未登录 Current Status and Future Directions: The Application of Artificial Intelligence/Machine Learning for Precision Medicine Naik, Kunal; Goyal, Rahul K.; Foschini, Luca; Chak, Choi Wai; Thielscher, Christian; Zhu, Hao; Lu, James; Lehar, Joseph; Pacanoswki, Michael A.; Terranova, Nadia; Mehta, Neha; Korsbo, Niklas; Fakhouri, Tala; Liu, Qi; Gobburu, Jogarao 分享 收藏
Quantifying neurologic disease using biosensor measurements in-clinic and in free-living settings in multiple sclerosis 在多发性硬化症的临床和自由生活环境中使用生物传感器测量来量化神经系统疾病 Chitnis, Tanuja; Glanz, Bonnie I.; Gonzalez, Cindy; Healy, Brian C.; Saraceno, Taylor J.; Sattarnezhad, Neda; Diaz-Cruz, Camilo; Polgar-Turcsanyi, Mariann; Tummala, Subhash; Bakshi, Rohit; Bajaj, Vikram S.; Ben-Shimol, David; Bikhchandani, Nikhil; Blocker, Alexander W.; Burkart, Joshua; Cendrillon, Raphael; Cusack, Michael P.; Demiralp, Emre; Jooste, Sarel Kobus; Kharbouch, Alaa; Lee, Amy A.; Lehar, Joseph; Liu, Manway; Mahadevan, Swaminathan; Murphy, Mark; Norton, Linda C.; Parlikar, Tushar A.; Pathak, Anupam; Shoeb, Ali; Soderberg, Erin; Stephens, Philip; Stoertz, Aaron H.; Thng, Florence; Tumkur, Kashyap; Wang, Hongsheng; Rhodes, Jane; Rudick, Richard A.; Ransohoff, Richard M.; Phillips, Glenn A.; Bruzik, Effie; Marks, William J.; Weiner, Howard L.; Snyder, Thomas M. 分享 收藏
Automated deep-neural-network surveillance of cranial images for acute neurologic events 用于急性神经系统事件的颅骨图像的自动深度神经网络监视 Titano, Joseph J.; Badgeley, Marcus; Schefflein, Javin; Pain, Margaret; Su, Andres; Cai, Michael; Swinburne, Nathaniel; Zech, John; Kim, Jun; Bederson, Joshua; Mocco, J.; Drayer, Burton; Lehar, Joseph; Cho, Samuel; Costa, Anthony; Oermann, Eric K. 分享 收藏
Natural Language-based Machine Learning Models for the Annotation of Clinical Radiology Reports Zech, John; Pain, Margaret; Titano, Joseph; Badgeley, Marcus; Schefflein, Javin; Su, Andres; Costa, Anthony; Bederson, Joshua; Lehar, Joseph; Oermann, Eric Karl 分享 收藏
Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model Chapeau, Emilie A.; Gembarska, Agnieszka; Durand, Eric Y.; Mandon, Emeline; Estadieu, Claire; Romanet, Vincent; Wiesmann, Marion; Tiedt, Ralph; Lehar, Joseph; de Weck, Antoine; Rad, Roland; Barys, Louise; Jeay, Sebastien; Ferretti, Stephane; Kauffmann, Audrey; Sutter, Esther; Grevot, Armelle; Moulin, Pierre; Murakami, Masato; Sellers, William R.; Hofmann, Francesco; Jensen, Michael Rugaard 分享 收藏
High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells Horn, Thomas; Ferretti, Stephane; Ebel, Nicolas; Tam, Angela; Ho, Samuel; Harbinski, Fred; Farsidjani, Ali; Zubrowski, Matthew; Sellers, William R.; Schlegel, Robert; Porter, Dale; Morris, Erick; Wuerthner, Jens; Jeay, Sebastien; Greshock, Joel; Halilovic, Ensar; Garraway, Levi A.; Caponigro, Giordano; Lehar, Joseph 分享 收藏
High order drug combinations are required to effectively kill colorectal cancer cells Horn, Thomas; Ferretti, Stephane; Ebel, Nicolas; Tam, Angela; Ho, Samuel; Harbinski, Fred; Farsidjani, Ali; Zubrowski, Matt; Sellers, William R.; Schlegel, Robert; Porter, Dale; Morris, Erick; Wuerthner, Jens; Jeay, Sebastien; Greshock, Joel; Halilovic, Ensar; Garraway, Levi A.; Caponigro, Giordano; Lehar, Joseph 分享 收藏
High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response 使用患者来源的肿瘤异种移植物进行高通量筛选以预测临床试验药物反应 Gao, Hui; Korn, Joshua M.; Ferretti, Stephane; Monahan, John E.; Wang, Youzhen; Singh, Mallika; Zhang, Chao; Schnell, Christian; Yang, Guizhi; Zhang, Yun; Balbin, O. Alejandro; Barbe, Stephanie; Cai, Hongbo; Casey, Fergal; Chatterjee, Susmita; Chiang, Derek Y.; Chuai, Shannon; Cogan, Shawn M.; Collins, Scott D.; Dammassa, Ernesta; Ebel, Nicolas; Embry, Millicent; Green, John; Kauffmann, Audrey; Kowa, Colleen; Leary, Rebecca J.; Lehar, Joseph; Liang, Ying; Loo, Alice; Lorenzana, Edward; McDonald, E. Robert, III; McLaughlin, Margaret E.; Merkin, Jason; Meyer, Ronald; Naylor, Tara L.; Patawaran, Montesa; Reddy, Anupama; Roeelli, Claudia; Ruddy, David A.; Salangsang, Fernando; Santacroce, Francesca; Singh, Angad P.; Tang, Yan; Tinetto, Walter; Tobler, Sonja; Velazquez, Roberto; Venkatesan, Kavitha; Von Arx, Fabian; Wang, Hui Qin; Wang, Zongyao; Wiesmann, Marion; Wyss, Daniel; Xu, Fiona; Bitter, Hans; Atadja, Peter; Lees, Emma; Hofmann, Francesco; Li, En; Keen, Nicholas; Cozens, Robert; Jensen, Michael Rugaard; Pryer, Nancy K.; Williams, Juliet A.; Sellers, William R. 分享 收藏
High allele frequency of KRAS functional mutations predicts resistance to MEK inhibitors: Evidence from cell lines and human tumor xenograft models Reddy, Anupama; Pinzon-Ortiz, Maria; Derti, Adnan; Korn, Joshua; Ruddy, David; Yang, Guizhi; Green, John; Gao, Hui; Lehar, Joseph; Caponigro, Giordano; Cao, Z. Alexander 分享 收藏
A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity 已批准药物和分子探针的筛选鉴定具有抗埃博拉病毒活性的治疗剂 Johansen, Lisa M.; DeWald, Lisa Evans; Shoemaker, Charles J.; Hoffstrom, Benjamin G.; Lear-Rooney, Calli M.; Stossel, Andrea; Nelson, Elizabeth; Delos, Sue E.; Simmons, James A.; Grenier, Jill M.; Pierce, Laura T.; Pajouhesh, Hassan; Lehar, Joseph; Hensley, Lisa E.; Glass, Pamela J.; White, Judith M.; Olinger, Gene G. 分享 收藏
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Inhibiting TNKS sensitizes KRAS mutant cancer cells to MEK inhibitors by suppressing FGFR2 feedback signaling Shao, Wenlin; Schoumacher, Marie; Hurov, Kristen; Lehar, Joseph; Yan-Neale, Yan; Mishina, Yuji; Sonkin, Dmitriy; Korn, Joshua; Flemming, Daisy; Jones, Michael; Antonakos, Brandon; Cooke, Vessilina; Stump, Mark; Danial, Nika; Sellers, William 分享 收藏
Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling Schoumacher, Marie; Hurov, Kristen E.; Lehar, Joseph; Yan-Neale, Yan; Mishina, Yuji; Sonkin, Dmitriy; Korn, Joshua M.; Flemming, Daisy; Jones, Michael D.; Antonakos, Brandon; Cooke, Vesselina G.; Steiger, Janine; Ledell, Jebediah; Stump, Mark D.; Sellers, William R.; Danial, Nika N.; Shao, Wenlin 分享 收藏
Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials 新型特异性PI3Kα 抑制剂NVP-BYL719的特征和临床试验患者分层策略的发展 Fritsch, Christine; Huang, Alan; Chatenay-Rivauday, Christian; Schnell, Christian; Reddy, Anupama; Liu, Manway; Kauffmann, Audrey; Guthy, Daniel; Erdmann, Dirk; De Pover, Alain; Furet, Pascal; Gao, Hui; Ferretti, Stephane; Wang, Youzhen; Trappe, Joerg; Brachmann, Saskia M.; Maira, Sauveur-Michel; Wilson, Christopher; Boehm, Markus; Garcia-Echeverria, Carlos; Chene, Patrick; Wiesmann, Marion; Cozens, Robert; Lehar, Joseph; Schlegel, Robert; Caravatti, Giorgio; Hofmann, Francesco; Sellers, William R. 分享 收藏
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Evaluation of prediction of in vivo activity from in vitro combinations: Examples using a MEK1/2 inhibitor combined with docetaxel in NSCLC models. Mcsheehy, Paul Martin J.; Cao, Alex; Caponigro, Giordi; Duhl, David; Firestone, Brant; Gesner, Tom; Guthy, Daniel; Holash, Jocelyn; King, Fred; Lehar, Joseph; Leroy, Christopher; Liu, Manway; Petruzzellil, Lilli; Porter, Dale; Menezes, Daniel; Reddy, Anupama; Roesel, Johannes; Schnell, Christian; Smith, Timothy; Stump, Mark; Wartmann, Markus; Wiesmann, Marion 分享 收藏
FDA-Approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection FDA批准的选择性雌激素受体调节剂抑制埃博拉病毒感染 Johansen, Lisa M.; Brannan, Jennifer M.; Delos, Sue E.; Shoemaker, Charles J.; Stossel, Andrea; Lear, Calli; Hoffstrom, Benjamin G.; DeWald, Lisa Evans; Schornberg, Kathryn L.; Scully, Corinne; Lehar, Joseph; Hensley, Lisa E.; White, Judith M.; Olinger, Gene G. 分享 收藏
Towards defining the genetic framework for clinical response to treatment with BYL719, a PI3Kalpha-specific inhibitor. Rodon, Jordi; Juric, Dejan; Gonzalez-Angulo, Ana-Maria; Bendell, Johanna; Berlin, Jordan; Bootle, Douglas; Gravelin, Kathlene; Huang, Alan; Derti, Adnan; Lehar, Joseph; Wuerthner, Jens; Boehm, Markus; van Allen, Eliezer; Wagle, Nikhil; Garraway, Levi A.; Yelensky, Roman; Stephens, Philip J.; Miller, Vincent A.; Schlegel, Robert; Quadt, Cornelia; Baselga, Jose 分享 收藏
The Cancer Cell Line Encyclopedia - Using Preclinical Models to Predict Anticancer Drug Sensitivity Barretina, J.; Caponigro, G.; Stransky, N.; Venkatesan, K.; Margolin, A. A.; Kim, S.; Wilson, C. J.; Lehar, J.; Kryukov, G. V.; Murray, L.; Morrissey, M. P.; Sellers, W. R.; Schlegel, R.; Garraway, L. A. 分享 收藏
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