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R

Ryan M. Esquejo

Pfizer
H指数:10
被引数:1,397

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Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61; an Orphan G Protein-Coupled Receptor

发现强效且能透过血脑屏障的GPR61反向激动剂；一种孤儿G蛋白偶联受体

Journal of Medicinal Chemistry
IF6.8
2026-03-150
PRE
Ethan L. Fisher; Anne-Marie Dechert Schmitt; Jamison B. Tuttle; Ray Unwalla; Gabrielle H. Lovett; Bethany L. Kormos; Karen J. Coffman; Dahui Zhou; Michael Moran; Jade Williams; Jun Xiao; Erik A. LaChapelle; Jean-Philippe Fortin; Abdul Q. Sheikh; Kimberly A. Stevens; Jimmy X. Kong; Emily A. G. Hughes; Ryan M. Esquejo; Stephanie Joaquim; Nalissa L. Amar; Danielle Archambault; Jeonifer Garren; Danna Breen; Srinath Jagarlapudi; Robert Dullea; Rebecca E. O’Connor; Erika Koslov-Davino; Ernesto Callegari; João M. Dias; Joshua A. Lees; Kris Borzilleri; Seungil Han; Jonathan Brooks; Felix F. Vajdos; Ashish Goyal; Lei Zhang; Yuan Zhang
GIPR signaling modulates PYY-induced hypophagia and malaise in rodents

GIPR信号通路调节啮齿动物中PYY诱导的食欲减退和不适感。

Molecular Metabolism
IF6.6
2026-02-100
OAAI
Tito Borner; Allison M. Pataro; Genevieve R. Curtis; Brandon Alonso; Jiayin Hu; Samantha M. Fortin; Richa Koul-Tiwari; Emily Hughes; Jimmy X. Kong; Emily Jordan; Robert Barnes; Barbara Bernardo; Maxwell Gardner; Wenzhe Ma; James R. Gosset; Ryan M. Esquejo; Jean-Philippe Fortin; Bart C. De Jonghe; Kendra K. Bence; Matthew R. Hayes
Uncovering the role of Gpr45 in obesity regulation

揭示Gpr45在肥胖调控中的作用

Molecular Metabolism
IF6.6
2025-05-290
OA
Eva O. Karolczak; Chia Li; Ivan C. Alcantara; Isabel M. Cohen; Claire Gao; Cuiying Xiao; Abigail I. Goldschmidt; Cynthia A. Pinkus; Junjie Li; Monica M. Li; Ryan M. Esquejo; Jean-Philippe Fortin; Kendra K. Bence; Marc L. Reitman; Michael J. Krashes
Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity
NATURE COMMUNICATIONS
IF15.7
2023-07-043
OAAI
Flaherty III, Stephen E.; Bezy, Olivier; Zheng, Wei; Yan, Dong; Li, Xiangping; Jagarlapudi, Srinath; Albuquerque, Bina; Esquejo, Ryan M.; Peloquin, Matthew; Semache, Meriem; Mancini, Arturo; Kang, Liya; Drujan, Doreen; Breitkopf, Susanne B.; Griffin, John D.; Jean Beltran, Pierre M.; Xue, Liang; Stansfield, John; Pashos, Evanthia; Shakey, Quazi; Pehmoller, Christian; Monetti, Mara; Birnbaum, Morris J.; Fortin, Jean-Philippe; Wu, Zhidan
AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism

AMPK激活足以增加骨骼肌葡萄糖摄取和糖原合成，但不是收缩介导的葡萄糖代谢增加所必需的

HELIYON
IF3.6
2022-10-016
OAAI
Esquejo, Ryan M.; Albuquerque, Bina; Sher, Anna; Blatnik, Matthew; Wald, Kyle; Peloquin, Matthew; Delmore, Jake; Kindt, Erick; Li, Wenlin; Young, Jamey D.; Cameron, Kim; Miller, Russell A.
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates

GDF-15中和减轻了基于铂的化疗引起的小鼠和非人灵长类动物的呕吐，厌食和体重减轻

CELL METABOLISM
IF30.9
2020-12-0199
OAAI
Breen, Danna M.; Kim, Hanna; Bennett, Donald; Calle, Roberto A.; Collins, Susie; Esquejo, Ryan M.; He, Tao; Joaquim, Stephanie; Joyce, Alison; Lambert, Matthew; Lin, Laura; Pettersen, Betty; Qiao, Shuxi; Rossulek, Michelle; Weber, Gregory; Wu, Zhidan; Zhang, Bei B.; Birnbaum, Morris J.
Growth differentiation factor 15 (GDF-15) inhibition attenuates platinum-based chemotherapy-induced emesis, anorexia and weight loss and increases survival
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Breen, Danna M.; Beaumont, Kevin; Bennett, Donald; Brosnan, Julia; Calle, Roberto; Chabot, Jeffrey R.; Collins, Susie; Cunio, Teresa; Esquejo, Ryan M.; Joaquim, Stephanie; Joyce, Alison; Kim, Hanna; Lin, Laura; Pettersen, Betty; Qiao, Shuxi; Rossulek, Michelle; Tierney, Brendan; Walters, Karen M.; Weber, Gregory; Wu, Zhidan; Zhang, Bei B.; Birnbaum, Morris J.
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

在啮齿动物和灵长类动物临床前模型中，用PF-06409577激活肝脏AMPK纠正NAFLD并降低胆固醇

EBIOMEDICINE
IF10.8
2018-05-01109
OAAI
Esquejo, Ryan M.; Salatto, Christopher T.; Delmore, Jake; Albuquerque, Bina; Reyes, Allan; Shi, Yuji; Moccia, Rob; Cokorinos, Emily; Peloquin, Matthew; Monetti, Mara; Barricklow, Jason; Bollinger, Eliza; Smith, Brennan K.; Day, Emily A.; Nguyen, Chuong; Geoghegan, Kieran F.; Kreeger, John M.; Opsahl, Alan; Ward, Jessica; Kalgutkar, Amit S.; Tess, David; Butler, Lynne; Shirai, Norimitsu; Osborne, Timothy F.; Steinberg, Gregory R.; Birnbaum, Morris J.; Cameron, Kimberly O.; Miller, Russell A.
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice

骨骼肌AMPK的激活促进非人灵长类动物和小鼠的葡萄糖处置和葡萄糖降低

CELL METABOLISM
IF30.9
2017-05-01219
OAAI
Cokorinos, Emily C.; Delmore, Jake; Reyes, Allan R.; Albuquerque, Bina; Kjobsted, Rasmus; Jorgensen, Nicolas O.; Tran, Jean-Luc; Jatkar, Aditi; Cialdea, Katherine; Esquejo, Ryan M.; Meissen, John; Calabrese, Matthew F.; Cordes, Jason; Moccia, Robert; Tess, David; Salatto, Christopher T.; Coskran, Timothy M.; Opsahl, Alan C.; Flynn, Declan; Blatnik, Matthew; Li, Wenlin; Kindt, Erick; Foretz, Marc; Viollet, Benoit; Ward, Jessica; Kurumbail, Ravi G.; Kalgutkar, Amit S.; Wojtaszewski, Jorgen F. P.; Cameron, Kimberly O.; Miller, Russell A.

研究方向

暂未获取到该数据
M
Morris J. Birnbaum
H 指数:109论文数:315被引数:5.1万
D
Danna M. Breen
H 指数:24论文数:53被引数:2,509
Z
Zhidan Wu
H 指数:38论文数:89被引数:2.3万
M
Matthew Peloquin
H 指数:10论文数:57被引数:804
S
Stephanie Joaquim
H 指数:5论文数:21被引数:433
B
Bina Albuquerque
H 指数:8论文数:21被引数:579
S
Susie M. Collins
H 指数:10论文数:40被引数:984
R
Roberto A. Calle
H 指数:31论文数:118被引数:3,612
R
Russell Miller
H 指数:23论文数:60被引数:6,516
L
Laura Lin
H 指数:30论文数:94被引数:3,129