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Acasunlimab, an Fc-inert PD-L1x4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects Acasunlimab，一种Fc无活性PD-L1x4-1BB双特异性抗体，与PD-1阻断联合应用可通过互补的免疫调节效应增强抗肿瘤免疫。 Capello, Michela; Sette, Angelica; Plantinga, Theo; Thalhauser, Craig J.; Spires, Vanessa M.; Nuermberger, Kristina B.; Blum, Jordan M.; Higgs, Brandon W.; Garrido Castro, Patricia; Yu, Christina; Costa Sa, Carol; Fellermeier-Kopf, Sina; Burm, Saskia M.; Strumane, Kristin; Toker, Aras; Imle, Andrea; de Andrade Pereira, Bruna; Muik, Alexander; Ahmadi, Tahamtan; Tuereci, Oezlem; Fereshteh, Mark; Sahin, Ugur; Jure-Kunkel, Maria; Pencheva, Nora 分享 收藏
Immunity against conserved epitopes dominates after two consecutive exposures to SARS-CoV-2 Omicron BA.1 Muik, Alexander; Quandt, Jasmin; Lui, Bonny Gaby; Bacher, Maren; Lutz, Sebastian; Gruenenthal, Maika; Toker, Aras; Grosser, Jessica; Ozhelvaci, Orkun; Blokhina, Olga; Shpyro, Svetlana; Vogler, Isabel; Salisch, Nadine; Tuereci, Ozlem; Sahin, Ugur 分享 收藏
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DuoBody-EpCAMx4-1BB mediates conditional T cell co-stimulation and promotes antitumor activity in preclinical Fellermeier-Kopf, S.; Ioan-Facsinay, A.; Imle, A.; Diks, A. M.; Nuermberger, K. B.; Guelen, L.; Koehne, M.; Houtkamp, M.; Toker, A.; Burm, S. M.; Gamse, J.; Janaitis, C.; Satijn, D.; Muik, A.; Ahmadi, T.; Tuereci, O.; Kemper, K.; Sahin, U.; Breij, E. 分享 收藏
Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T cell immunity Muik, Alexander; Lui, Bonny Gaby; Quandt, Jasmin; Diao, Huitian; Fu, Yunguan; Bacher, Maren; Gordon, Jessica; Toker, Aras; Grosser, Jessica; Ozhelvaci, Orkun; Grikscheit, Katharina; Hoehl, Sebastian; Kohmer, Niko; Lustig, Yaniv; Regev-Yochay, Gili; Ciesek, Sandra; Beguir, Karim; Poran, Asaf; Vogler, Isabel; Tuereci, Oezlem; Sahin, Ugur 分享 收藏
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SARS-CoV-2 Omicron variants: burden of disease, impact on vaccine effectiveness and need for variant-adapted vaccines (vol 14, 1130539, 2023) Pather, Shanti; Madhi, Shabir A. A.; Cowling, Benjamin J. J.; Moss, Paul; Kamil, Jeremy P. P.; Ciesek, Sandra; Muik, Alexander; Tuereci, Oezlem 分享 收藏
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GEN1046 (DuoBody®-PD-L1x4-1BB) in combination with PD-1 blockade potentiates anti-tumor immunity Capello, Michela; Sette, Angelica; Plantinga, Theo; Spires, Vanessa; Nuermberger, Kristina; Blum, Jordan; Muik, Alexander; Sa, Carol Costa; Jabado, Omar; Burm, Saskia; Toker, Aras; Fellermeier-Kopf, Sina; Ahmadi, Tahi; Higgs, Brandon; Couto, Suzana; Tureci, Ozlem; Fereshteh, Mark; Sahin, Ugur; Jure-Kunkel, Maria; Pencheva, Nora 分享 收藏
GEN1042 (DuoBody-CD40x4-1BB)®in combination with PD-1 blockade reverses T-cell exhaustion in vivo Spires, Vanessa M.; Masters, Gregg; Yu, Christina; Hancock, Matt; Luijten, Monique N.; Muik, Alexander; Nuermberger, Kristina; Gieseke, Friederike; Ahmadi, Tahamtan; Tureci, Ozlem; Jure-Kunkel, Maria; Sahin, Ugur; Fereshteh, Mark; Adams, Homer C.; Blum, Jordan M. 分享 收藏
Neutralization of BA.4-BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine 用二价疫苗中和BA.4-BA.5、BA.4.6、BA.2.75.2、BQ.1.1和XBB.1 Zou, Jing; Kurhade, Chaitanya; Patel, Sohil; Kitchin, Nicholas; Tompkins, Kristin; Cutler, Mark; Cooper, David; Yang, Qi; Cai, Hui; Muik, Alexander; Zhang, Ying; Lee, Dung-Yang; Sahin, Ugur; Anderson, Annaliesa S.; Gruber, William C.; Xie, Xuping; Swanson, Kena A.; Shi, Pei-Yong 分享 收藏
Early computational detection of potential high-risk SARS-CoV-2 variants Beguir, Karim; Skwark, Marcin J.; Fu, Yunguan; Pierrot, Thomas; Carranza, Nicolas Lopez; Laterre, Alexandre; Kadri, Ibtissem; Korched, Abir; Lowegard, Anna U.; Lui, Bonny Gaby; Saenger, Bianca; Liu, Yunpeng; Poran, Asaf; Muik, Alexander; Sahin, Ugur 分享 收藏
Toxicological Assessments of a Pandemic COVID-19 Vaccine-Demonstrating the Suitability of a Platform Approach for mRNA Vaccines Rohde, Cynthia M.; Lindemann, Claudia; Giovanelli, Michael; Sellers, Rani S.; Diekmann, Jan; Choudhary, Shambhunath; Ramaiah, Lila; Vogel, Annette B.; Chervona, Yana; Muik, Alexander; Sahin, Ugur 分享 收藏
Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccineexperienced humans and mice 在疫苗经验丰富的人类和小鼠中，暴露于BA.4/5 s蛋白会中和Omicron BA.1，BA.2，BA.2.12.1和BA.4/5 Muik, Alexander; Lui, Bonny Gaby; Bacher, Maren; Wallisch, Ann-Kathrin; Toker, Aras; Couto, Carla Iris Cadima; Gueler, Alptekin; Mampilli, Veena; Schmitt, Geneva J.; Mottl, Jonathan; Ziegenhals, Thomas; Fesser, Stephanie; Reinholz, Jonas; Wernig, Florian; Schraut, Karla-Gerlinde; Hefesha, Hossam; Cai, Hui; Yang, Qi; Walzer, Kerstin C.; Grosser, Jessica; Strauss, Stefan; Finlayson, Andrew; Kruger, Kimberly; Ozhelvaci, Orkun; Grikscheit, Katharina; Kohmer, Niko; Ciesek, Sandra; Swanson, Kena A.; Vogel, Annette B.; Tuereci, Oezlem; Sahin, Ugur 分享 收藏
Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trial BNT162b2 mRNA疫苗在中国成年人中的免疫原性和安全性: 一项2期随机临床试验 Hui, Ai -Min; Li, Jingxin; Zhu, Li; Tang, Rong; Ye, Huayue; Lin, Mei; Ge, Lei; Wang, Xiyuan; Peng, Fuzhong; Wu, Zhenggang; Guo, Xiling; Shi, Yunfeng; Pan, Hongxing; Zhu, Jiahong; Song, Zhizhou; Qiu, Jingjun; Wang, Wei; Zheng, Jianfei; Ozhelvaci, Orkun; Shpyro, Svetlana; Bushway, Meghan; Derhovanessian, Evelyna; Kuhnle, Marie-Cristine; Luxemburger, Ulrich; Muik, Alexander; Shishkova, Yoana; Khondker, Zakaria; Hu, Simin; Lagkadinou, Eleni; Sahin, Ugur; Tureci, Ozlem; Zhu, Fengcai 分享 收藏
Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes Quandt, Jasmin; Muik, Alexander; Salisch, Nadine; Lui, Bonny Gaby; Lutz, Sebastian; Krueger, Kimberly; Wallisch, Ann-Kathrin; Adams-Quack, Petra; Bacher, Maren; Finlayson, Andrew; Ozhelvaci, Orkun; Vogler, Isabel; Grikscheit, Katharina; Hoehl, Sebastian; Goetsch, Udo; Ciesek, Sandra; Tuereci, Oezlem; Sahin, Ugur 分享 收藏
Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection 三剂BNT162b2疫苗或BA.1感染对Omicron亚谱系和deltaacron SARS-CoV-2的中和作用 Kurhade, Chaitanya; Zou, Jing; Xia, Hongjie; Liu, Mingru; Yang, Qi; Cutler, Mark; Cooper, David; Muik, Alexander; Sahin, Ugur; Jansen, Kathrin U.; Ren, Ping; Xie, Xuping; Swanson, Kena A.; Shi, Pei-Yong 分享 收藏
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