未登录 A PHASE 1/2 TRIAL OF FOG-001, A FIRST-IN-CLASS DIRECT β-CATENIN:TCF4 INHIBITOR: SAFETY AND PRELIMINARY ANTITUMOR ACTIVITY IN ADAMANTINOMATOUS CRANIOPHARYNGIOMA (ACP) PATIENTS I期/II期FOG-001试验：一种首创的、直接作用于β-CATENIN:TCF4的抑制剂，在成釉细胞瘤性颅咽管瘤（ACP）患者中的安全性及初步抗肿瘤活性研究 Papadopoulos, Kyriakos P.; Brastianos, Priscilla K.; Cecchini, Michael; Khushman, Moh'd; Kummar, Shivaani; Pelster, Meredith; Rodon, Jordi; Sharma, Sunil; Yaeger, Rona; Rojo, Jonathan; Wells, Amber L.; Tipps, Megan; Berry, Wade; Garofalo, Amanda; Akella, Lalith; Yu, Ziyang; Ramos, Jorge D.; Nguyen, Marie Huong; Orford, Keith; Klempner, Samuel J. 分享 收藏
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Establishment and characterization of XPDX models with acquired or conditioned resistance to KRASG12C inhibitors Moriarty, A.; Flores, J.; Johnson, S.; Cesenes, P.; Graciano, G.; Lund, J.; Banos, N.; Papadopoulos, K.; Patnaik, A.; Rasco, D.; Moreno, V.; DeMiguel, M.; Wick, M. 分享 收藏
Initial results from a phase I/II study of BT7480, a novel nectin-4/CD137 bicycle tumor-targeted immune cell agonist, in patients (pts) with advanced solid tumors BT7480的一项I/II期研究初步结果，BT7480是一种新型的nectin-4/CD137双环肿瘤靶向免疫细胞激动剂，用于治疗晚期实体瘤患者(pts)。 Papadopoulos, K. P.; Dowlati, A.; Lopez, J. S.; Rodon, J.; Spira, A. I.; Stein, M.; Zibelman, M.; Feliu, W. I. Ortuzar; Dickson, A.; De, A.; Gu, X.; Cohen, H.; Li, M.; Bader, J.; Bray, C.; Santos, S.; Smith, J.; Lis, R.; Evans, T. R. J. 分享 收藏
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Open-label, dose-escalation FIGHT-101 study of pemigatinib combined with targeted therapy, chemotherapy, or immunotherapy in patients with advanced malignancies Saleh, M.; Barve, M.; Subbiah, V.; Papadopoulos, K. P.; Morgensztern, D.; Mettu, N. B.; Roychowdhury, S.; Spanggaard, I.; Veronese, M. L.; Tian, C.; Silverman, I. M.; Gutierrez, M. 分享 收藏
Activity of alpelisib in a panel of breast XPDX models harboring hotspot and uncommon PIK3CA mutations Castaneda, Mercedes; Simonson, Alyssa; Flores, Johnnie; DeBoer, Maci; Lund, Jim; Rouzbahan, Tahmi; Papadopoulos, Kyriakos P.; Lang, Amy; Rodriguez, Gladys; Elmi, Maryam; Rosenthal, Arthur; Rasco, Drew; Moreno, Victor; Patnaik, Amita; Hernandez, Tatiana; Calvo, Emiliano; Smith, Lon; Sharma, Manish; Beeram, Muralidhar; Wick, Michael 分享 收藏
Enfortumab vedotin (EV): Correlation of estrogen receptor status and Nectin-4 expression with single agent efficacy in breast XPDX models Moreno, Crystal; Flores, Johnnie; Simonson, Alyssa; DeBoer, Maci; Banos, Natalia; Diaz, Armando, III; Lynch, Morgan; Lund, Jim; Leykum, Leonora; Rouzbahan, Tahmi; Pedregal, Manuel; Papadopoulos, Kyriakos P.; Lang, Amy; Rosenthal, Arthur; Rasco, Drew; Rodriguez, Gladys; Rodriguez, Luis; Lakhani, Nehal; Beeram, Muralidhar; Patnaik, Amita; De Miguel, Maria; Drengler, Ronald; Abbate, Steven; Uribe, Bernard Doger de Speville; Wick, Michael 分享 收藏
A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with BRAF-Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation Yaeger, Rona; McKean, Meredith A.; Haq, Rizwan; Beck, J. Thaddeus; Taylor, Matthew H.; Cohen, Jonathan E.; Bowles, Daniel W.; Gadgeel, Shirish M.; Mihalcioiu, Catalin; Papadopoulos, Kyriakos P.; Diamond, Eli L.; Sturtz, Keren B.; Feng, Gang; Drescher, Stefanie K.; Reddy, Micaela B.; Sengupta, Bhaswati; Maity, Arnab K.; Brown, Suzy A.; Singh, Anurag; Brown, Eric N.; Baer, Brian R.; Wong, Jim; Mou, Tung-Chung; Wu, Wen-, I; Kahn, Dean R.; Gadal, Sunyana; Rosen, Neal; Gaudino, John J.; Lee, Patrice A.; Hartley, Dylan P.; Rothenberg, S. Michael 分享 收藏
Phase 1 trial of PF-07799933 ( ARRY-440), a next-generation BRAF inhibitor, for BRAF-mutant cancers Yaeger, Rona; McKean, Meredith; Haq, Rizwan; Beck, Joseph T.; Taylor, Matthew H.; Cohen, Jonathan; Bowles, Daniel; Gadgeel, Shirish M.; Mihalcioiu, Catalin; Papadopoulos, Kyriakos P.; Diamond, Eli L.; Sturtz, Keren B.; Feng, Gang; Drescher, Stefanie K.; Reddy, Micaela B.; Sengupta, Bhaswati; Maity, Arnab K.; Brown, Suzy A.; Singh, Anurag; Brown, Eric N.; Baer, Brian R.; Wong, Jim; Mou, Tung-Chung; Wu, Wen I.; Kahn, Dean; Gadal, Sunyana; Rosen, Neal; Gaudino, John J.; Lee, Patrice A.; Hartley, Dylan P.; Rothenberg, Stephen Michael 分享 收藏
Establishment and characterization of a panel of naive and pretreated small cell lung cancer (SCLC) XPDX models Morales, Gabriela Huelgas; Forofontov, Peter; Flores, Johnnie; Simonson, Alyssa; Diaz, Armando, III; Lund, Jim; Banos, Natalia; Papadopoulos, Kyriakos; Rasco, Drew; Patnaik, Amita; Abedi, Ali; Puente, Napoleon; Calvo, Emiliano; Moreno, Victor; Drengler, Ronald; Smith, Lon; Wick, Michael 分享 收藏
Enfortumab vedotin (EV): Efficacy comparison with trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) and its potential for combination benefit in bladder cancer XPDX models Flores, Johnnie; Sessions, Heaven; Simonson, Alyssa; Banos, Natalia; Rouzbahani, Tahmineh; Diaz, Armando, III; Lund, Jim; Calvo, Emiliano; Moreno, Victor; Papadopoulos, Kyriakos; Rasco, Drew; Patnaik, Amita; Ulmer, Scott; Rodriguez, Luis; Wick, Michael 分享 收藏
Phase I LITESPARK-001 study of belzutifan for advanced solid tumors: Extended 41-month follow-up in the clear cell renal cell carcinoma cohort Beztifan治疗晚期实体瘤的I期LITESPARK-001研究: 在透明细胞肾细胞癌队列中延长41个月的随访 Jonasch, Eric; Bauer, Todd M.; Papadopoulos, Kyriakos P.; Plimack, Elizabeth R.; Merchan, Jaime R.; Mcdermott, David F.; Michaelson, M. Dror; Appleman, Leonard J.; Roy, Ananya; Perini, Rodolfo F.; Liu, Yanfang; Choueiri, Toni K. 分享 收藏
Preliminary safety and anti-tumor activity of RMC-6291, a first-in-class, tri-complex KRASG12C(ON) inhibitor, in patients with or without prior KRASG12C(OFF) inhibitor treatment Janne, Pasi A.; Bigot, Frederic; Papadopoulos, Kyriakos; Eberst, Lauriane; Sommerhalder, David; Lebellec, Loic; Voon, Pei Jye; Pellini, Bruna; Kalinka, Ewa; Arbour, Kathryn; Herzberg, Benjamin; Boni, Valentina; Bordenave, Stephanie; Lee, Hyun Woo; Ou, Sai I.; Riess, Jonathan Wesley; Beck, Joseph T.; Ponz-Sarvise, Mariano; Ascierto, Paolo Antonio; Choi, Yoon Ji; Yang, Michelle; Bao, Lei; Raman, Rakesh; Yang, Luxi; Mu, Yunming; Wong, Sofia; Dua, Richa; Johnson, Melissa 分享 收藏
Establishment and characterization of a panel of prostate cancer XPDX models with differential AR-V7 staining and enzalutamide response Lund, Jim; Flores, Johnnie; Simonson, Alyssa; Diaz, Armand, III; Knol, Jared; Kella, Naveen; Rasco, Drew; Papadopoulos, Kyriakos P.; Campbell, Mark; Wick, Michael J. 分享 收藏
Phase I/II, open-label study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of SNS-101 (anti-VISTA) as monotherapy and in combination with cemiplimab in patients (pts) with advanced solid tumors Papadopoulos, K. P.; Call, J. A.; Sen, S.; Smith, D.; van der Horst, E. 分享 收藏
Phase I study of ABBV-706, an anti-SEZ6 antibody-drug conjugate, alone or in combination in adults with advanced solid tumors Chandana, S.; Garmezy, B.; Dowlati, A.; Sharma, M. R.; Henner, W.; Robinson, R.; Hingorani, P.; Jeng, E.; Papadopoulos, K. P. 分享 收藏
A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH, in advanced IDH-mutant cholangiocarcinoma and other solid tumors Rodon, Jordi; Goyal, Lipika; Mercade, Teresa Macarulla; Ikeda, Masafumi; Kondo, Shunsuke; Oh, Do-Youn; Bai, Li-Yuan; Ueno, Makoto; Italiano, Antoine; Papadopoulos, Kyriakos; Spigel, David; Kizilbash, Sani H.; Cosman, Rasha; Park, Joon Oh; Chen, Li-Tzong; Yokota, Tomoya; Turk, Anita A.; Liao, Chih-Yi; Shroff, Rachna; El-Khoueiry, Anthony; Satoh, Taroh; Hollebecque, Antoine; Borad, Mitesh J.; Azad, Nilofer; Jaeckle, Kurt A.; Loong, Herbert H.; Adeva, Jorge; Yong, Wei Peng; Zhao, Junjie; Liu, Hui; Szpurka, Anna M.; Gueorguieva, Ivelina; Pradhan, Kamnesh R.; Xu, Xiaojian; Harding, James J. 分享 收藏
Phase 1/2 study of the safety, pharmacokinetics, and preliminary clinical activity of BT7480 in patients with nectin-4 associated advanced malignancies Evans, Thomas R.; Dowlati, Afshin; Lopez, Juanita S.; Milhem, Mohammed M.; Ahnert, Jordi Rodon; Spira, Alexander; Carvajal, Richard D.; Zibelman, Matthew; Hazard, Sebastien J.; Dickson, Amy; Xu, Lei; Cohen, Heather; Bader, Justin; Hurov, Kristen; Sharma, Rajiv; Smethurst, Dominic; Papadopoulos, Kyriakos P. 分享 收藏
Preliminary analysis of pharmacokinetic (PK) and target engagement biomarkers from a first in human phase 1 study of immunomodulatory aryl hydrocarbon receptor (AhR) inhibitor BAY2416964 Papadopoulos, Kyriakos; Cecchini, Michael; Lopez, Juanita S.; Jager, Dirk; Chung, Ki Young; Platten, Michael; Prinz, Florian; Ishii, Yuko; Schaer, David; Gutcher, Ilona; Leder, Gabriele; Pencheva, Radost; Wagener, Thomas; Scheerans, Christian; Zieschang, Carsten; Wagner, Andrea; Stamatelos, Spyros; Dumbrava, Ecaterina 分享 收藏
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