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石乐明 封面图

石乐明 (Leming Shi)

fudan university邮箱:lemingshi@fudan.edu.cn
H指数:60
被引数:2.3万

个人简介

现任上海国际人类表型组研究院院长、复旦大学生命科学学院和附属肿瘤医院特聘教授、国家特聘专家、国际MAQC组学大数据质量控制学会首任主席和首席科学官，深圳微芯生物联合创始人。曾担任美国FDA资深PI十余年。主要研究方向为基于高质量大数据的精准医药创新，通过确保生物医学大数据产生、分析和整合的高质量、标准化和可靠性，建立挖掘可靠药物靶标和生物标志物的坚实基础。代表性成果包括创建化学基因组学药物研发平台，为1.1类抗癌新药西达本胺和1.1类抗糖尿病新药西格列他钠共同发明人；共同建立三阴性乳腺癌的精准分子分型和精准用药体系；领导研制全球首套多组学标准物质，创立基于比例定量(SRR)的多组学测量新范式，该进展被遴选为《中国2023年度重要医学进展》之一；创立国际MAQC组学大数据质量控制联盟。在组学数据质量控制与标准化方面的开创性工作被国际同行广泛采用，Nature Biotechnology评价其从根本上改变了组学数据分析的实践。

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

  1. 国家特聘专家
Ensuring multiomics data reproducibility for artificial intelligence with reference materials as a common calibrator

使用参考材料作为通用校准器，确保人工智能的多组学数据重现性

Nature Biotechnology
IF41.7
2026-09-010
PRE
Leming Shi; Wenjun Bao; Aedín C. Culhane; Xiang Fang; Cesare Furlanello; Ruixin Hao; Wendell D. Jones; Rebecca Kusko; Samir Lababidi; Christopher E. Mason; Andreas Scherer; Shraddha Thakkar; Weida Tong; Russell D. Wolfinger; Joshua Xu; Ying Yu; Rui Zhang; Yuanting Zheng
Distinct multi-omics signatures of clinical subgroups of type 2 diabetes define heterogeneous responses to an insulin sensitizer

2型糖尿病临床亚组的多组学特征差异定义了其对胰岛素增敏剂的异质性反应

Nature Communications
IF15.7
2026-08-290
OA
Zehui Cao; Ruolan Zhang; Haonan Chen; Naixin Zhang; Qiaochu Chen; Yuanbang Mai; Xintong Yao; Qingwang Chen; Jiaqi Li; Desi Pan; Linong Ji; Weiping Jia; Xianping Lu; Antonio Vidal-Puig; Leming Shi; Yan Zheng; Yuanting Zheng
The Influence of Sleep and Diet on Human Peripheral Immunity and Chronic Health Conditions

睡眠和饮食对人类外周免疫及慢性健康条件的影响

Research
IF10.7
2026-02-190
OA
Yiran Zhao; Wenran Li; Bingjie Li; Siyu Zhou; Xianlei Zhao; Qi Wang; Yingyu Cheng; Yali Luo; Jingxuan Han; Xuling Han; Helian Li; Jian Gao; Jialin Zhao; Zhonghan Sun; Mengmeng Kong; Xiaofeng Zhou; Ying Yu; Wanwan Hou; Qinsheng Chen; Jingxian Zhang; Xiaofeng Wang; Jingchun Luo; Li Jin; Leming Shi; Yan Zheng; ; ; Huiru Tang; Sijia Wang; Feng Qian
Methylation reference datasets from quartet DNA materials for benchmarking epigenome sequencing

四倍体DNA材料甲基化参考数据集，用于表观基因组测序的基准测试

Nature Communications
IF15.7
2025-10-160
OAAI
Xiaorou Guo; Qingwang Chen; Yuanfeng Zhang; Yujing Zhang; Yaqing Liu; Shumeng Duan; Yu Ma; Peng Ni; Jianxin Wang; Bo He; Luyao Ren; Ruiwen Ma; Wanwan Hou; Ying Yu; Bingsi Li; Fujun Qiu; Yuan Sun; Zhihong Zhang; Weihong Xu; Xiang Fang; Jinming Li; Leming Shi; Rui Zhang; Yuanting Zheng; Lianhua Dong
A standardized framework for circulating blood proteomics

循环血液蛋白质组学的标准化框架

Nature Genetics
IF0
2025-09-230
PRE
Xue Cai; Philipp E. Geyer; Yasset Perez-Riverol; Gilbert S. Omenn; Lianhua Dong; Robert Winkler; Sara Ahadi; Philip Lössl; Xiaobo Yu; Cheng Chang; Markus Ralser; Connie R. Jimenez; Yang Zhao; Yu-Ju Chen; Terence C. W. Poon; Nicolai Bache; Leming Shi; Xinhua Dai; Ziyue Wang; Yi Zhu; Xiang Fang; Jochen M. Schwenk; Jennifer E. Van Eyk; Uwe Völker; Tiannan Guo
Evaluative Methodology for HRD Testing: Development of Standard Tools for Consistency Assessment

贾 Z, 刘 Y, 曲 S, 李 W, 高 L, 董L, 等人. 人力资源开发测试的评估方法：一致性评估标准工具的开发. 基因组学与蛋白质组学信息学. (2025) 23:qzaf017. doi: 10.1093/gpbjnl/qzaf017

GENOMICS PROTEOMICS & BIOINFORMATICS
IF7.9
2025-01-010
OA
Zheng Jia; Yaqing Liu; Shoufang Qu; Wenbin Li; Lin Gao; Lin Dong; Yun Xing; Yadi Cheng; Huan Fang; Yuting Yi; Yuxing Chu; Chao Zhang; Yanming Xie; Chunli Wang; Zhe Li; Zhihong Zhang; Zhipeng Xu; Yang Wang; Wenxin Zhang; Xiaoping Gu; Shuang Yang; Jinghua Li; Liangshen Wei; Yuanting Zheng; Guohui Ding; Leming M. Shi; Xin Yi; Jianming Ying; Jie Huang
Evaluation of somatic copy number variation detection by NGS technologies and bioinformatics tools on a hyper-diploid cancer genome
GENOME BIOLOGY
IF9.4
2024-06-200
OAAI
Masood, Daniall; Ren, Luyao; Nguyen, Cu; Brundu, Francesco G.; Zheng, Lily; Zhao, Yongmei; Jaeger, Erich; Li, Yong; Cha, Seong Won; Halpern, Aaron; Truong, Sean; Virata, Michael; Yan, Chunhua; Chen, Qingrong; Pang, Andy; Alberto, Reyes; Xiao, Chunlin; Yang, Zhaowei; Chen, Wanqiu; Wang, Charles; Cross Jr, Frank; Catreux, Severine; Shi, Leming; Beaver, Julia A.; Xiao, Wenming; Meerzaman, Daoud M.
Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits
NATURE GENETICS
IF31.8
2024-04-193
OA
Peng, Qianqian; Liu, Xinxuan; Li, Wenran; Jing, Han; Li, Jiarui; Gao, Xingjian; Luo, Qi; Breeze, Charles E.; Pan, Siyu; Zheng, Qiwen; Li, Guochao; Qian, Jiaqiang; Yuan, Liyun; Yuan, Na; You, Chenglong; Du, Siyuan; Zheng, Yuanting; Yuan, Ziyu; Tan, Jingze; Jia, Peilin; Wang, Jiucun; Zhang, Guoqing; Lu, Xianping; Shi, Leming; Guo, Shicheng; Liu, Yun; Ni, Ting; Wen, Bo; Zeng, Changqing; Jin, Li; Teschendorff, Andrew E.; Liu, Fan; Wang, Sijia
Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project
SCIENTIFIC REPORTS
IF3.9
2024-03-254
OAAI
Gong, Binsheng; Li, Dan; Zhang, Yifan; Kusko, Rebecca; Lababidi, Samir; Cao, Zehui; Chen, Mingyang; Chen, Ning; Chen, Qiaochu; Chen, Qingwang; Dai, Jiacheng; Gan, Qiang; Gao, Yuechen; Guo, Mingkun; Hariani, Gunjan; He, Yujie; Hou, Wanwan; Jiang, He; Kushwaha, Garima; Li, Jian-Liang; Li, Jianying; Li, Yulan; Liu, Liang-Chun; Liu, Ruimei; Liu, Shiming; Meriaux, Edwin; Mo, Mengqing; Moore, Mathew; Moss, Tyler J.; Niu, Quanne; Patel, Ananddeep; Ren, Luyao; Saremi, Nedda F.; Shang, Erfei; Shang, Jun; Song, Ping; Sun, Siqi; Urban, Brent J.; Wang, Danke; Wang, Shangzi; Wen, Zhining; Xiong, Xiangyi; Yang, Jingcheng; Yin, Lihui; Zhang, Chao; Zhang, Ruolan; Bhandari, Ambica; Cai, Wanshi; Eterovic, Agda Karina; Megherbi, Dalila B.; Shi, Tieliu; Suo, Chen; Yu, Ying; Zheng, Yuanting; Novoradovskaya, Natalia; Sears, Renee L.; Shi, Leming; Jones, Wendell; Tong, Weida; Xu, Joshua

研究方向

基于高质量大数据的精准医药创新化学基因组学药物研发多组学标准物质多组学数据质量控制与标准化精准医学
Y
Yuanting Zheng
H 指数:38论文数:160被引数:5,586
郁
郁颖
H 指数:45论文数:233被引数:8,854
W
Weida Tong
H 指数:82论文数:556被引数:3.0万
H
Huixiao Hong
H 指数:73论文数:387被引数:2.0万
J
Jingcheng Yang
H 指数:21论文数:96被引数:2,485
B
Baitang Ning
H 指数:45论文数:173被引数:1.1万
任
任路瑶
H 指数:19论文数:91被引数:2,400
Q
Qingwang Chen
H 指数:14论文数:55被引数:718
Y
Yaqing Liu
H 指数:16论文数:89被引数:1,110
W
Wanwan Hou
H 指数:15论文数:81被引数:1,767