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宋

宋明柯 (Mingke Song)

shanghai jiao tong university

H指数:27

被引数:2,699

个人简介

任职于药理学与化学生物学系，教授，博士生导师。主要研究方向为神经药理学和神经退行性疾病。曾在美国埃默里大学进行博士后研究，并担任DSAC学生研究论坛特邀评委。目前担任上海市药理学会心血管专业委员会学术委员，美国神经科学学会会员，中国神经科学学会神经退行性疾病分会学术委员。主持多项国家自然科学基金项目及上海市高水平地方高校建设项目。研究领域涵盖阿尔茨海默病的早期生物标志物、干细胞移植修复缺血性脑损伤、光遗传学刺激促进神经分化、神经退行性疾病与胶质瘤的细胞死亡机制等。

教育背景

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工作经历

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荣誉奖项

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Imaging asparaginyl endopeptidase (AEP) in the live brain as a biomarker for Alzheimer's disease

JOURNAL OF NANOBIOTECHNOLOGY

IF12.6

2021-08-196

OAAI

Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer's disease-related pathologies in a senescence-accelerated mouse model

Δ-分泌酶抑制剂11对天冬酰胺酰内肽酶的药理抑制作用可减轻衰老加速小鼠模型中与阿尔茨海默氏病相关的病理

TRANSLATIONAL NEURODEGENERATION

IF15.2

2021-03-3144

OAAI

Psychological stress responses to COVID-19 and adaptive strategies in China

WORLD DEVELOPMENT

IF4.8

2020-12-0153

OAAI

Blockade of the forward Na+/Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+-mediated cell death

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2019-06-1727

OAAI

δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease

MOLECULAR PSYCHIATRY

IF10.1

2018-10-3155

OAAI

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease

NATURE COMMUNICATIONS

IF15.7

2017-03-27105

OAAI

Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice

NEUROBIOLOGY OF DISEASE

IF5.6

2017-02-0167

OAAI

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

NATURE COMMUNICATIONS

IF15.7

2015-11-09225

OAAI

iPSC Transplantation Increases Regeneration and Functional Recovery After Ischemic Stroke in Neonatal Rats

IF3.6

2014-11-2673

PREAI

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

NATURE MEDICINE

IF50

2014-10-19391

OAAI

Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells

IF3.4

2014-09-2680

OAAI

The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na+/Ca2+ exchanger and increasing intracellular Ca2+

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2014-06-2556

OAAI

Ionic Regulation of Cell Volume Changes and Cell Death after Ischemic Stroke

TRANSLATIONAL STROKE RESEARCH

IF4.3

2013-12-07112

OA

Restoration of Intracortical and Thalamocortical Circuits After Transplantation of Bone Marrow Mesenchymal Stem Cells Into the Ischemic Brain of Mice

CELL TRANSPLANTATION

IF3.2

2013-11-0167

PREAI

Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms

JOURNAL OF CELL BIOLOGY

IF6.4

2013-09-3035

OAAI

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer's Disease

7，8-二羟基黄酮可预防阿尔茨海默氏病小鼠模型的突触丧失和记忆缺陷

NEUROPSYCHOPHARMACOLOGY

IF7.1

2013-09-11213

OA

Highly efficient differentiation of neural precursors from human embryonic stem cells and benefits of transplantation after ischemic stroke in mice

STEM CELL RESEARCH & THERAPY

IF7.3

2013-08-0836

OAAI

Novel role of KCNQ2/3 channels in regulating neuronal cell viability

CELL DEATH AND DIFFERENTIATION

IF15.4

2010-10-0128

OAAI

Peripheral cholinoceptor antagonist anisodamine counteracts cholinergic adverse effects and facilitates cognitive amelioration of rivastigmine

JOURNAL OF NEURAL TRANSMISSION

IF4

2009-09-128

PREAI

Electrophysiological characterization of 14-benzoyltalatisamine, a selective blocker of the delayed rectifier K+ channel found in virtual screening

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2006-02-019

PREAI