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D

David C. Wedge

University of Manchester
H指数:87
被引数:6.2万

个人简介

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教育背景

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荣誉奖项

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The molecular heterogeneity and clinical impact of genomic driver alterations in prostate cancer

前列腺癌中基因组驱动突变的分子异质性与临床影响

Nature Communications
IF15.7
2026-10-160
OAAI
Diogo Pellegrina; Daria Kiriy; Kevin C. L. Cheng; Francesco Favero; Enrichetta Miletti; Zoe P. Klein; Barbara Hernando; Andre V. Olsen; Atef Sahli; Yunfan Fu; Pavlo Lutsik; Weerachai Jaratlerdsiri; William J. Hutchison; G. Steven Bova; Daniel S. Brewer; Mark Brook; Benedikt Brors; Adam Butler; Géraldine Cancel-Tassin; Niall M. Corcoran; Olivier Cussenot; Abraham Gihawi; Etsehiwot G. Girma; Vincent J. Gnanapragasam; Anis A. Hamid; Housheng Hansen He; Eddie Luidy L. Imada; G. Maria Jakobsdottir; Chol-hee Jung; Francesca Khani; Zsofia Kote-Jarai; Philippe Lamy; Gregory Leeman; Massimo Loda; Ramyar Molania; Lucio R. Queiroz; Tobias Rausch; Brian Robinson; Karina D. Sørensen; Sebastian Uhrig; Yaobo Xu; Takafumi N. Yamaguchi; Claudio Zanettini; Stefano Mangiola; Lena Voith von Voithenberg; Luigi Marchionni; Anthony T. Papenfuss; Bernard Pope; Vanessa M. Hayes; Thorsten Schlomm; Robert G. Bristow; Christopher M. Hovens; Ros A. Eeles; Colin S. Cooper; Clarissa Gerhauser; Geoff Macintyre; Andreas J. Gruber; David C. Wedge; Joachim Weischenfeldt; Jüri Reimand
Recurrent mechanisms of biallelic epigenetic inactivation reveal new putative tumour suppressor genes in prostate cancer

前列腺癌中双等位基因表观遗传失活的复发机制揭示了新的潜在肿瘤抑制基因

Nature Communications
IF15.7
2026-09-090
OAAI
Daria Kiriy; Francesco Favero; Clarissa Gerhäuser; Jessica Heilmann; Pavlo Lutsik; Francisco German Rodriguez Gonzalez; Alessio Locallo; Jakob Schmidt Jespersen; Andreas J. Gruber; Andre V. Olsen; Barbara Hernando; Kevin CL Cheng; Diogo Pellegrina; Geoff Macintyre; G. Steven Bova; Daniel S. Brewer; Robert G. Bristow; Mark N. Brook; Benedikt Brors; Adam Butler; Géraldine Cancel-Tassin; Niall M. Corcoran; Olivier Cussenot; Ros A. Eeles; Abraham Gihawi; Etsehiwot G. Girma; Vincent J. Gnanapragasam; Anis Hamid; Vanessa M. Hayes; Housheng Hansen He; Christopher M. Hovens; Eddie L. Imada; G. Maria Jakobsdottir; Chol-Hee Jung; Francesca Khani; Zsofia Kote-Jarai; Philippe P. Lamy; Gregory Leeman; Massimo Loda; Luigi Marchionni; Ramyar Molania; Anthony T. Papenfuss; Bernard Pope; Lucio R. Queiroz; Tobias Rausch; Brian Robinson; Atef Sahli; Karina D. Sørensen; Sebastian Uhrig; David C. Wedge; Yaobo Xu; Takafumi N. Yamaguchi; Claudio Zanettini; Colin S. Cooper; Thorsten Schlomm; Jüri Reimand; Joachim Weischenfeldt
Integrated signatures define mutational processes in prostate cancer

整合特征定义前列腺癌中的突变过程

Nature
IF48.5
2026-09-090
OAAI
Andreas J. Gruber; André V. Olsen; Barbara Hernando; Kevin C. L. Cheng; Clarissa Gerhäuser; Marina Torres; Francesco Favero; Daria Kiriy; Ángel Fernández-Sanromán; Juan Maria Roldan-Romero; Lucy Barton; Diogo Pellegrina; G. Steven Bova; Daniel S. Brewer; Mark N. Brook; Benedikt Brors; Adam Butler; Géraldine Cancel-Tassin; Niall M. Corcoran; Olivier Cussenot; Abraham Gihawi; Etsehiwot G. Girma; Vincent J. Gnanapragasam; Anis A. Hamid; Vanessa M. Hayes; Housheng Hansen He; Christopher M. Hovens; Eddie L. Imada; G. Maria Jakobsdottir; Chol-Hee Jung; Francesca Khani; Zsofia Kote-Jarai; Philippe Lamy; Gregory Leeman; Massimo Loda; Pavlo Lutsik; Luigi Marchionni; Ramyar Molania; Anthony T. Papenfuss; Bernard Pope; Lucio R. Queiroz; Tobias Rausch; Brian Robinson; Atef Sahli; Karina D. Sørensen; Takafumi N. Yamaguchi; Sebastian Uhrig; Yaobo Xu; Claudio Zanettini; Ronald Simon; Guido Sauter; Ros A. Eeles; Colin S. Cooper; Robert G. Bristow; David C. Wedge; Thorsten Schlomm; Geoff Macintyre; Jüri Reimand; Joachim Weischenfeldt
Author Correction: Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma

作者更正：揭示LINE-1在肺腺癌进化中的作用

Nature
IF48.5
2026-08-110
PRE
Tongwu Zhang; Wei Zhao; Christopher Wirth; Marcos Díaz-Gay; Jinhu Yin; Monia Cecati; Francesca Marchegiani; Phuc H. Hoang; Charles Leduc; Marina K. Baine; William D. Travis; Lynette M. Sholl; Philippe Joubert; Jian Sang; John P. McElderry; Michelle Antony; Alyssa Klein; Azhar Khandekar; Caleb Hartman; Jennifer Rosenbaum; Frank J. Colón-Matos; Mona Miraftab; Monjoy Saha; Olivia W. Lee; Kristine M. Jones; Neil E. Caporaso; Maria Pik Wong; Kin Chung Leung; Chao Agnes Hsiung; Chih-Yi Chen; Eric S. Edell; Jacobo Martínez Santamaría; Matthew B. Schabath; Sai S. Yendamuri; Marta Manczuk; Jolanta Lissowska; Beata Świątkowska; Anush Mukeria; Oxana Shangina; David Zaridze; Ivana Holcatova; Dana Mates; Sasa Milosavljevic; Milan Savic; Yohan Bossé; Bonnie E. Gould Rothberg; David C. Christiani; Valerie Gaborieau; Paul Brennan; Geoffrey Liu; Paul Hofman; Robert Homer; Soo-Ryum Yang; Angela C. Pesatori; Dario Consonni; Lixing Yang; Bin Zhu; Jianxin Shi; Kevin Brown; Nathaniel Rothman; Stephen J. Chanock; Ludmil B. Alexandrov; Jiyeon Choi; Maurizio Cardelli; Qing Lan; Martin A. Nowak; David C. Wedge; Maria Teresa Landi
Examining the role of extrachromosomal DNA in lung cancer

研究染色体外DNA在肺癌中的作用

JNCI: Journal of the National Cancer Institute
IF0
2026-08-050
PRE
Azhar Khandekar, PhD; Phuc H Hoang, PhD; Jens Luebeck, PhD; Marcos Díaz-Gay, PhD; Wei Zhao, PhD; John P McElderry, MS; Caleb Hartman, MS; Mona Miraftab, BS; Olivia W Lee, PhD; Kara M Barnao, MS; Kristine Jones, BS; Amy Hutchinson, MS; Belynda Hicks, MS; Erik N Bergstrom, PhD; Yang Yang, PhD; Martin A Nowak, PhD; Nathaniel Rothman, PhD; Angela C Pesatori, PhD; Dario Consonni, PhD; Robert Homer, MD, PhD; Marina K Baine, MD, PhD; Lynette M Sholl, MD; Philippe Joubert, MD, PhD; Charles Leduc, MD; William D Travis, MD; Soo-Ryum Yang, MD; Qing Lan, PhD; David C Wedge, PhD; Lixing Yang, PhD; Stephen J Chanock, MD, PhD; Tongwu Zhang, PhD; Ludmil B Alexandrov, PhD; Maria Teresa Landi, MD, PhD
Single base focal hypermutation cooccurs with structural variation as an early event in advanced prostate tumourigenesis with ancestry specific independence: a multi-ancestral observational study

单碱基局灶性超突变与结构变异同时发生，是晚期前列腺肿瘤发生的早期事件，具有祖先特异性独立性: 一项多祖先观察性研究

Genome Medicine
IF11.2
2026-04-250
OAAI
Jue Jiang; Avraam Tapinos; Ruotian Huang; M. S. Riana Bornman; Phillip D. Stricker; Shingai B. A. Mutambirwa; David C. Wedge; Weerachai Jaratlerdsiri; Vanessa M. Hayes
Longitudinal plasma nano-proteomics reveals acute systemic responses to radiotherapy and predictive biomarkers of late toxicity

纵向血浆纳米蛋白质组学揭示了放射治疗引起的急性全身反应和晚期毒性的预测生物标志物

Communications Medicine
IF6.3
2026-04-010
OAAI
Hanan Abumanhal-Masarweh; Salam A. Assi; Xinming Liu; Conrado Guerrero Quiles; Taha Lodhi; Kaye J. Williams; Eleanor J. Cheadle; Kostas Kostarelos; Ananya Choudhury; David C. Wedge; Catharine M. L. West; Marilena Hadjidemetriou
Clonal evolutionary analysis reveals patterns of malignant transformation of Intraductal Papillary Mucinous Neoplasms of the pancreas

克隆进化分析揭示了胰腺导管内乳头状黏液性肿瘤的恶性转化模式

Nature Communications
IF15.7
2026-03-040
OAAI
Antonio Pea; Xiaotong He; Rosie Upstill-Goddard; Claudio Luchini; Leonor Patricia Schubert Santana; Stephan Dreyer; Fraser Duthie; Nigel B. Jamieson; Colin J. McKay; Euan J. Dickson; Alessandra Pulvirenti; Selma Rebus; Paola Piccoli; Nicola Sperandio; Rita T. Lawlor; Michele Milella; Fieke E. M. Froeling; Roberto Salvia; Aldo Scarpa; Andrew V. Biankin; David C. Wedge; David K. Chang
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations

从不吸烟者中940肺癌的微生物组分析显示缺乏临床相关关联

Nature Communications
IF15.7
2025-12-120
OA
John P. McElderry; Tongwu Zhang; Wei Zhao; Phuc H. Hoang; Samuel Anyaso-Samuel; Jian Sang; Azhar Khandekar; Caleb Hartman; Frank J. Colón-Matos; Mona Miraftab; Monjoy Saha; Olivia Lee; Sunandini Sharma; Kristine M. Jones; Bin Zhu; Marcos Díaz-Gay; Luis Mas; Oscar Gerardo Arrieta Rodriguez; Eric S. Edell; Jacobo Martínez Santamaría; Matthew B. Schabath; Sai Yendamuri; Marta Manczuk; Jolanta Lissowska; Beata Świątkowska; Anush Mukeria; Oxana Shangina; David Zaridze; Ivana Holcatova; Vladimir Janout; Dana Mates; Simona Ognjanovic; Milan Savic; Milica Kontic; Yohan Bossé; Bonnie E. Gould Rothberg; David C. Christiani; Valerie Gaborieau; Paul Brennan; Geoffrey Liu; Paul Hofman; Maria Pik Wong; Kin Chung Leung; Chih-Yi Chen; Chao Agnes Hsiung; Nathaniel Rothman; Charles Leduc; Marina K. Baine; William D. Travis; Lynette M. Sholl; Philippe Joubert; Robert Homer; Soo-Ryum Yang; Qing Lan; Martin A. Nowak; David C. Wedge; Ludmil B. Alexandrov; Stephen J. Chanock; Emily Vogtmann; Christian C. Abnet; Jianxin Shi; Maria Teresa Landi
Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma

揭示LINE-1在肺腺癌进化中的作用

Nature
IF48.5
2025-12-100
PRE
Tongwu Zhang; Wei Zhao; Christopher Wirth; Marcos Díaz-Gay; Jinhu Yin; Monia Cecati; Francesca Marchegiani; Phuc H. Hoang; Charles Leduc; Marina K. Baine; William D. Travis; Lynette M. Sholl; Philippe Joubert; Jian Sang; John P. McElderry; Michelle Antony; Alyssa Klein; Azhar Khandekar; Caleb Hartman; Jennifer Rosenbaum; Frank J. Colón-Matos; Mona Miraftab; Monjoy Saha; Olivia W. Lee; Kristine M. Jones; Neil E. Caporaso; Maria Pik Wong; Kin Chung Leung; Chao Agnes Hsiung; Chih-Yi Chen; Eric S. Edell; Jacobo Martínez Santamaría; Matthew B. Schabath; Sai S. Yendamuri; Marta Manczuk; Jolanta Lissowska; Beata Świątkowska; Anush Mukeria; Oxana Shangina; David Zaridze; Ivana Holcatova; Dana Mates; Sasa Milosavljevic; Milan Savic; Yohan Bossé; Bonnie E. Gould Rothberg; David C. Christiani; Valerie Gaborieau; Paul Brennan; Geoffrey Liu; Paul Hofman; Robert Homer; Soo-Ryum Yang; Angela C. Pesatori; Dario Consonni; Lixing Yang; Bin Zhu; Jianxin Shi; Kevin Brown; Nathaniel Rothman; Stephen J. Chanock; Ludmil B. Alexandrov; Jiyeon Choi; Maurizio Cardelli; Qing Lan; Martin A. Nowak; David C. Wedge; Maria Teresa Landi
Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry

致病性变异揭示非洲血统男性前列腺癌遗传检测的候选基因

Nature Communications
IF15.7
2025-10-020
OAAI
Kazzem Gheybi; Pamela X. Y. Soh; Jue Jiang; Tumisang M. N. Mbeki; Melanie Louw; Daniel Burns; Piyushkumar Mundra; Daria Kiriy; Md. Mehedi Hasan; Weerachai Jaratlerdsiri; Maphuti Tebogo Lebelo; Raymond A. Campbell; Mulalo B. Radzuma; Mukudeni Nenzhelele; Muvhulawa Obida; Martin Obida; Winstar M. Ombuki; Micah O. Oyaro; Sean M. Patrick; Massimo Loda; David C. Wedge; Robert G. Bristow; Daniel S. Brewer; Colin S. Cooper; Jüri Reimand; Geraldine Cancel-Tassin; Olivier Cussenot; Chris M. Hovens; Niall M. Cocoran; Phillip D. Stricker; Thorsten Schlomm; Gail S. Prins; Karina Dalsgaard Sørensen; Joachim Weischenfeldt; Shingai B. A. Mutambirwa; Peter M. Ngugi; David M. Thomas; Zsofia Kote-Jarai; Rosalind A. Eeles; M. S. Riana Bornman; Vanessa M. Hayes
The mutagenic forces shaping the genomes of lung cancer in never smokers

在从不吸烟者中塑造肺癌基因组的诱变力

Nature
IF48.5
2025-07-020
PRE
Marcos Díaz-Gay; Tongwu Zhang; Phuc H. Hoang; Charles Leduc; Marina K. Baine; William D. Travis; Lynette M. Sholl; Philippe Joubert; Azhar Khandekar; Wei Zhao; Christopher D. Steele; Burçak Otlu; Shuvro P. Nandi; Raviteja Vangara; Erik N. Bergstrom; Mariya Kazachkova; Oriol Pich; Charles Swanton; Chao Agnes Hsiung; I-Shou Chang; Maria Pik Wong; Kin Chung Leung; Jian Sang; John P. McElderry; Caleb Hartman; Frank J. Colón-Matos; Mona Miraftab; Monjoy Saha; Olivia W. Lee; Kristine M. Jones; Pilar Gallego-García; Yang Yang; Xiaoming Zhong; Eric S. Edell; Jacobo Martínez Santamaría; Matthew B. Schabath; Sai S. Yendamuri; Marta Manczuk; Jolanta Lissowska; Beata Świątkowska; Anush Mukeria; Oxana Shangina; David Zaridze; Ivana Holcatova; Dana Mates; Sasa Milosavljevic; Millica Kontic; Yohan Bossé; Bonnie E. Gould Rothberg; David C. Christiani; Valerie Gaborieau; Paul Brennan; Geoffrey Liu; Paul Hofman; Lixing Yang; Martin A. Nowak; Jianxin Shi; Nathaniel Rothman; David C. Wedge; Robert Homer; Soo-Ryum Yang; Angela C. Pesatori; Dario Consonni; Qing Lan; Bin Zhu; Stephen J. Chanock; Jiyeon Choi; Ludmil B. Alexandrov; Maria Teresa Landi
APOBEC affects tumor evolution and age at onset of lung cancer in smokers

APOBEC影响吸烟者肺癌的肿瘤进化和发病年龄

NATURE COMMUNICATIONS
IF15.7
2025-05-210
OA
Zhang, Tongwu; Sang, Jian; Hoang, Phuc H.; Zhao, Wei; Rosenbaum, Jennifer; Johnson, Kofi Ennu; Klimczak, Leszek J.; McElderry, John; Klein, Alyssa; Wirth, Christopher; Bergstrom, Erik N.; Diaz-Gay, Marcos; Vangara, Raviteja; Colon-Matos, Frank; Hutchinson, Amy; Lawrence, Scott M.; Cole, Nathan; Zhu, Bin; Przytycka, Teresa M.; Shi, Jianxin; Caporaso, Neil E.; Homer, Robert; Pesatori, Angela C.; Consonni, Dario; Imielinski, Marcin; Chanock, Stephen J.; Wedge, David C.; Gordenin, Dmitry A.; Alexandrov, Ludmil B.; Harris, Reuben S.; Landi, Maria Teresa
Genomic landscape of diffuse glioma revealed by whole genome sequencing

Kinnersley, B.; Labussière, M.; Holroyd, A.; Di Stefano, A.L.; Broderick, P.; Vijayakrishnan, J.; Mokhtari, K.; Delattre, J.Y.; Gousias, K.; Schramm, J. 全基因组测序揭示弥漫性胶质瘤的基因组景观。Nat. Commun. 2025, 16, 4233. [Google Scholar] [CrossRef]

Nature Communications
IF15.7
2025-05-070
OAAI
Ben Kinnersley; Josephine Jung; Alex J. Cornish; Daniel Chubb; Ross Laxton; Anna Frangou; Andreas J. Gruber; Amit Sud; Giulio Caravagna; Andrea Sottoriva; David C. Wedge; Thomas Booth; Safa Al-Sarraj; Samuel E. D. Lawrence; Erminia Albanese; Giulio Anichini; David Baxter; Alexandros Boukas; Yasir A. Chowdhury; Pietro D’Urso; Robert Corns; Andrew Dapaah; Ellie Edlmann; Fay Greenway; Paul Grundy; Ciaran S. Hill; Michael D. Jenkinson; Sandhya Trichinopoly Krishna; Stuart Smith; Susruta Manivannan; Andrew J. Martin; Samir Matloob; Soumya Mukherjee; Kevin O’Neill; Puneet Plaha; Jonathan Pollock; Stephen Price; Ola Rominiyi; Bobby Sachdev; Fozia Saeed; Saurabh Sinha; Lewis Thorne; Ismail Ughratdar; Peter Whitfield; Amir Saam Youshani; Helen Bulbeck; Prabhu Arumugam; Richard Houlston; Keyoumars Ashkan
The landscape of microbial associations in human cancer
Science Translational Medicine
IF14.6
2025-01-010
PRE
Abraham Gihawi; Henry M. Wood; Jeremy Clark; Justin O’Grady; Rosalind A. Eeles; David C. Wedge; G. Maria Jakobsdottir; Gkikas Magiorkinis; Andrew Graeme Schache; Liam M. Masterson; Matt Lechner; Tim R. Fenton; Terence M. Jones; Adrienne Margaret Flanagan; Solange De Noon; Alex Rubinsteyn; Rachel Hurst; Colin S. Cooper; Daniel S. Brewer
Genomes and epigenomes of matched normal and tumor breast tissue reveal diverse evolutionary trajectories and tumor-host interactions

匹配的正常和肿瘤乳腺组织的基因组和表观基因组揭示了不同的进化轨迹和肿瘤-宿主相互作用

AMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
2024-12-010
PRE
Zhu, Bin; Tapinos, Avraam; Koka, Hela; Lee, Priscilla Ming Yi; Zhang, Tongwu; Zhu, Wei; Wang, Xiaoyu; Klein, Alyssa; Lee, Donghyuk; Tse, Gary M.; Tsang, Koon-ho; Wu, Cherry; Hua, Min; Highfill, Chad A.; Lenz, Petra; Zhou, Weiyin; Wang, Difei; Luo, Wen; Jones, Kristine; Hutchinson, Amy; Hicks, Belynda; Garcia-Closas, Montserrat; Chanock, Stephen; Tse, Lap Ah; Wedge, David C.; Yang, Xiaohong R.
Genomic landscape of adult testicular germ cell tumours in the 100,000 Genomes Project

100,000基因组计划中成人睾丸生殖细胞肿瘤的基因组景观

NATURE COMMUNICATIONS
IF15.7
2024-10-260
OAAI
Leathlobhair, Maire Ni; Frangou, Anna; Kinnersley, Ben; Cornish, Alex J.; Chubb, Daniel; Lakatos, Eszter; Arumugam, Prabhu; Gruber, Andreas J.; Law, Philip; Tapinos, Avraam; Jakobsdottir, G. Maria; Peneva, Iliana; Sahli, Atef; Smyth, Evie M.; Ball, Richard Y.; Sylva, Rushan; Benes, Ksenija; Stark, Dan; Young, Robin J.; Lee, Alexander T. J.; Wolverson, Vincent; Houlston, Richard S.; Sosinsky, Alona; Protheroe, Andrew; Murray, Matthew J.; Wedge, David C.; Verrill, Clare

研究方向

暂未获取到该数据
P
Peter Van Loo
H 指数:107论文数:458被引数:7.2万
L
Ludmil B. Alexandrov
H 指数:96论文数:482被引数:6.4万
P
Peter J. Campbell
H 指数:159论文数:766被引数:13.3万
M
Michael R. Stratton
H 指数:179论文数:655被引数:19.6万
D
Daniel Brewer
H 指数:52论文数:303被引数:2.2万
S
Serena Nik‐Zainal
H 指数:85论文数:311被引数:5.9万
I
Iñigo Martincorena
H 指数:84论文数:289被引数:4.7万
T
Tongwu Zhang
H 指数:39论文数:257被引数:5,418
R
Rosalind A. Eeles
H 指数:136论文数:1,135被引数:8.8万
G
Gunes Gundem
H 指数:55论文数:237被引数:3.3万