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SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response SOD2是蛋白酶体降解的调控因子，促进适应性细胞饥饿反应。 Ibrahim, Nurul Khalida; Schreek, Sabine; Cinar, Buesra; Stasche, Anna Sophie; Lee, Su Hyun; Zeug, Andre; Dolgner, Tim; Niessen, Julia; Ponimaskin, Evgeni; Shcherbata, Halyna; Fehlhaber, Beate; Bourquin, Jean-Pierre; Bornhauser, Beat; Stanulla, Martin; Pich, Andreas; Gutierrez, Alejandro; Hinze, Laura 分享 收藏
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation METTL1在tRNA氨酰化及癌基因转化中的甲基转移酶非依赖性作用 Ali, Raja H.; Orellana, Esteban A.; Lee, Su Hyun; Chae, Yun-Cheol; Chen, Yantao; Clauwaert, Jim; Kennedy, Alyssa L.; Gutierrez, Ashley E.; Papke, David J.; Valenzuela, Mateo; Silverman, Brianna; Falzetta, Amanda; Ficarro, Scott B.; Marto, Jarrod A.; Fletcher, Christopher D. M.; Perez-Atayde, Antonio; Alcindor, Thierry; Shimamura, Akiko; Prensner, John R.; Gregory, Richard I.; Gutierrez, Alejandro 分享 收藏
A noncatalytic role for mettl1 in oncogenic translation in soft tissue sarcoma Ali, Raja Hussain; Silverman, Brianna; Orellana, Esteban A.; Kennedy, Alyssa; Bowers, Caitlin; Gutierrez, Ashley; Papke, David; Fletcher, Christopher D.; Atayde, Antonio P.; Shimamura, Akiko; Gregory, Richard I.; Gutierrez, Alejandro 分享 收藏
Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression Emi1在斑马鱼胚胎发生过程中维持基因组完整性，并与p53协同抑制肿瘤 Rhodes, Jennifer; Amsterdam, Adam; Sanda, Takaomi; Moreau, Lisa A.; McKenna, Keith; Heinrichs, Stefan; Ganem, Neil J.; Ho, Karen W.; Neuberg, Donna S.; Johnston, Adam; Ahn, Yebin; Kutok, Jeffery L.; Hromas, Robert; Wray, Justin; Lee, Charles; Murphy, Carly; Radtke, Ina; Downing, James R.; Fleming, Mark D.; MacConaill, Laura E.; Amatruda, James F.; Gutierrez, Alejandro; Galinsky, Ilene; Stone, Richard M.; Ross, Eric A.; Pellman, David S.; Kanki, John P.; Look, A. Thomas 分享 收藏
Supramolecular assembly of GSK3α as a cellular response to amino acid starvation Hinze, Laura; Schreek, Sabine; Zeug, Andre; Ibrahim, Nurul Khalida; Fehlhaber, Beate; Loxha, Lorent; Cinar, Buesra; Ponimaskin, Evgeni; Degar, James; McGuckin, Connor; Chiosis, Gabriela; Eckert, Cornelia; Cario, Gunnar; Bornhauser, Beat; Bourquin, Jean-Pierre; Stanulla, Martin; Gutierrez, Alejandro 分享 收藏
JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia Bodaar, Kimberly; Yamagata, Natsuko; Barthe, Anais; Landrigan, Jack; Chonghaile, Triona Ni; Burns, Melissa; Stevenson, Kristen E.; Devidas, Meenakshi; Loh, Mignon L.; Hunger, Stephen P.; Wood, Brent; Silverman, Lewis B.; Teachey, David T.; Meijerink, Jules P.; Letai, Anthony; Gutierrez, Alejandro 分享 收藏
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation Orellana, Esteban A.; Liu, Qi; Yankova, Eliza; Pirouz, Mehdi; De Braekeleer, Etienne; Zhang, Wencai; Lim, Jihoon; Aspris, Demetrios; Sendinc, Erdem; Garyfallos, Dimitrios A.; Gu, Muxin; Ali, Raja; Gutierrez, Alejandro; Mikutis, Sigitas; Bernardes, Goncalo J. L.; Fischer, Eric S.; Bradley, Allan; Vassiliou, George S.; Slack, Frank J.; Tzelepis, Konstantinos; Gregory, Richard I. 分享 收藏
Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy Hinze, Laura; Labrosse, Roxane; Degar, James; Han, Teng; Schatoff, Emma M.; Schreek, Sabine; Karim, Salmaan; McGuckin, Connor; Sacher, Joshua R.; Wagner, Florence; Stanulla, Martin; Yuan, Chen; Sicinska, Ewa; Giannakis, Marios; Ng, Kimmie; Dow, Lukas E.; Gutierrez, Alejandro 分享 收藏
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PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis Garcia, E. G.; Veloso, A.; Oliveira, M. L.; Allen, J. R.; Loontiens, S.; Brunson, D.; Do, D.; Yan, C.; Morris, R.; Iyer, S.; Garcia, S. P.; Iftimia, N.; Van Loocke, W.; Matthijssens, F.; McCarthy, K.; Barata, J. T.; Speleman, F.; Taghon, T.; Gutierrez, A.; Van Vlierberghe, P.; Haas, W.; Blackburn, J. S.; Langenau, D. M. 分享 收藏
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia Aries, Ingrid M.; Bodaar, Kimberly; Karim, Salmaan A.; Chonghaile, Triona Ni; Hinze, Laura; Burns, Melissa A.; Pfirrmann, Maren; Degar, James; Landrigan, Jack T.; Balbach, Sebastian; Peirs, Sofie; Menten, Bjorn; Isenhart, Randi; Stevenson, Kristen E.; Neuberg, Donna S.; Devidas, Meenakshi; Loh, Mignon L.; Hunger, Stephen P.; Teachey, David T.; Rabin, Karen R.; Winter, Stuart S.; Dunsmore, Kimberly P.; Wood, Brent L.; Silverman, Lewis B.; Sallan, Stephen E.; Van Vlierberghe, Pieter; Orkin, Stuart H.; Knoechel, Birgit; Letai, Anthony G.; Gutierrez, Alejandro 分享 收藏
BCL-2 family compensation regulates T cell homeostasis and reveals a BIM: BCL-W axis in T-ALL Ludwig, Lindsey M.; Roach, Lauren E.; Katz, Samuel G.; Fisher, Jill K.; Burns, Melissa; Schnorenberg, Matthew R.; Bao, Riyue; Zewde, Makda; Nakamura, Yusuke; Gutierrez, Alejandro; Walensky, Loren D.; LaBelle, James L. 分享 收藏
JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia Mansour, Marc R.; He, Shuning; Li, Zhaodong; Lobbardi, Riadh; Abraham, Brian J.; Hug, Clemens; Rahman, Sunniyat; Leon, Theresa E.; Kuang, You-Yi; Zimmerman, Mark W.; Blonquist, Traci; Gjini, Evisa; Gutierrez, Alejandro; Tang, Qin; Garcia-Perez, Laura; Pike-Overzet, Karin; Anders, Lars; Berezovskaya, Alla; Zhou, Yi; Zon, Leonard I.; Neuberg, Donna; Fielding, Adele K.; Staal, Frank J. T.; Langenau, David M.; Sanda, Takaomi; Young, Richard A.; Look, A. Thomas 分享 收藏
Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia Burns, Melissa A.; Liao, Zi Wei; Yamagata, Natsuko; Pouliot, Gayle P.; Stevenson, Kristen E.; Neuberg, Donna S.; Thorner, Aaron R.; Ducar, Matthew; Silverman, Emily A.; Hunger, Stephen P.; Loh, Mignon L.; Winter, Stuart S.; Dunsmore, Kimberly P.; Wood, Brent; Devidas, Meenakshi; Harris, Marian H.; Silverman, Lewis B.; Sallan, Stephen E.; Gutierrez, Alejandro 分享 收藏
An off-the-shelf fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies Cooper, Matthew L.; Choi, Jaebok; Staser, Karl; Ritchey, Julie K.; Devenport, Jessica M.; Eckardt, Kayla; Rettig, Michael P.; Wang, Bing; Eissenberg, Linda G.; Ghobadi, Armin; Gehrs, Leah N.; Prior, Julie L.; Achilefu, Samuel; Miller, Christopher A.; Fronick, Catrina C.; O'Neal, Julie; Gao, Feng; Weinstock, David M.; Gutierrez, Alejandro; Fulton, Robert S.; DiPersio, John F. 分享 收藏
TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia Lobbardi, Riadh; Pinder, Jordan; Martinez-Pastor, Barbara; Theodorou, Marina; Blackburn, Jessica S.; Abraham, Brian J.; Namiki, Yuka; Mansour, Marc; Abdelfattah, Nouran S.; Molodtsov, Aleksey; Alexe, Gabriela; Toiber, Debra; de Waard, Manon; Jain, Esha; Boukhali, Myriam; Lion, Mattia; Bhere, Deepak; Shah, Khalid; Gutierrez, Alejandro; Stegmaier, Kimberly; Silverman, Lewis B.; Sadreyev, Ruslan I.; Asara, John M.; Oettinger, Marjorie A.; Haas, Wilhelm; Look, A. Thomas; Young, Richard A.; Mostoslavsky, Raul; Dellaire, Graham; Langenau, David M. 分享 收藏
Thymocyte selection-associated HMG box protein (TOX) induces genomic instability in T-cell acute lymphoblastic leukemia Lobbardi, Riadh; Pinder, Jordan; Martinez-Pastor, Barbara; Blackburn, Jessica; Abraham, Brian J.; Mansour, Marc; Abdelfattah, Nouran S.; Molodtsov, Aleksey; Alexe, Gabriela; Toiber, Debra; de Waard, Manon; Jain, Esha; Bhere, Deepak; Shah, Khalid; Gutierrez, Alejandro; Stegmaier, Kimberly; Silverman, Lewis B.; Sadreyev, Ruslan; Asara, John; Look, A. Thomas; Young, Richard A.; Mostoslaysky, Raul; Dellaire, Graham; Langenau, David M. 分享 收藏
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