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M

Mark T. Heise

University of North Carolina

60H指数
348论文数
1.4W被引数
收录论文 123
发表时间
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The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism核苷类似物CMX521通过双机制抑制冠状病毒RNA依赖性RNA聚合酶
errJournal of Biological Chemistry
IF3.9
err2026-09-16
err0
errOAAI
errAsif Rakib; Calvin J. Gordon; Thomas K. Anderson; John C. Marecki; Quinte Smitskamp; Nathaniel J. Moorman; Mark T. Heise; Heidi M. Colton; Dean Selleseth; Randall Lanier; Kevin D. Raney; Robert N. Kirchdoerfer; Matthias Götte; David Dulin
err分享
err收藏
Vaccine-Associated Enhanced Respiratory Disease: From Animal Models to Human Health疫苗相关增强性呼吸道疾病：从动物模型到人类健康
errVaccines
IF3.4
err2026-09-11
err0
errOAAI
errJacob A. Dillard; Reina A. Saldivar; Mark T. Heise; Victoria K. Baxter
err分享
err收藏
Structure-guided design of potent and selective covalent inhibitors of SARS-CoV-1 and SARS-CoV-2 papain-like proteases with antiviral activity基于结构的SARS-CoV-1和SARS-CoV-2木瓜样蛋白酶的高效选择性共价抑制剂及其抗病毒活性的设计
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-07-01
err0
PREAI
errAl-Homoudi, Abdullah I.; Kushwaha, Narva Deshwar; Aruri, Hariprasad; Galarza, Diego; Moorman, Nathaniel J.; Heise, Mark T.; Tartamella, Jacob; Ray, Dipankar; Kovari, Ladislau C.; Gavande, Navnath S.
err分享
err收藏
Novel Computational Pipeline to Identify Target Sites for Broad Spectrum Antiviral Drugs新型计算流程用于识别广谱抗病毒药物的目标位点
errAntiviral Research
IF4
err2025-12-01
err0
PREAI
errJohn D. Sears; Konstantin I. Popov; Paul Sylvester; Rebekah Dickmander; Jennifer Loome-Diaz; Che-Kang Chang; Julia Huff; Wes Sanders; Nicholas A. Saba; Madeleine Sorensen; Adam M. Drobish; Nicholas A. May; Kevin Namitz; Julia Fecko; Neela H. Yennawar; Thomas E. Morrison; Alexander Tropsha; Mark T. Heise; Nathaniel J. Moorman
err分享
err收藏
Adaptive immune response to West Nile virus infection in the Collaborative Cross mouse model: A database of cellular phenotypes and Quantitative Trait Loci西尼罗病毒感染在协作杂交小鼠模型中的适应性免疫应答：细胞表型数据库和数量性状位点
errScientific Data
IF6.9
err2025-11-21
err0
errOAAI
errSteven Chamberlin; Jessica Graham; Sophia Jeng; Jessica Swarts; Martin Ferris; Mark Heise; Ralph S. Baric; Shannon McWeeney; Jennifer Lund; Michael Mooney
err分享
err收藏
N -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-10-01
err0
PREAI
errGhoshal, Anirban; Sears, John D.; Hossain, Mohammad Anwar; Tse, Edwin G.; Howell, Stefanie; Burdick, Jane E.; Morales, Noah L.; Martinez, Sabian A.; Law, Isabella; Streblow, Zachary J.; Streblow, Daniel N.; Counago, Rafael M.; Moorman, Nathaniel J.; Heise, Mark T.; Willson, Timothy M.
err分享
err收藏
Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity手性选择性化学探针用于查加斯病毒nsP2解旋酶，并具有抗阿尔法病毒活性
errACS Infectious Diseases
IF3.8
err2025-07-18
err0
errOAAI
errBose Muthu Ramalingam; Hans J. Oh; John D. Sears; Chun-Hsing Chen; Anand Vala; Shubin Liu; Kacey M. Talbot; Mohammed Anwar Hossain; Peter J. Brown; Scott Houliston; Julia Garcia Perez; Fengling Li; Meareg G. Amare; Peter Halfmann; Jessica L. Smith; Alec J. Hirsch; Cheryl H. Arrowsmith; Levon Halabelian; Ava Vargason; Rafael M. Couñago; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson
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err收藏
Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity直接作用型nsP2解旋酶抑制剂的抗甲病毒活性鉴定
errJournal of Medicinal Chemistry
IF6.8
err2025-07-09
err0
errOAAI
errBose Muthu Ramalingam; John D. Sears; Kacey M. Talbot; Yuan-Wei Norman Su; Scott Houliston; Mohammed Anwar Hossain; Zachary W. Davis-Gilbert; Chunqing Zhao; Hans J. Oh; Peter J. Brown; Marcia K. Sanders; Stella R. Moorman; Durbadal Ojha; Jane E. Burdick; Isabella Law; Noah L. Morales; Sabian A. Martinez; Peter Loppnau; Julia Garcia Perez; Adam M. Drobish; Thomas E. Morrison; Zachary J. Streblow; Daniel N. Streblow; Cheryl H. Arrowsmith; Ava Vargason; Rafael M. Couñago; Levon Halabelian; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson
err分享
err收藏
A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity具有抗甲病毒活性和全蛋白质组选择性的基孔肯雅nsP2半胱氨酸蛋白酶的共价化学探针
errSCIENTIFIC REPORTS
IF3.9
err2025-03-01
err0
errOAAI
errGhoshal, Anirban; Tse, Edwin G.; Hossain, Mohammad Anwar; Asressu, Kesatebrhan Haile; Merten, Eric M.; Sears, John D.; Howell, Stefanie; Perveen, Sumera; Burdick, Jane; Morales, Noah L.; Martinez, Sabian A.; Law, Isabella; Davenport, Bennett J.; Morrison, Thomas E.; Streblow, Zachary J.; Streblow, Daniel N.; Mordant, Angie L.; Webb, Thomas S.; Cabrera, Aurora; Herring, Laura E.; Arrowsmith, Cheryl H.; Pearce, Kenneth H.; Moorman, Nathaniel J.; Heise, Mark T.; Counago, Rafael M.; Brown, Peter J.; Willson, Timothy M.
err分享
err收藏
Lethal COVID-19 associates with RAAS- induced inflammation for multiple organ damage including mediastinal lymph nodes
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-11-27
err0
errOAAI
errTopper, Michael J.; Guarnieri, Joseph W.; Haltom, Jeffrey A.; Chadburn, Amy; Cope, Henry; Frere, Justin; An, Julia; Borczuk, Alain; Sinha, Saloni; Kim, Jangkeun; Park, Jiwoon; Butler, Daniel; Meydan, Cem; Foox, Jonathan; Bram, Yaron; Richard, Stephanie A.; Epsi, Nusrat J.; Agan, Brian; Chenoweth, Josh G.; Simons, Mark P.; Tribble, David; Burgess, Timothy; Dalgard, Clifton; Heise, Mark T.; Moorman, Nathaniel J.; Baxter, Victoria K.; Madden, Emily A.; Taft-Benz, Sharon A.; Anderson, Elizabeth J.; Sanders, Wes A.; Dickmander, Rebekah J.; Beigel, Katherine; Widjaja, Gabrielle A.; Janssen, Kevin A.; Lie, Timothy; Murdock, Deborah G.; Angelin, Alessia; Albrecht, Yentli E. Soto; Olali, Arnold Z.; Cen, Zimu; Dybas, Joseph; Priebe, Waldemar; Emmett, Mark R.; Best, Sonja M.; Johnson, Maya Kelsey; Trovao, Nidia S.; Clark, Kevin B.; Zaksas, Victoria; Meller, Robert; Grabham, Peter; Schisler, Jonathan C.; Moraes-Vieira, Pedro M.; Pollett, Simon; Mason, Christopher E.; Wurtele, Eve Syrkin; Taylor, Deanne; Schwartz, Robert E.; Beheshti, Afshin; Wallace, Douglas C.; Baylin, Stephen B.
err分享
err收藏
Myeloperoxidase-ANCA IgG induces different forms of small vessel vasculitis based on type of synergistic immune stimuli
errKIDNEY INTERNATIONAL
IF12.6
err2024-11-01
err0
PREAI
errHu, Peiqi; Xiao, Hong; Alba, Marco A.; Atkins, Hannah M.; Gou, Shenju; Hu, Yanglin; Gomez, John C.; Jania, Corey M.; Martin, Jessica R.; Morrison, Thomas E.; Tilley, Stephen L.; Heise, Mark T.; Doerschuk, Claire M.; Falk, Ronald J.; Jennette, J. Charles
err分享
err收藏
Identification of a cell- active chikungunya virus nsP2 protease inhibitor using a covalent fragment- based screening approach
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-10-10
err0
PREAI
errMerten, Eric M.; Sears, John D.; Leisner, Tina M.; Hardy, P. Brian; Ghoshal, Anirban; Hossain, Mohammad Anwar; Asressu, Kesatebrhan Haile; Brown, Peter J.; Tse, Edwin G.; Stashko, Michael A.; Li, Kelin; Drouin, Jacqueline L. Norris -; Herring, Laura E.; Mordant, Angie L.; Webb, Thomas S.; Mills, Christine A.; Barker, Natalie K.; Streblow, Zachary J.; Perveen, Sumera; Arrowsmith, Cheryl H.; Counago, Rafael Miguez; Arnold, Jamie J.; Cameron, Craig E.; Streblow, Daniel N.; Moorman, Nathaniel J.; Heise, Mark T.; Willson, Timothy M.; Popov, Konstantin I.; Pearce, Kenneth H.
err分享
err收藏
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-05
err1
errOAAI
errGhoshal, Anirban; Asressu, Kesatebrhan Haile; Hossain, Mohammad Anwar; Brown, Peter J.; Nandakumar, Meganathan; Vala, Anand; Merten, Eric M.; Sears, John D.; Law, Isabella; Burdick, Jane E.; Morales, Noah L.; Perveen, Sumera; Pearce, Kenneth H.; Popov, Konstantin I.; Moorman, Nathaniel J.; Heise, Mark T.; Willson, Timothy M.
err分享
err收藏
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2
errMOLECULES
IF4.6
err2024-09-02
err0
errOAAI
errOng, Han Wee; Yang, Xuan; Smith, Jeffery L.; Taft-Benz, Sharon; Howell, Stefanie; Dickmander, Rebekah J.; Havener, Tammy M.; Sanders, Marcia K.; Brown, Jason W.; Counago, Rafael M.; Chang, Edcon; Kraemer, Andreas; Moorman, Nathaniel J.; Heise, Mark; Axtman, Alison D.; Drewry, David H.; Willson, Timothy M.
err分享
err收藏
Chikungunya Virus RNA Secondary Structures Impact Defective Viral Genome Production基孔肯雅病毒RNA二级结构影响有缺陷的病毒基因组生产
errMICROORGANISMS
IF4.2
err2024-08-29
err1
errOAAI
errLevi, Laura I.; Madden, Emily A.; Boussier, Jeremy; Erazo, Diana; Sanders, Wes; Vallet, Thomas; Bernhauerova, Veronika; Moorman, Nathaniel J.; Heise, Mark T.; Vignuzzi, Marco
err分享
err收藏
A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants
errNATURE COMMUNICATIONS
IF15.7
err2024-08-26
err0
errOAAI
errLiu, Xiang; Ng, Wern Hann; Zusinaite, Eva; Freitas, Joseph; Taylor, Adam; Yerragunta, Venugopal; Aavula, Shukra Madhaha; Gorriparthi, Sambaiah; Ponsekaran, Santhakumar; Bonda, Rama Lakshmi; Mani, Priyanka; Nimmagadda, Sridevi V.; Wang, Sainan; Lello, Laura Sandra; Zaid, Ali; Dua, Ujjwal; Taft-Benz, Sharon A.; Anderson, Elizabeth; Baxter, Victoria K.; Sarkar, Sanjay; Ling, Zheng L.; Ashhurst, Thomas M.; Cheng, Samuel M. S.; Pattnaik, Priyabrata; Kanakasapapathy, Anand Kumar; Baric, Ralph S.; Burt, Felicity J.; Peiris, Malik; Heise, Mark T.; King, Nicholas J. C.; Merits, Andres; Lingala, Rajendra; Mahalingam, Suresh
err分享
err收藏
Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-08-13
err1
errOAAI
errSchughart, Klaus; Smith, Amber M.; Tsalik, Ephraim L.; Threlkeld, Stephen C.; Sellers, Subhashini; Fischer, William A.; Schreiber, Jens; Luecke, Eva; Cornberg, Markus; Debarry, Jennifer; Woods, Christopher W.; McClain, Micah T.; Heise, Mark
err分享
err收藏
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-07-03
err2
errOAAI
errOng, Han Wee; Yang, Xuan; Smith, Jeffery L.; Dickmander, Rebekah J.; Brown, Jason W.; Havener, Tammy M.; Taft-Benz, Sharon; Howell, Stefanie; Sanders, Marcia K.; Capener, Jacob L.; Counago, Rafael M.; Chang, Edcon; Kraemer, Andreas; Moorman, Nathaniel J.; Heise, Mark; Axtman, Alison D.; Drewry, David H.; Willson, Timothy M.
err分享
err收藏
A 44-Nucleotide Region in the Chikungunya Virus 3′ UTR Dictates Viral Fitness in Disparate Host Cells
errVIRUSES-BASEL
IF3.5
err2024-05-28
err1
errOAAI
errAnder, Stephanie E.; Carpentier, Kathryn S.; Sanders, Wes; Lucas, Cormac J.; Jolly, Austin J.; Johnson, Cydney N.; Hawman, David W.; Heise, Mark T.; Moorman, Nathaniel J.; Morrison, Thomas E.
err分享
err收藏
Adjuvant-dependent impact of inactivated SARS-CoV-2 vaccines during heterologous infection by a SARS-related coronavirus
errNATURE COMMUNICATIONS
IF15.7
err2024-05-03
err1
errOAAI
errDillard, Jacob A.; Taft-Benz, Sharon A.; Knight, Audrey C.; Anderson, Elizabeth J.; Pressey, Katia D.; Parotti, Breantie; Martinez, Sabian A.; Diaz, Jennifer L.; Sarkar, Sanjay; Madden, Emily A.; de la Cruz, Gabriela; Adams, Lily E.; Dinnon, Kenneth H.; Leist, Sarah R.; Martinez, David R.; Schafer, Alexandra; Powers, John M.; Yount Jr, Boyd L.; Castillo, Izabella N.; Morales, Noah L.; Burdick, Jane; Evangelista, Mia Katrina D.; Ralph, Lauren M.; Pankow, Nicholas C.; Linnertz, Colton L.; Lakshmanane, Premkumar; Montgomery, Stephanie A.; Ferris, Martin T.; Baric, Ralph S.; Baxter, Victoria K.; Heise, Mark T.
err分享
err收藏

研究方向

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合作期刊
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