Rajasekharan Somasundaram

Wistar Institute

H指数:37

被引数:8,358

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NUMB as a Therapeutic Target for Melanoma

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2022-07-016

OAAI

Tumor-B-cell interactions promote isotype switching to an immunosuppressive IgG4 antibody response through upregulation of IL-10 in triple negative breast cancers

在三阴性乳腺癌中，肿瘤-b细胞相互作用通过上调IL-10促进同种型转换为免疫抑制性IgG4抗体反应

JOURNAL OF TRANSLATIONAL MEDICINE

IF7.5

2022-03-0712

OAAI

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

CANCER RESEARCH

IF16.6

2021-08-3014

OAAI

Liu, Jianglan; Rebecca, Vito W.; Kossenkov, Andrew, V; Connelly, Thomas; Liu, Qin; Gutierrez, Alexis; Xiao, Min; Li, Ling; Zhang, Gao; Samarkina, Anastasia; Zayasbazan, Delaine; Zhang, Jie; Cheng, Chaoran; Wei, Zhi; Alicea, Gretchen M.; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Aza-Blanc, Pedro; Yang, Chih-Cheng; Delvadia, Bela; Tong, Cynthia; Huang, Ye; Delvadia, Maya; Morias, Alice S.; Sproesser, Katrin; Brafford, Patricia; Wang, Joshua X.; Beqiri, Marilda; Somasundaram, Rajasekharan; Vultur, Adina; Hristova, Denitsa M.; Wu, Lawrence W.; Lu, Yiling; Mills, Gordon B.; Xu, Wei; Karakousis, Giorgos C.; Xu, Xiaowei; Schuchter, Lynn M.; Mitchell, Tara C.; Amaravadi, Ravi K.; Kwong, Lawrence N.; Frederick, Dennie T.; Boland, Genevieve M.; Salvino, Joseph M.; Speicher, David W.; Flaherty, Keith T.; Ronai, Ze'ev A.; Herlyn, Meenhard

ARID2 Deficiency Correlates with the Response to Immune Blockade in Melanoma

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2021-06-0129

OAAI

Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy

NATURE COMMUNICATIONS

IF15.7

2021-01-12132

OAAI

Somasundaram, Rajasekharan; Connelly, Thomas; Choi, Robin; Choi, Hyeree; Samarkina, Anastasia; Ling Li; Gregorio, Elizabeth; Chen, Yeqing; Thakur, Rohit; Abdel-Mohsen, Mohamed; Beqiri, Marilda; Kiernan, Meaghan; Perego, Michela; Fang Wang; Min Xiao; Brafford, Patricia; Xue Yang; Xu, Xiaowei; Secreto, Anthony; Danet-Desnoyers, Gwenn; Traum, Daniel; Kaestner, Klaus H.; Huang, Alexander C.; Hristova, Denitsa; Wang, Joshua; Fukunaga-Kalabis, Mizuho; Krepler, Clemens; Fang Ping-Chen; Zhou, Xiangyang; Gutierrez, Alexis; Rebecca, Vito W.; Vonteddu, Prashanthi; Dotiwala, Farokh; Bala, Shashi; Majumdar, Sonali; Dweep, Harsh; Wickramasinghe, Jayamanna; Kossenkov, Andrew, V; Reyes-Arbujas, Jorge; Santiago, Kenisha; Nguyen, Tran; Griss, Johannes; Keeney, Frederick; Hayden, James; Gavin, Brian J.; Weiner, David; Montaner, Luis J.; Qin Liu; Peiffer, Lukas; Becker, Juergen; Burton, Elizabeth M.; Davies, Michael A.; Tetzlaff, Michael T.; Muthumani, Kar; Wargo, Jennifer A.; Gabrilovich, Dmitry; Herlyn, Meenhard

Pre-clinical modeling of cutaneous melanoma

NATURE COMMUNICATIONS

IF15.7

2020-06-05153

OAAI

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

NATURE COMMUNICATIONS

IF15.7

2019-09-13257

OAAI

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

衰老皮肤中胶原蛋白基质的重塑促进黑色素瘤转移并影响免疫细胞运动

CANCER DISCOVERY

IF33.3

2019-01-09290

OAAI

Kaur, Amanpreet; Ecker, Brett L.; Douglass, Stephen M.; Kugel, Curtis H., III; Webster, Marie R.; Almeida, Filipe, V; Somasundaram, Rajasekharan; Hayden, James; Ban, Ehsan; Ahmadzadeh, Hossein; Franco-Barraza, Janusz; Shah, Neelima; Mellis, Ian A.; Keeney, Frederick; Kossenkov, Andrew; Tang, Hsin-Yao; Yin, Xiangfan; Liu, Qin; Xu, Xiaowei; Fane, Mitchell; Brafford, Patricia; Herlyn, Meenhard; Speicher, David W.; Wargo, Jennifer A.; Tetzlaff, Michael T.; Haydu, Lauren E.; Raj, Arjun; Shenoy, Vivek; Cukierman, Edna; Weeraratna, Ashani T.

IgG4 expressing B cells associate with poor survival in triple negative breast cancer

CANCER RESEARCH

IF16.6

2018-07-010

PRE

Escape form adaptive drug tolerance through OGT and TET1 mediated H3K4me3 remodeling in MAPKi resistant melanoma

CANCER RESEARCH

IF16.6

2018-07-010

PRE

Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma

EMBO MOLECULAR MEDICINE

IF8.3

2018-04-1170

OAAI

Echevarria-Vargas, Ileabett M.; Reyes-Uribe, Patricia I.; Guterres, Adam N.; Yin, Xiangfan; Kossenkov, Andrew V.; Liu, Qin; Zhang, Gao; Krepler, Clemens; Cheng, Chaoran; Wei, Zhi; Somasundaram, Rajasekharan; Karakousis, Giorgos; Xu, Wei; Morrissette, Jennifer J. D.; Lu, Yiling; Mills, Gordon B.; Sullivan, Ryan J.; Benchun, Miao; Frederick, Dennie T.; Boland, Genevieve; Flaherty, Keith T.; Weeraratna, Ashani T.; Herlyn, Meenhard; Amaravadi, Ravi; Schuchter, Lynn M.; Burd, Christin E.; Aplin, Andrew E.; Xu, Xiaowei; Villanueva, Jessie

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

NATURE COMMUNICATIONS

IF15.7

2017-09-19109

OAAI

Somasundaram, Rajasekharan; Zhang, Gao; Fukunaga-Kalabis, Mizuho; Perego, Michela; Krepler, Clemens; Xu, Xiaowei; Wagner, Christine; Hristova, Denitsa; Zhang, Jie; Tian, Tian; Wei, Zhi; Liu, Qin; Garg, Kanika; Griss, Johannes; Hards, Rufus; Maurer, Margarita; Hafner, Christine; Mayerhoefer, Marius; Karanikas, Georgios; Jalili, Ahmad; Bauer-Pohl, Verena; Weihsengruber, Felix; Rappersberger, Klemens; Koller, Josef; Lang, Roland; Hudgens, Courtney; Chen, Guo; Tetzlaff, Michael; Wu, Lawrence; Frederick, Dennie Tompers; Scolyer, Richard A.; Long, Georgina V.; Damle, Manashree; Ellingsworth, Courtney; Grinman, Leon; Choi, Harry; Gavin, Brian J.; Dunagin, Margaret; Raj, Arjun; Scholler, Nathalie; Gross, Laura; Beqiri, Marilda; Bennett, Keiryn; Watson, Ian; Schaider, Helmut; Davies, Michael A.; Wargo, Jennifer; Czerniecki, Brian J.; Schuchter, Lynn; Herlyn, Dorothee; Flaherty, Keith; Herlyn, Meenhard; Wagner, Stephan N.

A slow-cycling subpopulation of melanoma cells with highly invasive properties

ONCOGENE

IF7.3

2017-09-1861

OAAI

B lymphocytes promote upregulation of an IL-1-NfkB dependent signaling and increase invasiveness of triple negative breast cancer

CANCER RESEARCH

IF16.6

2017-07-010

PRE

The Multifaceted Roles of B Cells in Solid Tumors: Emerging Treatment Opportunities

TARGETED ONCOLOGY