuliya; Necula, Deanna; Lew, Irene; Petersen, Cathrine; Zahn, Allie; Yu, Gui-Qiu; Yu, Xinxing; Smith, Nicholas; Sayed, Faten A.; Gan, Li; Paz, Jeanne T.; Mucke, Lennart 分享 收藏
TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model 兴奋性神经元中的TAU消融和出生后TAU敲除可减少Dravet综合征模型中的癫痫，SUDEP和自闭症行为 Shao, Eric; Chang, Che-Wei; Li, Zhiyong; Yu, Xinxing; Ho, Kaitlyn; Zhang, Michelle; Wang, Xin; Simms, Jeffrey; Lo, Iris; Speckart, Jessica; Holtzman, Julia; Yu, Gui-Qiu; Roberson, Erik D.; Mucke, Lennart 分享 收藏
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Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1 人类APP转基因小鼠的行为和神经网络异常类似于App敲入小鼠，并且受家族性阿尔茨海默氏病突变的调节，但不受BACE1抑制的调节。 Johnson, Erik C. B.; Ho, Kaitlyn; Yu, Gui-Qiu; Das, Melanie; Sanchez, Pascal E.; Djukic, Biljana; Lopez, Isabel; Yu, Xinxing; Gill, Michael; Zhang, Weiping; Paz, Jeanne T.; Palop, Jorge J.; Mucke, Lennart 分享 收藏
A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease 第二条X染色体有助于阿尔茨海默病小鼠模型的恢复 Davis, Emily J.; Broestl, Lauren; Abdulai-Saiku, Samira; Worden, Kurtresha; Bonham, Luke W.; Minones-Moyano, Elena; Moreno, Arturo J.; Wang, Dan; Chang, Kevin; Williams, Gina; Garay, Bayardo, I; Lobach, Iryna; Devidze, Nino; Kim, Daniel; Anderson-Bergman, Cliff; Yu, Gui-Qiu; White, Charles C.; Harris, Julie A.; Miller, Bruce L.; Bennett, David A.; Arnold, Arthur P.; De Jager, Phil L.; Palop, Jorge J.; Panning, Barbara; Yokoyama, Jennifer S.; Mucke, Lennart; Dubal, Dena B. 分享 收藏
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Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model 纤维蛋白原在阿尔茨海默病模型中诱导小胶质细胞介导的脊柱消除和认知障碍 Merlini, Mario; Rafalski, Victoria A.; Coronado, Pamela E. Rios; Gill, T. Michael; Ellisman, Maya; Muthukumar, Gayathri; Subramanian, Keshav S.; Ryu, Jae Kyu; Syme, Catriona A.; Davalos, Dimitrios; Seeley, William W.; Mucke, Lennart; Nelson, Robert B.; Akassoglou, Katerina 分享 收藏
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Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration 纤维蛋白靶向免疫治疗可预防神经炎症和神经变性 Ryu, Jae Kyu; Rafalski, Victoria A.; Meyer-Franke, Anke; Adams, Ryan A.; Poda, Suresh B.; Coronado, Pamela E. Rios; Pedersen, Lars Ostergaard; Menon, Veena; Baeten, Kim M.; Sikorski, Shoana L.; Bedard, Catherine; Hanspers, Kristina; Bardehle, Sophia; Mendiola, Andrew S.; Davalos, Dimitrios; Machado, Michael R.; Chan, Justin P.; Plastira, Ioanna; Petersen, Mark A.; Pfaff, Samuel J.; Ang, Kenny K.; Hallenbeck, Kenneth K.; Syme, Catriona; Hakozaki, Hiroyuki; Ellisman, Mark H.; Swanson, Raymond A.; Zamvil, Scott S.; Arkin, Michelle R.; Zorn, Stevin H.; Pico, Alexander R.; Mucke, Lennart; Freedman, Stephen B.; Stavenhagen, Jeffrey B.; Nelson, Robert B.; Akassoglou, Katerina 分享 收藏
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Neuronal Neuronal levels and sequence of tau modulate the power of brain rhythms 神经元神经元水平和tau序列调节脑节律的力量 Das, Melanie; Maeda, Sumihiro; Hu, Bozhong; Yu, Gui-Qiu; Guo, Weikun; Lopez, Isabel; Yu, Xinxing; Tai, Chao; Wang, Xin; Mucke, Lennart 分享 收藏
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders 精神病细胞图计划: 一种融合的系统生物学方法，用于阐明神经精神障碍的关键分子途径 Willsey, A. Jeremy; Morris, Montana T.; Wang, Sheng; Willsey, Helen R.; Sun, Nawei; Teerikorpi, Nia; Baum, Tierney B.; Cagney, Gerard; Bender, Kevin J.; Desai, Tejal A.; Srivastava, Deepak; Davis, Graeme W.; Doudna, Jennifer; Chang, Edward; Sohal, Vikaas; Lowenstein, Daniel H.; Li, Hao; Agard, David; Keiser, Michael J.; Shoichet, Brian; von Zastrow, Mark; Mucke, Lennart; Finkbeiner, Steven; Gan, Li; Sestan, Nenad; Ward, Michael E.; Huttenhain, Ruth; Nowakowski, Tomasz J.; Bellen, Hugo J.; Frank, Loren M.; Khokha, Mustafa K.; Lifton, Richard P.; Kampmann, Martin; Ideker, Trey; State, Matthew W.; Krogan, Nevan J. 分享 收藏
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a MouseModel of Alzheimer's Disease Nav1.1-过度表达的中间神经元移植可恢复阿尔茨海默氏病模型的脑节律和认知 Martinez-Losa, Magdalena; Tracy, Tara E.; Ma, Keran; Verret, Laure; Clemente-Perez, Alexandra; Khan, Abdullah S.; Cobos, Inma; Ho, Kaitlyn; Gan, Li; Mucke, Lennart; Alvarez-Dolado, Manuel; Palop, Jorge J. 分享 收藏
Istradefylline reduces memory deficits in aging mice with amyloid pathology 伊斯特拉茶碱可减少淀粉样蛋白病理衰老小鼠的记忆缺陷 Orr, Anna G.; Lo, Iris; Schumacher, Heike; Ho, Kaitlyn; Gill, Michael; Guo, Weikun; Kim, Daniel H.; Knox, Anthony; Saito, Takashi; Saido, Takaomi C.; Simms, Jeffrey; Toddes, Carlee; Wang, Xin; Yu, Gui-Qiu; Mucke, Lennart 分享 收藏
Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture tau在Y18处的磷酸化，而不是tau-fyn结合，是tau调节原代神经元培养物中NMDA受体依赖性兴奋性毒性所必需的 Miyamoto, Takashi; Stein, Liana; Thomas, Reuben; Djukic, Biljana; Taneja, Praveen; Knox, Joseph; Vossel, Keith; Mucke, Lennart 分享 收藏
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