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Chun-Xia Yi
H指数:52
被引数:9,928
个人简介
Lab investigates how neurons and glial cells in the hypothalamus interact to regulate body weight and food intake, focusing on intercellular communication, intracellular metabolism, and organelle dynamics to understand cellular mechanisms underlying energy balance. A key area of interest is the role of microglia as immune regulators within the hypothalamic microenvironment, studying how neurotransmission shapes their phagocytic activity and inflammatory responses. To bridge molecular mechanisms with human health, postmortem brain tissue from individuals with obesity, type 2 diabetes, and Prader-Willi Syndrome is analyzed, and brain cell function in living patients is assessed using advanced imaging techniques such as MRI and PET. The long-term goal is to identify therapeutic targets in microglia and neurons that can restore hypothalamic function in hypercaloric environments and offer new treatment strategies for obesity and type 2 diabetes.
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作者更正: 小鼠下丘脑中的调节性T细胞控制免疫激活并改善高热量环境中的代谢障碍
Nature Communications
IF15.7
时间限制性喂养在饮食诱导的肥胖大鼠中提供了有限的微胶质细胞免疫代谢改善。
Cell Reports
IF6.9
1型或2型糖尿病患者的 Meynert 基底核神经病理学改变
时钟基因多态性与2型糖尿病的关联：一项系统综述和荟萃分析
小鼠下丘脑中的调节性T细胞控制免疫激活并改善高热量环境中的代谢障碍
NATURE COMMUNICATIONS
IF15.7
CELL METABOLISM
IF30.9
靶向细胞型纳米颗粒治疗中枢神经系统疾病: 挑战与希望
SCIENCE SIGNALING
IF6.6
FASEB JOURNAL
IF4.2
