D. Luke Fischer; Lea T. Grinberg; Jared T. Ahrendsen; Thomas G. Beach; Kevin F. Bieniek; Rudolph J. Castellani; Rati Chkheidze; Inma Cobos; Mark Cohen; John F. Crary; Dennis W. Dickson; Brittany N. Dugger; Sara R. Dunlop; Kurt Farrell; Bernardino Ghetti; Mohammad Haeri; William Harrison; Elizabeth Head; Annie Hiniker; Eric J. Huang; Anita Huttner; Pouya Jamshidi; Alifiya Kapasi; C. Dirk Keene; Julia Kofler; Caitlin S. Latimer; Ann C. McKee; Karin Mente; Michael B. Miller; Thomas J. Montine; Meaghan Morris; Melissa E. Murray; Peter T. Nelson; Kathy L. Newell; Richard J. Perrin; Biswarathan Ramani; R. Ross Reichard; Subhojit Roy; Johannes C. M. Schlachetzki; William W. Seeley; Geidy E. Serrano; Salvatore Spina; Andrew F. Teich; Shih-Hsiu J. Wang; Thomas Wisniewski; Edward B. Lee

Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders

结合血浆神经丝蛋白轻链和额颞叶萎缩，可提高对bvFTD与原发性精神障碍的鉴别诊断能力。

Alzheimer's & Dementia

IF11.1

2025-10-080

OAAI

Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease

连接性作为非典型阿尔茨海默病中tau进展的通用预测因子。

BRAIN

IF11.7

2025-10-012

PRE

de Bruin, Hannah; Groot, Colin; Barthel, Henryk; Bischof, Gerard N.; Blazhenets, Ganna; Boellaard, Ronald; Boon, Baayla D. C.; Brendel, Matthias; Cash, David M.; Coath, William; Day, Gregory S.; Dickerson, Bradford C.; Doering, Elena; Drzezga, Alexander; van Dyck, Christopher H.; van Eimeren, Thilo; van der Flier, Wiesje M.; Fredericks, Carolyn A.; Fryer, Tim D.; van de Giessen, Elsmarieke; Gordon, Brian A.; Graff-Radford, Jonathan; Grinberg, Lea T.; Hansson, Oskar; Hobbs, Diana A.; Hoenig, Merle C.; Hoglinger, Gunter; Irwin, David J.; Jones, P. Simon; Josephs, Keith A.; Katsumi, Yuta; La Joie, Renaud; Lee, Edward B.; Levin, Johannes; Malpetti, Maura; Mcginnis, Scott M.; Mecca, Adam P.; Mohanty, Rosaleena; Nasrallah, Ilya M.; O'Brien, John T.; O'Dell, Ryan S.; Palleis, Carla; Perneczky, Robert; Phillips, Jeffrey S.; Putcha, Deepti; Rabinovici, Gil D.; Rahmouni, Nesrine; Rosa-Neto, Pedro; Rowe, James B.; Rullmann, Michael; Sabri, Osama; Saur, Dorothee; Schildan, Andreas; Schott, Jonathan M.; Schroeter, Matthias L.; Seeley, William W.; Servaes, Stijn; Sintini, Irene; Smith, Ruben; Spina, Salvatore; Stevenson, Jenna; Stomrud, Erik; Strandberg, Olof; Therriault, Joseph; Tideman, Pontus; Touroutoglou, Alexandra; Trainer, Anne E.; Visser, Denise; Wekselman, Fattin; Weston, Philip S. J.; Whitwell, Jennifer L.; Wolk, David A.; Yong, Keir; Pijnenburg, Yolande A. L.; Franzmeier, Nicolai; Ossenkoppele, Rik

Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype

神经发育和神经环境决定了阿尔茨海默病的发病年龄和表型

Alzheimer's & Dementia

IF11.1

2025-09-170

OAAI

Zachary A. Miller; Rik Ossenkoppele; Neill R. Graff-Radford; Isabel E. Allen; Wendy Shwe; Lynne Rosenberg; Dustin J. Olguin; Michael G. Erkkinen; P. Monroe Butler; Salvatore Spina; Jennifer S. Yokoyama; Rahul S. Desikan; Philip Scheltens; Wiesje van der Flier; Yolande Pijnenburg; Emma Wolters; Rosa Rademakers; Daniel H. Geschwind; Joel H. Kramer; Howard J. Rosen; Katherine P. Rankin; Lea T. Grinberg; William W. Seeley; Virginia Sturm; David C. Perry; Bruce L. Miller; Gil D. Rabinovici; Maria Luisa Gorno-Tempini

A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain

一项单细胞、长读长、异构体解析的FTD病例对照研究揭示了人类大脑中细胞类型特异性和广泛的剪接失调。

Cell Reports

IF6.9

2025-09-050

OAAI

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity

β-amyloid诱导小胶质细胞表达GPC4和APOE，导致神经元tau病理和毒性增加。

Molecular Neurodegeneration

IF17.5

2025-09-010

OAAI

Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U

脑转录组学揭示了aFTLD-U中非神经元细胞中丰富的基因表达和剪接改变。

Acta Neuropathologica

IF9.3

2025-08-100

OAAI

Sara Alidadiani; Júlia Faura; Sarah Wynants; Nele Peeters; Marleen Van den Broeck; Linus De Witte; Rafaela Policarpo; Simon Cheung; Cyril Pottier; Nikhil B. Ghayal; Merel O. Mol; Marka van Blitterswijk; Evan Udine; Mariely DeJesus-Hernandez; Matthew Baker; NiCole A. Finch; Yan W. Asmann; Jeroen G. J. van Rooij; Aivi T. Nguyen; R. Ross Reichard; Alissa L. Nana; Oscar L. Lopez; Adam L. Boxer; Howard J. Rosen; Salvatore Spina; Jochen Herms; Keith A. Josephs; Ronald C. Petersen; Robert A. Rissman; Annie Hiniker; Lee-Cyn Ang; Lea T. Grinberg; Glenda M. Halliday; Bradley F. Boeve; Neill R. Graff-Radford; Harro Seelaar; Manuela Neumann; Julia Kofler; Charles L. White; William W. Seeley; John C. van Swieten; Dennis W. Dickson; Ian R. A. Mackenzie; Wouter De Coster; Rosa Rademakers

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation

G-蛋白偶联受体ADGRG1通过MYC激活驱动阿尔茨海默病中的一种保护性小胶质细胞状态

Neuron

IF15

2025-07-250

PRE

Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

作者更正: 脑脊液蛋白质组的大规模网络分析确定了额颞叶变性的分子特征

Nature Aging

IF19.4

2025-07-070

OAAI

Rowan Saloner; Adam M. Staffaroni; Eric B. Dammer; Erik C. B. Johnson; Emily W. Paolillo; Amy Wise; Hilary W. Heuer; Leah K. Forsberg; Argentina Lario-Lago; Julia D. Webb; Jacob W. Vogel; Alexander F. Santillo; Oskar Hansson; Joel H. Kramer; Bruce L. Miller; Jingyao Li; Joseph Loureiro; Rajeev Sivasankaran; Kathleen A. Worringer; Nicholas T. Seyfried; Jennifer S. Yokoyama; Salvatore Spina; Lea T. Grinberg; William W. Seeley; Lawren VandeVrede; Peter A. Ljubenkov; Ece Bayram; Andrea Bozoki; Danielle Brushaber; Ciaran M. Considine; Gregory S. Day; Bradford C. Dickerson; Kimiko Domoto-Reilly; Kelley Faber; Douglas R. Galasko; Tania Gendron; Daniel H. Geschwind; Nupur Ghoshal; Neill Graff-Radford; Chadwick M. Hales; Lawrence S. Honig; Ging-Yuek R. Hsiung; Edward D. Huey; John Kornak; Walter Kremers; Maria I. Lapid; Suzee E. Lee; Irene Litvan; Corey T. McMillan; Mario F. Mendez; Toji Miyagawa; Alexander Pantelyat; Belen Pascual; Joseph Masdeu; Henry L. Paulson; Leonard Petrucelli; Peter Pressman; Rosa Rademakers; Eliana Marisa Ramos; Katya Rascovsky; Erik D. Roberson; Rodolfo Savica; Allison Snyder; Anna Campbell Sullivan; M. Carmela Tartaglia; Marijne Vandebergh; Brad F. Boeve; Howie J. Rosen; Julio C. Rojas; Adam L. Boxer; Kaitlin B. Casaletto

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

与progranulin缺乏和额颞叶痴呆相关的鞘磷脂酶活性降低

Neurobiology of Disease

IF5.6

2025-07-070

PRE

Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau

前额颞叶痴呆tau蛋白干细胞模型中的细胞自主性小胶质细胞缺陷

Molecular Psychiatry

IF10.1

2025-06-170

OAAI

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

通过全基因组测序破译ftld-tdp病理亚型的不同遗传危险因素

NATURE COMMUNICATIONS

IF15.7

2025-04-250

Pottier, Cyril; Kuecuekali, Fahri; Baker, Matt; Batzler, Anthony; Jenkins, Gregory D.; van Blitterswijk, Marka; Vicente, Cristina T.; De Coster, Wouter; Wynants, Sarah; van de Walle, Pieter; Ross, Owen A.; Murray, Melissa E.; Faura, Julia; Haggarty, Stephen J.; van Rooij, Jeroen GJ.; Mol, Merel O.; Hsiung, Ging-Yuek R.; Graff, Caroline; Oeijerstedt, Linn; Neumann, Manuela; Asmann, Yan; Mcdonnell, Shannon K.; Baheti, Saurabh; Josephs, Keith A.; Whitwell, Jennifer L.; Bieniek, Kevin F.; Forsberg, Leah; Heuer, Hilary; Lago, Argentina Lario; Geier, Ethan G.; Yokoyama, Jennifer S.; Oddi, Alexis P.; Flanagan, Margaret; Mao, Qinwen; Hodges, John R.; Kwok, John B.; Domoto-Reilly, Kimiko; Synofzik, Matthis; Wilke, Carlo; Onyike, Chiadi; Dickerson, Bradford C.; Evers, Bret M.; Dugger, Brittany N.; Munoz, David G.; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Suh, Eunran; Gefen, Tamar; Geula, Changiz; Weintraub, Sandra; Diehl-Schmid, Janine; Farlow, Martin R.; Edbauer, Dieter; Woodruff, Bryan K.; Caselli, Richard J.; Donker Kaat, Laura L.; Huey, Edward D.; Reiman, Eric M.; Mead, Simon; King, Andrew; Roeber, Sigrun; Nana, Alissa L.; Ertekin-Taner, Nilufer; Knopman, David S.; Petersen, Ronald C.; Petrucelli, Leonard; Uitti, Ryan J.; Wszolek, Zbigniew K.; Ramos, Eliana Marisa; Grinberg, Lea T.; Tempini, Maria Luisa Gorno; Rosen, Howard J.; Spina, Salvatore; Piguet, Olivier; Grossman, Murray; Trojanowski, John Q.; Keene, C. Dirk; Jin, Lee-Way; Prudlo, Johannes; Geschwind, Daniel H.; Rissman, Robert A.; Cruchaga, Carlos; Ghetti, Bernardino; Halliday, Glenda M.; Beach, Thomas G.; Serrano, Geidy E.; Arzberger, Thomas; Herms, Jochen; Boxer, Adam L.; Honig, Lawrence S.; Vonsattel, Jean P.; Lopez, Oscar L.; Kofler, Julia; White, Charles L.; Gearing, Marla; Glass, Jonathan; Rohrer, Jonathan D.; Irwin, David J.; Lee, Edward B.; Van Deerlin, Vivianna; Castellani, Rudolph; Mesulam, Marsel M.; Tartaglia, Maria C.; Finger, Elizabeth C.; Troakes, Claire; Al-Sarraj, Safa; Dalgard, Clifton L.; Miller, Bruce L.; Seelaar, Harro; Graff-Radford, Neill R.; Boeve, Bradley F.; Mackenzie, Ian RA.; van Swieten, John C.; Seeley, William W.; Sleegers, Kristel; Dickson, Dennis W.; Biernacka, Joanna M.; Rademakers, Rosa

Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra

阿尔茨海默病中选择性神经元易损性的通路：对比易损的蓝斑核与有抵抗力的黑质

ALZHEIMERS & DEMENTIA

IF11.1

2025-03-260

OAAI

Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration TDP-43 A and B

散发性和遗传性额颞叶变性TDP-43 A和B的临床和影像学特征

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

IF3.9

2025-03-010

OAAI