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Cooperative Hedgehog/GLI and JAK/STAT signaling drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer 协同Hedgehog/GLI和JAK/STAT信号通过协同诱导IDO1在皮肤癌中驱动免疫抑制性色氨酸/犬尿氨酸代谢 Elmer, Dominik P.; Stockmaier, Georg; Grund-Groeschke, Sandra; Strobl, Victoria; Dang, Hieu-Hoa; Wiederstein, Markus; Licha, David; Strobl, Anna; Eglseer, Anna; Sternberg, Christina; Tesanovic, Suzana; Gruber, Wolfgang; Wolff, Florian; Moriggl, Richard; Risch, Angela; Reischl, Roland; Huber, Christian G.; Krenn, Peter W.; Fortelny, Nikolaus; Horejs-Hoeck, Jutta; Aberger, Fritz 分享 收藏
Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma 双重特异性STAT3/5降解剂有效阻断急性髓系白血病和自然杀伤/T细胞淋巴瘤 Poloske, Daniel; Sorger, Helena; Schoenbichler, Anna; de Araujo, Elvin D.; Neubauer, Heidi A.; Orlova, Anna; Timonen, Sanna H.; Abdallah, Diaaeldin I.; Ianevski, Aleksandr; Kuusanmaki, Heikki; Surbek, Marta; Heyes, Elisabeth; Eder, Thomas; Wagner, Christina; Suske, Tobias; Metzelder, Martin L.; Bergmann, Michael; Dahlhoff, Maik; Grebien, Florian; Fleck, Roman; Pirker, Christine; Berger, Walter; Hadzijusufovic, Emir; Sperr, Wolfgang R.; Kenner, Lukas; Valent, Peter; Aittokallio, Tero; Herling, Marco; Mustjoki, Satu; Gunning, Patrick T.; Moriggl, Richard 分享 收藏
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression JUN介导衰老相关的分泌表型和免疫细胞募集以预防前列腺癌进展 Redmer, Torben; Raigel, Martin; Sternberg, Christina; Ziegler, Roman; Probst, Clara; Lindner, Desiree; Aufinger, Astrid; Limberger, Tanja; Trachtova, Karolina; Kodajova, Petra; Hoegler, Sandra; Schlederer, Michaela; Stoiber, Stefan; Oberhuber, Monika; Bolis, Marco; Neubauer, Heidi A.; Miranda, Sara; Tomberger, Martina; Harbusch, Nora S.; Garces de los Fayos Alonso, Ines; Sternberg, Felix; Moriggl, Richard; Theurillat, Jean-Philippe; Tichy, Boris; Bystry, Vojtech; Persson, Jenny L.; Mathas, Stephan; Aberger, Fritz; Strobl, Birgit; Pospisilova, Sarka; Merkel, Olaf; Egger, Gerda; Lagger, Sabine; Kenner, Lukas 分享 收藏
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R-STAT5B-driven neoplasms Sumaria, Nital; Fiala, Gina J.; Inacio, Daniel; Curado-Avelar, Marta; Cachucho, Ana; Pinheiro, Ruben; Wiesheu, Robert; Kimura, Shunsuke; Courtois, Lucien; Blankenhaus, Birte; Darrigues, Julie; Suske, Tobias; Almeida, Afonso R. M.; Minguet, Susana; Asnafi, Vahid; Lhermitte, Ludovic; Mullighan, Charles G.; Coffelt, Seth B.; Moriggl, Richard; Barata, Joao T.; Pennington, Daniel J.; Silva-Santos, Bruno 分享 收藏
JAK-STAT signaling maintains homeostasis in T cells and macrophages Fortelny, Nikolaus; Farlik, Matthias; Fife, Victoria; Gorki, Anna-Dorothea; Lassnig, Caroline; Maurer, Barbara; Meissl, Katrin; Dolezal, Marlies; Boccuni, Laura; Geetha, Aarathy Ravi Sundar Jose; Akagha, Mojoyinola Joanna; Karjalainen, Anzhelika; Shoebridge, Stephen; Farhat, Asma; Mann, Ulrike; Jain, Rohit; Tikoo, Shweta; Zila, Nina; Esser-Skala, Wolfgang; Krausgruber, Thomas; Sitnik, Katarzyna; Penz, Thomas; Hladik, Anastasiya; Suske, Tobias; Zahalka, Sophie; Senekowitsch, Martin; Barreca, Daniele; Halbritter, Florian; Macho-Maschler, Sabine; Weninger, Wolfgang; Neubauer, Heidi A.; Moriggl, Richard; Knapp, Sylvia; Sexl, Veronika; Strobl, Birgit; Decker, Thomas; Mueller, Mathias; Bock, Christoph 分享 收藏
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia 过度活跃的STAT5劫持T细胞受体信号并驱动未成熟的T细胞急性淋巴细胞白血病 Suske, Tobias; Sorger, Helena; Manhart, Gabriele; Ruge, Frank; Prutsch, Nicole; Zimmerman, Mark W.; Eder, Thomas; Abdallah, Diaaeldin I.; Maurer, Barbara; Wagner, Christina; Schoenefeldt, Susann; Spirk, Katrin; Pichler, Alexander; Pemovska, Tea; Schweicker, Carmen; Poeloeske, Daniel; Hubanic, Emina; Jungherz, Dennis; Mueller, Tony Andreas; Aung, Myint Myat Khine; Orlova, Anna; Pham, Ha Thi Thanh; Zimmel, Kerstin; Krausgruber, Thomas; Bock, Christoph; Mueller, Mathias; Dahlhoff, Maik; Boersma, Auke; Ruelicke, Thomas; Fleck, Roman; Araujo, Elvin Dominic de; Gunning, Patrick Thomas; Aittokallio, Tero; Mustjoki, Satu; Sanda, Takaomi; Hartmann, Sylvia; Grebien, Florian; Hoermann, Gregor; Haferlach, Torsten; Staber, Philipp Bernhard; Neubauer, Heidi Anne; Look, Alfred Thomas; Herling, Marco; Moriggl, Richard 分享 收藏
Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia 小鼠肠道Cdc42的单基因缺陷导致粘膜炎症，从而诱导隐窝发育异常 Zhang, Dongsheng; Tang, Wenjuan; Niu, Haitao; Tse, William; Ruan, Hai-Bin; Dolznig, Helmut; Knoesel, Thomas; Karl-Heinz, Friedrich; Themanns, Madeleine; Wang, Jiang; Song, Mingquan; Denson, Lee; Kenner, Lukas; Moriggl, Richard; Zheng, Yi; Han, Xiaonan 分享 收藏
Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors Keeley, Aaron B.; Kopranovic, Aleksandra; Di Lorenzo, Vincenzo; Abranyi-Balogh, Peter; Jaensch, Niklas; Lai, Linh N.; Petri, Laszlo; Orgovan, Zoltan; Poeloeske, Daniel; Orlova, Anna; Nemeth, Andras Gyoergy; Desczyk, Charlotte; Imre, Timea; Bajusz, David; Moriggl, Richard; Meyer-Almes, Franz-Josef; Keserue, Gyoergy M. 分享 收藏
ABCC1 and glutathione metabolism limit the efficacy of BCL-2 inhibitors in acute myeloid leukemia ABCC1和谷胱甘肽代谢限制BCL-2抑制剂在急性髓系白血病中的疗效 Ebner, Jessica; Schmoellerl, Johannes; Piontek, Martin; Manhart, Gabriele; Troester, Selina; Carter, Bing Z.; Neubauer, Heidi; Moriggl, Richard; Szakacs, Gergely; Zuber, Johannes; Koecher, Thomas; Andreeff, Michael; Sperr, Wolfgang R.; Valent, Peter; Grebien, Florian 分享 收藏
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway STAT3/LKB1通过调控mTORC1/CREB通路调控转移性前列腺癌 Pencik, Jan; Philippe, Cecile; Schlederer, Michaela; Atas, Emine; Pecoraro, Matteo; Grund-Groeschke, Sandra; Li, Wen (Jess); Tracz, Amanda; Heidegger, Isabel; Lagger, Sabine; Trachtova, Karolina; Oberhuber, Monika; Heitzer, Ellen; Aksoy, Osman; Neubauer, Heidi A.; Wingelhofer, Bettina; Orlova, Anna; Witzeneder, Nadine; Dillinger, Thomas; Redl, Elisa; Greiner, Georg; D'Andrea, David; Ostman, Johnny R.; Tangermann, Simone; Hermanova, Ivana; Schaefer, Georg; Sternberg, Felix; Pohl, Elena E.; Sternberg, Christina; Varady, Adam; Horvath, Jaqueline; Stoiber, Dagmar; Malcolm, Tim I.; Turner, Suzanne D.; Parkes, Eileen E.; Hantusch, Brigitte; Egger, Gerda; Rose-John, Stefan; Poli, Valeria; Jain, Suneil; Armstrong, Chris W. D.; Hoermann, Gregor; Goffin, Vincent; Aberger, Fritz; Moriggl, Richard; Carracedo, Arkaitz; McKinney, Cathal; Kennedy, Richard D.; Klocker, Helmut; Speicher, Michael R.; Tang, Dean G.; Moazzami, Ali A.; Heery, David M.; Hacker, Marcus; Kenner, Lukas 分享 收藏
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Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid cells and mammary epithelial cells Moriggl, R; Berchtold, S; Friedrich, K; Standke, GJR; Kammer, W; Heim, M; Wissler, M; Stocklin, E; Gouilleux, F; Groner, B 分享 收藏
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Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma 在白血病皮肤T细胞淋巴瘤中通过直接或上游激酶靶向阻断STAT3/5 Sorger, Helena; Dey, Saptaswa; Vieyra-Garcia, Pablo Augusto; Poeloeske, Daniel; Teufelberger, Andrea R.; de Araujo, Elvin D.; Sedighi, Abootaleb; Graf, Ricarda; Spiegl, Benjamin; Lazzeri, Isaac; Braun, Till; Alonso, Ines Garces de Los Fayos; Schlederer, Michaela; Timelthaler, Gerald; Kodajova, Petra; Pirker, Christine; Surbek, Marta; Machtinger, Michael; Graier, Thomas; Perchthaler, Isabella; Pan, Yi; Fink-Puches, Regina; Cerroni, Lorenzo; Ober, Jennifer; Otte, Moritz; Albrecht, Jana D.; Tin, Gary; Abdeldayem, Ayah; Manaswiyoungkul, Pimyupa; Olaoye, Olasunkanmi O.; Metzelder, Martin L.; Orlova, Anna; Berger, Walter; Wobser, Marion; Nicolay, Jan P.; Andre, Fiona; Nguyen, Van Anh; Neubauer, Heidi A.; Fleck, Roman; Merkel, Olaf; Herling, Marco; Heitzer, Ellen; Gunning, Patrick T.; Kenner, Lukas; Moriggl, Richard; Wolf, Peter 分享 收藏
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